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| 1 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 2 | 独立新风系统(DOAS)研究(1):综述显示文摘介绍了独立新风系统的概念、背景、组成、特点和历史及其与建筑物的环境安全性、绿色建筑评估体系的关系。指出这种系统能明显提高室内空气品质、人体舒适感 。 | 殷平 Stanley A.Mumma | 2003 | 暖通空调2003，33，6： | 45 |
| 3 | 蜜瓜和西瓜果汁的射频介电特性及其与糖度的关系显示文摘为了解果汁的介电特性与其主要内部品质——糖度之间的关系,该文利用末端开路的同轴探头和阻抗分析仪测量了10 MHz~1.8 GHz的频率范围内不同成熟度的3个品种密瓜汁和4个品种西瓜汁的介电特性,同时测量了反映果汁糖度的可溶性固形物含量和果肉的含水率,分析了介电特性和糖度间的关系。结果显示:密瓜和西瓜果汁的相对介电常数和介质损耗因数皆随频率的增大单调减小,品种间的差异对介电特性有影响;1.8 GHz下密瓜汁的损耗角正切与糖度有较好的线性关系,其决定系数为0.784,但西瓜汁的介电特性与糖度的相关性较差;密瓜和西瓜果汁的糖度与果肉的含水率有很好的线性相关性,其决定系数分别为0.973和0.906。该研究将为基于介电特性的果汁糖度检测仪的开发提供了研究基础。 | 郭文川 Smart O. Nelson Samir Trabelsi Stanley J. Kays | 2008 | 农业工程学报2008，24，5： | 38 |
| 4 | 贾湖遗址人骨的稳定同位素分析显示文摘古代人类食谱研究是生物考古的重要组成部分,也是当前国际科技考古领域的研究前沿.利用稳定同位素分析方法,尝试揭示贾湖遗址先民的食物结构以及生活方式的变化.人骨的骨胶原含量、C含量以及N含量,尤其是骨胶原C/N摩尔比的分析表明,28个样品中13个已经受到埋藏环境的污染,不能用作食谱分析.其余样品骨胶原的δ13C((-20.37±0.53)‰),表明先民主要以C3类作为食物来源.根据骨胶原中δ13C和δ15N的不同,先民的食谱可划分为4类.两者相关性的缺乏,当与该遗址以农耕经济为主有关.骨胶原δ15N和羟磷灰石δ13C纵贯整个文化段的变化,反映了先民从狩猎转向采集、捕捞直至发展稻作农业和家畜饲养的改变.而羟磷灰石中δ18O则无明显变化,揭示了该遗址气候较为稳定. | 胡耀武 Stanley H.Ambrose 王昌燧 | 2007 | 中国科学(D辑)2007，37，1： | 29 |
| 5 | 中西方减压贮藏研究概述显示文摘减压贮藏系统用调节大气压力控制O2浓度,其技术与效果与CA完全不同。低压下,空气进入真空室会膨胀,使其中的CO2、C2H4,及挥发性污染物浓度减少99%;增强气体扩散及减弱呼吸,使不同物品能忍受0.1%-0.2%的02浓度。气体扩散增强还促进CO2、NH3和GH4从物品内部逸出,连续换气将其排到室外。在1.33—2.67kPa极低压力下,物品呼吸热少相应的能蒸的水分就少,高湿度和防止对流及辐射减少物品失水。极低压时O2极稀薄,园艺品呼吸热和传热能力因对流抑制了90%。极低压防止细菌和霉菌生长,杀灭昆虫,抑制GH4生成量〉90%,防止CO2伤害,抑制有毒的琥珀酸盐形成,限制Vc损失,阻止GH4形成酶,因此减压设备极有利于园艺品贮藏。概述西方减压研究成果与发展,评价中西方在减压研究上存在的重要差异。 | Stanley P.Burg 郑先章 | 2007 | 制冷学报2007，28，2： | 29 |
| 6 | 中文版Kutcher青少年抑郁量表测评青少年样本的效度与信度显示文摘目的:检验中文版Kutcher青少年抑郁量表(11项)(KADS-11)的效度、信度,确定其敏感度、特异度和划界值等,以期对中国青少年抑郁症状的筛查提供有用的工具。方法:选取黑龙江、辽宁、河北、河南、江西、湖南6个省和上海市的11-17岁中小学学生3180例,使用KADS-11和儿童抑郁量表(CDI)对全部样本进行抑郁症状的筛查,并由精神科医生对CDI≥19分的学生(435例)使用DSM-IV做抑郁症的诊断评估,1个月后从上海地区的样本随机抽取73例以同样的程序对KADS-11、CDI进行重测。结果:探索性因子分析结果显示KADS-11有2个因子,使用验证性因子分析检验,两因子模型适配度较好,并且优于单因子模型,KADS-11与CDI总分之间呈正相关(r=0.74,P〈0.01),经诊断的抑郁症组在KADS-11各条目及总分得分上均高于非抑郁症组(P〈0.001);KADS-11量表在受试者工作特征曲线(ROC)下的面积AUC=0.94,11个条目的 AUC值都在0.7-0.9之间,选取总分≥9分作为KADS-11的划界值,此时,敏感度为89%,特异度为90%;KADS-11的Cronbachα系数为0.84,奇偶分半相关系数为0.77(P〈0.01),间隔1个月的重测信度为0.77(P〈0.01)。结论:中文版Kutcher青少年抑郁量表(11项)具有良好的效度、信度,且对青少年抑郁症筛查的准确性较高,可以用于对我国青少年抑郁症状的筛查。 | 周慧鸣 郝楠 杜亚松 刘艳玉 隋雨彤 王艳华 崔亚男 钟秋平 焦秀娟 魏屹峰 KUTCHER Stanley | 2015 | 中国心理卫生杂志2015，29，6： | 23 |
| 7 | 原发性不宁腿综合征的患病率调查——来自上海社区的流行病学研究显示文摘不宁腿综合征(restless legs syndrome,RLS)是一种与睡眠密切相关的神经系统疾病,主要表现为下肢不适感,不得不去活动下肢以缓解这种症状。症状在静坐或睡眠时出现,具有昼夜变化的特点,通常影响睡眠,导致各种慢性失眠症,严重影响患者的生活质量。目前流行病学研究提示,RLS在发达国家是一种常见疾病,患病率为15%左右。然而,来自于日本、韩国、新加坡和中国台湾的流行病学资料显示,亚洲人群的患病率较低,波动于0.1%-3.0%,而目前中国内地尚未见报道。所以,我们在中国上海市卢湾区的五里桥街道进行了一项关于原发性RLS的患病率调查研究。 | 马建芳 辛晓瑜 梁楺 刘丽华 方嵘 张英杰 王道义 Stanley Fahn 汤荟冬 陈生弟 | 2012 | 中华神经科杂志2012，45，12： | 19 |
| 8 | 狼逼门前:1994~2000的好莱坞和中国电影市场(上)显示文摘 | 斯坦利.罗森(Stanley Rosen) 戚锰 钟静宁 龚湘凌 | 2003 | 北京电影学院学报2003，，1： | 18 |
