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| 1 | Precise Editing of a Target Base in the Rice Senome Using a Modified CRISPR/Cas9 System显示文摘 | Yuming Lu Jian-Kang Zhu | 2017 | Molecular Plant2017，10，3： | 87 |
| 2 | Multiplex Gene Editing in Rice Using the CRISPR-Cpf1 System显示文摘 | Mugui Wang Yanfei Mao Yuming Lu Xiaoping Tao Jian-kang Zhu | 2017 | Molecular Plant2017，10，7： | 56 |
| 3 | Plasma-assisted fabrication of monolayer phosphorene and its Raman characterization显示文摘 | Wanglin Lu Haiyan Nan Jinhua Hong Yuming Chen Chen Zhu Zheng Liang Xiangyang Ma Zhenhua Ni Chuanhong Jin Ze Zhang | 2014 | Nano Research2014，7，6： | 36 |
| 4 | Gene Targeting by Homology-Directed Repair in Rice Using a Geminivirus-Based CRISPR/Cas9 System显示文摘 | Mugui Wang Yuming Lu Jose Ramon Botella Yanfei Mao Kai Hua Jian-kang Zhu | 2017 | Molecular Plant2017，10，7： | 34 |
| 5 | Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System显示文摘 | Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen | 2017 | Molecular Plant2017，10，9： | 28 |
| 6 | Multiplex gene editing in rice with simplified CRISPR-Cpf1 and CRISPR-Cas9 systems显示文摘We developed simplified single transcriptional unit(SSTU) CRISPR systems for multiplex gene editing in rice using FnCpf1, LbCpf1 or Cas9, in which the nuclease and its cr RNA array are co-expressed from a single Pol Ⅱ promoter, without any additional processing machinery. Our SSTU systems are easy to construct and effective in mediating multiplex genome editing. | Mugui Wang Yanfei Mao Yuming Lu Zhidan Wang Xiaoping Tao Jian-Kang Zhu | 2018 | Journal of Integrative Plant Biology2018，60，8： | 21 |
| 7 | Intelligent construction technology of railway engineering in China显示文摘Intelligent construction technology has been widely used in the field of railway engineering.This work first analyzes the connotation,function,and characteristics of intelligent construction of railway engineering(ICRE)and establishes its system structure from three dimensions,namely,life cycle,layers of management,and intelligent function,to deeply understand the development situation of intelligent railway construction in China.Second,seven key technical support systems of ICRE,which include building information modeling(BIM)standard system for China’s railway sector,technology management platform and life cycle management based on BIM-hGIS(geography information system),ubiquitous intelligent perception system,intelligent Intemet-of-Things(IoT)communication system based on mobile interconnection,construction management platform based on cloud computing and big data,unmanned operation system based on artificial intelligence,intelligent machinery and robot,and intelligent operation and maintenance system based on BIM and PHM(prediction and health management),are established.Third,ICRE is divided into three development stages:primary(perception),intermediate(substitution),and advanced(intelligence).The evaluation index system of each stage is provided from the aspects of technology and function.Finally,this work summarizes and analyzes the application situation of ICRE in the entire railway sector of China,represented by Beijing-Zhangjiakou and Beijing-Xiong’an high-speed railways.Result shows that the technical support systems of the ICRE have emerged in China and are still in the process of deepening basic technology research and preliminary application.In the future,the ICRE of China’s railway sector will develop toward a higher stage. | Chunfang LU Junfei LIU Yanhong LIU Yuming LIU | 2019 | Frontiers of Engineering Management2019，6，4： | 6 |
| 8 | Genome editing for plant research and crop improvement显示文摘The advent of clustered regularly interspaced short palindromic repeat(CRISPR) has had a profound impact on plant biology, and crop improvement. In this review, we summarize the state-of-the-art development of CRISPR technologies and their applications in plants, from the initial introduction of random small indel(insertion or deletion) mutations at target genomic loci to precision editing such as base editing, prime editing and gene targeting. We describe advances in the use of class 2, types II, V, and VI systems for gene disruption as well as for precise sequence alterations, gene transcription, and epigenome control. | Xiangqiang Zhan Yuming Lu Jian-Kang Zhu Jose Ramon Botella | 2021 | Journal of Integrative Plant Biology2021，63，1： | 5 |
