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| 1 | Hydrogen sulfide suppresses transforming growth factor-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts显示文摘In heart disease, transforming growth factor-β1(TGF-β1) converts fibroblasts into myofibroblasts, which synthesize and secrete fibrillar type I and III collagens. The purpose of the present study was to investigate how hydrogen sulfide(H2S) suppresses TGF-β1-induced differentiation of human cardiac fibroblasts to myofibroblasts. Human cardiac fibroblasts were serum-starved in fibroblast medium for 16 h before exposure to TGF-β1(10 ng m L-1) for 24 h with or without sodium hydrosulfide(Na HS, 100 μmol L-1, 30 min pretreatment) treatment. Na HS, an exogenous H2 S donor, potently inhibited the proliferation and migration of TGF-β1-induced human cardiac fibroblasts and regulated their cell cycle progression. Furthermore, Na HS treatment led to suppression of fibroblast differentiation into myofibroblasts, and reduced the levels of collagen, TGF-β1, and activated Smad3 in TGF-β1-induced human cardiac fibroblasts in vitro. We therefore conclude that H2 S suppresses TGF-β1-stimulated conversion of fibroblasts to myofibroblasts by inhibiting the TGF-β1/Smad3 signaling pathway, as well as by inhibiting the proliferation, migration, and cell cycle progression of human cardiac myofibroblasts. These effects of H2 S may play significant roles in cardiac remodeling associated with heart failure. | ZHANG YouEn WANG JiaNing LI Hua YUAN LiangJun WANG Lei WU Bing GE JunBo | 2015 | Science China(Life Sciences)2015，58，11： | 11 |
| 2 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 3 | The age of the plant fossil assemblage in the Liuqu Conglomerate of southern Tibet and its tectonic significance显示文摘Liuqu 集团企业,位于到 Yarlung Tsangbo 缝术地区(YTSZ ) 的南方,一套糖蜜在在印第安人和 Eurasion 的二个盘子之间的碰撞以后在喜玛拉雅的 orogenic 带的低岬盆被形成。大意义大意义构造进化和西藏高原的高举的历史。然而,这件糖蜜西装的年龄和它到在南部的西藏散布的另外的同步阶层的关联很长时间在大争论。特别在最近的年里,在它的年龄争论与这糖蜜的大沉积构造意义的识别猛烈地正在成长。在最近在这件糖蜜西装上执行的域工作期间,很多计划石块被发现阶层在这的上面的部分处于相当好的条件保存了,它具有在决定的大帮助是它的年龄。由鉴定,植物 fosils 的集合属于一条回归线代替在中间期间在北半球超级大陆的南部的边缘开发到以后的 Eocence 的回归线植物群,它能在它的形成年龄提供好限制。这篇论文是给植物集合和它的年龄的简短介绍,并且讨论他们的构造意义。 | FANG Aimin YAN Zhen LIU Xiaohan PAN Yusheng LI Jiliang YU Liangjun HUANG Feixing TAO Junrong | 2006 | Progress in Natural Science:Materials International2006，16，1： | 9 |
| 4 | 16 × 16 silicon Mach–Zehnder interferometer switch actuated with waveguide microheaters显示文摘We experimentally demonstrate a 16 × 16 reconfigurably nonblocking optical switch fabric using a Benes architecture. The switch fabric consists of 56 2 × 2 Mach–Zehnder interferometer based elementary switches, with each integrated with a pair of waveguide microheaters. The average on-chip insertion loss is ~5.2 dB for both of the 'all-cross' and the 'all-bar' states, with a loss variation of 1 dB over all routing paths. The cross talk for all switching states is better than -30 d B. The switching time of the switch element is about 22 μs. The switching functionality is verified by transmission of a 40 Gb∕s quadrature phase-shift keying optical signal. | Shuoyi Zhao Liangjun Lu Linjie Zhou Dong Li Zhanzhi Guo Jianping Chen | 2016 | Photonics Research2016，4，5： | 7 |
| 5 | Valuation of the flexibility in decision-making for revamping installations―A case from fertilizer plants显示文摘This paper puts forward a valuation model for the flexibility of revamping urea plants based on the substitutability of switching between the internationally accepted fertilizer feedstock fuel oil and natural gas. The paper first builds a stochastic mean-reversion model for fuel oil prices and natural gas prices respectively, then estimates and tests the parameters using the fuel oil and natural gas prices data from the U.S. market. This paper also conducts a sensitivity analysis with important parameters. The results show that the real option method can be applied successfully to evaluate the flexibility in decision-making for revamping installations in fertilizer plants or other similar plants. | WANG Zhen LI Liangjun | 2010 | Petroleum Science2010，7，3： | 4 |
