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| 1 | Perioperative and long-term outcome of thymectomy for myasthenia gravis: comparison of surgical approaches and prognostic analysis显示文摘 | LIU Cheng-wu LUO Meng MEI Jian-dong ZHU Yun-ke PU Qiang MA Lin CHE Guo-wei LIN Yi-dan WU Zhu WANG Yun KOU Ying-li LIU Lun-xu | 2013 | Chinese Medical Journal2013，，1： | 8 |
| 2 | Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury显示文摘Tissue factor (TF)-dependent coagulation contributes to lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice expressing either a membrane-tethered human tissue factor pathway inhibitor (hTFPI) or hirudin fusion protein on CD31^+ cells, including vascular endothelial cells (ECs). ALI was induced by intratracheal injection of LPS, and after 24 h the expression of TF and protease-activated receptors (PARs) on EC in lungs were assessed, alongside the extent of inflammation and injury. The expression of TF and PARs on the EC in lungs was upregulated after ALI. In the two strains of transgenic mice, expression of either of hTFPI or hirudin by EC was associated with significant reduction of inflammation, as assessed by the extent of leukocyte infiltration or the levels of proinflammatory cytokines, and promoted survival after LPS-induced ALI. The beneficial outcomes were associated with inhibition of the expression of chemokine CCL2 in lung tissues. The protection observed in the CD31-TFPI-transgenic strain was abolished by injection of an anti-hTFPI antibody, but not by prior engraftment of the transgenic strains with WT bone marrow, confirming that the changes observed were a specific transgenic expression of anticoagulants by EC. These results demonstrate that the inflammation in ALI is TF and thrombin dependent, and that expression of anticoagulants by EC significantly inhibits the development of ALI via repression of leukocyte infiltration, most likely via inhibition of chemokine gradients. These data enhance our understanding of the pathology of ALI and suggest a novel therapeutic strategy for treatment. | Jian Lou Yue Hu Min-dan Wu Luan-qing Che Yin-fang Wu Yun Zhao Bao-ping Tian Zheng-qiang Bao Chen Zhu Yan-ping Wu Lu-lu He Chun-xue Bai Jian Zhou Song-min Ying Wen Li Zhi-hua Chen Da-xin Chen Anthony Dorling Hua-hao Shen | 2019 | Acta Pharmacologica Sinica2019，40，6： | 7 |
| 3 | Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure显示文摘Programmed cell death(PCD),including apoptosis,apoptotic necrosis,and pyroptosis,is involved in various organ dysfunction syndromes.Recent studies have revealed that a substrate of caspase-3,gasdermin E(GSDME),functions as an effector for pyroptosis;however,few inhibitors have been reported to prevent pyroptosis mediated by GSDME.Here,we developed a class of GSDME-derived inhibitors containing the core structure of DMPD or DMLD.Ac-DMPD-CMK and Ac-DMLD-CMK could directly bind to the catalytic domains of caspase-3 and specifically inhibit caspase-3 activity,exhibiting a lower IC50 than that of Z-DEVD-FMK.Functionally,Ac-DMPD/DMLD-CMK substantially inhibited both GSDME and PARP cleavage by caspase-3,preventing apoptotic and pyroptotic events in hepatocytes and macrophages.Furthermore,in a mouse model of bile duct ligation that mimics intrahepatic cholestasis-related acute hepatic failure,Ac-DMPD/DMLD-CMK significantly alleviated liver injury.Together,this study not only identified two specific inhibitors of caspase-3 for investigating PCD but also,more importantly,shed light on novel lead compounds for treating liver failure and organ dysfunctions caused by PCD. | Wan-feng Xu Quan Zhang Chu-jie Ding Hui-yong Sun Yuan Che Hai Huang Yun Wang Jia-wei Wu Hai-ping Hao Li-juan Cao | 2021 | Acta Pharmacologica Sinica2021，42，1： | 7 |
