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| 1 | Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer显示文摘AIM:To investigate M2 isoform of pyruvate kinase(PKM2) expression in gastric cancers and evaluate its potential as a prognostic biomarker and an anticancer target.METHODS:All tissue samples were derived from gastric cancer patients underwent curative gastrectomy as a primary treatment.Clinical and pathological information were obtained from the medical records.Gene expression microarray data from 60 cancer and 19 noncancer gastric tissues were analyzed to evaluate the expression level of PKM2 mRNA.Tissue microarrays were constructed from 368 gastric cancer patients.Immunohistochemistry was used to measure PKM2 expression and PKM2 positivity of cancer was determined by proportion of PKM2-positive tumor cells and staining intensity.Association between PKM2 expression and the clinicopathological factors was evaluated and the correlation between PKM2 and cancer prognosis was evaluated.RESULTS:PKM2 mRNA levels were increased more than 2-fold in primary gastric cancers compared to adjacent normal tissues from the same patients(log transformed expression level:7.6 ± 0.65 vs 6.3 ± 0.51,P < 0.001).Moreover,differentiated type cancers had significantly higher PKM2 mRNA compared to undifferentiated type cancers(log transformed expression level:7.8 ± 0.70 vs 6.7 ± 0.71,P < 0.001).PKM2 protein was mainly localized in the cytoplasm of primary cancer cells and detected in 144 of 368(39.1%) human gastric cancer cases.PKM2 expression was not related with stage(P = 0.811),but strongly correlated with gastric cancer differentiation(P < 0.001).Differentiated type cancers expressed more PKM2 protein than did the undifferentiated ones.Well differentiated adenocarcinoma showed 63.6% PKM2-positive cells;in contrast,signet-ring cell cancers showed only 17.7% PKM2-positive cells.Importantly,PKM2 expression was correlated with shorter overall survival(P < 0.05) independent of stage only in signet-ring cell cancers.CONCLUSION:PKM2 expression might be an adverse prognostic factor for signet-ring cell carcinomas.Its function and potential as a prognostic marker should be further verified in gastric cancer. | Jae Yun Lim Sun Och Yoon So Young Seol Soon Won Hong Jong Won Kim Seung Ho Choi Jae Yong Cho | 2012 | World Journal of Gastroenterology2012，18，30： | 19 |
| 2 | Bacterial entombment by intratubular mineralization following orthograde mineral trioxide aggregate obturation: a scanning electron microscopy study显示文摘The time domain entombment of bacteria by intratubular mineralization following orthograde canal obturation with mineral trioxide aggregate(MTA) was studied by scanning electron microscopy(SEM). Single-rooted human premolars(n560) were instrumented to an apical size #50/0.06 using ProF ile and treated as follows: Group 1(n510) was filled with phosphate buffered saline(PBS); Group 2(n510) was incubated with Enterococcus faecalis for 3 weeks, and then filled with PBS; Group 3(n520) was obturated orthograde with a paste of OrthoM TA(BioM TA, Seoul, Korea) and PBS; and Group 4(n520) was incubated with E. faecalis for 3 weeks and then obturated with OrthoM TA–PBS paste. Following their treatments, the coronal openings were sealed with PBS-soaked cotton and intermediate restorative material(IRM), and the roots were then stored in PBS for 1, 2, 4, 8 or 16 weeks. After each incubation period, the roots were split and their dentin/MTA interfaces examined in both longitudinal and horizontal directions by SEM. There appeared to be an increase in intratubular mineralization over time in the OrthoM TA-filled roots(Groups 3 and 4). Furthermore, there was a gradual entombment of bacteria within the dentinal tubules in the E. faecalis inoculated MTA-filled roots(Group 4). Therefore, the orthograde obturation of root canals with OrthoM TA mixed with PBS may create a favorable environment for bacterial entombment by intratubular mineralization. | Jun Sang Yoo Seok-Woo Chang So Ram Oh Hiran Perinpanayagam Sang-Min Lim Yeon-Jee Yoo Yeo-Rok Oh Sang-Bin Woo Seung-Hyun Han Qiang Zhu Kee-Yeon Kum | 2014 | International Journal of Oral Science2014，6，4： | 5 |
