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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 3 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 4 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 5 | Study on the recovery of hydrogen from refinery (hydrogen+methane) gas mixtures using hydrate technology显示文摘A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen from (H2 + CH4) feed mixtures with various hydrogen contents (mole fraction x = 40%-90%). The experimental results showed that the hydrogen content could be enriched to as high as ~94% for various feed mixtures using the proposed hydrate technology under a temperature slightly above 0℃ and a pressure below 5.0 MPa. With the addition of a small amount of suitable additives, the rate of hydrate formation could be increased significantly. Anti-agglomeration was used to disperse hydrate particles into the condensate phase. Instead of preventing hydrate growth (as in the kinetic inhibitor tests), hydrates were allowed to form, but only as small dispersed particles. Anti-agglomeration could keep hydrate particles suspended in a range of condensate types at 1℃ and 5 MPa in the water-in-oil emulsion. | WANG XiuLin CHEN GuangJin YANG LanYing ZHANG LinWei | 2008 | Science China Chemistry2008，51，2： | 17 |
| 6 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
| 7 | Precipitation seesaw phenomenon and its formation mechanism in the eastern and western parts of Northwest China during the flood season显示文摘Extending across three major plateaus,namely the Qinghai-Tibetan Plateau,the Inner Mongolia-Xinjiang Plateau and the Loess Plateau,Northwest China has the complex terrain and spatio-temporal climate variations,and is affected by the interactions among different circulation systems,such as the summer monsoon,the westerlies and the plateau monsoon.The understanding of the climate variability,as well as its characteristics and evolution mechanisms in this area has been limited so far.In this paper,the precipitation characteristics and mechanisms in the eastern and western parts of Northwest China during the flood season are compared and analyzed based on the data from 192 national meteorological observational sites in Northwest China in 1961-2016.The results show that,divided by the northern boundary of the East Asian summer monsoon,there are huge differences in the precipitation variation characteristics between the eastern and western parts.The inter-annual variations,interdecadal variations and total trends in the two parts all show a significant seesaw phenomenon.Moreover,it is found that the seesaw phenomenon of precipitation variation is closely related to the opposite variation between the East Asian summer monsoon index(MI)and the westerly circulation index(WI).In addition,the inverse variations on different time scales are only related to the contributions of precipitation at specific grades.Besides,in the two matching patterns of precipitation in the seesaw phenomenon,the middle and high latitudes are occupied by the'high-low-high'wave trains in the precipitation increases in the east of Northwest China(ENWC)and decreases in the west of Northwest China(WNWC)pattern,meaning precipitation increases in ENWC and decreases in WNWC.Whereas the opposite'low-high-low'wave trains at 500 hPa height are observed in the middle and high latitudes in the WH-EA pattern at 500 hPa height,meaning precipitation increases in WNWC and decreases in ENWC.Thus,the atmosphere circulation situation with two wave train types can support both the precipitation seesaw phenomenon and the opposite variation between MI and WI.Moreover,the seesaw phenomenon is shown to be related to the separate or joint effects of the South Asian High,ENSO and the plateau heating on the common but opposite effect on the summer monsoon and the westerlies,in which the South Asian High probably plays a more critical role.This study could deepen the scientific understanding of precipitation mechanisms and improve the weather forecast technology in Northwest China during the flood season. | Qiang ZHANG Jingjing LIN Weicheng LIU Lanying HAN | 2019 | Science China Earth Sciences2019，62，12： | 11 |
| 8 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 9 | Effect of Linguizhugan decoction on hyperlipidemia rats with intermittent fasting显示文摘OBJECTIVE:To explore the effect of Linguizhugan decoction on hyperlipidemia rats with caloric restriction.METHODS:The hyperlipidemia model of rat was induced by high fat diet for 8 weeks.After the model was established,26 rats were randomly divided into 4 groups:the control group(n=6),the model group(n=6),the intermittent fasting(IF) group(n= 8),and the IF and herbal medicine(IFH) group(n= 6).IF group was applied intermittent fasting every other day.The IFH group was given Linguizhugan decoction every day and intermittent fasting every other day.Blood samples were taken at the end of 16 weeks,and serum ghrelin and lipid was tested.RESULTS:Serum ghrelin in the IF group significantly increased(P<0.01).Serum ghrelin in IFH group was lower than the IF group(P<0.05),but higher than the model group(P<0.01).CONCLUSION:Linguizhugan decoction may play a part in regulation of energy and appetite in hyperlipidemia rats with IF. | Yubin Yang Jian Qin Bin Ke Junjie Zhang Lanying Shi Qiong Li | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 6 |