| 4 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 5 | Isolation and Complete Genomic Sequence Analysis of a New Sindbis-like Virus显示文摘象 Sindbis 一样病毒首先在 1986 在中国被发现。它的完全的染色体组的顺序由编码超过 3 的超过 11 000 bp 组成 700 氨基酸。它在一个非结构的区域包含 5 鈥?n on-transcriptional 区域(5 鈥?N TR ) ,四非结构的蛋白质(nsP1, nsP2, nsP3, nsP4 ) 区域,衣壳在保存;非保存的区域;结构的 E1, E2, E3, 6K 区域;3 鈥?n on-transcriptional 区域(3 鈥?N TR ) 。Sindbis-IMB 从怀疑有脑炎的一个病人的血被孤立,;被鉴定跟随;经过。病毒核糖核酸在感染的房间从病毒上层清液被提取;整个染色体被划分成 12 碎片;RT-PCR 然后被执行为完全的定序放大 12 碎片。结果证明 Sindbis-IMB 的整个染色体组的顺序由编码 3 的 11 717 bp 组成 773 氨基酸。象 Sindbis 一样孤立的与其它一起的相同比较证明最高的类似是有在云南省孤立的 1% 紧张的一个变化的 YN87448;第二最高与锝? 的一个变化拉紧到 SAAR86 2% 。核苷酸序列变化在非结构的区域是在场的,导致氨基酸 K, E, N, R, H,;在在位置的蛋白质序列的 L 230, 231, 443,781, 1 582,;1746 在新隔离分别地。而且,三另外的氨基酸—glutamic,丝氨酸;丙氨酸—作为与 YN87448 isolate 相比在 nsp4 终点被注意。 | Jing-jing WANG Hai-lin ZHANG Yan-chun CHE Li-chun WANG Shang-hui MA Long-ding LIU Yun LIAO Qi-han LI | 2008 | Virologica Sinica2008，23，1： | 6 |
| 6 | Comparative Skin Histology of Frogs Reveals High-elevation Adaptation of the Tibetan Nanorana parkeri显示文摘Adaptations to extreme environmental conditions are intriguing. Animal skin, which directly interacts with external environment, plays diverse and important roles in adaptive evolution. The thin and bare skin of amphibians is sensitive to external environmental conditions and, thus, it facilitates investigations into adaptations for living in extreme environments. Herein, we compare the structures of skin in four anuran species living at elevations ranging from 100 m to 4500 m to assess phenotypic innovations in the skin of Nanorana parkeri, which lives at extremely high elevations. Analyses reveal similar basic skin structures, but N. parkeri differs from the other species by having more epidermal capillaries and granular glands, which correlate highly with responses to hypoxia and/or ultraviolet(UV) radiation. Further intraspecific comparisons from frogs taken at ~4500 m and ~2900 m reveal that all of the changes are fixed. Changes occurring only in the higher elevation population, such as possessing more skin pigments, may represent local adaptations to coldness and/or UV radiation. These results provide a morphological basis for understanding further the molecular adaptations of these frogs. | Chunhua YANG Tingting FU Xinqiang LAN Yun ZHANG Lotanna Micah NNEJI Robert W.MURPHY Yanbo SUN Jing CHE | 2019 | Asian Herpetological Research2019，10，2： | 3 |
| 7 | Direct sunlight exposure reduces hair cortisol levels in rhesus monkeys(Macaca mulatta)显示文摘DEAR EDITOR,Major depressive disorder (MDD), commonly known as depression, is a mental disease characterized by a core symptom of low mood. It lasts at least two weeks (Badamasi et al., 2019;Wang et al., 2019) and is frequently accompanied by low self-esteem, loss of interest in routinely enjoyable activities, low energy, and unexplained pain (Huey et al., 2018;Park et al., 2012;Post & Warden, 2018;Rice et al., 2019;Xiao et al., 2018). Approximately 2%–8% of adults with MDD commit suicide (Richards & O'Hara, 2014;Strakowski & Nelson, 2015), and around half of suicidal individuals suffer depression or other mood disorders (Bachmann, 2018). | Xiao-Li Feng He-Long Che Xi Ning Xue-Ying Ba Juan-Li Jing-Fang Zhang Yun Wang Zheng-Fei Hu Xin-Tian Hu Xiao-Feng Ren | 2019 | Zoological Research2019，40，6： | 2 |
