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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Down-scaled regional ocean modeling system (ROMS) for high-resolution coastal hydrodynamics in Korea显示文摘A down-scaled operational oceanographic system is developed for the coastal waters of Korea using a regional ocean modeling system(ROMS).The operational oceanographic modeling system consists of atmospheric and hydrodynamic models.The hydrodynamic model,ROMS,is coupled with wave,sediment transport,and water quality modules.The system forecasts the predicted results twice a day on a 72 h basis,including sea surface elevation,currents,temperature,salinity,storm surge height,and wave information for the coastal waters of Korea.The predicted results are exported to the web-GIS-based coastal information system for real-time dissemination to the public and validation with real-time monitoring data using visualization technologies.The ROMS is two-way coupled with a simulating waves nearshore model,SWAN,for the hydrodynamics and waves,nested with the meteorological model,WRF,for the atmospheric surface forcing,and externally nested with the eutrophication model,CE-QUAL-ICM,for the water quality.The operational model,ROMS,was calibrated with the tidal surface observed with a tide-gage and verified with current data observed by bottom-mounted ADCP or AWAC near the coastal waters of Korea.To validate the predicted results,we used real-time monitoring data derived from remote buoy system,HF-radar,and geostationary ocean color imager(GOCI).This down-scaled operational coastal forecasting system will be used as a part of the Korea operational oceanographic system(KOOS) with other operational oceanographic systems. | LIM Hak-Soo KIM Chang S PARK Kwang-Soon SHIM Jae Seol CHUN Insik | 2013 | Acta Oceanologica Sinica2013，32，9： | 4 |
| 3 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 4 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 5 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 6 | A GA paradigm for learning fuzzy rules 显示文摘 | Lim M H Rahardja S Gwee B H | 1996 | Fuzzy Sets and Systems1996，72，2： | 2 |
| 7 | Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease显示文摘 | María Inés Vargas-Rojas Alejandra Ramírez-Venegas Leonardo Limón-Camacho Leticia Ochoa Rafael Hernández-Zenteno Raúl H. Sansores | 2011 | Respiratory Medicine2011，，11： | 2 |
| 8 | Signal reconstruction from phase or magnitude显示文摘 | Hayes H M Lim J S Oppenheim A V | 1980 | IEEE Trans on Acoustics Speech and Signal Processing1980，28，6： | 2 |
| 9 | Age-related macular degeneration显示文摘 | Laurence S Lim Paul Mitchell Johanna M Seddon Frank G Holz Tien Y Wong | 2012 | The Lancet . 2012 (9827)2012，，9827： | 2 |
| 10 | Operating characteristics of aerated submerged biofilm reactors for drinking water treatment 显示文摘 | Lim K H Shin H S | 1997 | Wat Sci Tech1997，36，12： | 2 |
| 11 | Surface modification of silicon nitride powder with alumina 显示文摘 | HANK R LIM C S HONG M J | 1996 | J Am Ceram Soc1996，79，2： | 2 |
| 12 | High frequency magnetic proper-ties of polymer-bonded Terfenol-D composites显示文摘 | Pasquale M Lim S | 1999 | J Appl Phys1999，85，8： | 2 |
| 13 | Immunogenicity of the E1E2 proteins of hepatitis C virus expressed by recombinant adenoviruses 显示文摘 | Seong Y R Choi S Lim J S | 2001 | Vaccine2001，19，2022： | 2 |
| 14 | The unimportance of phase in speech enhancement 显示文摘 | Wang D L Lim J S | 1982 | IEEE Transactions on Acoustics Speech Signal Processing1982，30，4： | 2 |
| 15 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 16 | Preparation method of submicrometer sized α alumina by surface modification of γ-alumina with aluminasol显示文摘 | HANK R LIM C S | 2000 | J Am Ceram Soc2000，83，4： | 2 |
| 17 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 18 | Effect of carbon nanotube addition on tribological behavior of UHMWPE显示文摘 | Zoo Y S An J W Lim D P | 2004 | Tribology Letters2004，16，： | 1 |
| 19 | New nanoporous carbon materials with high adsorption capacity and rapid adsorption kinetics for removing humic acids 显示文摘 | Han S Kim S Lim H | 2003 | Micropor Mesopor Mat2003，58，2： | 1 |
| 20 | Type studies on Phellinus baumii and Phellinus linte us 显示文摘 | LIM Y W LEE J S JUNG H S | 2003 | Mycotaxon2003，，85： | 1 |
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