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| 1 | Essential functions of iron-requiring proteins n DNA replication, repair and cell cycle contro显示文摘 | Caiguo Zhang | 2014 | Protein & Cell2014，5，10： | 13 |
| 2 | Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities显示文摘过量铁紧通过包括催化诱变的氢氧根激进分子的形成的许多机制在多重人的癌症类型与 tumorigenesis 被联系,调整 DNA 复制,修理和房间周期前进,在癌症房间影响信号 transduction,并且为增殖的肿瘤房间充当必要营养素。因此,多重治疗学的策略在癌症治疗基于铁剥夺被开发了。在过去几年期间,我们在铁和 tumorigenesis 之间的基因协会和分子的机制的理解极其膨胀了。在这评论,我们简短在哺乳动物总结铁动态平衡,并且在在众多的癌症类型理解异常的铁新陈代谢讨论最近的进步,与揭示在癌症房间的改变的信号 transduction 的研究的一个焦点。 | Caiguo Zhang Fan Zhang | 2015 | Protein & Cell2015，6，2： | 11 |
| 3 | Genetic Components of Heterosis for Seedling Traits in an Elite Rice Hybrid Analyzed Using an Immortalized F2 Population显示文摘Utilization of heterosis has greatly contributed to rice productivity in China and many Asian countries. Superior hybrids usually show heterosis at two stages: canopy development at vegetative stage and panicle development at reproductive stage resulting in heterosis in yield. Although the genetic basis of heterosis in rice has been extensively investigated, all the previous studies focused on yield traits at maturity stage. In this study, we analyzed the genetic basis of heterosis at seedling stage making use of an 'immortalized F2' population composed of 105 hybrids produced by intercrossing recombinant inbred lines(RILs) from a cross between Zhenshan 97 and Minghui 63,the parents of Shanyou 63, which is an elite hybrid widely grown in China. Eight seedling traits, seedling height, tiller number, leaf number, root number, maximum root length, root dry weight, shoot dry weight and total dry weight, were investigated using hydroponic culture. We analyzed single-locus and digenic genetic effects at the whole genome level using an ultrahigh-density SNP bin map obtained by population re-sequencing. The analysis revealed large numbers of heterotic effects for seedling traits including dominance, overdominance and digenic dominance(epistasis) in both positive and negative directions. Overdominance effects were prevalent for all the traits, and digenic dominance effects also accounted for a large portion of the genetic effects. The results suggested that cumulative small advantages of the single-locus effects and two-locus interactions, most of which could not be detected statistically, could explain the genetic basis of seedling heterosis of the F_1 hybrid. | Dan Zhu Gang Zhou Caiguo Xu Qifa Zhang | 2016 | Journal of Genetics and Genomics2016，43，2： | 8 |
| 4 | Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition显示文摘细胞的 deoxyribonucleotide triphosphates (dNTP ) 由把 ribonucleotides 变换成相应 deoxy 形式分享使用基于激进分子的化学的 Ribonucleotide reductase (RNR ) 供应。真核细胞的 RNR 包括并且子单元:包含催化并且 allosteric 地点;房子一个 diferric-tyrosyl 激进分子余因子(FeIII 2-Y?? | Caiguo ZHANG Guoqi LIU Mingxia HUANG | 2014 | Frontiers in Biology2014，9，2： | 3 |
| 5 | Comparative analysis of gene expression at early seedling stage between a rice hybrid and its parents using a cDNA microarray of 9198 uni-sequences显示文摘Using a cDNA microarray consisting of 9198 expressed sequence tags,we surveyed the gene expression profiles in shoots and roots of a rice hybrid,Liangyoupei 9 and its parents Peiai 64s and 93-11 at 72 h after germination. A total of 8587 sequences had detectable signals in both shoots and roots of the three genotypes. A total of 1571 sequences exhibited significant (P<0.01) expression differences in shoots or roots among the three genotypes,of which 121 showed expression poly-morphisms in both shoots and roots,and 870 revealed significant expression differences between the hybrid and one of the parents. The expression polymorphism of the sequences was associated with the functional categories of the sequences. They occurred more frequently in categories of carbohy-drate,energy and lipid metabolisms and stress response than expected,while less frequently in categories of amino acid metabolism,transcription and translation regulation,and signal transduction. A total of 214 sequences exhibited significant (P<0.05) mid-parent heterosis in expression,of which 117 had homology to genes with known functions,assigned in the categories of basic metabolism,genetic information processing,cell growth and death,signal transduction,transportation and stress response. The results may provide useful information for exploring the relationship between gene expression polymorphism and phenotypic variation,and for characterizing the molecular mechanism of seedling development and heterosis in rice. | HUANG Yi LI Lihua CHEN Ying LI Xianghua XU Caiguo WANG Shiping ZHANG Qifa | 2006 | Science China(Life Sciences)2006，49，6： | 2 |
