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| 1 | 三江源地区生长季气候变化趋势及草地植被响应显示文摘三江源地区草地植被生长状况不仅关系着当地的生态环境和牧畜业生产,而且对中国和亚洲的生态环境都有重要的影响.但以往的研究集中于年、季尺度降水和气温的变化趋势分析上,很少研究草地植被生长季的气候变化以及草地植被的响应.为此,本文利用三江源地区1961~2007年气温、降水、日照时数和1982年以来NOAA/AVHRR植被指数以及牧业气象站1994年有完整观测以来围封草地的牧草高度、生物量和草层覆盖度等资料,构建气候变化评价模型和草地植被生长气候适宜度模型,综合分析了三江源地区生长季气候变化趋势、草地植被生长气候适宜度变化趋势以及草地植被对气候变化的响应.结果表明,1961年以来三江源地区生长季4~8月平均气温、降水量和日照时数均呈增加趋势,增加幅度分别为每10年0.24℃,2.32mm和2.81h;4~5和6~8月平均气温分别增高0.17和0.30℃,降水量增幅分别为2.80和?0.38mm,日照时数分别增加2.15和1.2h.三江源地区草地植被生长气候适宜度呈上升趋势,其中4~5月上升的速度快于6~8月,整体气候朝着有利于草地植被生长的方向变化.三江源地区1982年以来植被指数整体呈弱的增加趋势,2004年以来草地植被变好趋势明显,草地植被的生长对气候已呈现出正响应的变化.为此,建议三江源地区应充分利用气温升高、降水增加,有利于草地植被生长的暖湿化趋势,加大草地保护力度,促进草地生态环境尽快恢复. | 钱拴 伏洋 PAN F F | 2010 | 中国科学:地球科学2010，40，10： | 26 |
| 2 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 3 | 一类随机算子方程随机解的存在性显示文摘研究了一类随机算子方程的随机解 ,推广了几个重要的定理 .同时 ,得到了若干新的结果 . | 朱传喜 Pan Y F | 2003 | 数学物理学报(A辑)2003，23，3： | 13 |
| 4 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 5 | Nomogram for predicting transmural bowel infarction in patients with acute superior mesenteric venous thrombosis显示文摘BACKGROUND The prognosis of acute mesenteric ischemia(AMI)caused by superior mesenteric venous thrombosis(SMVT)remains undetermined and early detection of transmural bowel infarction(TBI)is crucial.The predisposition to develop TBI is of clinical concern,which can lead to fatal sepsis with hemodynamic instability and multi-organ failure.Early resection of necrotic bowel could improve the prognosis of AMI,however,accurate prediction of TBI remains a challenge for clinicians.When determining the eligibility for explorative laparotomy,the underlying risk factors for bowel infarction should be fully evaluated.AIM To develop and externally validate a nomogram for prediction of TBI in patients with acute SMVT.METHODS Consecutive data from 207 acute SMVT patients at the Wuhan Tongji Hospital and 89 patients at the Guangzhou Nanfang Hospital between July 2005 and December 2018 were included in this study.They were grouped as training and external validation cohort.The 207 cases(training cohort)from Tongji Hospital were divided into TBI and reversible intestinal ischemia groups based on the final therapeutic outcomes.Univariate and multivariate logistic regression analyses were conducted to identify independent risk factors for TBI using the training data,and a nomogram was subsequently developed.The performance of the nomogram was evaluated with respect to discrimination,calibration,and clinical usefulness in the training and external validation cohort.RESULTS Univariate and multivariate logistic regression analyses identified the following independent prognostic factors associated with TBI in the training cohort:The decreased bowel wall enhancement(OR=6.37,P<0.001),rebound tenderness(OR=7.14,P<0.001),serum lactate levels>2 mmol/L(OR=3.14,P=0.009)and previous history of deep venous thrombosis(OR=6.37,P<0.001).Incorporating these four factors,the nomogram