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| 1 | Infliximab to treat severe ulcerative colitis显示文摘A 48-year-old female with severe ulcerative colitis refractory to conventional therapy was referred to our facility for management. The patient showed extensive ulcerative colitis since the age of 20 years and had failed therapy with 5-aminosalicylic acid agents and azathioprine. The disease remained active despite treatment with steroids and cyclosporine. The clinical and endoscopic parameters were consistent with severe disease. Infectious precipitants were ruled out. Given the severity of the disease and in order to avoid a colectomy, we started the patient on infliximab therapy. A dramatic clinical and endoscopic response was observed and she remained in remission at the end of a 1-year follow-up period. We discuss findings in the literature regarding the use ofinfliximab therapy in patients with ulcerative colitis who have failed steroids and cyclosporine. | Dídia Bisamra Cury Marcelo de Souza Cury Geraldo Vinicius Hemerly Elias Sender Jankiel Mizsputen | 2009 | World Journal of Gastroenterology2009，15，14： | 6 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Treatment of interstitial cystitis with a quercetin supplement显示文摘 | Katske F Shoskes DA Sender M | 2001 | Tech Urol2001，7，1： | 1 |
| 4 | International Prognostic Index, Type of Transplant and Response to Rituximab Are Key Parameters to Tailor Treatment in Adults With CD20‐Positive B Cell PTLD: Clues From the PTLD‐1 Trial显示文摘 | R. U. Trappe S. Choquet D. Dierickx P. Mollee J. M. Zaucha M. H. Dreyling U. Dührsen C. Tarella O. Shpilberg M. Sender G. Salles F. Morschhauser A. Jaccard T. Lamy P. Reinke R. Neuhaus H. Lehmkuhl H. A. Horst M. Leith?user P. Schlattmann I. Anagnostopoulo | 2015 | American Journal of Transplantation2015，，4： | 1 |
| 5 | Failu:,: mode and effects analysis:a novel approach to avoiding dangerous medica tion errors and aecidents显示文摘 | Cohen MR Senders J Davis NM | 1994 | Hospital pharmacy1994，29，4： | 1 |
| 6 | Schoolmistresses and Head- mistresses:Elites and Education in Nineteenth Century England显示文摘 | Pedersen Joyce Senders | 1975 | The Journal of British Studies1975，，1： | 1 |
| 7 | Results of aphase I/Ⅱ trial of recombinant human granulocyte-macrophage colonystimulating factor in very low birth wight neonates: significant induction of circulatory neutrophils, monocytes, platelets and bone marrow neutrophils显示文摘 | Cairo MS Christensen RD Sender LS | 1995 | Blood1995，86，7： | 1 |
| 8 | A CMOS bandgap reference for differential signal processing显示文摘 | NICOLLINI G SENDER D | 1991 | IEEE Journal of Solid-State Circuits1991，26，1： | 1 |
| 9 | Bone contusion patterns of the knee at MR imaging: footprint of the mechanism of injury显示文摘 | Sender TG Feller JF Medynski MA | 2000 | Radiographics2000，20，： | 1 |
| 10 | Heuristics for solving a capacita- ted multiple allocation hub location problem with application in German wagonload traffic显示文摘 | SENDER J CLAUSEN U | 2013 | Electronic Notes in Discrete Mathematics2013，，41： | 1 |
| 11 | Transcutaneous bilirubin measurement: a multicenter evaluation of a new device显示文摘 | Rubaltelli FF Gourley GR Loskamp N Modi N Roth-Kleiner M Sender A | 2001 | Pediatrics2001，107，6： | 1 |
| 12 | The use of interfe- ron alpha-2a for life-threatening hemangiomas显示文摘 | MaeArthur CJ Senders CW Katz J | 1995 | Arch O- tolaryngol Head Neck Surg1995，121，6： | 1 |
| 13 | The use of interferon alfa-2a for life-threatening hemangiomas 显示文摘 | MacArthur CJ Senders CW Katz J | 1995 | Arch Otolaryngol Head Neck Surg1995，121，6： | 1 |
| 14 | Failure mode and effects analysis: a novel approach to avoiding dangerous medication errors and accidents显示文摘 | Cohen M R Senders J Davis N M | 1994 | Hosp Pharm1994，29，4： | 1 |
| 15 | Serum calprotectin levels correlate with biochemical and histological markers of disease activity in TNBS colitis显示文摘 | Didia Bismara Cury Sender Jankiel Mizsputen Clara Versolato Luciana Odashiro Miiji Edson Pereira Maria Aparecida Delboni Nestor Schor Alan C. Moss | 2013 | Cellular Immunology2013，，1： | 1 |
| 16 | Prognosis of airway obstruction and feeding difficulty in the Robin sequence 显示文摘 | Smith MC Senders CW | 2006 | Int J Pediatr Otorhinolaryngol2006，70，2： | 1 |
| 17 | Initial validation of a numeric zero to ten scale to measure children's state anxiety 显示文摘 | Crandall M Lammers C Senders C | 2007 | Anesth Analg2007，105，5： | 1 |
| 18 | Force requirements for artificial muscle to create an eyelid blink with eyelid sling显示文摘 | Senders CW Tollefson TT Curtiss S | 2010 | Arch Facial Plast Surg2010，12，1： | 1 |
| 19 | Multilevel socioeco nomic effects on quality of life in adolescent and young a dult survivors of leukemia and lymphoma显示文摘 | Erin E Leonard S Sender RA | 2013 | Qual Life Res2013，22，15： | 1 |
| 20 | Female pelvic floor anatomy:the pelvic floor,suppo ring st ructures,and pelvic organs显示文摘 | Sender H | | 0，，5： | 1 |
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