|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Presentation,management,and outcome of newly diagnosed glioblastoma in elderly patients显示文摘OBJECT: Optimum management for elderly patients with newly diagnosed glioblastoma(GBM) in the temozolomide(TMZ) era is not well defined.The object of this study was to clarify outcomes in this population.METHODS: The authors retrospectively reviewed 105 consecutive cases involving elderly patients(age ≥ 65 years) with newly diagnosed GBM who were treated at the Mayo Clinic between 2003 and 2008.RESULTS: The patients' median age was 74 years(range 66-87 years),and the median Karnofsky Performance Status(KPS) score was 80(range 40-90).Half of the patients underwent biopsy and half underwent resection.Patients with deep-seated lesions(19 patients [18%]) or multifocal lesions(34 patients [32%]) were more likely to have biopsy than resection(p = 0.0001 and 0.0009,respectively).New persistent neurological deficits developed in 7 patients(6.7%).Postoperative hemorrhage occurred in 6 patients(5.7%),all of whom underwent biopsy.Complete follow-up data regarding adjuvant treatment was available in 84 patients.Forty-one(49%) were treated with chemotherapy(mostly TMZ) and radiation therapy(RT),and 23(27%) with RT alone.Nineteen(23%) received only palliative care after surgery(more common with biopsy,p = 0.03).Chemotherapy complications occurred in 28.6%(Grade 3 or 4 hematological complications in 11.9%).The median values for progression-free survival(PFS) and overall survival(OS) were 3.5 and 5.5 months.In a multivariate analysis,younger age(p = 0.03,risk ratio [RR] 0.34,95% CI 0.13-0.89),single lesion(p = 0.02,RR 0.51,95% CI 0.30-0.89),resection(p = 0.04,RR 0.54,95% CI 0.31-0.94),and adjuvant treatment(p = 0.0001,RR 0.24,95% CI 0.11-0.49) were associated with better OS.Only adjuvant treatment was significantly associated with prolonged PFS(p = 0.0007,RR 0.27,95% CI 0.13-0.57).With combined therapy with resection,RT,and chemotherapy,the median PFS and OS were 8 and 12.5 months,respectively.CONCLUSIONS: The prognosis for GBM worsens with increasing age in elderly patients.With important risks,resection and adjuvant treatment are associated with prolonged survival.Although selection bias cannot be excluded in this retrospective study,advanced age alone should not necessarily preclude optimal resection followed by adjuvant radiochemotherapy. | Tanaka S Meyer FB Buckner JC Uhm JH Yan ES Parney IF | 2013 | 中国神经肿瘤杂志2013，11，1： | 4 |
| 2 | Retinal vascular changes associated with transpupillary thermotherapy for choroidal melanomas显示文摘 | Currie ZI Rennie IF Talbot JF | 2000 | Retina2000，20，： | 2 |
| 3 | GENCODE: The reference human genome annotation for The ENCODE Project显示文摘 | Jennifer Harrow Adam Frankish Jose M. Gonzalez Electra Tapanari Mark Diekhans Felix Kokocinski Bronwen L. Aken Daniel Barrell Amonida Zadissa Stephen Searle If Barnes Alexandra Bignell Veronika Boychenko Toby Hunt Mike Kay Gaurab Mukherjee Jeena Rajan Glo | 2012 | Genome Research2012，，9： | 2 |
| 4 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 5 | Assessment of coke oven emission exposure among coking workers显示文摘 | Chen ML Mao IF Wu MT | 1999 | Am Ind Hyg Assoc J1999，60，1： | 2 |
| 6 | Semantic Data Integration in Hierarchical Domains显示文摘 | CRUZ IF RAJENDRAN A | 2003 | IEEE Intelligent Systems2003，18，2： | 2 |
| 7 | Hyperleptinaemia as a component of metabolic syndrome of cardovascular risk显示文摘 | Leyva F Godsland IF Ghatei M | 1998 | Arterioscler Thromb Vasc Biol1998，18，6： | 2 |
| 8 | Cholinergic parameters and the retrieval of learned and re-learned spatial informarion: a study using a model of Wernicke Korsakoff Syndrome显示文摘 | Pires RG Pereira SR Oliveira Silva IF | 2005 | Behav Brain Res2005，162，1： | 1 |
| 9 | Classification and treatment of spontaneous carotid-cavernous sinus fistulas显示文摘 | Spector RH Braun IF | 1985 | J Neurosurg1985，62，2： | 1 |
| 10 | Clarithromycin resistance and efficacy of clarithromycin-containing triple eradication therapy for Helicobacter pylori infection in type 2 diabetes mellitus patients显示文摘 | Hung IF Chan P Leung S | 2009 | Helicobacter2009，14，6： | 1 |
| 11 | Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions:a high-resolution MRI study显示文摘 | Klein IF Lavalle PC Mazighi M | 2010 | Stroke2010，41，7： | 1 |
| 12 | Bicarbonateincreases tumor pH and inhibits spontaneous metastases显示文摘 | Robey IF Baggett BK Kirkpatrick ND | 2009 | Cancer Res2009，69，： | 1 |
| 13 | The penetration of anticaneer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells显示文摘 | Grantab R Sivananthan S Tannoek IF | 2006 | Cancer Res2006，66，2： | 1 |
| 14 | Elevated intra-abdominal pressure increases plasma rennin activity and aldosterone leves显示文摘 | Bloomfied GL Blocher CR Fakhry IF | 1997 | J Trauma1997，42，6： | 1 |
| 15 | Orexin gene expression is increased during states of hypertriglyceridemia 显示文摘 | Wortley If E Chang Guo-Qing Davydova Z | 2003 | AJP-Regul Integr Comp Physial2003，284，： | 1 |
| 16 | Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults 显示文摘 | Bellamy MF McDowell IF Ramsey MW | 1998 | Circulation1998，98，： | 1 |
| 17 | Radiation treatment planning with an integrated positron emission and computer tomography(PET/CT): a feasibility study显示文摘 | Ciernik IF Dizendorf E Baumert BG | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 18 | Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia : pooled data from three 6-week, placebo-controlled studies 显示文摘 | MELTZER HY BOBO WV NUAMAH IF | 2008 | J Clin Psychiat2008，69，5： | 1 |
| 19 | The salfetg and du-ration of nomoperative treatment for adhesive small bowel obstraction 显示文摘 | Cox MR Gunn IF Eastman MC | 2007 | Aust NZJ Sury2007，63，5： | 1 |
| 20 | The salfetg and duˉration ofnomoperative treatment for adhesive small bowel obstraction显示文摘 | Cox MR Gunn IF Eastman MC | 2009 | Aust NZJ Sury2009，63，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员