| 9 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 10 | Tetrahymena Gene Expression Database (TGED):A resource of microarray data and co-expression analyses for Tetrahymena显示文摘Tetrahymena thermophila is a model eukaryotic organism. Functional genomic analyses in Tetrahymena present rich opportunities to address fundamental questions of cell and molecular biology. The Tetrahymena Gene Expression Database (TGED; available at http://gffzz5d146715fb2e495ehf0qvqbbvxqxv6qcb.ffgz.tsg.suse.edu.cn) is the first expression database of a ciliated protozoan. It covers three major physiological and developmental states: growth, starvation, and conjugation, and can be accessed through a user-friendly web interface. The gene expression profiles and candidate co-expressed genes for each gene can be retrieved using Gene ID or Gene description searches. Descriptions of standardized methods of sample preparation and the opportunity to add new Tetrahymena microarray data will be of great interest to the Tetrahymena research community. TGED is intended to be a resource for all members of the scientific research community who are interested in Tetrahymena and other ciliates. | XIONG Jie LU XingYi LU YuMing ZENG HongHui YUAN DongXia FENG LiFang CHANG Yue Josephine BOWEN Martin GOROVSKY FU ChengJie MIAO Wei | 2011 | Science China(Life Sciences)2011，54，1： | 5 |
| 11 | Prognostic value of systemic immune- inflammation index in acute/subacute patients with cerebral venous sinus thrombosis显示文摘Objective To evaluate the prognosis values of systemic immune-inflammation index(SII)in non-chronic cerebral venous sinus thrombosis(CVST).Methods patients with CVST,admitted to the First Affiliated Hospital of Zhengzhou University,were retrospectively identified from January 2013 to December 2018.We selected patients in acute/subacute phase from database.Functional outcomes of patients were evaluated with the modified Rankin Scale(mRS)-mRS 3-6 as poor outcomes and mRS 6 as death.The overall survival time was defined as the date of onset to the date of death or last follow-up date.Survival analysis was described by the Kaplan-Meier curve and Cox regression analysis.Multivariate logistic regression analysis assessed the relationship between SII and poor functional outcome.The area under the Receiver Operating Curve curve(AUC)was estimated to evaluate the ability of SII in prediction.Results A total of 270 patients were included and their duration of follow-up was 22 months(6-66 months),of whom 31 patients had poor outcomes and 24 patients dead.Cox regression analysis showed that SII(HR=1.304,95%CI:1.101 to 1.703,p=0.001)was a predictor of death in non-chronic CVST.Patients with higher SII presented lower survival rates(p=0.003).The AUC of SII was 0.792(95%CI:0.695 to 0.888,p=0.040)with a sensitivity of 69.6%and specificity of 80.1%.Subgroups analysis demonstrated that SII was an important predictor of poor outcomes in male(OR=1.303,95%CI:1.102 to 1.501,p=0.011)and pregnancy/puerperium female(OR=1.407,95%CI:1.204 to 1.703,p=0.034).Conclusions SII was a potential predictor in the poor prognosis of patients with acute/subacute CVST,especially in male and pregnancy/puerperium female. | Shen Li Kai Liu Yuan Gao Lu Zhao Rui Zhang Hui Fang Yongli Tao Hongbing Liu Jiawei Zhao Zongping Xia Yuming Xu Bo Song | 2020 | Stroke & Vascular Neurology2020，5，4： | 3 |
| 12 | Fullerenes for rechargeable battery applications:Recent developments and future perspectives显示文摘The development of high-performance batteries is inseparable from the exploration of new materials.Among them,fullerene C60 as an allotrope of carbon has many unique properties that are beneficial for battery applications,including precise structure,controllable derivatization,good solubility,and rich redox chemistry.In this review,we summarize the recent progress of fullerene-based materials in the field of rechargeable batteries and the key issues that need to be solved in the future application of fullerene.We hope this review can provide guidance and stimulate research about the applications of fullerenes in the field of energy storage. | Zhipeng Jiang Yuming Zhao Xing Lu Jia Xie | 2021 | Journal of Energy Chemistry2021，30，4： | 3 |
| 13 | In vitro Screening of Fusarium Wilt-resistant Germplasm Resources of Red Edible Seed Watermelon( Citrullus lanatus ssp. vulgaris var. megalaspermus Lin et Chao)显示文摘[Objective]This study aimed to establish an appropriate technology system for in vitro screening of Fusarium wilt-resistant germplasm resources of red edible seed watermelon and obtain variants resistant to fusaric acid,thus providing resistant materials for breeding Fusarium wilt-resistant red edible seed watermelon. [Method] Using Zhongxin No. 1 red edible seed watermelon adventitious buds as screening materials and fusaric acid( FA) as a stress agent,in vitro screening of Fusarium wilt-resistant red edible seed watermelon clonal variants and identification of Fusarium wilt-resistance of the germplasm resources of red edible seed watermelon were performed. [Result]The results showed that the appropriate FA for in vitro screening of Fusarium wilt-resistant red edible seed watermelon variants was 15 mg/L. In vitro screening system for Fusarium wilt-resistant red edible seed watermelon variants was established preliminarily and FA-resistant regenerated plants were obtained. Among the 36 germplasm resources of red edible seed watermelon,there were 2 highly resistant materials,6 moderately resistant materials,11 slightly resistant materials and 17 highly susceptible materials. [Conclusion]This study confirmed preliminarily that in vitro screening method is effective for obtaining resistant materials of red edible seed watermelon. | Tangjing LIU Ke ZHANG Yuming LU Rixin HONG Suping WU | 2014 | Agricultural Biotechnology2014，3，1： | 2 |