| 9 | Dextran sulfate sodium-induced colitis-associated neoplasia:a promising model for the development of chemopreventive interventions显示文摘与 ulcerative 大肠炎诊断的个人面对开发颜色的显著地增加的风险表面的发育异常和癌症在他们的一生期间。迄今为止,注意为葡聚糖硫酸盐钠(决策支持系统)的这个 high-riskpopulation.The 鼠标模型被给了 chemopreventive 干预的开发的很少导致了大肠炎代表两个都描绘面对发炎为肿瘤形成要求的分子的事件并且估计精选代理人的能力到的一个优秀现出症状之前的潜的系统在在长期的大肠炎的建立和颜色的开发喝水结果禁止决策支持系统的 thisprocess.Cyclic 管理有人的联系大肠炎的瘤形成类似于那些的病理学的特征的表面的发育异常和癌症。观察的损害的发生和复合变化取决于使用的鼠标紧张(即,瑞士韦伯斯特, C57BL/6J , CBA , ICR )并且剂量(0.7%-5.0%)和瘤形成的 DSS.Theincidence 的时间表( 1-15 周期与或没有一个随后的恢复时期)能被增加,它到侵略癌症的前进由与已知的冒号致癌物在联合管理决策支持系统显著地加速了( azoxymethane ( AOM ), 2-ammo-3-methylimidazo [ 4,5-f ]喹啉( IQ ), 2-amino-l-methyl-6-phenylimidazo [ 4,5-b ] pyridine ( PhTP ))在遗传上定义的老鼠的联系大肠炎的瘤形成的最近的正式就职拉紧的 oriron.More 提供了新卓见进特定的基因的角色(即, adenomatous polyposiscoli ( Apc ), p53 ,可诱导的氮的氧化物 synthase ( i NOS ), Msh2 )在从 chemopreventive 干预的 colitis-associatedneoplasias.Emerging 数据的开发,研究在禁止导致决策支持系统的瘤形成记录几个代理人的功效并且提供 colitis-associatedcolorectal 瘤形成是可防止的疾病的大诺言。 | Margie Lee CLAPPER Harry Stanley COOPER Wen-Chi Lee CHANG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 17 |
| 10 | Reducing neonatal mortality and respiratory distress syndrome associated with preterm birth:a scoping review on the impact of antenatal corticosteroids in low-and middle-income countries显示文摘Background The most common cause of death among preterm infants in low-and middle-income countries is respiratory distress syndrome.The purpose of this review was to assess whether antenatal corticosteroids given to women at risk of preterm birth at≤34 weeks of gestation reduce rates of neonatal mortality and respiratory distress syndrome in low-and middle-income countries.Methods Two reviewers independently searched four databases including MEDLINE(through PubMed),CINAHL,Embase,and Cochrane Libraries.We did not apply any language or date restrictions.All publications up to April 2020 were included in this search.Results The search yielded 71 articles,10 of which were included in this review(3 randomized controlled trials,7 observa-tional studies,36,773 neonates).The majority of studies reported associations between exposure to antenatal corticosteroids and lower rates of neonatal mortality and respiratory distress syndrome.However,a few studies reported that antenatal corticosteroids were not associated with improved preterm birth outcomes.Conclusions Most of the studies in low-and middle-income countries showed that use of antenatal corticosteroids in hospitals with high levels of neonatal care was associated with lower rates of neonatal mortality and respiratory distress syndrome.However,the findings are inconclusive because some studies in low-resource settings reported that antenatal corticosteroids had no benefit in reducing rates of neonatal mortality or respiratory distress syndrome.Further research on the impact of antenatal corticosteroids in resource-limited settings in low-income countries is a priority. | Stanley Mwita Mary Jande Deogratias Katabalo Benjamin Kamala Deborah Dewey | 2021 | World Journal of Pediatrics2021，17，2： | 17 |