| 8 | A New High-throughput Real-time PCR Assay for the Screening of Multiple Antimicrobial Resistance Genes in Broiler Fecal Samples from China显示文摘Objective Antimicrobial resistance(AMR)has become a global concern and is especially severe in China.To effectively and reliably provide AMR data,we developed a new high-throughput real-time PCR assay based on microfluidic dynamic technology,and screened multiple AMR genes in broiler fecal samples.Methods A high-throughput real-time PCR system with an new designed integrated fluidic circuit assay were performed AMR gene detection.A total of 273 broiler fecal samples collected from two geographically separated farms were screened AMR genes.Results The new assay with limits of detection ranging from 40.9 to 8,000 copies/reaction.The sensitivity rate,specificity rate,positive predictive value,negative predictive value and correct indices were 99.30%,98.08%,95.31%,99.79%,and 0.9755,respectively.Utilizing this assay,we demonstrate that AMR genes are widely spread,with positive detection rates ranging from 0 to 97.07%in 273 broiler fecal samples.bla CTX-M,bla TEM,mcr-1,fex A,cfr,optr A,and int I1 showed over 80%prevalence.The dissemination of AMR genes was distinct between the two farms.Conclusions We successfully established a new high-throughput real-time PCR assay applicable to AMR gene surveillance from fecal samples.The widespread existence of AMR genes detected in broiler farms highlights the current and severe problem of AMR. | CHE Jie LU Jin Xing LI Wen Ge ZHANG Yun Fei ZHAO Xiao Fei YUAN Min BAI Xue Mei CHEN Xia LI Juan | 2019 | Biomedical and Environmental Sciences2019，32，12： | 2 |
| 9 | The mass recognizing property of DLC film for formic acid vapors显示文摘The carbon films are prepared by r.f. plasma method with n butylamine as carbon source. The analysis of Raman spectrosecopy shows that this kind of carbon film has diamond_like structure, and IR spectroscopy measurement indicats that there are SP 2 bonding, SP 3 bonding and amino group in the film. It is the existence of amino group and hydrogen atom that cause the amorphous structure and the deformation of bonding to increase, thus leading the Raman spectrum to form a broad absorption band. The quartz crystal microbalance (QCM) deposited with this kind of carbon film as recognizing coating is very sensitive to formic acid vapors. This QCM sensor has good reproducibility, high stability, rapid response and long lifetime. | Yonghong Yan Yun Zeng Jiannan Xiang Xia Yin Jiucheng Jin Zengzhang Che | 1998 | Chinese Science Bulletin1998，43，15： | 2 |
| 10 | Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair显示文摘为癌症治疗的一个助手在动物模特儿和临床的应用被报导了的人参摘录的使用,而是它的分子的机制充分没被阐明。Mitomycin C (MMC ) , anticancer 抗菌素为非小的房间肺癌(NSCLC ) 在治疗用作首要或第二线的政体,当独自使用了时,引起严肃的不利反应。由在 vitro 并且在 vivo 实验使用,这里,我们为 NSCLC 为最佳的治疗向证据提供全部的人参皂甙摘录(TGS ) 当与 MMC 的相对低的集中在联合使用了时,它显著地在 vitro 对 NSCLC A549 和 PC-9 房间提高了导致 MMC 的 cytotoxicity。一个 NSCLC 异种皮移植老鼠模型被用来证实在里面有 MMC 的 TGS 的联合的 vivo synergistic 效果。进一步的调查表明 TGS 能显著地颠倒导致 MMC 的 S 阶段房间周期拘捕并且禁止调停 Rad51 的 DNA 损坏修理,它被 phospho-MEK1/2, phospho-ERK1/2 和 Rad51 蛋白质和 Rad51 的 translocation 的 TGS on the levels 的禁止的效果响应 MMC 从细胞质证实到原子核。在摘要,我们的结果证明 TGS 能有效地在 vitro 并且在 vivo 对 NSCLC 房间提高 MMC 的 cytotoxicity,从而揭示 TGS 的新奇辅助 anticancer 机制。有 TGS 和 MMC 罐头的联合治疗显著地降低 MMC 的要求的集中并且能进一步减少副作用的风险,建议为 NSCLC 病人的一种更好的治疗选择。 | Min ZHAO Dan-dan WANG Yuan CHE Meng-qiu WU Qing-ran LI Chang SHAO Yun WANG Li-juan CAO Guang-ji WANG Hai-ping HAO | 2018 | Acta Pharmacologica Sinica2018，39，3： | 2 |
| 11 | A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5显示文摘Studies of herpes simplex virus type 1(HSV-1)infection have shown that many known and unknown cellular molecules involved in viral proliferation are up-regulated following HSV-1 infection.In this study,using two-dimensional polyacrylamide gel electrophoresis,we found that the expression of the HSV-1 infection response repressive protein(HIRRP,GI 16552881)was up-regulated in human L02 cells infected with HSV-1.HIRRP,an unknown protein,was initially localized in the cytoplasm and then translocated into the nucleus of HSV-1-infected cells.Further analysis showed that HIRRP represses HSV-1proliferation by inhibiting transcription of the viral genome by interacting with the cellular transcription factor,ATF5,via its N-terminal domain.ATF5 represses the transcription of many host genes but can also act as an activator of genes containing a specific motif.We found that ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection;HIRRP then induces feedback repression of this transcription by interacting with ATF5. | WU LianQiu ZHANG XueMei CHE YanChun ZHANG Ying TANG SongQing LIAO Yun NA RuiXiong XIONG XiangLin LIU LongDing LI QiHan | 2013 | Science China(Life Sciences)2013，56，12： | 2 |
