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| 1 | Changes in retinal and choroidal morphology after cerebrospinal fluid pressure reduction: a Beijing iCOP study显示文摘Dear Editor,Glaucoma is a multifunctional neurodegenerative disease and is the leading cause of irreversible blindness. It is characterized by progressive loss of retinal ganglion cells and their axons leading to visual field defects. | Lu Liu Xiaoxia Li Hanspeter E Killer Kai Cao Jing Li Ningli Wang | 2019 | Science China(Life Sciences)2019，62，2： | 7 |
| 2 | The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis显示文摘 | Kai Sun Philipp E Scherer | 2012 | Cell Research2012，22，10： | 7 |
| 3 | Concentration profile of jet gas in the feed injection zone of a FCC riser显示文摘喷气气体的集中侧面被使用一种氢踪迹技术在一个冷模型的 FCC 起床人的 feed 注射地区调查。试验性的结果表明喷气气体集中侧面的四种类型能被用来描述在喷气气体之间混合并且预先提起在 feed 注射地区的气体。四种类型是为弱混合,为完整的混合的为中等混合的模糊塑造 M 的侧面,为强壮的混合的锋利的侧面,和抛物线的侧面的不同塑造 M 的侧面。为起始、完整的混合还原剂的区域的高度当减少时喷气气体速度或增加预先提起气体速度。而且,动量比率, Mj/Mr,(在 Mj 是喷气气体的动量的地方,先生是混合动量预先提起煤气、稳固的粒子) 被介绍在喷气气体集中分发上描述煤气的稳固的物理性质,操作条件,和设备配置的效果。为区域的高度起始、完整在喷气气体之间混合并且预先提起气体被发现当时,是 0 0.375 和 0.375 0.675 m Mj/Mr <
0.29 , 0.375 0.675 和 1.075 1.375 m 什么时候 Mj/Mr >
0.54 ,和 0 0.375 和 0.675 1.075 m 什么时候在 0.29 和 0.54 之间的 Mj/Mr ,分别地。 | Chenglin E Yiping Fan Kai Zhang Hu Zhang | 2008 | Progress in Natural Science:Materials International2008，18，10： | 6 |
| 4 | The m^(6)A methylome of SARS-CoV-2 in host cells显示文摘The newly identified Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)has resulted in a global health emergency because of its rapid spread and high mortality.The molecular mechanism of interaction between host and viral genomic RNA is yet unclear.We demonstrate herein that SARS-CoV-2 genomic RNA,as well as the negative-sense RNA,is dynamically N6-methyladenosine(m^(6)A)-modified in human and monkey cells.Combined RIP-seq and miCLIP analyses identified a total of 8 m^(6)A sites at single-base resolution in the genome.Especially,epidemic strains with mutations at these identified m^(6)A sites have emerged worldwide,and formed a unique cluster in the US as indicated by phylogenetic analysis.Further functional experiments showed that m^(6)A methylation negatively regulates SARS-CoV-2 infection.SARS-CoV-2 infection also triggered a global increase in host m^(6)A methylome,exhibiting altered localization and motifs of m^(6)A methylation in mRNAs.Altogether,our results identify m^(6)A as a dynamic epitranscriptomic mark mediating the virus–host interaction. | Jun’e Liu Yan-Peng Xu Kai Li Qing Ye Hang-Yu Zhou Hanxiao Sun Xiaoyu Li Liu Yu Yong-Qiang Deng Rui-Ting Li Meng-Li Cheng Bo He Jia Zhou Xiao-Feng Li Aiping Wu Chengqi Yi Cheng-Feng Qin | 2021 | Cell Research2021，31，4： | 5 |
| 5 | Chaperone-mediated autophagy:roles in neuroprotection显示文摘Chaperone-mediated autophagy(CMA), one of the main pathways of lysosomal proteolysis, is characterized by the selective targeting and direct translocation into the lysosomal lumen of substrate proteins containing a targeting motif biochemically related to the pentapeptide KFERQ. Along with the other two lysosomal pathways, macro- and micro-autophagy, CMA is essential for maintaining cellular homeostasis and survival by selectively degrading misfolded, oxidized, or damaged cytosolic proteins. CMA plays an important role in pathologies such as cancer, kidney disorders, and neurodegenerative diseases. Neurons are post-mitotic and highly susceptible to dysfunction of cellular quality-control systems. Maintaining a balance between protein synthesis and degradation is critical for neuronal functions and homeostasis. Recent studies have revealed several new mechanisms by which CMA protects neurons through regulating factors critical for their viability and homeostasis. In the current review, we summarize recent advances in the understanding of the regulation and physiology of CMA with a specific focus on its possible roles in neuroprotection. | Zhibiao Cai Weijun Zeng Kai Tao Zhen E Bao Wang Qian Yang | 2015 | Neuroscience Bulletin2015，31，4： | 4 |
