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| 1 | Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes显示文摘在从经由单性生殖和男性单性生殖的老鼠的胚胎的干细胞(haESCs ) 启用了在修改基因的动物的哺乳动物的房间和代的基因屏蔽的 haploid 的推导的最近的成功。然而, haESCs 是否能从首领被导出,仍然保持未知。这里,我们从 Macaca fascicularis 猴子的单性生殖的胚囊报导 haESCs 的推导。这些房间,作为 PG-haESCs 称为,是 pluripotent 并且能在 vitro 或在 vivo 区分到三胚胎的细菌层的房间。有趣地,一根猴子 PG-haESC 线(MPH1 ) 的 haploidy 与另一个(MPH2 ) 的相比是更稳定的,作为没有排序的激活荧光的房间(FACS ) ,由 haploid 房间的存在出现超过 140 天 haploid 房间的丰富。重要地,转基因的猴子 PG-haESC 线能被 lentivirus- 和 piggyBac 产生调停 transposon 的基因转移。而且,基因屏蔽在猴子 PG-haESCs 是可行的。我们的结果证明 PG-haESCs 能从猴子被产生,提供为在首领的基因分析的一个理想的工具。 | Hui Yang Zhen Liu Yu Ma Cuiqing Zhong Qi Yin Chikai Zhou Linyu Shi Yijun Cai Hanzhi Zhao Hui Wang Fan Tang Yan Wang Chenchen Zhang Xin-yuan Liu Dongmei Lai Ying Jin Qiang Sun Jinsong Li | 2013 | Cell Research2013，23，10： | 22 |
| 2 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
| 3 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 4 | A MyD88-JAK1-STAT1 complex directly induces SOCS-1 expression in macrophages infected with Group A Streptococcus显示文摘一些病原体能使用表明 1 的 cytokine (SOCS-1 ) 的主人 suppressor,一个重要否定反馈的分子,有免疫力的避免的主要模式。这里,我们发现那个组 A 链球菌(气体) 能够在 RAW264.7 和 BMDM 巨噬细胞导致 SOCS-1 表示。IFN-β在由气体跟随 cytokine 表示的正式就职的巨噬细胞在导致气体的 SOCS-1 表示起一个作用,代表 SOCS-1 表示的古典小径。然而,当感染气体的房间与 anti-IFN-β 被孵化时,气体也导致了 STAT1 激活和 SOCS-1 表示;在这研究的 monoclonal 抗体。而且,在把 TLR4 −/− BMDM 巨噬细胞与作比较之上野类型(WT ) 房间,我们发现 TLR4 也在 SOCS-1 的正式就职起一个必要作用。MyD88,是为 TLR4 的适配器蛋白质,由与 Janus kinase 形成建筑群贡献 STAT1 激活和 phosphorylation 1 (JAK1 ) 并且信号变换器和在巨噬细胞的抄写 1 的使活跃之物(STAT1 ) 。而 JAK1 的表示是未受影响的, STAT1 的刺激气体的表示严重地在 MyD88 −/− 巨噬细胞被损害,建议 MyD88 涉及 STAT1 表示和 phosphorylation。一起,这些数据除了 IFN-β 表明了那;发信号并且 MyD88 复杂形成, JAK1 和 STAT1 在一条新奇小径行动直接在感染气体的巨噬细胞导致 SOCS-1 表示,它可能对快速的细菌的感染更导致。 | Jinghua Wu Cuiqing Ma Haixin Wang Shuhui Wu Gao Xue Xinli Shi Zhang Song Lin Wei | 2015 | Cellular & Molecular Immunology2015，12，3： | 5 |
| 5 | Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice显示文摘Group A streptococcus(GAS),an important human pathogen,can cause various kinds of infections including superficial infections and potentially lethal infections,and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA(an Fn-binding protein expressed on the surface of GAS) with that of M protein,the best immunogen of GAS. Assay for immune response showed that FbaA,similar to M protein,could induce protein-specific high IgG titer in BALB/c mice. Furthermore,following GAS challenge,the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. | Cuiqing Ma Caihong Li Xiurong Wang Ruihong Zeng Xiaolin Yin Huidong Feng Lin Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 4 |
| 6 | Preparation of microbial desulfurization catalysts显示文摘A Rhodococcus sp. lawq, a bacterium isolated from the soil cleaving the C-S bond of dibenzothiophene (DBT) via specific pathway, was investigated for cell growth and for its role in desulfurization. Clearly, the end product, 2-hydroxybiphenyl, inhibited the growth of the strain, the synthesis of the desulfurization enzymes, and the activity of the enzymes. The effects of sulfate on the DBT degradation enzymes were examined in the Rhodococcus sp. lawq growth system with DBT; the sulfate served, concurrently, as the sulfur source. The condition of the resting cells that were used in desulfurization, was also studied. The optimal concentration of the resting cells and the reaction conditions were determined. It was documented that there is no difference between desulfurization activity for resting cells cultured with sulfate as the sole sulfur source and that with the mixture of DBT and sulfate as the sulfur source. | XU Ping MA Cuiqing LI Fuli TONG Mingyou ZENG Yiyong WANG Shuning H.D.Blankespoor | 2002 | Chinese Science Bulletin2002，47，13： | 4 |
