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| 1 | Tectonics of South China Continent and its implications显示文摘This paper aims at exploring the tectonic characteristics of the South China Continent(SCC)and extracting the universal tectonic rules from these characteristics,to help enrich the plate tectonic theory and better understand the continental dynamic system.For this purpose,here we conduct a multi-disciplinary investigation and combine it with the previous studies to reassess the tectonics and evolution of SCC and propose that the tectonic framework of the continent comprises two blocks,three types of tectonic units,four deformation systems,and four evolutionary stages with distinctive mechanism and tectonic characteristics since the Neoproterozoic.The four evolutionary stages are:(1)The amalgamation and break-up of the Neoproterozoic plates,typically the intracontinental rifting.(2)The early Paleozoic and Mesozoic intracontinental orogeny confined by plate tectonics,forming two composite tectonic domains.(3)The parallel operation of the Yangtze cratonization and intracontinental orogeny,and multi-phase reactivation of the Yangtze craton.(4)The association and differentiation evolution of plate tectonics and intracontinental tectonics,and the dynamic characteristics under the Meso-Cenozoic modern global plate tectonic regime. | ZHANG GuoWei GUO AnLin WANG YueJun LI SanZhong DONG YunPeng LIU ShaoFeng HE DengFa CHENG ShunYou LU RuKui YAO AnPing | 2013 | Science China Earth Sciences2013，56，11： | 88 |
| 2 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 3 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 4 | Carboniferous Arc Setting in Central Hainan: Geochronological and Geochemical Evidences on the Andesitic and Dacitic Rocks显示文摘Volcanic rocks in the Bangxi-Chenxing tectonic zone provide important carries for better understanding the Late Paleozoic tectonic evolution in Hainan and its temporal-spatial pattern of the eastern Paleotethyan evolution. This paper presents a set of new geochronological and geochemical data on the andesitic and dacitic rocks along the Bangxi-Chenxing tectonic zone in central Hainan. The representative andesitic and dacitic samples yield similar zircon U-Pb ages of 353±3 and 351±7 Ma, respectively, being of Early Carboniferous origin. These volcanic rocks are characterized by low TiO_2 and high Al_2O_3 contents and are enriched in LILEs and LREEs but depletion in HFSEs, along with negative ε_(Nd)(t) values of-1.4–-4.7 and high ^(87)Sr/^(86)Sr(i) ratios of 0.707 2–0.710 1. Geochemical signatures suggest that the andesitic and dacitic samples might originate from a metasomatized wedge modified by the slab-derived component in a continental arc setting. In combination with the available data, it is proposed for the development of a Carboniferous continental arc in response to the eastern Paleotethyan evolution. The Bangxi-Chenxing tectonic zone might westerly link with the Jinshajiang-Ailaoshan-Song Ma suture zone, constituting an assemblage boundary between the South China and Indochina blocks. | Shubo Li Huiying He Xin Qian Yuejun Wang Aimei Zhang | 2018 | Journal of Earth Science2018，29，2： | 6 |
| 5 | Papaya Ring Spot Virus:An Understanding of a Severe Positive-Sense Single Stranded RNA Viral Disease and Its Management显示文摘Viral diseases have been studied in-depth for reducing quality,yield,health and longevity of the fruit,to highlight the economic losses.Positive-sense single-stranded RNA viruses are more devastating among all viruses that infect fruit trees.One of the best examples is papaya ringspot virus(PRSV).It belongs to the genus Potyvirus and it is limited to cause diseases on the family Chenopodiaceae,Cucurbitaceae and Caricaceae.This virus has a serious threat to the production of papaya,which is famous for its high nutritional and pharmaceutical values.The plant parts such as leaves,latex,seeds,fruits,bark,peel and roots may contain the biological compound that can be isolated and used in pharmaceutical industries as a disease control.Viral disease symptoms consist of vein clearing and yellowing of young leaves.Distinctive ring spot patterns with concentric rings and spots on fruit reduce its quality and taste.The virus has two major strains P and W.The former cause disease in papaya and cucurbits while the later one in papaya.Virion comprises 94.4%protein,including a 36 kDa coat protein which is a component responsible for a non-persistent transmission through aphids,and 5.5%nucleic acid.Cross protection,development of transgenic crops,exploring the resistant sources and induction of pathogen derived resistance have been recorded as effective management of PRSV.Along with these practices reduced aphid population through insecticides and plant extracts have been found ecofriendly approaches to minimize the disease incidence.Adoption of transgenic crops is a big challenge for the success of disease resistant papaya crops.The aim of this review is to understand the genomic nature of PRSV,detection methods and the different advanced control methods.This review article will be helpful in developing the best management strategies for controlling PRSV. | Muhammad Umer Mustansar Mubeen Yasir Iftikhar Haider Ali Muhammad Zafar-ul-Hye Rafia Asghar Mazhar Abbas Malik Abdul Rehman Ernesto A.Moya-Elizondo Yuejun He | 2022 | Phyton-International Journal of Experimental Botany2022，91，10： | 1 |