achieved good calibration in the training set[area under the receiver operator characteristic curve(AUC)0.860;95%CI:0.771-0.925]and the external validation set(AUC 0.851;95%CI:0.796-0.897).The positive and negative predictive values(95%CIs)of the nomogram were calculated,resulting in positive predictive values of 54.55%(40.07%-68.29%)and 53.85%(43.66%-63.72%)and negative predictive values of 93.33%(82.14%-97.71%)and 92.24%(85.91%-95.86%)for the training and validation cohorts,respectively.Based on the nomogram,patients who had a Nomo-score of more than 90 were considered to have high risk for TBI.Decision curve analysis indicated that the nomogram was clinically useful.CONCLUSION The nomogram achieved an optimal prediction of TBI in patients with AMI.Using the model,the risk for an individual patient inclined to TBI can be assessed,thus providing a rational therapeutic choice. | Meng Jiang Chang-Li Li Chun-Qiu Pan Wen-Zhi Lv Yu-Fei Ren Xin-Wu Cui Christoph F Dietrich | 2020 | World Journal of Gastroenterology2020，26，26： | 4 |
| 6 | Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis显示文摘endomembrane 系统是建筑群和动态细胞内部的 trafficking 网络。它很正在质问在实时追踪单个泡和他们的货物;然而,亲密关系纯化允许泡处于他们的自然状态被孤立以便他们的成分蛋白质能被识别。在植物开创这条途径,我们孤立 SYP61 trans-Golgi 网络分隔空间并且与从另外的细胞器的仅仅最小的干扰执行了它的内容的全面 proteomic 分析。SYP61 的 proteome 揭示了以前没被归功于到这分隔空间的未知功能的蛋白质的协会。我们识别了完全的 SYP61 圈套建筑群,包括规章的蛋白质并且由显示出在 planta 与 SYP61 联系的几这些蛋白质验证了 proteome 数据。我们进一步识别了 SYP121 复杂并且纤维素 synthases,建议那 SYP61 在 exocytic trafficking 和房间墙部件的运输起一个作用到血浆膜。在包括针鼹鼠的 SYP61 proteome 的未知功能的蛋白质的存在提供机会识别新奇 trafficking 部件和货物。处于他们的自然状态的植物泡的亲密关系纯化为复杂 endomembrane 网络的进一步的分析和解剖提供一个基础。途径是广泛地适用的并且能在植物负担得起几张泡人口的学习,它能与 SYP61 泡 proteome 相比。 | Georgia Drakakaki Wilhelmina van de Ven Songqin Pan Yansong Miao Junqi Wang Nana F Keinath Brent Weatherly Liwen Jiang Karin Schumacher Glenn Hicks Natasha Raikhel | 2012 | Cell Research2012，22，2： | 4 |
| 7 | Methods for measuring soil infiltration:State of the art显示文摘Soil infiltration is the process by which water on the soil surface penetrates the soil.Quantifying the soil infiltration capacity(soil infiltrability)is very important for determining components of the hydrological modeling,irrigation design and many other natural or man made processes.In this paper,commonly used methods for soil infiltration rate measurement with their principles and application conditions are introduced.The advantages and disadvantages of each method under various application conditions are discussed for comparison.Three new methods for soil infiltrability measurement,including the corresponding algorithm models,and the experimental apparatus and procedures are introduced.These analyses should facilitate the choice of method used for soil infiltrability measurement. | Mao Lili V F Bralts Pan Yinghua Liu Han Lei Tingwu | 2008 | International Journal of Agricultural and Biological Engineering2008，1，1： | 2 |
