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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Forrn-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes显示文摘 | Leader B Lira H Carabatsos MJ | 2002 | Nat Cell Biol2002，4，： | 1 |
| 3 | Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes 显示文摘 | Leader B Lim H Carabatsos M J Harrington A Ecsedy J Pellman D Maas R Leder P | 2002 | Nature Cell Biology2002，4，： | 1 |
| 4 | A novel protein containing a death domain that interacts with Fas/Apo-1(CD95) in yeast and causes cell death 显示文摘 | STRANGE R B I LEADER P LEE T H | 1995 | Cell1995，81，： | 1 |
| 5 | Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators 显示文摘 | Ashani Y Bhattacharjee A K Leader H | 2003 | Biochem Pharmacol2003，66，： | 1 |
| 6 | Care of pin sites 显示文摘 | Bell A Leader M Lloyd H | 2008 | Nurs Stand2008，22，33： | 1 |
| 7 | Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators显示文摘 | Ashani Y Bhattacharjee A K Leader H | 2003 | Biochem Pharmacol2003，66，： | 1 |
| 8 | Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes显示文摘 | Leader B Lim H Carabatsos MJ | 2002 | Nat Cell Biol2002，4，12： | 1 |
| 9 | Pharmacokinetics optimization of vancomycin therapy 显示文摘 | LEADER W G CHANDLER M H CASTIGLIA M | 1995 | Clin Pharmacokinet1995，28，4： | 1 |
| 10 | Formin - 2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes 显示文摘 | Leader B Lim H Carabatsos M J | 2002 | Nat Cell Biol2002，4，12： | 1 |
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