| 12 | Three new polycatenation networks based on 4,4-oxybis(benzoate)and bis(imidazole)ligands:synthesis,structure and photoluminescence显示文摘 | XU Yun CHEN Pangkuan CHE Yunxia | 2010 | Eur J Inorg Chem2010，，： | 1 |
| 13 | Growth and characterization of l -histidine nitrate single crystal, a promising semiorganic NLO material显示文摘 | Yun Zhang Hua Li Bin Xi Yunxia Che Jimin Zheng | 2007 | Materials Chemistry and Physics2007，，2： | 1 |
| 14 | Template-mediated strategy to regulate hierarchically nitrogen-sulfur co-doped porous carbon as superior anode material for lithium capacity显示文摘Considering its rapid lithiation/delithiation process and robust capacitive energy storage,hierarchical porous carbon is regarded as a promising candidate for lithium-ion batteries(LIBs).However,it remains a great challenge to construct a porous structure and prevent structure stacking for carbon-based materials.Herein,a templatemediated approach is developed to synthesize hierarchical nitrogen-sulfur co-doped porous carbon(NSPC)using low-cost asphalt precursors.The strategy for synthesis uses g-C_(3)N_(4) and NaHCO_(3) as gaseous templates and NaCl as a solid template,which causes the formation of hierarchical porous carbon with a high specific surface area.The resultant porous structure and nitrogen-doping process can prevent the aggregation of nanosheets,maintain the structural stability upon cycling,and achieve rate-capable lithium storage.Serving as a LIBs anode,reversible specific capacities of the NSPC24 electrode reach 788 and 280 mAh·g^(-1) at 0.1 and 1 A·g^(-1),respectively.Furthermore,its specific capacity remains at 830 mAh·g^(-1) after 115 cycles at 0.1 A·g^(-1).Even after 500 cycles,high specific capacities of 727 mAh·g^(-1) at 0.5 A·g^(-1) and 624 mAh·g^(-1) at 1 A·g^(-1) are achieved,demonstrating excellent cycling performance.The gas-solid bifunctional template-mediated approach can guide the design of porous materials very well,meanwhile realizing the high value-added utilization of asphalt. | Yun LI Wang YANG Hanlin LIU Zhiqiang TU Sai CHE Bo JIANG Chong XU Guang MA Guoyong HUANG Yongfeng LI | 2022 | Frontiers of Materials Science2022，16，1： | 1 |
| 15 | Industrial solid waste flow analysis of eco-industrial parks: implications for sustainable waste management in China显示文摘在工业生态学观点的持续浪费管理在工业公园(IP ) 把庞大的挑战带到浪费分析的存在方法论规模。在这研究,一个四步的方法为工业稳固的废物(ISW ) 被建议 eco 工业的公园(EIP ) 的流动分析并且在东方中国适用于二 IP。根据由从 2006 ~ 2008 的调查的 619 家工业企业和 105 张问询表的公园宽的普查,结果显示了那:1 ) 在企业规模,超过 60% 企业是在有效浪费管理上遇到了大困难的 small-ISW-generation 企业;2 ) 尽管二 IP 建立了他们的自己的环境管理系统并且传递了 ISO 14001 证明,在 IP 规模, ISW 管理系统的效率还得在工业生态学观点被改进;并且 3 ) 在地区性的规模,超过 97% ISW 流动在省的区域以内,显示省的政府阻止了浪费流进他们的自己的背院子。有效浪费管理应该被放在一个更宽广的观点。持续浪费管理的途径可以包括浪费交换,有效浪费和信息流动,虚拟 EIP,浪费最小化俱乐部和浪费管理的区域化。 | Yongpeng LU Kai YANG Yue CHE Zhaoyi SHANG Jun TAI Yun JIAN | 2012 | Frontiers of Environmental Science & Engineering2012，6，4： | 1 |
