|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes 显示文摘 | Leader B Lim H Carabatsos M J Harrington A Ecsedy J Pellman D Maas R Leder P | 2002 | Nature Cell Biology2002，4，： | 1 |
| 3 | Pharmacikinetics optimization of vancomycin therapy显示文摘 | LEADER W G CHANDLER M CASTIGLIA M | 1995 | Clin Pharmacokinet1995，28，2： | 1 |
| 4 | Thyrotropin levels within the lower normal range are associated with an increased risk of hip fractures in euthyroid women, but not men, over the age of 65 years显示文摘 | Leader A Ayzenfeld RH Lishner M | 2014 | J Clin Endocfinol Metab2014，99，8： | 1 |
| 5 | Analysis of p16 expression and allelic imbalance// loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas显示文摘 | Gray SE Kay E Leader M | 2006 | J Cell Mol Med2006，10，3： | 1 |
| 6 | CD44V6:a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays显示文摘 | Grace A Leader M | 2003 | Eur J Gastroenterol Hepatol2003，15，9： | 1 |
| 7 | Prenatal stress,the hypothalamic-pituitary-adrenal axis, and fetal and infant neurobehaviour 显示文摘 | Austin M P Leader L R Reilly N | 2005 | Early Hum Dev2005，81，11： | 1 |
| 8 | Adenomatous polyposis coli gene, beta-catenin, and E-cadherin expression in proximal and distal gastric cancers and precursor lesions: an immunohistochemical study using tissue microarrays 显示文摘 | Gulmann C Grace A Leader M | 2003 | Appl Immunohistochem Mol Morphol2003，11，3： | 1 |
| 9 | Adjunctive therapiesin Nutritional support显示文摘 | Leader L M Jonas C R | 1997 | Nutrition1997，13，9： | 1 |
| 10 | Maternal trait anxiety, depression and life event stress in pregnancy: relation- ships with infant temperament显示文摘 | Austin M P Hadzi-Pavlovic D Leader L | 2005 | Early Hum Dev2005，81，2： | 1 |
| 11 | Primary malignant melanoma of the oesophagus:a case report显示文摘 | Kelly J Leader M Broe P | | 0，，： | 1 |
| 12 | Focal loss of anterior horn cells in the cervical cord in motor neuron disease 显示文摘 | Swash M Leader M Brown A | 1986 | Brain1986，109，5： | 1 |
| 13 | Multiple perifollicular fibromas显示文摘 | McKenna DB Barry-Walsh C Leader M | | 0，，03： | 1 |
| 14 | A novel approach to the treatment of ascites associated with ovarian hyperstimulation syndrome显示文摘 | AI-Ramahi M Leader A Claman P | 1997 | Human Reproduction1997，12，12： | 1 |
| 15 | Ex traskeletal myxoid chondrosarcoma of the maxillary sinus 显示文摘 | Jawad J Lang J Leader M | 1991 | J Laryngol Otol1991，105，8： | 1 |
| 16 | CD44v6:a potential marker of malignant trans-formation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays显示文摘 | Gulmann C Grace A Leader M | 2003 | European Journal of Gastroenterology and Hepatology2003，15，9： | 1 |
| 17 | The problem with KIT: clinical implications and practical difficulties with CDll7 immunostaining显示文摘 | Sabah M Leader M Kay E | 2003 | Appl Immunohistochem Mol Morphol2003，11，1： | 1 |
| 18 | Pharmacokinetics optimisation of vancomycin in therapy显示文摘 | LEADER W G CHANDLER M CASTIGLIA M | 1995 | Clin pharmacokinet1995，28，： | 1 |
| 19 | The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease显示文摘 | BON J M LEADER J K WEISSFELD | 2009 | PLOS One2009，4，8： | 1 |
| 20 | Automated lung segmentation in X-ray computed tomography: development and evaluation of a heuristic threshold-based scheme 显示文摘 | Leader J K Zheng B Rogers R M | 2003 | AcadRadiol2003，10，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员