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| 1 | Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow. | Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 无 | 2018 | Stroke & Vascular Neurology2018,3,3: | 37 |
| 2 | Phase Ⅰ/Ⅱ randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke显示文摘AIM To examine the safety and efficacy of mesenchymal stem cell(MSC) therapy for intracerebral haemorrhage with neurological dysfunctions for a year.METHODS MSC were ex vivo expanded from 29 mL(17-42 mL) autologous bone marrow. Patients were randomized to have two intravenous injections of autologous MSC or placebos in four weeks apart. Neurological functions and clinical outcomes were monitored before treatment and at 12^(th), 16^(th), 24^(th), 36^(th) and 60^(th) week upon completion of^(th)e treatment. RESULTS A mean of 4.57 × 10~7(range: 1.43 × 10~7-8.40 × 10~7) MSC per infusion was administered accounting to 8.54 × 10~5(2.65 × 10~5-1.45 × 10~6) per kilogram body weight in two occasions. There was neither adverse event at time of administration nor sign of de novo tumour development among patients after monitoring for a year post MSC therapy. Neuro-restoration and clinical improvement in terms of modified Barthel index, functional independence measure and extended Glasgow Outcome Scale were evident among patients having MSC therapy compared to patients receiving placebos. CONCLUSION Intravenous administration of autologous bone marrowderived MSC is safe and has the potential of improving neurological functions in chronic stroke patients with severe disability. | Kam Sze Tsang Chi Ping Stephanie Ng Xian Lun Zhu George Kwok Chu Wong Gang Lu Anil Tejbhan Ahuja Ka Sing Lawrence Wong Ho Keung Ng Wai Sang Poon | 2017 | World Journal of Stem Cells2017,9,8: | 3 |
| 3 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://gffzz25d7f5dd9bdf4c9ehnnxbnkbkv6u06qcx.ffgz.tsg.suse.edu.cn/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019,22,5: | 2 |
| 4 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009,,2: | 2 |
| 5 | Clopidogrel plus as-pirin versus aspirin alone for reducing embolisation in patients with a-cute symptomatic cerebral or carotid artery stenosis(CLAIR study):arandomised,open-label,blinded-endpoint trial显示文摘 | Ka Sing Lawrence Wong Christopher Chen | 2010 | Lancet Neural2010,9,: | 1 |
| 6 | From sus- pect to patient: tuberculosis diagnosis and treatment initiation in health facilities in South Africa 显示文摘 | BOTHA E DEN BOON S LAWRENCE KA | 2008 | Int J Tuberc Lung Dis2008,12,8: | 1 |
| 7 | Polioviruses and other enteroviruses iso-lated from faecal samples of patients withacute flaccid paralysis in Australia, 1996-2004 显示文摘 | Kelly H Brussen KA Lawrence A | 2006 | J Paediatr Child Health2006,42,6: | 1 |
| 8 | Polioviruses and other enteroviruses isolated from faecal samples of patients with acute flaccidparalysis in Australia,1996-2004显示文摘 | Kelly H Brussen KA Lawrence A | 2006 | J Paediatr Child Health2006,42,6: | 1 |
| 9 | Polioviruses and other enteroviruses isolated from faecal samples of patients with acute flaccid paralysis in Australia, 1996-2004显示文摘 | Kelly H Bmssen KA Lawrence A | 2006 | J Paediatr Child Health2006,42,6: | 1 |
| 10 | Polioviruses and other enteroviruses isolated from faecal samples of patients with acute flaccid paralysis in Australia, 1996- 2004显示文摘 | Kelly H Brussen KA Lawrence A | 2006 | J Paediatr Child Health2006,42,37: | 1 |
| 11 | Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B 显示文摘 | Brown-Shimer S Johnson KA Lawrence JB | 1990 | Proc Natl Acad Sci U S A1990,87,13: | 1 |
| 12 | Polioviruses and other enteroviruses isolated from faecal samples of pa- tients with acute flaccid paralysis in Australia, 1996 - 2004显示文摘 | Kelly H Brussen KA Lawrence A | 2006 | d Pediatr Child Health2006,42,6: | 1 |
| 13 | Polioviruses and other enteroviruses isolated from faecal samples of patients with acute flaccid paralysis in Australia, 1996- 2004 显示文摘 | Kelly H Brussen KA Lawrence A | 2006 | J Paediatr Child Health2006,42,6: | 1 |
| 14 | Polioviruses and other en- teroviruses isolated from faecal samples of patients with acute flaccid pa- ralysis in Australia 1996 - 2004 显示文摘 | Keuy H Bmssen KA Lawrence A | 2006 | J Paediatr Child Health2006,42,6: | 1 |
| 15 | The calciumsensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA显示文摘 | Blankenship KA Williams JJ Lawrence MS | 2001 | Am J Physiol Renal Physiol2001,280,5: | 1 |
| 16 | The impact of system of care support in adherence to wraparound principles in Child and Family Teams in child welfare in North Carolina显示文摘 | Snyder EH Lawrence CN Dodge KA | | 0,,04: | 1 |
| 17 | Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial显示文摘 | Ka Sing Lawrence Wong Christopher Chen Jianhui Fu Hui Meng Chang Nijasri C Suwanwela Yining N Huang Zhao Han Kay Sin Tan Disya Ratanakorn Pavithra Chollate Yudong Zhao Angeline Koh Qing Hao Hugh S Markus | 2010 | Lancet Neurology2010,,5: | 1 |
| 18 | GuaA and GuaB Are Es- sential for Borrelia burgdorferi Survival in the Tick - Mouse Infec- tion Cycle显示文摘 | Jewett MW Lawrence KA Bestor A | 2009 | J of bacteriology2009,191,20: | 1 |
| 19 | Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B 显示文摘 | Brown-Shimer S Johnson KA Lawrence JB | 1990 | Proc Nati Acad Sci USA1990,87,13: | 1 |
| 20 | New developments in craniofacial reconstruction 显示文摘 | Matthew KA Lawrence MJ | 2002 | Curr Opin Otolaryngol Head Neck Surg2002,10,4: | 1 |