| 16 | Effect of Iodine Supplementation on Iodine Nutrition and Thyroid Function in Pregnant Women:A Cross-Sectional Study显示文摘This study aimed to describe the situation of iodine supplementation in pregnant women,and to explore the effects of such supplementation measures on iodine nutrition and thyroid function.Pregnant women in seven provinces were selected by multi-stage sampling.Basic information was collected and a food frequency questionnaire was administered.Salt iodine,urinary iodine,and thyroid function were determined.Subjects were divided into five groups based on iodine supplementation.For pregnant women,the median urinary iodine concentration(MUIC)in seven provinces was 164.3μg/L,and thyroid nodules(15.75%)were a common thyroid disease.Gestation,iodine supplementation,etc.impacted iodine nutrition and thyroid function.Compared with other groups,simultaneous iodine supplementation with iodized salt,iodine-rich foods,and iodine preparations(the ISFP group)was the most effective approach for improving iodine nutrition;supplementation via iodine-rich foods only showed the lowest prevalence of TPOAb-positive(5.48%)and TgAb-positive(1.37%)diseases.In addition,pregnant women with MUIC in the 150–249μg/L range showed higher rates of TPOAb-positive(13.78%)disease and sub-hypothyroidism(5.38%)compared to those with MUIC in the 100–149μg/L range;however,goiter showed the opposite trend.Our results indicate that iodine supplementation needs vary from person to person. | SUN Rong QIAN Ting Ting LIU Lan Chun ZHAO Meng CHE Wen Jing ZHANG Ling LI Wei Dong JIA Qing Zhen WANG Jian Hui LI Jin Shu CHEN Zhi Hui ZHANG Bi Yun LIU Peng | 2022 | Biomedical and Environmental Sciences2022，35，7： | 1 |
| 17 | Relationship between Dining Place, Iodine Source, and Iodine Nutrition in School-Age Children: A Cross-Sectional Study in China显示文摘Objective This study assesses the impact of iodine-rich processed foods and dining places on the iodine nutritional status of children.Methods School-aged children(SAC) in seven provinces in China were selected by school-based multistage sampling. Urinary iodine, salt iodine, and thyroid volume(TVOL) were determined. Questionnaires were used to investigate dining places and iodine-rich processed foods. The water iodine was from the2017 national survey. Multi-factor regression analysis was used to find correlations between variables.Results Children ate 78.7% of their meals at home, 15.1% at school canteens, and 6.1% at other places.The percentage of daily iodine intake from water, iodized salt, iodine-rich processed foods, and cooked food were 1.0%, 79.2%, 1.5%, and 18.4%, respectively. The salt iodine was correlated with the urinary iodine and TVOL, respectively(r = 0.999 and-0.997, P < 0.05). The iodine intake in processed foods was weakly correlated with the TVOL(r = 0.080, P < 0.01). Non-iodized salt used in processed foods or diets when eating out had less effect on children’s iodine nutrition status.Conclusion Iodized salt remains the primary source of daily iodine intake of SAC, and processed food has less effect on iodine nutrition. Therefore, for children, iodized salt should be a compulsory supplement in their routine diet. | QIAN Ting Ting SUN Rong LIU Lan Chun CHE Wen Jing ZHAO Meng ZHANG Ling LI Wei Dong JIA Qing Zhen WANG Jian Hui LI Jin Shu CHEN Zhi Hui ZHANG Bi Yun LIU Peng | 2023 | Biomedical and Environmental Sciences2023，36，1： | 1 |
| 18 | C50 for Propofol-Remifentanil Target-Controlled Infusion and Bispectral Index at Loss of Consciousness and Response to Painful Stimulus in Chinese Patients: A Multicenter Clinical Trial显示文摘 | Zhipeng Xu Fang Liu Yun Yue Tiehu Ye Bingxi Zhang Mingzhang Zuo Mingjun Xu Rongrong Hao Yuan Xu Ning Yang Xiangming Che | 2009 | Anesthesia & Analgesia2009，，2： | 1 |
| 19 | Synthesis,structures,and adsorption properties of two new LaIII-MgIIheterometallic polymers显示文摘 | XU Yun CHE Yunxia CHENG Fangyi | 2011 | Eur J Inorg Chem2011，34，52： | 1 |
| 20 | A cadmium coordination polymer with a (4,6)-connected 3D network: syn- thesis, crystal structure, and luminescent properties 显示文摘 | XU Yun CHE Yunxia ZHENG Jimin | 2012 | Z Anorg Allg Chem2012，638，： | 1 |
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