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| 1 | Truncated Human LMP-1 Triggers Differentiation of C2C12 Cells to an Osteoblastic Phenotype in vitro显示文摘秘鲁利玛机场之代号矿化作用 protein-1 (LMP-1 ) 是被显示了在 vitro 并且在 vivo.LMP-1 导致骨头形成的新奇细胞内部的 osteoinductiveprotein 包含 anN 终端 PDZ 领域和三个 C 终端秘鲁利玛机场之代号领域。在这研究,我们调查了是否人的 LMP-1 的一种截断的形式( hLMP-l [ t ]),缺乏三个C终端秘鲁利玛机场之代号领域, weretransiently 触发 pluripotent myoblastic C2C12 房间的区别到造骨细胞 lineage.C2C12 房间有 Ad5-hLMP-l (t)绿色的 transduced 荧光灯的蛋白质和截断的蛋白质被检验。结果证明 thathLMP-l (t) 在 C2C12 文化堵住了 myotube 形成并且显著地提高了碱性磷酸酶(高山) 活动。另外,形态基因的蛋白质(BMP )-2 和 BMP-7 基因也是的高山, osteocalcin,和骨头的表情增加了。这些关键 osteogenic 标记的正式就职建议 hLMP-l (t)能触发 pluripotent myoblastic C2C12 房间区分 intoosteoblastic 系,因此扩大我们 LMP-1 和 LMP-1 (t)提高的以前的观察在房间的文化的 theosteoblastic 显型已经承诺了 osteoblasticlineage.Therefore , C2C12 房间是为 osteoblastic 显型和 LMP-1 行动的机制的学习感应的 LMP-1 的考试的一个适当模型系统。 | Qinming FEI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 8 |
| 2 | Workshop tutorials:普通物理教学中一种新的尝试显示文摘介绍了澳大利亚悉尼大学物理学院在普通物理教学中采用的一种新的教学形式———Workshoptutorials.它是一种交互式的、相互合作、以学生为中心的教学方式,适应学生不同的学习风格,特别适合在普通物理教学中培养学生的自主学习、合作学习、科学研究、批判性思维、团队工作等科研能力. | 张萍 Manjula D.Sharma | 2004 | 大学物理2004，23，6： | 4 |
| 3 | Value of multi-disciplinary input into laparoscopic management of rectal cancer-An observational study显示文摘AIM To assess the impact of multi-disciplinary teams(MDTs)management in optimising the outcome for rectal cancers.METHODS We undertook a retrospective review of a prospectively maintained database of patients with rectal cancers(defined as tumours≤15 cm from anal verge)discussed at our MDT between Jan 2008 and Jan 2011.The data was validated against the national database to ensure completeness of dataset.The clinical course and follow-up data was validated using the institution’s electronic patient records.The data was analysed in terms of frequencies and percentages.Significance of any differences were analysed usingχ2 test.A Kaplan-Meier analysis was performed for overall survival and disease free survival.RESULTS Following appropriate staging,one hundred and thirtythree patients were suitable for potentially curative resections.Seventy two(54%)were upper rectal cancer(URC)-tumour was>6 cm from the anal verge and 61(46%)were lower rectal cancers(LRC)-lower extent of the tumour was palpable≤6 cm.Circumferential resection margin(CRM)appeared threatened on preoperative MRI in 19/61(31%)patients with LRC requiring neo-adjuvant therapy(NAT).Of the 133 resections,118(89%)were attempted laparoscopically(5%conversion rate).CRM was positive in 9(6.7%)patients;Median lymph node harvest was 12(2-37).Major complications occurred in 8(6%)patients.Median follow-up was 53 mo(0-82).The 90-d mortality was 2(1.5%).Over the followup period,disease related mortality was 11(8.2%)and overall mortality was 39(29.3%).Four(3%)patients had local recurrence and 22(16.5%)patients had distant metastases.CONCLUSION Management of rectal cancers can be optimized with multidisciplinary input to attain acceptable long-term oncological outcomes even when incorporating a laparoscopic approach to rectal cancer resection. | Pawan Kumar Dhruva Rao Sooriyaratchige Pradeep Manjula Peiris Seema Safia Arif Rhodri A Davies Ashraf Gergies Masoud Puthucode Narayanan Haray | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 2 |
| 4 | Chemical, mechanical, and thermal expansion properties of a carbon nanotube-reinforced aluminum nanocomposite显示文摘In the present study,the chemical and mechanical properties and the thermal expansion of a carbon nanotube(CNT)-based crystalline nano-aluminum(nano Al) composite were reported.The properties of nanocomposites were tailored by incorporating CNTs into the nano Al matrix using a physical mixing method.The elastic moduli and the coefficient of thermal expansion(CTE) of the nanocomposites were also estimated to understand the effects of CNT reinforcement in the Al matrix.Microstructural characterization of the nanocomposite reveals that the CNTs are dispersed and embedded in the Al matrix.The experimental results indicate that the incorporation of CNTs into the nano Al matrix results in the increase in hardness and elastic modulus along with a concomitant decrease in the coefficient of thermal expansion The hardness and elastic modulus of the nanocomposite increase by 21%and 20%,respectively,upon CNT addition.The CTE of CNT/A1 nanocomposite decreases to 70%compared with that of nano Al. | Manjula Sharma Vimal Sharma | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，2： | 2 |
