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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 3 | 通过业余时间运动的中老年的运动心电图:100次运动试验足以确定一个无症状心肌缺血的心脏事件风险显示文摘运动心电图在预防运动员心脏事件方面的重要性一直存在争议。为了确定运动心电图中无症状心肌缺血(silent myocardial ischemia,SMI)的频率及运动心电图与冠状动脉造影评估结果和潜在可预防的心脏事件的关系。Hupin等纳入2011-2014年就诊于Saint-Etienne大学医院运动医学科年龄≥35岁的无症状业余运动员,进行前瞻性队列研究。 | 刘青 叶鹏 Hupin D Edouard P Oriol M Laukkanen J Abraham P Doutreleau S Guy JM CarréF Barthélémy JC Roche F Chatard JC | 2018 | 中华高血压杂志2018，26，4： | 6 |
| 4 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 5 | Rigid polyurethane foam prepared from extruded starch-derived glycol glucosides as chemical intermediates显示文摘 | Carr M E Cunn Ingham R L | 1992 | Starch/Staerke1992，44，5： | 1 |
| 6 | Neural mechanisms of empathy in humans:A relay from neural systems for imitation to limbic areas 显示文摘 | Carr L Iacoboni M Dubeau M-C Mazziotta JC Lenzi GL | 2003 | Proceedings of the National Academy of Sciences of USA2003，，100： | 1 |
| 7 | European reference method for the in vivo determination of metabolizable energy with adult cockerels:reproducibility,effect of food intake and comparison with individual laboratory methods显示文摘 | BOURDILLON A CARRE B CONAN L | 1990 | British Poultry Science1990，31，： | 1 |
| 8 | Polyamines and related enzymesin rice seeds differing in germination potential显示文摘 | BONNEAU L CARRE M TANGUY J M | 1994 | Plant Growth Regula-tion1994，15，： | 1 |
| 9 | Insights and new direc- tions from demand-side approaches to technology inno- vation, entrepreneurship, and strategic management re- search显示文摘 | Priem R L Li S Carr J C | 2012 | Journal of Management2012，38，1： | 1 |
| 10 | Nanofabrication and electrostatic operation of single- crystal silicon paddle oscillators 显示文摘 | EvoY S CARR D W SEKARIC L | 1999 | Journal of Applied Physics1999，86，： | 1 |
| 11 | Risk factors associ- ated with acute hip prosthetic joint infections and outcomeof treatment with a rifampinbased regimen 显示文摘 | Choong PF l)owsey MM Carr D | 2007 | Acta Or- thop2007，78，6： | 1 |
| 12 | Histochemistry and morphology of porcine mast cells 显示文摘 | Xu L R Carr M M Bland A P | 1993 | Histochem J1993，25，： | 1 |
| 13 | Polyamine metabolism duringseeding development显示文摘 | BONNEAU L CARRE M DREUMONT C | 1994 | Plant Growth Regulation1994，15，： | 1 |
| 14 | Semivariogram textural classification of JERS-1(FUYO-1) SAR data obtained over a flooded area of the Amazonian rainforest显示文摘 | Miranda F P Fonseca L E N Carr J R | 2000 | International Journal of Remote Sensing2000，19，3： | 1 |
| 15 | On the Fragility of Skilled Performance:WhatGoverns Choking Under Pressure 显示文摘 | BEILOCK S L CARR T H | 2001 | Journal of Experimental Psychology:General2001，130，4： | 1 |
| 16 | Engineering the polymer backbone to strengthen nonfouling sulfobetaine hydrogels显示文摘 | Carr L Cheng G Xue H | 2010 | Langmuir2010，26，14： | 1 |
| 17 | Measurement of mechanical resonance and losses in nanometer scale silicon wires 显示文摘 | CARR D W EvoY S SEKARIC L | 1999 | Applied Physics Letters1999，75，： | 1 |
| 18 | Influence of yeast and vegetable shortening on physical and texturalparameters of frozen part baked French bread 显示文摘 | Carr L G Tadini C C | 2003 | LWT-Food Science and Technology2003，36，： | 1 |
| 19 | Functionalizable and nonfouling zwitterionic carboxybetaine hydrogels with a carboxybetaine dimethacrylate crosslinker显示文摘 | Carr L R Xue H Jiang S | 2011 | Biomaterials2011，32，4： | 1 |
| 20 | Theory and evidence on the dynamic interactions between sovereign credit default swaps and currency options显示文摘 | Carr P Wu L | | 0，，08： | 1 |
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