| 10 | Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines显示文摘Seasonal influenza epidemics and influenza pandemics caused by influenza A virus(IAV)has resulted in millions of deaths in the world.The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics.Hemagglutinin(HA)of IAV plays a critical role in viral binding,fusion and entry,and contains the major neutralizing epitopes.Therefore,HA is an attractive target for developing anti-IAV drugs and vaccines.Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines. | Shibo Jiang Runming Li Lanying Du Shuwen Liu | 2010 | Protein & Cell2010，1，4： | 5 |
| 11 | Exploitation of methane in the hydrate by use of carbon dioxide in the presence of sodium chloride显示文摘The replacement process of CH4 from CH4 hydrate formed in NaCl solution by using pressurized CO2 was investigated with a self-designed device at temperatures of 271.05,273.15 and 275.05 K and a constant pressure of 3.30 MPa.The mass fraction of the NaCl solution was either 0.5 wt% or 1.0 wt%.The effects of temperature and concentration of NaCl solution on the replacement process were investigated.Experimental results showed that high temperature was favorable to the replacement reaction but high NaCl concentration had a negative effect on the replacement process.Based on the experimental data,kinetic models of CH4 hydrate decomposition and CO2 hydrate formation in NaCl solution were established.The calculated activation energies suggested that both CH4 hydrate decomposition and CO2 hydrate formation are dominated by diffusion in the hydrate phase. | Zunzhao Li Xuqiang Guo Lanying Yang Xiaona Ma | 2009 | Petroleum Science2009，6，4： | 5 |
| 12 | A Complete Embryonic Developmental Table of Microhyla fissipes(Amphibia,Anura,Microhylidae)显示文摘Access to embryonic developmental stages is essential basic work for understanding how organisms develop. In this study, seven egg clutches(range 209–564 eggs) of ornamented pygmy frog Microhyla fissipes(Amphibia, Anura, Microhylidae) were obtained from seven breeding pairs in laboratory. One egg clutch of them was observed for the embryonic development, and the staging table of normal development was constructed based on morphological and physiological characteristics. Forty-five developmental stages were defined for M. fissipes, and two major developmental periods were designated: 1) early embryonic development period(stages 1–28), from fertilization to operculum completion stage, lasted for 82.6 hours at water temperature(WT) 23–25℃; 2) larval development period(stages 29–45), from operculum completion to tail complete absorption stage, took 38 days at WT 22–26.5℃, showing that the embryos of this species develop rapidly. In addition, the tadpoles were transparent, which is similar to those in field. These characteristics suggest that M. fissipes would be a good model to study developmental biology, adaptive mechanisms from aquatic to terrestrial phases, environmental toxicology, and human disease. | Shouhong WANG Lanying ZHAO Lusha LIU Dengwei YANG Janak Raj KHATIWADA Bin WANG Jianping JIANG | 2017 | Asian Herpetological Research2017，18，2： | 5 |
| 13 | A tropical paleosol at high elevation in the Yulong Mountains and its implication on the uplift of the Tibetan Plateau显示文摘A paleosol dated for about 500-700 kaBP and developed on a glacial deposit at -3 000 in a.s.l. in the Yulong Mountains is studied using soil chemical, morphological and mineralogical methods. The analytical results indicate that this soil was formed under tropical and humid conditions and can be classified as red soil, which cannot be formed in the present alpine environment at the studied site. This implies that the southeast margin of the Tibetan Plateau has experienced intense uplift since the formation of the paleosol. According to the necessary conditions for the formation of the modern red soil in China, we estimate that the | Zhengtang Guo Xiaofeng Yao Xitao Zhao Lanying Wei | 2001 | Chinese Science Bulletin2001，46，1： | 5 |
| 14 | A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)highlights the need to develop effective and safe vaccines.Similar to SARS-CoV,SARS-CoV-2 recognizes angiotensin-converting enzyme 2(ACE2)as receptor for host cell entry.1,2 SARS-CoV-2 spike(S)protein consists of S1,including receptor-binding domain(RBD),and S2 subunits.3,4 We previously demonstrated that RBDs of SARS-CoV and MERS-CoV serve as important targets for the development of effective vaccines. | Wanbo Tai Xiujuan Zhang Aleksandra Drelich Juan Shi Jason CHsu Larry Luchsinger Christopher D.Hillyer Chien-Te KTseng Shibo Jiang Lanying Du | 2020 | Cell Research2020，30，10： | 5 |