| 6 | Effects of arrangement of surge-root irrigation emitters on growth,yield and water use efficiency of apple trees显示文摘Six-year old apple trees were selected for field experiment.The objective of this study was to obtain the reasonable arrangement of surge-root irrigation emitters in apple orchards.There were three factors:the buried depth H(25,40,55 cm),the horizontal distance L(30,40,60 cm)between the emitters and the trunk of the experimental tree,and the number of the irrigation emitters N(1,2,4).The effect of the arrangement of surge-root irrigation emitters on the growth,yield and irrigation water use efficiency(IWUE)of apple trees were studied in Northern Shaanxi where the irrigation quota takes 60%-75%of the field water capacity.The results showed that the arrangement of emitters for surge-root irrigation had a significant effect on apple tree yield and IWUE,especially,the yield and IWUE reached 28388.17 kg/hm2 and 16.83 kg/m3 in treatment T3,respectively.At the same L and N levels(T1,T2,and T3),the yield and IWUE in treatment T3 were the highest,and the yields in treatments T1 and T2 were decreased by 26.22%and 31.48%,while IWUE is reduced by14.02%and 18.12%compared with T3,respectively.At the same H and N levels(T3,T4,and T5),the yield and IWUE of apple trees were decreased with increasing L level.Especially,when L was 30 cm(T3),the yield and IWUE were the highest.The same L and H levels(T3,T6,and T7)could promote the growth of apple trees when N was 2(T3).Compared with treatment T3,it was found that the increment of new shoots was decreased by 8.07%-18.71%,and the fruit diameter was decreased by 5.41%-9.11%.Therefore,two emitters should be arranged symmetrically on both sides of an apple tree,each was buried at a 40 cm depth and 30 cm away from the trunk of the tree to effectively improve the yield and IWUE of the apple tree in mountainous areas in Northern Shaanxi. | LI Zhongjie FEI Liangjun HAO Kun LIU Teng CHEN Nanshu ZHANG Quanju HUANG Deliang | 2020 | 排灌机械工程学报2020，38，7： | 4 |
| 7 | 4×4 nonblocking optical switch fabric based on cascaded multimode interferometers显示文摘We experimentally demonstrate a 4 × 4 nonblocking silicon thermo-optic(TO) switch fabric consisting of three stages of tunable generalized Mach–Zehnder interferometers. All 24 routing states for nonblocking switching are characterized. The device's footprint is 4.6 mm × 1.0 mm. Measurements show that the worst cross talk of all switching states is-7.2 dB. The on-chip insertion loss is in the range of 3.7–13.1 dB. The average TO switching power consumption is 104.8 mW. | Zuxiang Li Linjie Zhou Liangjun Lu Shuoyi Zhao Dong Li Jianping Chen | 2016 | Photonics Research2016，4，1： | 2 |
| 8 | Minimum Bedrock Exposure Ages and Their Implications:Larsemann Hills and Neighboring Bolingen Islands,East Antarctica显示文摘可观的争吵在广泛的冻结成冰是否在 Larsemann 山发生在全球上次冰川的最大值(LGM ) 期间上存在。在这研究,我们使用在里面 situ 生产了 cosmogenic 核种 10Be (半生活 1.51 妈) 提供最小的暴露年龄让六件基岩样品和一块乖僻的大石头以便在 Larsemann 山并且在附近的 Bolingen 岛上决定冰川的消失的最后时期。从友谊山拿的三件基岩样品(镜子半岛上的最高的山峰, Larsemann 山;从冰表的 2 km ) 有最小的暴露年龄从 40.0 ~ 44.7 ka 。从山峰 106 的乖僻的大石头(就在冰表的边) 有仅仅 8.8 ka 的更年轻的最小的暴露年龄。为从 Blundell 的二件基岩样品的最小的暴露年龄达到顶点(Stornes 半岛上的最高的山峰, Larsemann 山;从冰表的 2 km ) 是大约 17 和 18 ka。在 Bolingen 岛上(西南到 Larsemann 山;从冰表的 10 km ) ,为一件基岩样品的最小的暴露年龄在友谊山类似于那(即, 44 ka ) 。我们的结果显示在 Larsemann 山并且在附近的 Bolingen 岛上的基岩暴露在全球 LGM 前显然开始了(即, 2022 ka ) ,并且在南极海岸区域的基岩侵蚀率可能显然比在内部陆地高。 | HUANG Feixin LI Guangwei LIU Xiaohan KONG Ping JU Yitai David FINK FANG Aimin YU Liangjun | 2010 | Acta Geologica Sinica(English Edition)2010，84，3： | 2 |