| 6 | An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development显示文摘Genetic composition plays critical roles in the pathogenesis of autism spectrum disorder(ASD).Especially,inherited and de novo intronic variants are often seen in patients with ASD.However,the biological significance of intronic variants is difficult to address.Here,among a Chinese ASD cohort,we identified a recurrent inherited intronic variant in the CHD7 gene,which is specifically enriched in East Asian populations.CHD7 has been implicated in numerous developmental disorders including CHARGE syndrome and ASD.To investigate whether the ASD-associated CHD7 intronic variant affects neural development,we established human embryonic stem cells carrying this variant using CRISPR/Cas9 methods and found that the level of CHD7 mRNA significantly decreased compared to control.Upon differentiation towards the forebrain neuronal lineage,we found that neural cells carrying the CHD7 intronic variant exhibited developmental delay and maturity defects.Importantly,we found that TBR1,a gene also implicated in ASD,was significantly increased in neurons carrying the CHD7 intronic variant,suggesting the intrinsic relevance among ASD genes.Furthermore,the morphological defects found in neurons carrying CHD7 intronic mutations were rescued by knocking down TBR1,indicating that TBR1 may be responsible for the defects in CHD7-related disorders.Finally,the CHD7 intronic variant generated three abnormal forms of transcripts through alternative splicing,which all exhibited loss-of-function in functional assays.Our study provides crucial evidence supporting the notion that the intronic variant of CHD7 is potentially an autism susceptibility site,shedding new light on identifying the functions of intronic variants in genetic studies of autism. | Ran Zhang Hui He Bo Yuan Ziyan Wu Xiuzhen Wang Yasong Du Yuejun Chen Zilong Qiu | 2021 | Neuroscience Bulletin2021，37，8： | 1 |
| 7 | Studies on influence of zinc immersion and fluoride on nickel electroplating on magnesium alloy AZ91D显示文摘 | Ziping Zhang Gang Yu Yuejun Ouyang Xiaomei He Bonian Hu Jun Zhang Zhenjun Wu | 2009 | Applied Surface Science2009，，17： | 1 |
| 8 | Single-cell analysis reveals the potential mechanisms of pyrotinib resistance in non-small cell lung cancer显示文摘Dear Editor,Lung cancer still remains the leading cause of cancer death worldwide,80-90%of which are non-small cell lung cancer(NSCLC).In 2-3%of NSCLC patients,mutations in human epidermal growth factor receptor 2(HER2)have been identified as oncogenic drivers.However,HER2 has been poorly reported as a therapeutic target for advanced NSCLC despite of the outstanding improvements in breast cancer receiving HER2-targeting regimens. | Xinfeng Wang Yuan Li Runsen Jin Sufei Zheng Yuejun Luo Peng Wu Zhanyu Wang Yuxin Yao Nan Sun Jie He | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 9 | Mycorrhizal Networks Interacting with Litter Improves Nutrients and Growth for One Plant through the Vary of N/P Ratio under Karst Soil显示文摘Arbuscular mycorrhizae(AM)fungi affect nutrient uptake for host plants,while it is unclear how AM fungi interacting with soil litter affect plant growth and nutrient utilization through mycorrhizal networks in karst soil of deficient nutrients beyond the rhizosphere.An experiment was conducted in a microcosm composed of a planting compartment for Cinnamomum camphora seedlings with or without Glomus mosseae fungus(M+vs.M−)and an adjacent litter compartment containing or not containing additional litter material of Arthraxon hispidus(L+vs.L−),where the compartments are connected either by nylon mesh of 20μm or 0.45μm which either allow available mycorrhizal networks within the litter compartment or prevent mycelium entering into the litter compartment(N+vs.N−).Plant biomass and nutrients were measured.The results showed that the addition of litter changed the symbiotic process in mycorrhizal colonization,spore,and hyphal density,which when in association with the host plant then affected the biomass,and accumulations of N(nitrogen)and P(phosphorus)in the individual plant as well as root,stem,and leaf respectively.AM fungi increased N and P accumulations and N/P ratio in individual plants and plant tissues.A decrease of the N/P ratio of the individual plant was observed when AM fungus interacted significantly with litter through mycorrhizal networks in the litter compartment.The results indicate that the C.camphora seedlings benefited from litter in nutrient utilization of N and P through the vary of N/P ratio when accessing mycorrhizal networks.These findings suggest that mycorrhizal networks interacting with litter improve growth and nutrients of N and P for plants through the vary of N/P ratio in order to alleviate nutrient limitation under karst soil. | Liling Kang Yuejun He Lipeng Zang Jianpeng Si Ying Yang Kaiping Shen Tingting Xia Qiyu Tan Bangli Wu Yun Guo Wei Wang Qin Liang | 2021 | Phyton-International Journal of Experimental Botany2021，90，3： | 0 |
