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| 1 | Gut microbiota,inflammation and colorectal cancer显示文摘Although genes contribute to colorectal cancer,the gut microbiota are an important player.Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression.A variety of bacterial species and tumor-promoting virulence mechanisms have been investigated.Significant advances have been made in understanding the composition and functional capabilities of the gut microbiota and its roles in cancer.In the current review,we discuss the novel roles of microbiota in the progression of colon cancer.Although microbiota technically include organisms other than bacteria e.g.,viruses and fungi,this review will primarily focus on bacteria.We summarize epidemiological studies of human microbiome and colon cancer.We discuss the progress in the scientific understanding of the interplay between the gut microbiota,barrier function,and host responses in experimental models.Further,we discuss the potential application in prevention,diagnosis,and therapy of colon cancer by targeting microbiota.We discuss the challenges lie ahead and the future direction in studying gut microbiome in colon cancer to close the gap between the basic sciences and clinical application. | Jun Sun Ikuko Kato | 2016 | Genes & Diseases2016，3，2： | 16 |
| 2 | A predictive factor for the response to S-1 plus cisplatin in gastric cancer显示文摘AIM:To prove that the protein expression level of thymidylate synthase is a predictive factor for the response to S-1/cisplatin(CDDP)chemotherapy in gastric cancer.METHODS:We measured the protein expression levels of thymidylate synthase(TS),dihydropyrimidine dehydrogenase(DPD),and orotate phosphoribosyltrans-ferase(OPRT)in advanced gastric cancer.Before S-1/CDDP chemotherapy,tumor specimens from primary sites were obtained by endoscopic biopsy and analyzed by enzyme-linked immunosorbent assay.The chemo-therapeutic effects on the primary sites were evaluated by endoscopic biopsy performed more than once after S-1/CDDP chemotherapy.The effects are a predictive factor for the response to S-1/CDDP chemotherapy inpatients with advanced gastric cancer,as evaluated by endoscopic biopsy over time.RESULTS:The protein expression level of TS was significantly higher(P<0.05)in the tumor than in the normal tissue,and significantly lower(P<0.05)in the responders than in the non-responders.We were able to evaluate the correlation between changes in the protein expression levels of TS,DPD and OPRT and chemotherapeutic responses in 7 patients by assessing tumor tissues more than twice.In the responders,the protein expression level of TS was<40 ng/mg protein.However,there were significant increases in the protein expression levels of TS(P<0.01)and DPD(P<0.05)after chemotherapy in 3 patients.In these cases,the patient assessment changed from'responder'to'non-responder'.In the non-responders,the protein expression level of TS was>40 ng/mg protein.CONCLUSION:We have confirmed that the protein expression level of TS is a predictive factor for the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer. | Ikuko Miyazaki Takashi Kawai Youji Harada Fuminori Moriyasu | 2010 | World Journal of Gastroenterology2010，16，36： | 8 |
| 3 | Identification and Dynamics of Arabidopsis Adaptor Protein-2 Complex and Its Involvement in Floral Organ Development[W]显示文摘 | Shohei Yamaoka Yuki Shimono Makoto Shirakawa Yoichiro Fukao Takashi Kawase Noriyuki Hatsugai Kentaro Tamura Tomoo Shimada Ikuko Hara-Nishimura | 2013 | The Plant Cell2013，，8： | 1 |