| 15 | Advanced prediction for multiple disaster sources of laneway under complicated geological conditions显示文摘The driving safety in the laneway is often controlled by multiple disaster sources which include fault fracture zone, water-bearing body, goaf and collapse column. The advanced prediction of them has become a hotspot. Based on analysis of physical characteristics of the disaster sources and comparative evaluation of accuracy of the main advanced geophysical detection methods, we proposed a comprehen- sive judging criterion that tectonic interface can be judged by the elastic wave energy anomaly, strata water abundance can be discriminated by apparent resistivity response difference and establish a reason- able advanced prediction system. The results show that the concealed disaster sources are detected effec- tively with the accuracy rate of 80% if we use advanced prediction methods of integrated geophysics combined with correction of seismic and electromagnetic parameters, moreover, applying geological data, we may then distinguish types of the disaster sources and fulfill the qualitative forecast. Therefore, the advanced prediction system pays an important referential and instructive role in laneway driving project. | Wang Bo Liu Shengdong Liu Jing Huang Lanying Zhao Ligui | 2011 | Mining Science and Technology2011，21，5： | 5 |
| 16 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 17 | A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling显示文摘Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. | Wan Chen Xiaonan Guo Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 18 | Weathering Signals of Millennial-Scale Oscillations of the East-Asian Summer Monsoon over the Last 220 ka显示文摘This study generated a high-resolution paleoweathering record of the loess-soilsequence from the central Loess Plateau covering the last 220 ka using the ratio between the CBD(citrate-bicarbonate-dithionite) extractable free Fe2O3 (Fed) and total Fe2O3 (Fet). The new proxyshows a series of millennial oscillations, which are not necessarily documented by magneticsusceptibility from the same site. Because chemical weathering in the region depends mainly uponsummer precipitation and temperature, we interpret these changes to be a result of millennial-scalevariations in the strength of the East-Asian summer monsoon. Over the last glacial period, there isgeneral agreement between the loess weathering record and the GRIP ice δ18O record. The firstsuggests a rather stable summer monsoon pattern during the Last Interglacial period (marine δ18Ostage 5e). Large amplitude millennial oscillations of the summer monsoon seem to be particularlycharacteristic of the last glacial period whereas the fluctuations for the older periods are smoother. | GU0 Zhengtang PENG Shuzhen WEI Lanying LIU Tungsheng Institute of Geology, Chinese Academy of Sciences. P. O. Box 9825, Beijing 100029, China | 1999 | Chinese Science Bulletin1999，44，S1： | 5 |
| 19 | Contaminant removal from low-concentration polluted river water by the bio-rack wetlands显示文摘The bio-rack is a new approach for treating low-concentration polluted river water in wetland systems.A comparative study of the efficiency of contaminant removal between four plant species in bio-rack wetlands and between a bio-rack system and control system was conducted on a small-scale (500 mm length × 400 mm width × 400 mm height) to evaluate the decontamination effects of four different wetland plants.There was generally a significant difference in the removal of total nitrogen (TN),ammonia nitrogen (NH 3-N) and total phosphorus (TP),but no significant difference in the removal of permanganate index (COD Mn) between the bio-rack wetland and control system.Bio-rack wetland planted with Thalia dealbata had higher nutrient removal rates than wetlands planted with other species.Plant fine-root (root diameter 3 mm) biomass rather than total plant biomass was related to nutrient removal efficiency.The study suggested that the nutrient removal rates are influenced by plant species,and high fine-root biomass is an important factor in selecting highly effective wetland plants for a bio-rack system.According to the mass balance,the TN and TP removal were in the range of 61.03-73.27 g/m2 and 4.14-5.20 g/m2 in four bio-rack wetlands during the whole operational period.The N and P removal by plant uptake constituted 34.9%-43.81% of the mass N removal and 62.05%-74.81% of the mass P removal.The study showed that the nitrification/denitrification process and plant uptake process are major removal pathways for TN,while plant uptake is an effective removal pathway for TP. | Ji Wang Lanying Zhang Shaoyong Lu Xiangcan Jint Shu Gan | 2012 | Journal of Environmental Sciences2012，24，6： | 4 |
| 20 | Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses显示文摘Dear Editor,The 2002–2003 global pandemic caused by severe acute respiratory syndrome coronavirus(SARS-CoV)infected around 8,000 people with 10%mortality(http://gffzz36b398b81f8a4a4ch99659kobvb0k6590.ffgz.tsg.suse.edu.cn/csr/sars/en/).The virus has a positivestranded RNA genome that encodes a large polyprotein(1a and 1ab),four structural proteins,including spike(S), | Lei-Ping Zeng Xing-Yi Ge Cheng Peng Wanbo Tai Shibo Jiang Lanying Du Zheng-Li Shi | 2017 | Science China(Life Sciences)2017，60，12： | 4 |
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