| 6 | Additive and additive × additive interaction make important contributions to spikelets per panicle in rice near isogenic (Oryza sativa L.) lines显示文摘Epistasis plays an important role in the genetic basis of rice yield traits. Taking interactions into account in breeding programs will help the development of high-yielding rice varieties. In this study, three sets of near isogenic lines (NILs) targeting three QTLs for spikelets per panicle (SPP), namely qSPP1, qSPP2 and qSPP7, which share the same Zhenshan 97 genetic background, were used to produce an F 2 population in which the three QTLs segregated simultaneously. The genotypes of the individual F 2 plants at the three QTLs were replaced with three markers that are closely linked to the corresponding QTLs. These QTLs were validated in the F 2 and F 3 popula- tions at the single marker level. qSPP7 exhibited major pleiotropic effects on SPP, plant height and heading date. Multifactor analysis of variance was performed for the F 2 population and its progeny. Additive × additive interaction between qSPP2 and qSPP7 had significant effects on SPP in both the F 2 population and its progeny. Both additive and additive × additive interactions could explain about 73% of the total SPP phenotypic variance. The SPP performance of 27 three-locus combinations was ranked and favorable combinations were rec- ommended for rice breeding in different ecosystems. | Qin He Kexin Zhang Caiguo Xu Yongzhong Xing | 2010 | Journal of Genetics and Genomics2010，37，12： | 2 |
| 7 | Quantitative trait loci for panicle size, heading date and plant height co-segregating in trait-performance derived near-isogenic lines of rice ( Oryza sativa )显示文摘 | Yushan Zhang Lijun Luo Caiguo Xu Qifa Zhang Yongzhong Xing | 2006 | Theoretical and Applied Genetics2006，，2： | 1 |
| 8 | Four rice QTL controlling number of spikelets per panicle expressed the characteristics of single Mendelian gene in near isogenic backgrounds显示文摘 | Yushan Zhang Lijun Luo Touming Liu Caiguo Xu Yongzhong Xing | 2009 | Theoretical and Applied Genetics2009，，6： | 1 |
| 9 | Transgenic indica rice plants harboring a synthetic cry2A* gene of Bacillus thuringiensis exhibit enhanced resistance against lepi-dopteran rice pests显示文摘 | Hao Chen Wei Tang Caiguo Xu | 2005 | Theoretical and Applied Genetics2005，111，7： | 1 |
| 10 | 显示文摘 | Gong Caiguo Frechet J M J | 2000 | Macromole-Cules2000，33，14： | 1 |
| 11 | GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein显示文摘 | Chuchuan Fan Yongzhong Xing Hailiang Mao Tingting Lu Bin Han Caiguo Xu Xianghua Li Qifa Zhang | 2006 | Theoretical and Applied Genetics2006，，6： | 1 |
| 12 | GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein显示文摘 | Chuchuan Fan Yongzhong Xing Hailiang Mao Tingting Lu Bin Han Caiguo Xu Xianghua Li Qifa Zhang | 2006 | Theoretical and Applied Genetics2006，，6： | 1 |
| 13 | GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein显示文摘 | Chuchuan Fan Yongzhong Xing Hailiang Mao Tingting Lu Bin Han Caiguo Xu Xianghua Li Qifa Zhang | 2006 | Theoretical and Applied Genetics2006，，6： | 1 |
| 14 | Quantitative trait loci for panicle size, heading date and plant height co-segregating in trait-performance derived near-isogenic lines of rice (Oryza sativa)显示文摘 | Yushan Zhang Lijun Luo Caiguo Xu Qifa Zhang Yongzhong Xing | 2006 | Theoretical and Applied Genetics2006，，2： | 1 |
| 15 | Targeting xa13, a recessive gene for bacterial blight resistance in rice显示文摘 | Zhaohui Chu Binying Fu Hong Yang Caiguo Xu Zhikang Li A. Sanchez Y. J. Park J. L. Bennetzen Qifa Zhang Shiping Wang | 2006 | Theoretical and Applied Genetics2006，，3： | 1 |
| 16 | QTLs for low nitrogen tolerance at seedling stage identified using a recombinant inbred line population derived from an elite rice hybrid显示文摘 | Xingming Lian Yongzhong Xing Hua Yan Caiguo Xu Xianghua Li Qifa Zhang | 2005 | Theoretical and Applied Genetics2005，，1： | 1 |
| 17 | GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein显示文摘 | Chuchuan Fan Yongzhong Xing Hailiang Mao Tingting Lu Bin Han Caiguo Xu Xianghua Li Qifa Zhang | 2006 | Theoretical and Applied Genetics2006，，6： | 1 |
| 18 | Genetic analysis for drought resistance of rice at reproductive stage in field with different types of soil显示文摘 | Bing Yue Lizhong Xiong Weiya Xue Yongzhong Xing Lijun Luo Caiguo Xu | 2005 | Theoretical and Applied Genetics2005，，6： | 1 |
| 19 | Heterosis and polymorphisms of gene expression in an elite rice hybrid as revealed by a microarray analysis of 9198 unique ESTs显示文摘 | Yi Huang Lida Zhang Jianwei Zhang Dejun Yuan Caiguo Xu Xianghua Li Daoxiu Zhou Shiping Wang Qifa Zhang | 2006 | Plant Molecular Biology (-)2006，，4： | 1 |
| 20 | GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein显示文摘 | Chuchuan Fan Yongzhong Xing Hailiang Mao Tingting Lu Bin Han Caiguo Xu Xianghua Li Qifa Zhang | 2006 | Theoretical and Applied Genetics2006，，6： | 1 |
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