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| 1 | Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction显示文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction(AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography(PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3;more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance,sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients. | Wei Wu Linyang Cui Ying Fu Qianqian Tian Lei Liu Xuan Zhang Ning Du Ying Chen Zhijun Qiu Yijun Song Fu-Dong Shi Rong Xue | 2016 | Neuroscience Bulletin2016，32，4： | 28 |
| 2 | Prediction of the coupled heat radiation and conduction parameters and boundary condition using the unscented Kalman filter显示文摘The boundary emissivity, thermal conductivity, and boundary time-varying heat flux in the participating media are retrieved in this work. In the forward model, the coupled radiation-conduction heat transfer in the participating medium is resolved by the finite volume method combined with discrete ordinates method. The inverse model utilizes the temperature signals at the appropriate position of the medium as the known information and uses the unscented Kalman filter(UKF) as an optimization tool to reconstruct the boundary emissivity, thermal conductivity, and boundary time-varying heat flux. It is found that when the emissivity, thermal conductivity, and boundary time-varying heat flux are reconstructed simultaneously, only the temperature information of two locations is required. The influence of the measurement noise, sampling interval, absorption coefficient,process noise covariance, measurement noise covariance on the accuracy and stability of the retrieval results is investigated in detail. All the reconstruction results indicate that the UKF technique is effective and robust for estimating the photothermal parameters and boundary condition of the radiation-conduction heat transfer problems. | WEN Shuang QI Hong WANG YiFei REN YaTao WEI LinYang RUAN LiMing | 2020 | Science China(Technological Sciences)2020，63，3： | 2 |
| 3 | High-speed adaptive photoacoustic microscopy显示文摘Optical-resolution photoacoustic microscopy(OR-PAM)is capable of observing the distribution of optical absorbers inside bio-tissues with a high spatial resolution of micrometers.Unfortunately,due to the employment of a tight optical focus,it suffers from a limited depth of field(DOF),making it challenging to achieve highresolution imaging of targets with arbitrary surfaces.Here,we propose a high spatiotemporal adaptive photoacoustic focusing mechanism through integrating a high-speed optical focuser,a time-of-flight contour deriving algorithm,and the rotary-scanning photoacoustic microscopy.The developed system,named high-speed adaptive photoacoustic microscopy(HA-PAM),features an ultrashort focus-shifting time of 5 ms and an enlarged DOF of up to 5 mm.With the assistance of the proposed mechanism,we can achieve a homogeneous lateral resolution of 6μm over a 10 mm circular imaging domain within 5 s.We demonstrate the advantages of HA-PAM through imaging phantoms with curved surfaces,subcutaneous tumor-bearing mice,resected rabbit kidneys,and pulsating mouse brains.The imaging results suggest that this approach provides a high and consistent spatial resolution for imaging bio-tissues with arbitrary surfaces without sacrificing the imaging speed,and has the potential to extend the fundamental and clinical applications of OR-PAM. | LINYANG LI WEI QIN TINGTING LI JUNNING ZHANG BAOCHEN LI LEI XI | 2023 | Photonics Research2023，11，12： | 0 |
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