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| 1 | Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients显示文摘瞄准:为了两个都调查胃的癌症的风险是否与 Ile/Val 被联系,挑选人的表皮的生长因素 receptor-2 (HER-2 ) 的核苷酸多型性(SNP ) 在 655 上的鳕鱼和在在一个土耳其语的病人的胃的癌症案例中的 HER-2 表示的建议存在的编码域的区域组织的 transmembrane。方法:限制跟随的聚合酶链反应(PCR ) 碎裂长度多型性(RFLP ) 策略被用来在 655 上在鳕鱼分析 HER-2 SNP 的存在。c-erbB-2 表示模式被免疫组织化学分析。结果在胃的癌组和长期的胃炎组之间,以及在 clinicopathological 参数和癌之间被比较。结果:结果证明 Ile/Val 遗传型在长期的胃炎组在土耳其语的胃的癌组,和没有以内占了 20% ,并且这 genotyping 与阶段 IV 胃的癌症(P=0.04 ) 被联系。在另一方面,积极膜的 HER-2 免疫反应从长期的胃炎盒子在土耳其语的胃的癌组和没有以内占了 24% ;进一步,它与肠的类型癌(P=0.007 ) 被相关,并且上演 III-IV 癌(P=0.004 ) 。结论:这些观察暗示测试 HER-2 SNP 可以参予胃的癌症的发展和前进。在与大样品组一起证实这些结果以后,因此,在表示上的 655 SNP 或 c-erbB-2 上的 HER-2 鳕鱼可以也为胃的癌被用作差的预示的指示物。 | N Lale Satiroglu-Tufan Ferda Bir Nese Calli-Demirkan | 2006 | World Journal of Gastroenterology2006，12，20： | 4 |
| 2 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 3 | Ascorbic Acid (Vitamin C) and Iloprost Attenuate the Lung Injury Caused by Ischemia/Reperfusion of the Lower Extremities of Rats显示文摘 | Ahmet Baltalarli MD Vefa Ozcan MD Bir Ferda MD Hulya Aybek MD Mustafa Sacar MD Gokhan Onem MD Ibrahim Goksin MD Suleyman Demir MD Teke Zafer | 2006 | Annals of Vascular Surgery2006，，1： | 1 |
| 4 | Association of rare intestinal malformations: Colonic atresia and intestinal neuronal dysplasia显示文摘 | Nergul Corduk Ugur Koltuksuz Ferda Bir Murat Karabul Ozkan Herek Akile Sarioglu-Buke | 2007 | Advances in Therapy2007，，： | 1 |
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