| 11 | 颅内血管神经介入治疗的适应证美国心脏协会心血管放射学和介入委员会、卒中委员会、心血管外科和麻醉委员会、外周血管病跨学科委员会以及护理质量和转归研究跨学科委员会的联合学术声明显示文摘颅内血管内介入是一种使用微侵袭血管内技术治疗脑血管病的方法。该专业领域在过去10年里取得了巨大进展,而且随着该学科得到越来越多的临床认可,这种进步的速度还在加快。 | Philip M. Meyers H. Christian Schumacher Randall T. Higashida Stanley L. Barnwell Mark A. Creager Rishi Gupta Cameron G. McDougall Dilip K. Pandey David Sacks Lawrence R. Wechsler 乔梵(译) 刘建民(译) 洪波(译) | 2009 | 国际脑血管病杂志2009，17，10： | 16 |
| 12 | 基于生物可给性的某冶炼厂土壤重金属健康风险评价显示文摘为科学评价重金属污染场地的人体健康风险,以某冶炼厂土壤为研究对象,采用PBET(Physiologically-Based Extraction Test)和IVG(In-Vitro gastrointestinal)两种方法测定了As、Cd、Cu、Pb、Zn的生物可给性,并对比了只考虑重金属总量与基于生物可给性的人体健康风险.结果表明,场地土壤As、Cd、Pb的平均含量分别高达7063,691,3811mg/kg,严重超过国家环境质量标准.在PBET和IVG测试中,5种重金属的平均生物可给性介于1.81%~44.8%与1.78%~30.1%之间.As是PBET中生物可给性最高的重金属元素,而在IVG中Cd的生物可给性最高;含磷矿物的存在使Pb的生物可给性最低.提取液pH值及组成组分与重金属元素间的化学行为是造成两种方法结果差异的主要原因.在模型假设的条件下,土壤原有重金属的总危险商与总致癌系数为27.2与2.95×10^-3.考虑生物可给性使二者降低了59.9%~84.4%与55.6%~79.4%,且两个系数大小均呈现PBET胃液>PBET胃肠液>IVG胃液>IVG胃肠液的规律.调整后可以认为Pb不再具有健康风险,Cd仅具有致癌风险,只有As同时具有非致癌风险与致癌风险.尽管考虑重金属生物可给性后场地仍具有不可忽视的人体健康风险,但经过调整后能更准确地识别重金属的危害程度,避免场地的过度修复. | 冯康宏 范缙 Lik Ung Stanley Hii 罗启仕 曹心德 续晓云 | 2021 | 中国环境科学2021，41，1： | 14 |
| 13 | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein显示文摘最新新兴的中东呼吸症候群 coronavirus (MERS-CoV ) 能在人引起严重、致命的急性呼吸疾病。尽管有全球努力,潜力为一联系在未来流行不能被排除。有效相对的措施的发展是迫切的。MERS-CoV-specific 抗病毒的药或疫苗是还没可得到的。使用 MERS-CoV (MERS-RBD ) 的尖铁受体绑定领域使老鼠免疫,我们识别了二抵销 monoclonal 抗体(mAbs ) 4C2 和 2E6。两 mAbs potently 与高功效在 vitro 绑在 MERS-RBD 和块病毒入口。我们进一步由使在 Fab 碎片和 RBD 之间的建筑群结晶调查了他们中立化的机制,并且解决了 4C2 Fab/MERS-RBD 建筑群的结构。结构证明 4C2 认出部分重叠的 epitope 在 MERS-RBD 的受体绑定脚印,从而由位的阻碍者和接口残余竞争防碍病毒 / 受体相互作用。2E6 也堵住受体绑定,并且为绑定与 4C2 竞争到 MERS-RBD。基于结构,我们进一步由保存仅仅 paratope 残余并且从人的免疫球蛋白与对应物代替留下的氨基酸使 4C2 人性化。人性化的 4C2 (4C2h ) 抗体支撑了类似的抵销的活动和生物化学的特征到父母老鼠抗体。最后,我们证明 4C2h 能显著地在感染 MERS-CoV 的 Ad5-hCD26-transduced 鼠标的肺消除病毒 titers,因此在临床的设置为预防和治疗代表一个有希望的代理人。 | Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan | 2015 | Cell Research2015，25，11： | 14 |
| 14 | Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics显示文摘Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high vs.low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals. | Chao-Gan Yan Zhen Yang Stanley J. Colcombe Xi-Nian Zuo Michael P. Milham | 2017 | Science Bulletin2017，62，23： | 13 |
| 15 | Pioneer of prostate cancer: past, present and the future of FOXA1显示文摘Prostate cancer is the most commonly diagnosed noncutaneous cancers in North American men.While androgen deprivation has remained as the cornerstone of prostate cancer treatment,resistance ensues leading to lethal disease.Forkhead box A1(FOXA1)encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription factors.Through direct interactions with the Androgen Receptor(AR),FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer cells.FOXA1 also possesses an AR-independent role of regulating epithelial-to-mesenchymal transition(EMT).In prostate cancer,mutations