| 7 | Degradation of n -alkanes and polycyclic aromatic hydrocarbons in petroleum by a newly isolated Pseudomonas aeruginosa DQ8显示文摘 | Zhengzhi Zhang Zhaowei Hou Chunyu Yang Cuiqing Ma Fei Tao Ping Xu | 2010 | Bioresource Technology2010，，5： | 1 |
| 8 | Medium optimization by combination of response surface methodology and desirability function: an application in glutamine production显示文摘 | Jinshan Li Cuiqing Ma Yanhe Ma Yan Li Wei Zhou Ping Xu | 2007 | Applied Microbiology and Biotechnology2007，，3： | 1 |
| 9 | Efficient conversion of phenylpyruvic acid to phenyllactic acid by using whole cells of Bacillus coagulans SDM显示文摘 | ZHENG Zhaojuan MA Cuiqing GAO Chao | 2011 | PLoS One2011，6，19： | 1 |
| 10 | 显示文摘 | Guofang Lin Qingwen Ma Jigang Chen Jianhua Shen Cuiqing Xiang Klaus Golka Dongsheng Zhang | 2001 | Archives of Toxicology2001，，9： | 1 |
| 11 | Biotechnological routes based on lactic acid production from biomass显示文摘 | Chao Gao Cuiqing Ma Ping Xu | 2011 | Biotechnology Advances2011，，6： | 1 |
| 12 | Medium Optimization by Combination of Response Surface Methodology and Desirability Function :an Application in Glutamine Production显示文摘 | Jinshan Li Cuiqing Ma Yanhe Ma | 2007 | Appl Micrabiol Biotechnol2007，74，： | 1 |
| 13 | Relativecatalytic efficiency of IdhL- and ldhD-encoded products is crucialfor optical purity of lactic acid produced by Lactobacillus strains 显示文摘 | ZHENG Zhaojuan SHENG Binbin MA Cuiqing | 2012 | Applied and Environmental Microbiology2012，78，9： | 1 |
| 14 | Degradation of n -alkanes and polycyclic aromatic hydrocarbons in petroleum by a newly isolated Pseudomonas aeruginosa DQ8显示文摘 | Zhengzhi Zhang Zhaowei Hou Chunyu Yang Cuiqing Ma Fei Tao Ping Xu | 2010 | Bioresource Technology2010，，5： | 1 |
| 15 | Efficient utilization of hemicellulose hydrolysate for propionic acid production using Propionibacterium acidipropionici显示文摘 | Zhen Liu Cuiqing Ma Chao Gao Ping Xu | 2012 | Bioresource Technology2012，，： | 1 |
| 16 | Enhanced 2,3-butanediol production by Klebsiella pneumoniae SDM显示文摘 | Cuiqing Ma Ailong Wang Jiayang Qin Lixiang Li Xulu Ai Tianyi Jiang Hongzhi Tang Ping Xu | 2009 | Applied Microbiology and Biotechnology2009，，1： | 1 |
| 17 | Analysis of the Implementation of Integrated Healthcare Management in Preoperative Preparation显示文摘Objective:To strengthen preoperative preparation management and reduce preoperative preparation defects.Methods:We set up a special medical care management team to investigate the preoperative preparation in surgical departments,analyze the causes of the shortcomings in preoperative preparation,and propose countermeasures.The medical staff jointly formulated plans related to preoperative preparation management including clear outline of responsibilities,strengthening of training,integrated medical care,timely feedback,and continuous improvement.Besides,the preoperative preparation of patients before and after the improvement measures were compared using statistical analysis.Results:The rate of inadequate preoperative preparation was 11.14 per thousand before the integrated management model was implemented.After the implementation of the integrated management model,the rate of inadequate preoperative preparation decreased to 2.99 per thousand,and the difference was statistically(P<0.05).Conclusion:The integrated management of preoperative preparation can help reduce the rate of preoperative complications and ensure the safety of surgery. | Huiling Liu Xuling Li Xinyi Liu Yuhua Ma Haomin Li Cuiqing Liu | 2023 | Journal of Clinical and Nursing Research2023，7，3： | 0 |
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