| 10 | Development of a Kind of Immunomagnetic Bead Kit to Separate and Enrich Salbutamol显示文摘An immunomagnetic bead kit to separate and enrich salbutamol was prepared through the reaction between salbutamol and 4-aminobenzoic acid.The kit had a catch of 20 ng/ml to salbutamol in samples,and showed no cross reaction with competitive drugs with structure and function similar to salbutamol: clenbuterol,ractopamine,phenylethanolamine A, bromchlorbuterol, brombuterol, terbutaline, hydroxymethyl salbutamol,cimaterol,tulobuterol,mapenterol,cimbuterol,clenpenterol,zilpaterol,penbutolol,clenproperol,mabuterol and clorprenaline. | Yuping WAN Xiaosheng WU Fangfang JIA Jing LI Zhaoqin WANG Yuejun FENG Meihong DU Fangyang HE | 2018 | Agricultural Biotechnology2018，7，6： | 0 |
| 11 | The combination of novel immune checkpoints HHLA2 and ICOSLG:A new system to predict survival and immune features in esophageal squamous cell carcinoma显示文摘Studies on immune checkpoint inhibitors targeting B7-CD28 family pathways in esophageal squamous cell carcinoma(ESCC)have shown promising results.However,a comprehensive understanding of B7-CD28 family members in ESCC is still limited.This study aimed to construct a novel B7-CD28 family-based prognosis system to predict survival in patients with ESCC.We collected 179 cases from our previously published microarray data and 86 cases with qPCR data.Specifically,119 microarray data(GSE53624)were used as a training set,whereas the remaining 60 microarray data(GSE53622),all 179 microarray data(GSE53625)and an independent cohort with 86 qPCR data were used for validation.The underlying mechanism and immune landscape of the system were also explored using bioinformatics and immunofluorescence.We examined 13 well-defined B7-CD28 family members and identified 2 genes(ICSOLG and HHLA2)with the greatest prognostic value.A system based on the combination HHLA2 and ICOSLG(B7-CD28 signature)was constructed to distinguish patients as high-or low-risk of an unfavorable outcome,which was further confirmed as an independent prognostic factor.As expected,the signature was well validated in the entire cohort and in the independent cohort,as well as in different clinical subgroups.The signature was found to be closely related to immune-specific biological processes and pathways.Additionally,high-risk group samples demonstrated high infiltration of Tregs and fibroblasts and distinctive immune checkpoint panels.Collectively,we built the first,practical B7-CD28 signature for ESCC that could independently identify high-risk patients.Such information may help inform immunotherapy-based treatment decisions for patients with ESCC. | Chaoqi Zhang Feng Wang Nan Sun Zhen Zhang Guochao Zhang Zhihui Zhang Yuejun Luo Yun Che Hong Cheng Jiagen Li Jie He | 2022 | Genes & Diseases2022，9，2： | 0 |
| 12 | Nivolumab plus ipilimumab:a potential regimen to rewrite treatment guidelines for ESCC显示文摘The recent research published in The New England Journal of Medicine by Y.Doki et al.has reported the interim findings from the CheckMate 648,which is an international,multi-center,openlabel,and randomized phase 3 clinical trial to explore the role of dual immune checkpoints inhibitors combination for patients with advanced esophageal squamous cell carcinoma(ESCC)1. | Yuejun Luo Nan Sun Jie He | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
| 13 | AM真菌和枯落物互作下两种喀斯特植物种间竞争较种内竞争更能促进植物养分利用显示文摘枯落物是植物养分获取和土壤养分转化的关键载体。丛枝菌根(Arbuscular mycorrhizae,AM)对植物养分摄取的影响已被广泛认知。然而,在养分亏缺的喀斯特生境中,不同竞争方式的植物如何通过AM真菌和枯落物利用养分尚不清楚。本研究对两种喀斯特适生植物构树(Broussonetia papyrifera)和云贵鹅耳枥(Carpinus pubescens)进行种内竞争和种间竞争种植处理,并通过幼套球囊霉(Glomus etunicatum)接种或不接种处理,以及土壤中添加或不添加两物种叶片混合枯落物处理,测定了植物生物量以及氮、磷、钾浓度等指标,研究植物的生长和养分利用。研究结果表明,AM真菌对两种植物养分摄取影响不同,AM真菌显著提高了种内和种间竞争下构树的养分摄取量,但降低了云贵鹅耳枥的养分摄取量。种间竞争下接种AM真菌,枯落物添加促进了云贵鹅耳枥对氮的摄取,抑制了构树对氮的摄取。接种AM真菌和添加枯落物条件下,种间竞争的构树对氮、磷和钾的摄取量及云贵鹅耳枥对氮的摄取量均高于种内竞争;种间竞争下两物种养分竞争力呈现明显差异,即构树对磷和钾养分竞争力显著提高,对氮则不显著;云贵鹅耳枥仅对钾的养分竞争力显著降低,对氮和磷则无显著影响。这些结果说明,在AM真菌与枯落物相互作用下,两种喀斯特植物种间竞争较种内竞争更能促进植物养分利用。 | Yun Guo Yuejun He Pan Wu Bangli Wu Yan Lin Minhong He Xu Han Tingting Xia Kaiping Shen Liling Kang Qiyu Tan Wenda Ren Yan Sun Qing Li | 2022 | Journal of Plant Ecology2022，15，2： | 0 |
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