| 5 | Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study Equations: Risk Factors for and Complications of CKD and Mortality in the Kidney Early Evaluation Program (KEEP)显示文摘 | Lesley A. Stevens Suying Li Manjula Kurella Tamura Shu-Cheng Chen Joseph A. Vassalotti Keith C. Norris Adam T. Whaley-Connell George L. Bakris Peter A. McCullough | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 6 | Direct injection HILIC-MS/MS analysis of darunavir in rat plasma applying supported liquid extraction显示文摘A novel bioanalytical method was developed and validated for the quantitative determination of darunavir(DRV) in rat plasma by employing hydrophilic interaction chromatography and tandem mass spectrometry(HILIC-MS/MS) with supported liquid extraction(SLE).lrbesartan(IRB) was used as an internal standard(IS).The analyte in rat plasma(200 μL) was isolated through SLE using ethyl acetate as the eluting solvent.The chromatographic separation was achieved on Luna-HILIC(250 mm × 4.6 mm,5 μm)column with a mobile phase of 0.1% of formic acid in water:acetonitrile(5:95,v/v),at a constant flow rate of 1.0mL/min.The MS/MS ion transitions for DRV(548.1→392.0) and IS(429.2→207.1) were monitored on an ion trap mass spectrometer,operating in the multiple reaction monitoring(MRM) mode.The lower limit of quantitation(LLOQ) was 0.2 ng/mL and quantitation range was 0.2-5000 ng/mL.The method was validated for its selectivity,sensitivity,carryover,linearity,precision,accuracy,recovery,matrix effect and stability.The method was successfully applied to pharmacokinetic study in rats. | Bokka Ramesh Nemali Manjula Sistla Ramakrishna Potturi Sita Devi | 2015 | Journal of Pharmaceutical Analysis2015，5，1： | 2 |
| 7 | Imperfect debugging study of SRGM with fault reduction factor and multiple change point显示文摘 | JAIN M MANJULA T GULATI T R | 2014 | International Journal of Mathematics in Operational Research2014，6，2： | 1 |
| 8 | Enhanced molecular volume of conservatively pegylated Hb:(SP-PEG5K)6-HbA is non-hypertensive显示文摘 | Acharya SA Friedman JM Manjula BN | 2005 | Artif Cells Blood Substit Immobil Biotechnol2005，33，3： | 1 |
| 9 | Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation:influence on hemoglobin structure and function显示文摘 | Manjula BN Tsai AG Intaglietta M | 2005 | The Protein Journal2005，24，1： | 1 |
| 10 | Grape seed proanthoeyanidin lowers brain oxidative stress in adult and middle aged rats显示文摘 | Devi SA Chandrasekar BKS Manjula KR | 2011 | Fxp Geronto/2011，46，： | 1 |
| 11 | Anti-jammming Broadcast Communication Using Uncoordinated Frequency Hopping 显示文摘 | Manjula P Sharmila S | 2013 | International Jour- nal of Application or Innovation inEngineering & Management2013，2，6： | 1 |
| 12 | Correlation between Electronegativity and superconductity显示文摘 | MANJULA R | 1989 | Physical Review B1989，39，： | 1 |
| 13 | Effect of new hyperbranched polyester of varying generations on toughening of epoxy resin through interpenetrating polymer networks using urethane linkages显示文摘 | D Manjula Dhevi S N Jaisankar Madhvesh Pathak | 2013 | European Polymer Journal2013，49，11： | 1 |
| 14 | Inhibition of MAP klnases by crude extract and pure compound isolated from Commiphom mukul leads to down regulation of TNF-alpha, IL-1beta and IL-2显示文摘 | MANJULA N GAYATHRI B VINAYKUMAR K S | 2006 | Int Immunopharmacol2006，6，2： | 1 |
| 15 | Pectoralis major flap for head and neck re- construction in era of free flaps显示文摘 | KEKATPURE V D TRIVEDI N P MANJULA B V | 2012 | Int J Oral Maxil- lofac Surg2012，41，： | 1 |
| 16 | Multi Level Feature Priority algorithm based text extraction from heterogeneous and hybrid textual image 显示文摘 | CHITRAKALA G MANJULA D | 2009 | International Journal of Signal and Imaging Systems Engineering2009，2，4： | 1 |
| 17 | Effect of new hyperbranehed polyester of varying generations on toughening of epoxy resin through interpenetrating poly- mer networks using urethane linkages 显示文摘 | Manjula Dhevi D Jaisankar S N Pathak M | 2013 | European Polymer Journal2013，，： | 1 |
| 18 | Dementia and cognitive impairment in ESRD :diagnostic and therapeutic strategies显示文摘 | Manjula Kurella Tamura Kristine Yaffe | 2011 | Kid- ney Int2011，79，： | 1 |
| 19 | India's image as a tourist destination: a perspective of foreign tourists 显示文摘 | Chaudhary Manjula | 2000 | Tourism Management2000，，21： | 1 |
| 20 | Blood Coagulation and Living Tissue Sterilization by Floating-Electrode Dielectric Barrier Discharge in Air显示文摘 | Gregory Fridman Marie Peddinghaus Manjula Balasubramanian Halim Ayan Alexander Fridman Alexander Gutsol Ari Brooks | 2006 | Plasma Chemistry and Plasma Processing2006，，4： | 1 |
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