| 9 | Overview of recent progress in condition monitoring for insulated gate bipolar transistor modules:Detection,estimation,and prediction显示文摘The insulated gate bipolar transistor(IGBT)is one of the most fragile components in power electronics converters.In order to improve the reliability of IGBTs,various measurements are taken according to the condition monitoring(CM)technique.Traditional CM techniques include the measurement and estimation of the device operation conditions.Recently,emerging techniques have been developed,not only for the detection and estimation but also for the prognostics of IGBTs with the condition data.In this paper,a review is performed on the recent progress in the CM techniques for IGBTs.First,some emerging electrical and thermal measurements are reviewed.Based on the sensed data,the health indicator estimation techniques are summarised.Moreover,for the emerging prognostics and health management applications,some remaining using lifetime(RUL)prediction methods are reviewed.Finally,the research gaps and directions are discussed for the CM in IGBT applications. | Meng Huang Haoran Wang Liangjun Bai Kang Li Ju Bai Xiaoming Zha | 2021 | High Voltage2021，6，6： | 2 |
| 10 | Sedimentary environment of the Dajin conglomerate in Tibet, age of foraminiferan assemblages and their tectonic significance显示文摘Dajin 集团企业,它在先是 Xigaze 的最重要的沉积继任之一在西藏的弧盆,中国,由忍受货币石, Assilina, Alveolina 和 Lock-hartia 的深浅的海洋的 tuffaceousturbidites 和棒麴霉素组成。这些石块很类似于有孔虫目动物一在里面在 Gangbaand Dingri 区域的 Jialazi 和 Maila 集团企业,和那些。他们发展了在始新世。由分析西藏高原和有孔虫目动物的 Eocenesedimentary 环境的空间变化一在里面 Dajin 集团企业,我们发现了那始新世沉积应该发生在 Yarlung Tsangpo 缝术的双方上,并且晚始新世的构造高举应该做在先弧盆从海水平暴露并且开始收到非海洋的存款。 | YAN Zhen FANG Aimin PAN Yusheng LI Jiliang LIU Xiaohan YU Liangjun ZHANG Binggao | 2005 | Progress in Natural Science:Materials International2005，15，11： | 2 |
| 11 | For initial alignment of inertial navigation system显示文摘 | HAO Yanling CHEN Minghui LI Liangjun XU Bo | 2008 | Journal of Marine Science and Application2008，，7： | 1 |
| 12 | Effect of Mo 2 C content on the structure and photocatalytic property of Mo 2 C/TiO 2 catalysts显示文摘 | Huiquan Li Wenshan Hong Yumin Cui Suhua Fan Liangjun Zhu | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 13 | Simultaneous detection of porcine circovirus type 2, classical swine fever virus, porcine parvovirus and porcine reproductive and respiratory syndrome virus in pigs by multiplex polymerase chain reaction显示文摘 | Yonghou Jiang Hanwu Shang Hui Xu Liangjun Zhu Weijie Chen Lingyan Zhao Li Fang | 2008 | The Veterinary Journal2008，，2： | 1 |
| 14 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 15 | Exploring a particle-size-reduction strategy of YAG:Ce phosphor via a chemical breakdown method显示文摘Particle size reduction of Y_(3)Al_(5)O_(12):Ce(YAG:Ce) phosphor is highly needed for micro-LED display applications.In this work,size control of YAG:Ce phosphor particles is achieved via carbon coating and further heat treatment.A thin layer of carbon is deposited on the surface of YAG:Ce by chemical vapor deposition.During the heat treatment,carbon reacts with oxygen element in the phosphor and escapes from phosphor particles.The reaction results in the phosphor breaking into smaller particles.The phosphors were characterized by laser light scattering for particle size distribution,scanning electron microscopy(SEM),transmission electron microscopy for morphologies,X-ray diffraction refinements for crystal structure and electron energy-loss spectroscopy for elemental analysis.It is demonstrated that the median diameter(D_(50)) of the phosphor particle size is significantly reduced from 19.1 to 0.96 μm yet the photoluminescent properties have little changes.The carbon coating and further heat treatment method show potential application in size control of phosphors. | Hongren Chen Licheng Ju Li Zhang Xin Wang Linbo Zhang Xin Xu Lin Gao Kehui Qiu Liangjun Yin | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 16 | Analysis of power flow in a counter-rotating epicyclic gearing for electrical propulsion system 显示文摘 | Shi Wankai Li Liangjun Qin Datong | 2011 | Journal of Mechanical Engineering Science2011，225，12： | 1 |