| 6 | Assessment of the Off-season Rainfall of January to February 2020 and Its Socio Economic Implications in Tanzania: A Case Study of the Northern Coast of Tanzania显示文摘This article examines the off season rainfall in northern coast Tanzania(NCT)including Zanzibar which occurred in January and February 2020(JF).Like the JF rainfalls of 2001,2004,2010,2016 and 2018,the JF(2020)rainfall was more unique in damages including loss of lives,properties and infrastructures.The study used the NCEP/NCAR reanalysis data to examine the cause of uniqueness of JF rainfall in 2001,2004,2010,2016,2018 and 2020 over NCT and Zanzibar.These datasets include monthly mean u,v wind at 850,700,500,and 200 mb;SSTs,mean sea level pressure(MSLP)anomalies,Dipole Mode Index(DMI),and monthly rainfall from NCT and Zanzibar stations.Datasets were processed and calculated into long term,seasonal,and monthly averages,indeed,Precipitation Index(PI)was calculated.Correlation analysis between the rainfall(December to January),SST,DMI and 850 mb wind vectors;and long-term percentage contribution of investigated parameters was calculated.Results revealed significant positive and negative correlations between JF rainfall,SSTs and DMI.Moreover,JFs of 2004 and 2016 had higher rainfalls of 443 mm with percentage contribution of up to 406%,while January and February,2020 had the highest of 269.1 and 101.1mm in Zanzibar and 295 and 146.1 mm over and NCT areas,with highest January long-term rainfall contribution of 356%in Zanzibar and 526%over NCT.The DJF(2019/20)had the highest rainfall record of 649.5 mm in Zanzibar contributing up to 286%,while JF 2000 rainfall had a good spatial and temporal distribution over most NCT areas.JF,2020 rainfall had impacts of more than 20 people died in Lindi and several infrastructures including Kiyegeya Bridge in Morogoro were damaged.Conclusively,more research works on understanding the dynamics of wet and dry JF seasons should be conducted. | Kombo Hamad Kai Sarah E Osima Agnes Laurence Kijazi Mohammed Khamis Ngwali Asya Omar Hamad | 2021 | Journal of Atmospheric Science Research2021，4，2： | 2 |
| 7 | Adipose tissue remodeling and obesity显示文摘 | Sun Kai Kusminski Christine M Scherer Philipp E | 2011 | Journal of Clinical Investigation2011，，6： | 2 |
| 8 | The stem cell niche: theme and-variations 显示文摘 | Ohlstein B Kai T Dccetto E | 2004 | Curr Opin Cell Biol2004，16，6： | 1 |
| 9 | Full-coverage film cooling part 1:Comparison of heat transfer data for three injection angles 显示文摘 | CRAWFORD M E KAYS W M MOFFAT R J | 1980 | ASME Journal of Engineering for Power1980，102，： | 1 |
| 10 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 11 | Inhibition of photosynthesis by ethylene-a stomatal effect显示文摘 | James E Pallas J R Kays S J | 1982 | Plant Physiology1982，70，2： | 1 |
| 12 | Synthesis,characterization,and ceramic conversion reactions of borazine-modified hydridopolysilazanes:new polymeric precursors to silicon nitride carbide boride (SiNCB) ceramic composites显示文摘 | KAI S EDWARD E R GREGG A S | 1993 | Chem Mater1993，5，4： | 1 |
| 13 | Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers显示文摘 | Demure A Mina E Kayed R | 2005 | J Biol Chem2005，280，17： | 1 |
| 14 | Common struc- ture of soluble amyloid oligomers implies common mechanism of pathogenesis 显示文摘 | KAYED R HEAD E THOMPSON L J | 2003 | Science2003，300，5618： | 1 |
| 15 | Near-infrared reflectance model for the rapid prediction of total fat in cereal foods显示文摘 | Vines L L Kays S E Koehler P E | 2005 | Journal of Agriculture and Food Chemistry2005，53，5： | 1 |
| 16 | A method for oral DNA delivery with N-acetylated chitosan显示文摘 | Kai E Ochiya T | 2004 | Pharmaceutical Research2004，21，5： | 1 |
| 17 | Rapid charge transport in dye-sensitized solar cells made from vertically aligned single-crystal rutile TiO2 nanowires 显示文摘 | Feng Xinjian Zhu Kai Frank Arthur J Grimes Craig A Mallouk Thomas E | 2012 | Angewandte Chemie International Edition2012，51，11： | 1 |
| 18 | Influence of mesoscaleeddies on spatial structuring of top predators'communities in the Mozambique Channel 显示文摘 | TEW KAI E MARSAC F | 2010 | Progress in Oceanography2010，86，1： | 1 |
| 19 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease 显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，4： | 1 |
| 20 | Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis显示文摘 | Kayed R Head E Thompson J L | 2003 | Science2003，300，5618： | 1 |
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