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| 1 | IR - 780 dye loaded tumor targeting theranostic nanopartieles for NIR imaging and photothermal therapy 显示文摘 | Caixia Yue Peng Liu Mingbin Zheng | 2013 | Biomaterials2013，34，： | 1 |
| 2 | Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma显示文摘Background and Aims:Numerous studies have explored the important role of N6-methyladenosine(m^(6)A)in cancer.Nonetheless,the interaction between m^(6)A and long noncoding RNAs(lncRNAs)is poorly investigated.Herein,we systematically analyzed the role and prognostic value of m^(6)A-related lncRNAs in hepatocellular carcinoma(HCC).Methods:The m^(6)A-related lncRNAs were identified based on the correlation coefficients with m^(6)A-related genes in HCC from The Cancer Genome Atlas.Subsequently,a novel risk score model was determined using the least absolute shrinkage and selection operator Cox regression analyses.Univariate and multivariate Cox analyses were used to identify independent prog-nostic factors for overall survival(OS)of HCC;thereafter,a prognostic nomogram was constructed.Results:A total of 259 lncRNAs showed significant correlations with m^(6)A in HCC,while 29 lncRNAs had prognostic significance.Further,six critical m^(6)A-related lncRNAs(NRAV,SNHG3,KDM4A-AS1,AC074117.1,AC025176.1,and AL031985.3)were screened out to construct a novel risk score model which classified HCC patients into high-and low-risk groups.Survival analy-ses revealed that patients in the high-risk group exhibited worse OS,both in the training and validation groups.The risk score was also identified as an independent prognostic factor of OS,and a nomogram was established and verified with superior prediction capacity.Besides,the risk score signifi-cantly correlated with the expression of immune checkpoint genes and immune subtypes.Conclusions:These findings indicated the significant role of m^(6)A-related lncRNAs in HCC and the potential application of the novel risk score model for prognostic prediction. | Tianxing Dai Jing Li Linsen Ye Haoyuan Yu Mingbin Deng Wei Liu Hua Li Yang Yang Guoying Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 1 |
| 3 | Real-time transition dynamics and stability of chipscale dispersion-managed frequency microcombs显示文摘Femtosecond mode-locked laser frequency combs have served as the cornerstone in precision spectroscopy,alloptical atomic clocks,and measurements of ultrafast dynamics.Recently frequency microcombs based on nonlinear microresonators have been examined,exhibiting remarkable precision approaching that of laser frequency combs,on a solid-state chip-scale platform and from a fundamentally different physical origin.Despite recent successes,to date,the real-time dynamical origins and high-power stabilities of such frequency microcombs have not been fully addressed.Here,we unravel the transitional dynamics of frequency microcombs from chaotic background routes to femtosecond mode-locking in real time,enabled by our ultrafast temporal magnifier metrology and improved stability of dispersion-managed dissipative solitons.Through our dispersion-managed oscillator,we further report a stability zone that is more than an order-of-magnitude larger than its prior static homogeneous counterparts,providing a novel platform for understanding ultrafast dissipative dynamics and offering a new path towards high-power frequency microcombs. | Yongnan Li Shu-Wei Huang Bowen Li Hao Liu Jinghui Yang Abhinav Kumar Vinod Ke Wang Mingbin Yu Dim-Lee Kwong Hui-Tian Wang Kenneth Kin-Yip Wong Chee Wei Wong | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 4 | Effect of icariin on bone resorption activity of osteoclasts显示文摘 | LU Mingbin LIU Xingyan GE Baofeng | 2007 | Chin J Orthop & Trauma2007，20，8： | 1 |
| 5 | An empirical approach to predict regional organic carbon in deep soils显示文摘Deep soil organic carbon(SOC)plays an important role in carbon cycling.Precisely predicting deep SOC at the regional scale is crucial for the accurate assessment of carbon sequestration potential in soils but has been challenging for a century.Herein,we developed a depth distribution function-based empirical approach to predict SOC in deep soils at the regional scale.We validated this approach with a dataset from four regions of the world and examined the application of this approach in China’s Loess Plateau.We found that among the reported depth distribution functions describing vertical patterns of SOC,the negative exponential function performed