converge onto the coding sequence and c/s-regulatory elements(CREs)of FOXA1,leading to functional alterations.In addition,FOXA1 activity in prostate cancer can be modulated post-translationally through various mechanisms such as LSD1-mediated protein demethylation.In this review,we describe the latest discoveries related to the function and regulation of FOXA1 in prostate cancer,pointing to their relevance to guide future clinical interventions. | Mona Teng Stanley Zhou Changmeng Cai Mathieu Lupien Housheng Hansen He | 2021 | Protein & Cell2021，12，1： | 12 |
| 16 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
| 17 | 细胞因子诱导支气管上皮细胞表达嗜酸粒细胞趋化因子显示文摘Eotaxin和新近发现的Eotaxin-2在支气管上皮细胞中的表达以及Th2型细胞因子的调节作用。以支气管上皮细胞株BEAS-2B细胞为研究对象,通过RT-PCR的方法测定Th2型细胞因子IL-4、IL-13以及促炎症因子TNF-α单独和协同刺激下BEAS-2B细胞Eotaxin和Eotaxin-2的基因表达,通过ELISA方法测定细胞培养上清液中Eotaxin蛋白的表达。EotaxinmRNA在TNF-α刺激12h后表达最高,Th2型细胞因子IL-4和IL-13与TNF-α协同刺激后表达进一步增强,Eotaxin蛋白的表达在协同刺激下也呈剂量和时间依赖性增高(P<0.01)。Eotaxin-2mRNA在TNF-α的刺激下于8h表达最高,IL-4或IL-13与TNF-α的协同刺激也使表达进一步增强,Eotaxin和Eotaxin-2两者基因表达具有相关性(P<0.05)。Th2型细胞因子可与促炎症因子TNF-α协同刺激支气管上皮细胞增强表达嗜酸粒细胞趋化因子Eotaxin和Eotaxin-2,从而吸引嗜酸粒细胞浸润至气道参与哮喘炎症过程。 | 汤葳 Albert Chan Stanley Chik Adrain Wu 邓伟吾 | 2005 | 现代免疫学2005，25，1： | 11 |
| 18 | Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence显示文摘AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatocellular carcinoma(HCC) recurrence for up to 3 year following curative resection. METHODS: A total of 143 patients(83.1% of the 172 participants in the phase Ⅱ study) participated in the follow-up study. Of these patients, 50 had received no treatment, 48 had received 160 mg/d PI-88, and 45 had received 250 mg/d PI-88 during the phase Ⅱ trial. Safety parameters and the following efficacy endpoints were investigated:(1) time to recurrence;(2) diseasefree survival; and(3) overall survival. RESULTS: PI-88 at 160 mg/d delayed the onset and frequency of HCC recurrence, and provided a clinically significant survival advantage for up to 3 years after treatment compared with those of the control group:(1) the recurrence-free rate increased from 50% to 63%, and(2) time to recurrence at the 36 th percentile was postponed by 78%. The efficacy of administering PI-88 at 250 mg/d was confounded by a high dropout rate(11 out of 54 patients). Additionally, subgroup analyses of patients with(1) multiple tumors or a single tumor ≥ 2 cm; and(2) hepatitis B or C revealed that administering PI-88 at 160 mg/d conferred the most significant survival advantage(56.8% improvement in disease-free survival, P = 0.045) for patients with both risk factors for recurrence. CONCLUSION: Administering PI-88 at 160 mg/d is a safe and well-tolerated dosage that may confer significant clinical benefits for patients with HCC. | Chun-Jen Liu Juliana Chang Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Yih-Jyh Lin King-Tong Mok Wei-Chen Lee Hong-Zen Yeh Ming-Chih Ho Sheng-Shun Yang Mei-Due Yang Ming-Chin