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17篇 您的检索式:作者名="LEADER J K"
    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Phosphorus sorbing materials : sorption dynamics and physicochemical characteristics 显示文摘Leader J W Dunne E J Reddy K R 2008Journal of Environment Quality2008,37,1:1
3A Computational Geometry Approach to Automated Pulmonary Fissure Segmentation in CT Examinations显示文摘Pu J T Leader J K Zheng B 2009IEEE Transactions on Medical Imaging2009,28,5:1
4The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease显示文摘BON J M LEADER J K WEISSFELD 2009PLOS One2009,4,8:1
5Antibody re- sponses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pal- lidum subsp, pallidum 显示文摘LEADER BT HEVNER K MOLIN1 B J 2003Infect Immun2003,71,10:1
6Automated lung segmentation in X-ray computed tomography: development and evaluation of a heuristic threshold-based scheme 显示文摘Leader J K Zheng B Rogers R M 2003AcadRadiol2003,10,12:1
7Phosphorus sorbing materials: sorption dynamics and physicochemical characteris- tics显示文摘LEADER J W DUNNE E J REDDY K R 2008Journal of Environment Quality2008,37,1:1
8Automated lung segmentation in X-ray computed tomography:development and evaluation of a heuristic threshold-based scheme显示文摘Leader J K Zheng Bin 2003Acad Radiol2003,10,:1
9An Ellipse-fitting Based Method for Efficient Registration of Breast Masses on Two Mammographic Views显示文摘Pu Jiantao Zheng Bin Leader J K 2008Medical Physics2008,35,2:1
10A comprehensive vertebrate phylogeny using vector representations of protein se- quences from whole genomes 显示文摘STUART G W MOFFET K LEADER J J 2002Mol Biol Evol2002,19,4:1
11elegan 显示文摘Takacs A M Denker J A Perrine K G A 22-nucleotide spliced leader sequence in the human parasite nematode Brugia malayia identical to the trans spliced leader exon in C 1988Proc Natl Acad Set USA1988,85,:1
12How best to use partial meal replacement in managing overweight or obese patients with poorly controlled type 2 diabetes显示文摘Leader N J Ryan L Molyneaux L Yue D K 2013Obesity(Sliver Spring)2013,21,:1
13Separation of left and right lungs using 3-dimensional information of sequential computed tomography images and a guided dynamic programming algorithm显示文摘Park S C Leader J K Tan J 2011Journal of Computer Assisted Tomography2011,35,2:1
14An automated CT based lung nodule detection scheme using geometric analysis of signed distance field显示文摘Pu J T Zheng B Leader K 2008Med Phys2008,35,8:1
15Computerized estimation of the lung volume removed during lung volume reduction surgery显示文摘Gilbert S Zheng B Leader J K 2006Acad Radiol2006,13,11:1
16Pulmonary Lobe Segmentation in CT Examinations Using Implicit Surface Fitting 显示文摘Pu Jiantao Zheng Bin Leader J K 2009IEEE Trans on Medical Imaging2009,28,12:1
17A computational geometry approach to automated pulmonary fissure segmentation in CTexaminations显示文摘Pu J Leader J K Zheng B 2009IEEE Transactions on Medical Imaging2009,28,5:1
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