best in fitting SOC along the soil profile in various regions.Moreover,the parameters(i.e.,Ceand k)of the negative exponential function were linearly correlated to surface SOC(0–20 cm)and the changing rates of SOC within the topsoil(0–40 cm).Based on the above relationships,the empirical equations for predicting the negative exponential parameters are established.The validation results from site-specific and regional dataset showed that combining the negative exponential function and such empirical equations can precisely predict SOC concentration in soils down to 500 cm depth.Our study provides a simple,rapid and accurate method for predicting deep soil SOC at the regional scale,which could simplify the assessment of deep soil SOC in various regions. | Jingjing WANG Xiaorong WEI Xiaoxu JIA Mingbin HUANG Zhipeng LIU Yufei YAO Ming’an SHAO | 2023 | Science China Earth Sciences2023，66，3： | 0 |
| 6 | Stimulated generation of deterministic platicon frequency microcombs显示文摘Dissipative Kerr soliton generation in chip-scale nonlinear resonators has recently observed remarkable advances,spanning from massively parallel communications, to self-referenced oscillators, and to dual-comb spectroscopy.Often working in the anomalous dispersion regime, unique driving protocols and dispersion in these nonlinear resonators have been examined to achieve the soliton and soliton-like temporal pulse shapes and coherent frequency comb generation. The normal dispersion regime provides a complementary approach to bridge the nonlinear dynamical studies, including the possibility of square pulse formation with flattop plateaus, or platicons.Here we report observations of square pulse formation in chip-scale frequency combs through stimulated pumping at one free spectral range and in silicon nitride rings with +55 fs~2∕mm normal group velocity dispersion.Tuning of the platicon frequency comb via a varied sideband modulation frequency is examined in both spectral and temporal measurements. Determined by second-harmonic autocorrelation and cross correlation, we observe bright square platicon pulse of 17 ps pulse width on a 19 GHz flat frequency comb. With auxiliary-laser-assisted thermal stabilization, we surpass the thermal bistable dragging and extend the mode-locking access to narrower 2 ps platicon pulse states, supported by nonlinear dynamical modeling and boundary limit discussions. | HAO LIU SHU-WEI HUANG WENTING WANG JINGHUI YANG MINGBIN YU DIM-LEE KWONG PIERRE COLMAN CHEE WEI WONG | 2022 | Photonics Research2022，10，8： | 0 |
| 7 | Thermally tunable GeSi electro-absorption modulator with a wide effective operating wavelength range显示文摘We demonstrate a GeSi electro-absorption modulator with on-chip thermal tuning for the first time,to the best of our knowledge.Theoretical simulation proves that the device temperature can be tuned and the effective operating wavelength range can be broadened.When the heater power is 4.63 mW,the temperature of the waveguide increases by about 27 K and the theoretical operating wavelength range is broadened by 23.7 nm.The experimental results show that the optical transmission line shifted to the longer wavelength by 4.8 nm by every 1 mW heater power.The effective static operating wavelength range of the device is increased from 34.4 nm to 60.1 nm,which means it is broadened by 25.7 nm.The band edge shift coefficient of 0.76 nm/K is obtained by temperature simulation and linear fitting of the measured data.The device has a 3 dB EO bandwidth of 89 GHz at 3 V reverse bias,and the eye diagram measurement shows a data rate of 80 Gbit/s for non-return-to-zero on–off keying modulation and 100 Gbit/s for 4 pulse amplitude modulation in the 1526.8 nm to 1613.2 nm wavelength range as the heater power increases from 0 mW to 10.1 mW. | YUFEI LIU JIALIANG SUN XINYU LI SHUXIAO WANG WENCHENG YUE YAN CAI MINGBIN YU | 2023 | Photonics Research2023，11，8： | 0 |
| 8 | Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor显示文摘The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic malignancies.However,unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.Herein we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in vivo.Briefly,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial ligand-receptor.Functional groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T cells.In vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood cancer.Surprisingly,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid tumor.Click CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients. | Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He Mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin Jiang Ting Yin Ruijing Liang Yifan Ma Lintao Cai | 2021 | Bioactive Materials2021，6，4： | 0 |
