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| 1 | The spatial-temporal pattern and influencing factors of negative air ions in urban forests, Shanghai, China显示文摘Negative air ions are natural components of the air we breathe. Forests are the main continuous natural source of negative air ions(NAI). The spatio-temporal patterns of negative air ions were explored in Shanghai, based on monthly monitoring in 15 parks from March 2009 to February 2010. In each park, sampling sites were selected in forests and open spaces. The annual variation in negative air ion concentrations(NAIC) showed peak values from June to October and minimum values from December to January. NAIC were highest in summer and autumn, intermediate in spring, and lowest in winter. During spring and summer, NAIC in open spaces were significantly higher in rural areas than those in suburban areas. However, there were no significant differences in NAIC at forest sites among seasons. For open spaces, total suspended particles(TSP) were the dominant determining factor of NAIC in summer, and air temperature and air humidity were the dominant determining factors of NAIC in spring, which were tightly correlated with Shanghai's ongoing urbanization and its impacts on the environment. It is suggested that urbanization could induce variation in NAIC along the urban-rural gradient, but that may not change the temporal variation pattern. Furthermore, the effects of urbanization on NAIC were limited in non-vegetated or less-vegetated sites, such as open spaces, but not in well-vegetated areas, such as urban forests. Therefore, we suggest that urban greening, especially urban forest, has significant resistance to theeffect of urbanization on NAIC. | Hong Liang Xiaoshuang Chen Junguang Yin Liangjun Da | 2014 | Journal of Forestry Research2014，25，4： | 19 |
| 2 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 3 | Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering显示文摘Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature.Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue.Here,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue engineering.These include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling pathways.Transcriptional and epigenetic regulation of chondrogenesis will also be discussed.Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. | Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.Lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham | 2015 | Genes & Diseases2015，2，4： | 9 |
| 4 | Carbon-Based Electrode Materials for Supercapacitor: Progress, Challenges and Prospective Solutions显示文摘 | Xian Jian Shiyu Liu Yuqi Gao Wei Tian Zhicheng Jiang Xiangyun Xiao Hui Tang Liangjun Yin | 2016 | Journal of Electrical Engineering2016，4，2： | 2 |
| 5 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 6 | Exploring a particle-size-reduction strategy of YAG:Ce phosphor via a chemical breakdown method显示文摘Particle size reduction of Y_(3)Al_(5)O_(12):Ce(YAG:Ce) phosphor is highly needed for micro-LED display applications.In this work,size control of YAG:Ce phosphor particles is achieved via carbon coating and further heat treatment.A thin layer of carbon is deposited on the surface of YAG:Ce by chemical vapor deposition.During the heat treatment,carbon reacts with oxygen element in the phosphor and escapes from phosphor particles.The reaction results in the phosphor breaking into smaller particles.The phosphors were characterized by laser light scattering for particle size distribution,scanning electron microscopy(SEM),transmission electron microscopy for morphologies,X-ray diffraction refinements for crystal structure and electron energy-loss spectroscopy for elemental analysis.It is demonstrated that the median diameter(D_(50)) of the phosphor particle size is significantly reduced from 19.1 to 0.96 μm yet the photoluminescent properties have little changes.The carbon coating and further heat treatment method show potential application in size control of phosphors. | Hongren Chen Licheng Ju Li Zhang Xin Wang Linbo Zhang Xin Xu Lin Gao Kehui Qiu Liangjun Yin | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 7 | Bone morphogenetic protein 2 inhibits the proliferation and growth ofhuman colorectal cancer cells显示文摘 | Yunyuan Zhang Xian Chen Min Qiao Bing-Qiang Zhang Ning Wang Zhonglin Zhang Zhan Liao Liyi Zeng Youlin Deng Fang Deng Junhui Zhang Liangjun Yin Wei Liu Qian Zhang Zhengjian Ya Jixing Ye Zhongliang Wang Lan Zhou Hue Luu Rex Haydon Tong-Chuan He Hongyu Zhang | 2014 | Oncology Reports2014，，3： | 1 |
| 8 | DNA repair-and nucleotide metabolism-related genes exhibit differential CHG methylation patterns in natural and synthetic polyploids (Brassica napus L.)