| 17 | Synthesis of AgInS_2 QDs in droplet microreactors:Online fluorescence regulating through temperature control显示文摘For the synthesis of AgInS_2 quantum dots(QDs), a suitable temperature is extremely important for control of the size, shape and fluorescence properties of QDs. Most of synthesis methods for AgInS_2 QDs are based on batch reactors, which bring uneven distribution of temperature, affecting their fluorescence properties and size uniformity. Here we designed a droplet microreactor with a temperature-controllable region, and successfully synthesized water-soluble AgInS_2 QDs. By accurately controlling temperature,we also studied how the reaction temperature affected the fluorescence properties of AgInS_2 QDs. The results showed that with the increasing of reaction temperature, the QDs size increased and the fluorescence peak constantly red-shifted along with enhanced fluorescence intensity. Based on the droplet microreactor, we could achieve more appropriate reaction condition to synthesize AgInS_2 QDs with higher fluorescence quantum yield(QY) and intensity. | Haotian Ma Liangjun Pan Ji Wang Li Zhang Zhiling Zhang | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 18 | Temporal variations of surface water quality in urban, suburban and rural areas during rapid urbanization in Shanghai, China显示文摘 | Junying Wang Liangjun Da Kun Song Bai-Lian Li | 2007 | Environmental Pollution2007，，2： | 1 |
| 19 | Ultrathin covalent organic framework nanosheet-based photoregulated metal-free oxidase-like nanozyme显示文摘The exploration of low-cost and metal-free nanozymes with oxidase-mimicking activity is highly desired due to their attractive properties and potential applications.However,it is still challenging and remains unexploited to fully realize oxidase-like nanozyme in the emerging covalent organic frameworks(COFs)due to their polymeric nature and weak photoelectric activity.We herein report the first example of the preparation and oxidase-mimicking activity of novel ultrathin two-dimensional(2D)COF(termed as TTPA-COF)nanosheets.The ultrathin TTPA-COF nanosheets with hexagonal layered structure are constructed from two flexible photoactive(diarylamino)benzene-based linkers,and exhibit remarkable catalytic activity toward the oxidation of 3,3',5,5'-tetramethylbenzidine(TMB)in the presence of O_(2) due to their large specific surface areas and abundant active sites.Moreover,it is worth noting that the nanozyme activity could be regulated by external light irradiation.Based on the oxidasemimicking activity of TTPA-COF nanosheets,a green colorimetric sensor is proposed for the sensitive and selective determination of glutathione(GSH)in a wide linear range of 0.5–40μM with a detection limit of 0.5μM.This work reported here would open new avenues for the exploration of low-cost and high-efficiency nanozymes,as well as extend the application of 2D COF nanosheets in the fields of catalysis and sensing. | Yongwu Peng Minchu Huang Liangjun Chen Chengtao Gong Nanjun Li Ying Huang Changming Cheng | 2022 | Nano Research2022，15，10： | 1 |
| 20 | SJES14110700244377显示文摘 | Lei Chen JinFa Chen Ying Guo JianRong Li YiQiang Yang LiangJun Xu FengFu Fu | 2014 | Food Chemistry2014，，： | 1 |
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