| 8 | 饲料中添加蛋白酶对肉鸡性能、养分利用率、肠道形态和胴体品质的影响显示文摘试验在饲喂玉米、高粱为主的肉鸡日粮中补充大豆,并添加蛋白酶,研究蛋白酶对肉鸡性能、养分消化率、肠道形态和胴体品质的影响。试验选取1日龄AA肉仔鸡(43.8±1.31 g)256只,均为公鸡,随机分配到2×2试验设计方阵中,方阵包括正常组(玉米组和高粱组)和蛋白酶组(空白组和添加蛋白酶150 mg·kg^(-1)的试验组)。试验1~21 d为第一阶段,22~42 d为第二阶段。试验结果表明,第二阶段中,日粮中添加蛋白酶极显著提高肉鸡的平均日增重(ADG,P<0.01),在整个试验过程中显著提高(P<0.05)。在各个时期,正常组对肉鸡生产性能均无显著影响(P>0.05)。19~21 d时,添加蛋白酶可显著提高肉鸡的表观代谢能(AME),干物质(DM)、总能量(GE)和养分消化率(P<0.05)。此外,日粮以高粱为主时,AME、GE消化率有降低趋势(P=0.05),氮沉积率也有降低趋势(P=0.08)。40~42 d时,日粮中添加蛋白酶可显著提高AME,DM、GE和氮沉积率(P<0.05)。21 d时,日粮中添加蛋白酶极显著增加肠绒毛高度、肠绒毛与隐窝深度比值,极显著降低十二指肠、空肠、回肠的隐窝深度(P<0.01)。42 d时,日粮中添加蛋白酶显著增加空肠肠绒毛高度、绒毛高度与隐窝深度比值,显著降低隐窝深度(P<0.05)。日粮中添加蛋白酶显著增加胸肌重、24 h p H,显著降低胸肌的滴水损失(P<0.05)。试验结果表明,饲养阶段日粮中添加复合蛋白酶可提高肉鸡ADG;在第一阶段可改善AME、DM、GE和氮沉积率和肠道形态。补充蛋白酶可提高出栏重、胸肌重和24 h pH,降低胸肌的滴水损失。低单宁高粱日粮与玉米日粮相比,对肉鸡性能的影响相近。 | Xu X Wang H L Pan L Ma X K Tian Q Y Xu Y T Long S F Zhang Z H Piao X S | 2017 | 饲料博览2017，0，1： | 2 |
| 9 | Gain and noise in ytterbium-sensitized erbium-doped fiber amplifiers:measurements and simulations 显示文摘 | ACHTENHAGEN M BEESON R J PAN F | 2001 | IEEE J Lightwave Technol2001，19，10： | 2 |
| 10 | An antagonist decoy receptor and a death domain-containing receptor for TRAIL 显示文摘 | Pan G Ni J Wei Y F | 1997 | Science1997，277，5327： | 2 |
| 11 | Antioxidant properties of water and ethanol extract from hot air-dried and freeze-dried daylily flowers 显示文摘 | Mao L Pan X Que F | 2006 | Eur Food Res & Tech2006，222，34： | 1 |
| 12 | The effects of enzyme and phosphorus supplements in wheat- and rye-based diets on laying hen performance, energy and phosphorus availability 显示文摘 | Pan C F Igbasan F A Guenter W | 1998 | Poultry Science1998，77，7： | 1 |
| 13 | Alternative block poly- urethanes based on poly(3-hydroxybutyrate-co-4-hydroxybu- tyrate) and poly(ethylene glycol) 显示文摘 | PAN J Y LI G Y CHEN Z F | 2009 | Biomaterials2009，30，16： | 1 |
| 14 | Effect of composition on the microstructure and mechanical properties of Mg-Zn-Al alloys 显示文摘 | ZHANG J GUO Z X PAN F S LI Z S LUO X D | 2007 | Mater Sci Eng A2007，456，12： | 1 |
| 15 | Solid - Phase Grafting of Glycidyl Methacrylate onto Polypropylane显示文摘 | Y K PAN J M RUAN D F ZHAN | 1996 | J Appl Polym Sci1996，65，： | 1 |
| 16 | Improved Nitrogen Transport in Surface Nanocrystallized Low Carbon Steels during Gaseous Nitridation 显示文摘 | Gu J F Bei D H Pan J S | 2002 | Mater Lett2002，55，： | 1 |
| 17 | Mechanical properties and microstructure of Fe40Al/TiC composites with low content of intermetallic显示文摘 | Gao M X Oliveira F J Pan Y | 2004 | Materials Science Forum2004，，： | 1 |
| 18 | Effects of prolactin-releasing peptide on tuberoinfundibular dopaminergic neuronal activity andprolactin secretion in estrogen-treated female rats显示文摘 | Yuan Z F Yang S C Pan J T | 2002 | J Biomed Sci2002，9，： | 1 |
| 19 | Efficient and robust watermarking algorithm with vector quantisation显示文摘 | Huang H C Wang F H Pan J S | 2001 | Electron Lett2001，37，13： | 1 |
| 20 | FasL-Fas interactions regulate neovascolarization in the cornea显示文摘 | Stuart PM Pan F Plambeck S | 2003 | Invest Ophthalmol Vis Sci2003，44，1： | 1 |
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