显示文摘Polyploidization plays a crucial role in the evolution of angiosperm species.Almost all newly formed polyploids encounter genetic or epigenetic instabilities.However,the molecular mechanisms contributing to genomic instability in synthetic polyploids have not been clearly elucidated.Here,we performed a comprehensive transcriptomic and methylomic analysis of natural and synthetic polyploid rapeseeds(Brassica napus).Our results showed that the CHG methylation levels of synthetic rapeseed in different genomic contexts(genes,transposon regions,and repeat regions)were signi fi cantly lower than those of natural rapeseed.The total number and length of CHG-DMRs between natural and synthetic polyploids were much greater than those of CG-DMRs and CHH-DMRs,and the genes overlapping with these CHG-DMRs were signi fi cantly enriched in DNA damage repair and nucleotide metabolism pathways.These results indicated that CHG methylation may be more sensitive than CG and CHH methylation in regulating the stability of the polyploid genome of B.napus.In addition,many genes involved in DNA damage repair,nucleotide metabolism,and cell cycle control were significantly differentially expressed between natural and synthetic rapeseeds.Our results highlight that the genes related to DNA repair and nucleotide metabolism display differential CHG methylation patterns between natural and synthetic polyploids and reveal the potential connection between the genomic instability of polyploid plants with DNA methylation defects and dysregulation of the DNA repair system.In addition,it was found that the maintenance of CHG methylation in B.napus might be partially regulated by MET1.Our study provides novel insights into the establishment and evolution of polyploid plants and offers a potentialidea for improving the genomic stability of newly formed Brassica polyploids. | Liqin Yin Zhendong Zhu Liangjun Huang Xuan Luo Yun Li Chaowen Xiao Jin Yang Jisheng Wang Qiong Zou Lanrong Tao Zeming Kang Rong Tang Maolin Wang Shaohong Fu | 2021 | Horticulture Research2021，8，1： | 0 |
| 9 | Self-supported porous heterostructure WC/WO_(3−x)ceramic electrode for hydrogen evolution reaction in acidic and alkaline media显示文摘Tungsten carbide(WC)-based materials are widely considered as the hydrogen evolution reaction(HER)process catalysts due to their“Pt-like”electronic structure.Nonetheless,traditional powder electrodes have a high cost,and display problems related to the process itself and the poor stability over operation time.This paper presented a self-supported asymmetric porous ceramic electrode with WO_(3-x)whiskers formed in situ on the walls of the finger-like holes and membrane surface,which was prepared by combining phase inversion tape-casting,pressureless sintering,and thermal treatment in a CO_(2) atmosphere.The optimized ceramic electrode displayed good catalytic HER activity and outstanding stability at high current densities.More specifically,it demonstrated the lowest overpotentials of 107 and 123 mV and the lowest Tafel slopes of 59.3 and 72.4 mV·dec^(-1)at 10 mA·cm^(-2)in acidic and alkaline media,respectively.This superior performance was ascribed to the structure of the ceramic membrane and the charge transfer efficiency,which was favored by the in situ developed WC/WO_(3-x)heterostructure and the oxygen vacancies. | Feihong WANG Binbin DONG Junwei WANG Nianwang KE Chuntian TAN Anding HUANG Yutong WU Luyuan HAO Liangjun YIN Xin XU Yuxi XIAN Simeon AGATHOPOULOS | 2022 | Journal of Advanced Ceramics2022，11，8： | 0 |
| 10 | Effects of water and nitrogen conditions under surge-root irrigation on growth and yield of apple trees显示文摘In order to explore the effects of different irrigation and nitrogen application on growth cha-racteristics and yield of apple trees under surge-root irrigation in mountainous areas of northern Shaanxi, field experiments were carried out with different apple trees. Three irrigation levels were applied: 85%-100%(H1), 70%-85%(H2) and 55%-70%(H3) of the field water capacity, respectively, and three nitrogen levels were N1(360 g/plant), N2(240 g/plant) and N3(120 g/plant). The results show that irrigation and nitrogen application has significant effects on new shoot length, flowering and fruit setting, fruit diameter, fruit volume and yield of apple. The leaf area index(LAI) shows a single trend during the growth period, and the peak value appears in the middle of July. Under the same irrigation level, compared with N3, N1 increases in yield, new shoot length, LAI, transverse diameter, longitudinal diameter, volume, flowering and fruit setting by 17.91%, 28.31%, 18.75%, 11.38%, 10.13%, 36.60%, 20.92% and 5.19%, respectively, while N2 also increases by 12.40%, 15.63%, 4.86%, 5.40%, 5.11%, 17.01%, 26.17% and 13.74%, respectively. The rate of flowering and fruit setting decreases with the increase of nitrogen application. Under the same nitrogen level, compared with H3, H1 increases in yield, new shoot length, LAI, transverse diameter, longitudinal diameter, volume, flowering and fruit setting by 34.65%, 15.49%, 30.77%, 3.93%, 4.95%, 12.86%, 33.15% and 28.62%, respectively, while H2 also increases by 33.67%, 16.42%, 67.52%, 3.81%, 2.97%, 11.57%, 43.45% and 27.26%, respectively. The rate of flowering and fruit setting decreases first and then increases with the increase of irrigation amount. Compared with H3N3, the yield of other treatments increases by 2.69%-52.20%, while H2N1 treatment has the highest yield(26 852.55 kg/ha). Considering from the point of view of promoting growth and increasing yield, the best water and nitrogen combination mode of mountain apple in northern Shaanxi is medium water deficit irrigation and high nitrogen(H2N1) treatment. The results from this study can provide a theoretical basis for apple water and nitrogen management in mountainous areas of northern Shaanxi. | YIN Yongle FEI Liangjun LI Zhe LIU Teng LI Zhongjie HAO Kun PENG Youliang | 2023 | 排灌机械工程学报2023，41，2： | 0 |
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