| 3 | Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time显示文摘 | Keun Ho Ryu Hye Young Han So Young Lee Sun Duck Jeon Guang-Jin Im Bong Yong Lee Keunyoung Kim Kyung-Min Lim Jin-Ho Chung | 2009 | Thrombosis Research2009，，3： | 2 |
| 4 | Cisplatin ototoxicity involves cytokines and STAT6 signaling network显示文摘我们此处调查了在支持 inflammatory cytokines 和 cisplatin ototoxicity 的生产表明串联的 STAT 的角色。cisplatin 注射引起的一个重要听觉缺陷在 Balb/c 被观察(野类型, WT ) 并且 STAT4 −/−, 然而并非在 STAT6 −/− 老鼠。而且,蛋白质的表示层次和支持 inflammatory cytokines 的 mRNA,包括 TNF-α, IL-1β,并且 IL-6,显著地在 WT 和 STAT4 −/−, 然而并非 STAT6 −/− 老鼠的浆液和蜗被增加。Organotypic 文化表明 stereocilia 捆的形状和在从 STAT6 −/− 鼠标的 Corti 的机关的感觉毛细胞层的数组在有 cisplatin 的处理以后是未经触动的,而那些高度在处理以后从 WT 和 STAT4 −/− 鼠标被弄歪并且弄乱。Cisplatin 在 HEI-OC1 听觉的房间导致了 STAT6 的 phosphorylation,并且由显著地保护的 STAT6 特定的 siRNA 的 STAT6 击倒从导致 cisplatin 的房间死亡的 HEI-OC1 听觉的房间和禁止的支持 inflammatory cytokine 生产。我们进一步证明 cisplatin 导致的 IL-4 和 IL-13 与 IL-4 受体 alpha 和 IL-13Rα 由绑定调制了 STAT6 的 phosphorylation; 1。这些调查结果建议发信号的 STAT6 在调停 cisplatin 的支持 inflammatory cytokine 生产和 ototoxicity 起一个枢轴的作用。 | Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park | 2011 | Cell Research2011，21，6： | 2 |
| 5 | Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis显示文摘 | Hyoung‐Mo Yang Seung‐Jea Tahk Hong‐Seok Lim Myeong‐Ho Yoon So‐Yeon Choi Byoung‐Joo Choi Xiong Jie Jin Gyo‐Seung Hwang Jin‐Sun Park Joon‐Han Shin | 2014 | Intervent2014，，3： | 1 |
| 6 | Reduction of hospital stay and cost after the implementation of a clinical pathway for radical gas-trectomy for gastric cancer显示文摘 | SO J B LIM Z L LIN H A | 2008 | Gastric Cancer2008，11，： | 1 |
| 7 | Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux显示文摘 | Merati AL Lim H J Ulualp SO | 2005 | Ann Otol Rhinol Laryngol2005，114，3： | 1 |
| 8 | A national survey on the practice andoutcomes of mechanical ventilation in Korean intensive care units显示文摘 | Koh Y Lim CM Koh SO | 2009 | Anaesth Intensive Care2009，37，2： | 1 |
| 9 | Electrospinning of collagen nanofibers: Effects on behavior of normal human keratinocytes and early wound healing显示文摘 | Kyong So Rho Lim Jeong Gene Lee | 2006 | Biomaterials2006，27，： | 1 |
| 10 | Comparison of incidences of emergence delirium from sevoflurane anesthesia in school and preschool children显示文摘 | Lim KJ Choi KS So KY | | 0，，02： | 1 |
| 11 | A Study of MPEG-4 Rate Control Scheme and Its Improvements 显示文摘 | Pan F Li Z Lim K and so on | 2003 | IEEE Transactions On Circuits And Systems For Video Technology2003，13，5： | 1 |
| 12 | Notchl differentially regu- lates oncogenesis by wildtype p53 overexpressian and p53 muta- tion in grade In hepatocellular carcinoma 显示文摘 | Lim SO Park YM Kim HS | 2011 | Hepatology2011，53，4： | 1 |
| 13 | Ictal scalp EEG in temporal lobe epilepsy with unitemporal versus bitemporal interictal epileptic form discharges显示文摘 | Steinhoff BJ So NK Lim S | 1995 | Neurology1995，45，5： | 1 |
| 14 | Proteome analysis of hepatocellular carcinoma显示文摘 | Lim SO Park SJ Kim W | 2002 | Biochem Biophys Res Commun2002，291，4： | 1 |
| 15 | Endoscopic cyclophotocoagulation for the treatment of glaucoma:an Asian experience显示文摘 | Yip LW Yong SO Earnest A Ji J Lim BA | | 0，，07： | 1 |
| 16 | Proteome analysis of hepatocellular carcinoma显示文摘 | Lim SO Park S J Kim w | 2002 | Biochem Biophys Res Commun2002，291，4： | 1 |
| 17 | Meta analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux 显示文摘 | MERATI AL LIM HJ ULUALP SO | 2005 | Ann Otol Rhinol Laryngol2005，114，3： | 1 |
| 18 | Proteomics analysis of hepatocellular carcinoma显示文摘 | Lim SO Park SJ Kim W | 2002 | Biochem Biophys Res Commun2002，291，4： | 1 |
| 19 | Point to a referent,and say,'What is this?' Gesture as a potential cue to identify referents in discourse显示文摘 | So W C Lim J Y | 2012 | Applied Psycholinguistics2012，33，2： | 1 |
| 20 | Development of a test bed for high-speed power line communication显示文摘 | LIM C K SO P L GUNAWAN E | 2000 | Power System Technology2000，，1： | 1 |
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