| 9 | CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice显示文摘Myocardial infarction (MI), the most serious of the ischemic heart diseases, is accompanied by myocardial metabolic disorders and the loss of cardiomyocytes. Increasing evidence has shown that long noncoding RNAs (lncRNAs) are involved in various pathological conditions such as cancer and cardiovascular diseases (CVDs), and are emerging as a novel biomarker for these disorders. This study aims to investigate the regulatory role and mechanisms of lncRNAs in myocardial remodeling in the setting of MI. We find that post-infarcted hearts exhibit a reduction of adenosine triphosphate (ATP) and an alteration of the glucose and lipid metabolism genes cluster of differentiation 36 (CD36), hexokinase 1 (HK1), and clucose transporter 4 (GLUT4), accompanied by cardiomyocyte pyroptosis. We then identify a previously unknown conserved lncRNA, AK009126 (cardiomyocyte pyroptosis-associated lncRNA, CPAL), which is remarkably upregulated in the myocardial border zone of MI mice. Importantly, the adeno-associated virus 9 (AAV9)-mediated silencing of endogenous CPAL by its short hairpin RNA (shRNA) partially abrogates myocardial metabolic alterations and cardiomyocyte pyroptosis during MI in mice. Mechanistically, CPAL is shown to bind directly to nuclear factor kappa B (NFκB) and to act as an activator of NFκB to induce NFκB phosphorylation in cardiomyocytes. We also find that CPAL upregulates caspase-1 expression at the transcriptional level and consequently promotes the release of interleukin (IL)-18 and IL-1β from cardiomyocytes. Collectively, our findings reveal the conserved lncRNA CPAL as a new regulator of cardiac metabolic abnormalities and cardiomyocyte pyroptosis in the setting of MI and suggest CPAL as a new therapeutic target to protect cardiomyocytes against ischemic injury in infarcted hearts. | Jiamin Li Hongru Xue Ning Xu Liling Gong Ming Li Sijia Li Di Huang Qingwei Zhang Pengyu Li Qingsui Li Hang Yu Yining Liu Yadong Xue Haixin Chen Jiali Liu Wanyu Zhang Mingbin Liu Siyu Chang Xianzhi Lang Xingmiao Zhao Weijie Du Benzhi Cai Ning Wang Baofeng Yang | 2023 | Engineering2023，，1： | 0 |
| 10 | Upregulation of TMCO3 Promoting Tumor Progression and Contributing to the Poor Prognosis of Hepatocellular Carcinoma显示文摘Background and Aims:TMCO3,a member of the monovalent cation:proton antiporter-2 family,has been annotated as a Na^(+)/H^(+)antiporter,but its pathophysiological role is still unclear.We aimed to investigate the expression profile,prognostic significance,and oncogenic role of TMCO3 in hepatocellular carcinoma(HCC).Methods:Bioinformatic analyses were conducted using transcriptome data from public databases to determine the expression,prognosis,and functional enrichment of TMCO3 in HCC.TMCO3 expression was further validated in an independent HCC cohort from our institution.The oncogenic role of TMCO3 in HCC was evaluated using in vitro and in vivo experiments.Results:The upregulated expression of TMCO3 was identified and verified in multiple HCC cohorts,and worse overall survival and recurrence-free survival were observed in patients with high TMCO3 expression.The overexpression and knockdown of TMCO3 could affect the proliferation and metastasis of HCC cells,which might be associated with the p53-induced cell cycle regulation and epithelial-mesenchymal transition,respectively.Notably,significant correlations were found between dysregulated TMCO3 and various antitumor agents.Its role in sorafenib sensitivity was further identified by in vitro experiments and the potential mechanism might be related to the regulation of apoptosis.Positive correlations were also identified between upregulation of TMCO3 and the increased infiltration of various immune cells and the elevated expression of multiple immune checkpoint genes in HCC.Conclusions:Upregulated TMCO3 could act as an oncogenic mediator and promote sorafenib resistance in HCC,providing a potential therapeutic target for HCC treatment. | Tianxing Dai Linsen Ye Mingbin Deng Guozhen Lin Rongqiang Liu Haoyuan Yu Wei Liu Yang Yang Guoying Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 0 |
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