Yu Rey-Heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 19 | Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer显示文摘AIM:To assess quantitative endoscopic ultrasound (EUS)guided elastography in the nodal staging of oesophagogastric cancers.METHODS:This was a single tertiary centre study assessing 50 patients with established oesophago-gastric cancer undergoing EUS-guided fine needle aspiration biopsy (FNAB) of lymph nodes between July 2007 and July 2009.EUS-guided elastography of lymph nodes was performed before EUS-FNAB.Standard EUS characteristics were also described.Cytological determination of whether a lymph node was malignant or benign was used as the gold standard for this study.Comparisons of elastography and standard EUS characteristics were made between the cytologically benign and malignant nodes.The main outcome measure was the accuracy of elastography in differentiating between benign and malignant lymph nodes in oesophageal cancers.RESULTS:EUS elastography and FNAB were performed on 53 lymph nodes.Cytological malignancy was found in 23 nodes,one was indeterminate,one was found to be a gastrointestinal stromal tumor and 25 of the nodes were negative for malignancy.On 3 occasions insufficient material was obtained for analysis.The area under the curve for the receiver operating characteristic curve for elastography strain ratio was 0.87 (P<0.0001).Elastography strain ratio had a sensitivity 83%,specificity 96%,positive predictive value 95%,and negative predictive value 86% for distinguishing between malignant and benign nodes.The overall accuracy of elastography strain ratio was 90%.Elastography was more sensitive and specific in determining malignant nodal disease than standard EUS criteria.CONCLUSION:EUS elastography is a promising modality that may complement standard EUS and help guide EUS-FNAB during staging of upper gastrointestinal tract cancer. | Stuart Paterson Fraser Duthie Adrian J Stanley | 2012 | World Journal of Gastroenterology2012，18，9： | 10 |
| 20 | Increasing the use of biocompatible,glucose-free peritoneal dialysis solutions显示文摘A major concern inhibiting some clinicians from embracing peritoneal dialysis(PD) as the preferred first modality of dialysis is the effects of PD solutions on the peritoneal membrane. These anatomical and functional changes predispose to complications like peritonitis,encapsulating peritoneal sclerosis and ultrafiltration failure. In recent years, 'biocompatible' and glucosesparing PD regimens have been developed to minimize damage to the peritoneal membrane. Can the use of these more expensive solutions be justified on current evidence? In this review of the literature, we explore how we may individualize the prescription of biocompatible PD fluid. | Ahad Qayyum Elizabeth Ley Oei Klara Paudel Stanley L Fan | 2015 | World Journal of Nephrology2015，4，1： | 10 |
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