| 4 | The antioxidant edaravone attenuates pressure overload-Induced left ventricular hypertrophy显示文摘 | Ikuko Ts Shungo Hi Osamu Ya | 2005 | Hypertension2005，45，5： | 1 |
| 5 | β-Eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation显示文摘 | EN-LONG Ma YAN-CHUN Li HIROSHI Tsuneki JIN-FANG Xiao MING-YU Xia MIN-WEI Wang IKUKO Kimura | 2008 | Journal of Asian Natural Products Research2008，，2： | 1 |
| 6 | p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells显示文摘 | Yasusei Kudo Takashi Takata Ikuko Ogawa | 2000 | Clinical Cancer Research2000，6，3： | 1 |
| 7 | Identification of proteoglycan from salmon nasal cartilage显示文摘 | Ikuko K Yota T Mitsuo M | 2011 | Archivesof Biochemistryand Biophysics2011，506，1： | 1 |
| 8 | Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage显示文摘 | Koichi Suzuki Ikuko Suzuki Andreas Leodolter Sergio Alonso Shina Horiuchi Kentaro Yamashita Manuel Perucho | 2006 | Cancer Cell2006，，： | 1 |
| 9 | Activation of an ER-body-localized β-Glucosidase via a cytosolic binding partner in damaged tissues of Arabidopsis thaliana 显示文摘 | Atsushi J N Ryo M Ikuko H N | 2005 | Plant & cell Physiology2005，46，7： | 1 |
| 10 | Antiangiogenic activity of β-eudesmol in vitro and in vivo显示文摘 | Hiroshi Tsuneki En-Long Ma Shinjiro Kobayashi Naoto Sekizaki Kouji Maekawa Toshiyasu Sasaoka Min-Wei Wang Ikuko Kimura | 2005 | European Journal of Pharmacology2005，，2： | 1 |
| 11 | Carcinogenic activity of Farfugium japonicum and Senecio eannabifolius显示文摘 | Iwao Hirono Ikuko Ueno Shigetoshi Aiso | 1983 | Cancer Letters1983，20，2： | 1 |
| 12 | Comparison between the effects of ultrasound and γ-rays on the inactivation of Saccharomyces cerevisiae : Analyses of cell membrane permeability and DNA or RNA synthesis by flow cytometry显示文摘 | Ikuko Oyane Tomo Takeda Yasunori Oda Takashi Sakata Masakazu Furuta Kenji Okitsu Yasuaki Maeda Rokuro Nishimura | 2009 | Ultrasonics - Sonochemistry2009，，4： | 1 |
| 13 | Functional Role of a Novel Ternary Complex Comprising SRF and CREB in Expression of Krox - 20 in Early Embryos of Xenopus Laevis 显示文摘 | Takashi W Ikuko H | | Developmental Biology0，277，： | 1 |
| 14 | Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients 显示文摘 | Masahide F Ikuko Y Satohiro M | 2006 | Clin Pharmacol Ther2006，80，： | 1 |
| 15 | Risk factors and retreatment results of intraoperative flap complications in LASIK显示文摘 | Mitsutoshi ho Yoshiko Hori-Komai Ikuko Toda | 2004 | J Cataract Refract Surg2004，30，6： | 1 |
| 16 | Medical Benefits of Using Natural com- pounds and Their Derivatives Having Multiple Pharmaco- logical Aetions显示文摘 | Ikuko Kimura | 2006 | Yakugaku Zasshi2006，126，3： | 1 |
| 17 | Lithium perchlorate catalyzed acetylation of alcohols under mild reaction conditions显示文摘 | Yasuyuki Nakae Ikuko Kusaki Tsuneo Sato | 2001 | Synlett2001，，10： | 1 |
| 18 | Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous β-catenin显示文摘 | Yasusei K Shojiro K Ikuko O | 2004 | Clin Cancer Res2004，，10： | 1 |
| 19 | Motional induction effect on the planetary-scale geoelectric potential in the eastern North Pacific显示文摘 | FUJII IKUKO CHAVE AD | 1999 | Journal of Geophysical Research1999，104，1： | 1 |
| 20 | Antihyperglycemic effects of N-containing sugars from xanthocerc is zambesiaca,morus bombycis,aglaonema treubii,and castanospermum autrale in streptozotocin-diabetic mice显示文摘 | Hiroshi Nojima Ikuko Kimura Fu-jun Chen | 1998 | Nat Prod1998，61，： | 1 |
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