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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 3 | TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients显示文摘 | Juan Carlos Garcia–Pagán Mathis Heydtmann Sebastian Raffa Aurélie Plessier Sarwa Murad Federica Fabris Giovanni Vizzini Juan Gonzales Abraldes Simon Olliff Antonio Nicolini Angelo Luca Massimo Primignani Harry L.A. Janssen Dominique Valla Elwyn Elias Jaum | 2008 | Gastroenterology2008，，3： | 3 |
| 4 | A Novel Line Immunoassay Based on Recombinant Virulence Factors Enables Highly Specific and Sensitive Serologic Diagnosis of Helicobacter pylori Infection显示文摘 | Luca Formichella Laura Romberg Christian Bolz Michael Vieth Michael Geppert Gereon G?ttner Christina N?lting Dirk Walter Wolfgang Schepp Arne Schneider Kurt Ulm Petra Wolf Dirk H. Busch Erwin Soutschek Markus Gerhard | 2013 | Clinical and Vaccine Immunology2013，，11： | 2 |
| 5 | The first pterosaur 3-D egg:Implications for Pterodaustro guinazui nesting strategies,an Albian filter feeder pterosaur from central Argentina显示文摘The increasing number of fossil pterosaur eggs sheds light on nesting environments and breeding behaviors of these extinct flying reptiles.Here we report the first partial three-dimensional egg of the pterosaur,Pterodaustro guinazui,from central Argentina.The specimen was discovered from the same Albian deposits as the exceptional P.guinazui embryo described in 2004.Microscopic characterizations indicate a pristine preservation of the 50 mm thick calcium carbonate,which differs significantly from the soft shell of Chinese pterosaur eggs.Estimate of the eggshell conductance implies that the nest had a minimum moisture content of 75%.This moisture estimate,combined with geological and taphonomical data,suggests that P.guinazui may have adopted a nesting strategy similar to those of grebes and flamingos rather than being buried on land,as previously hypothesized.Moreover,our results demonstrate that the nesting paleoenvironment of this pterosaur species was closely linked to a mesohaline lacustrine ecosystem in a basin governed by regional tectonic subsidence,a setting characteristic for the feeding and reproduction of modern flamingos. | Gerald Grellet-Tinner Michael B.Thompson Lucas E.Fiorelli Eloísa Argaaraz Laura Codorniú E.Martín Hechenleitner | 2014 | Geoscience Frontiers2014，5，6： | 2 |
| 6 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 7 | IL-27 regulates IL-12 responsiveness of naive CD4 + T cells through Statl-dependent and-independent mechanisms 显示文摘 | Lucas S Ghilardi N Li J | 2003 | Proc Natl Acad Sci USA2003，100，15： | 1 |
| 8 | Optimal fiscal and monetary policy in an economy without capital 显示文摘 | Lucas Jr R E Stokey N | 1983 | Journal of Monetary Economics1983，12，： | 1 |
| 9 | The role of EGF - related peptides in tumor growth 显示文摘 | Normanno N Bianco C De Luca A | 2001 | Front Biosci2001，6，5： | 1 |
| 10 | The promoter of the Arabidopsis thaliana BAN gene is active in proanthoc- yanidin-accumulating cells of the Brassica napus seed coat显示文摘 | Nesi N Lucas M O Auger B | 2009 | Plant CellRep2009，28，： | 1 |
| 11 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 12 | BCL10 and MALT1,independent targets of chromosomal translocation in MALT lymphoma,cooperate in a novel NF-κB signaling pathway显示文摘 | Lucas PC Yonezumi M Inohara N | 2001 | J Biol Chem2001，276，19： | 1 |
| 13 | The role of EGF-related peptldes in tumor growth 显示文摘 | NORMANNO N BIANCO C DE LUCA A | 2001 | Front Biosci2001，6，1： | 1 |
| 14 | Preproeedural Thrombolysis in Myocardial Infarction (TIMI) flow significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute anterior myocardial infarction treated by primary angioplasty显示文摘 | De Luca G Ernst N vant Hof AW | 2005 | Am Heart J2005，150，： | 1 |
| 15 | Target-based therapies in breast cancer: current status and future perspectives显示文摘 | Normanno N Morabito A De Luca A | 2009 | Endocr Relat Cancer2009，16，3： | 1 |
| 16 | Intelligent modeling and control of washing machine using locally linear neuro-fuzzy ( LL- NF) modeling and modified brain emotional learning based Intel- ligent controller(BELBIC) 显示文摘 | LUCAS C MILASI R M ARAABI B N | 2006 | Asian Journal of Control2006，8，4： | 1 |
| 17 | Mechanical properties of the ice I-magnesium sulfate eutectic: A comparison with freshwater ice in reference to Europa显示文摘 | Golding N Burks C E Lucas K N | 2013 | Cold Region Science and Technology2013，，225： | 1 |
| 18 | Indentation power-law creepof high-purity indium 显示文摘 | LUCAS B N OLIVER W C | 1999 | Metallurgical and MaterialsTransactions A1999，30，3： | 1 |
| 19 | Resistance to antimicrobial agents in lactobacilli isolated from caper fermentations显示文摘 | PULIDO R P OMAR N B LUCAS R | 2005 | Antonie van Leeuwenhoek2005，88，34： | 1 |
| 20 | Preprocedura) -r/M flow and mortality in patients with acute myocardial infarction treated by primary angioplasty显示文摘 | De Luca G Srnst N Zhistra | 2004 | J Am Coil Cardiol2004，43，8： | 1 |
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