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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Mapmaker:an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘 | Lander E S P Green Abraham | 1987 | Genomics1987，，1： | 1 |
| 3 | MAPMAKER:An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘 | LANDER E S GREEN P ABRAHAMSON J | 1987 | Genomics1987，1，： | 1 |
| 4 | Retesting after initial failure, coaching rumors, and warnings against faking in online personality measures for selection显示文摘 | Landers R N Sackett P R Tuzinski K A | 2011 | Journal of Applied Psychology2011，96，1： | 1 |
| 5 | Hydrogenation in vitro of α-linoleic acid to stearic acid by mixed cuhures of pure strains of rumen bacteria显示文摘 | KEMP P LANDER D J | 1984 | J Gen Microbiol1984，130，3： | 1 |
| 6 | Aseptic necrosis of the talus and calcaneal insufficiency fractures in a patient with pancreatitis, subcutaneous fat necrosis, and arthritis显示文摘 | Baron M Paltiel H Lander P | 1984 | Arthritis Rheum1984，27，11： | 1 |
| 7 | An apple a day creates a waste problem , and cornel turns it into fuel 显示文摘 | Blaine P Fried lander Jr | 1995 | Sience News1995，3，： | 1 |
| 8 | Principles and signal processing techniques of the high-resolution electrocardiogram 显示文摘 | Berbari EJ | 1992 | Progr Cardiovasc Dis1992，3，： | 1 |
| 9 | Construction of muhilocus genetic maps in human s显示文摘 | Lander E S Green P | 1987 | Proc Nat Acad Sci USA1987，84，： | 1 |
| 10 | Abnormal intra-QRS potentials associated with percutaneous trasluminal coronary angiography-inducd transient myocardial ischemis显示文摘 | Lander P Gomis P Warren S | 2006 | J Electrocardiol2006，39，3： | 1 |
| 11 | Mapmaker: An interactive computer package for constructing primary ge- netic linkage maps of experimental and natural popula- tions 显示文摘 | Lander E S Green P Abrahamson J | 1987 | Genomics1987，1，： | 1 |
| 12 | MAPMAKER: an interactive computer package for constructing primary genetic maps of experimental and natural populations显示文摘 | Lander E S Green P Abrahamson J Barlow A Day M J Lincoln S E Newbury L | 1987 | Genetics1987，1，： | 1 |
| 13 | A comparison of modeling and imaginary in the acqui- sition and retention of motor skills 显示文摘 | Ram N Riggs S M Landers D M McCullagh P | 2007 | Journal of Sports Sciences2007，25，5： | 1 |
| 14 | A new,non-contact wide field viewing system for vitreous surgery显示文摘 | Landers MB Peyman GA Wessels IF Whalen P Morales V | | 0，，01： | 1 |
| 15 | MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘 | Lander E S Green P Abrahamson J | 1987 | Genomies1987，1，： | 1 |
| 16 | Abnormal intra-QRS potentials associated with percutaneous transluminal coro- nary angiography-induced transient myocardial ischemia 显示文摘 | Lander P Gomis P Warren S | 2006 | J Electrocardio12006，39，3： | 1 |
| 17 | An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘 | Lander E S Green P Abrahamson J | 1987 | Genomics1987，1，： | 1 |
| 18 | Hydrogenation in vitro of alpha-linoleic acid to stearic acid by mixed cultures of pure strains of rumen bacteria显示文摘 | Kemp P Lander D J | 1984 | Journal of Genetic Microbiology1984，130，： | 1 |
| 19 | MAPMAKER:an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘 | LANDER E S GREEN P ABRAHAMSON J | 1987 | Genomics1987，1，2： | 1 |
| 20 | Mapmaker:An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘 | Lander E S Green P Abrahamson J | 1987 | Genomics1987，1，： | 1 |
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