| 14 | Rice Protein Tagging Project:A Call for International Collaborations on Genome-wide In-Locus Tagging of Rice Proteins显示文摘In September 1997,the International Rice Genome Sequencing Project was launched.This initiative pooled the resources of ten nations to obtain the first complete rice genome sequence,and promoted rice research and breeding into the post-genomics era(Li et al.,2018).In 2008,an internationally coordinated project named 'RICE2020' was proposed to systematically and fully characterize all rice genes,transcripts,and proteins(Zhang et al.,2008).While genes and their transcripts can be readily characterized by sequencing-and PCR-based methods,the characterization of protein dynamics including protein levels,subcellular localizations,post-transla-tional modifications,and interactions with macromolecules(e.g.,proteins,DNA,RNA,carbohydrates,and lipids)and small molecules(e.g.,metabolites and ligands)is much more challenging and usually requires antibodies that specifically recognize the protein of interest.Because it is very difficult to systematically produce reliable antibodies for the specific recognition of individual plant proteins,a common practice is to transform a tag-fused open reading frame(ORF)of a gene to the corresponding loss-of-function mutant plants.However,such an ectopically expressed tagged protein may not fully reca-pitulate the properties of the endogenous protein due to the random insertion of the transgene,even when the transgene is expressed under the endogenous gene promoter.A preferred so-lution is to genetically label the coding sequence of the gene of interest,at its in vivo locus,with a sequence encoding a fluores-cent protein tag or an affinity tag such as FLAG or HA.Such 'in-locus' protein tagging,as we are naming it here,has been carried out genome-wide in yeast,Caenorhabditis elegans,fly,and mammalian cultured cells,greatly facilitating the characterization of proteins in these organisms(Jiang et al.,2018).In 2017,a Genome Tagging Project was launched in mice,aiming to label every protein using a CRISPR/Cas9-based 'artificial spermatids'method(Jiang et al.,2018).Significant funding and efforts have been put into this project,which is expected to provide valuable mouse resources to accelerate biomedical research.In higher plants,in-locus tagging of proteins has been extremely challenging technically. | Yuming Lu Pamela C.Ronald Bin Han Jiayang Li Jian-Kang Zhu | 2020 | Molecular Plant2020，13，12： | 2 |
| 15 | Efficient Multi-Tenant Virtual Machine Allocation in Cloud Data Centers显示文摘Virtual Machine(VM) allocation for multiple tenants is an important and challenging problem to provide efficient infrastructure services in cloud data centers. Tenants run applications on their allocated VMs, and the network distance between a tenant's VMs may considerably impact the tenant's Quality of Service(Qo S). In this study, we define and formulate the multi-tenant VM allocation problem in cloud data centers, considering the VM requirements of different tenants, and introducing the allocation goal of minimizing the sum of the VMs' network diameters of all tenants. Then, we propose a Layered Progressive resource allocation algorithm for multi-tenant cloud data centers based on the Multiple Knapsack Problem(LP-MKP). The LP-MKP algorithm uses a multi-stage layered progressive method for multi-tenant VM allocation and efficiently handles unprocessed tenants at each stage. This reduces resource fragmentation in cloud data centers, decreases the differences in the Qo S among tenants, and improves tenants' overall Qo S in cloud data centers. We perform experiments to evaluate the LP-MKP algorithm and demonstrate that it can provide significant gains over other allocation algorithms. | Jiaxin Li Dongsheng Li Yuming Ye Xicheng Lu | 2015 | Tsinghua Science and Technology2015，20，1： | 2 |
| 16 | Efficacy and safety of entecavir compared to lamivudine in nucleoside-na?ve patients with chronic hepatitis B: a randomized double-blind trial in China显示文摘 | Guangbi Yao Chengwei Chen Weilun Lu Hong Ren Deming Tan Yuming Wang Daozheng Xu Zhengrong Jiang Jessica Liu Dong Xu Laurie MacDonald | 2007 | Hepatology International2007，，3： | 1 |
| 17 | An improved accuracy measure for rough sets显示文摘 | Xu Baowen Zhou Yuming Lu Hongmin | 2005 | Journal of Computer and System Sciences2005，71，2： | 1 |
| 18 | 植物生长潜力而非系统发育关系预测荒废农田土壤生物对外来和本土植物的作用显示文摘植物能够调控土壤生物群落,而后者将对后期发生的植物适合度和群落结构产生显著影响。长期种植的单一农作物能够显著调控土壤生物群落,而新近荒废农田中土壤生物如何调控外来和本土杂草定植目前还不清楚,这严重束缚了农田杂草治理能力的提升。本研究采集新近荒废的玉米地表层土壤,选取58种华中地区常见农田杂草(28种外来和30种本土植物)为对象开展实验。通过将植物种植于伽马射线灭菌或未灭菌土壤,定量评价了土壤生物对植物地上、地下和总生物量的影响,探讨了实验物种-玉米系统发育距离和土壤效应是否相关,探究了能够预测土壤效应的关键植物性状。结果发现:(i)总体而言,土壤生物显著抑制实验植物生长,表明土壤拮抗生物(如病原菌等)发挥主导作用;(ii)伴随植物生长潜力提升,土壤生物对植物的抑制作用逐渐增强,而土壤生物对实验植物的调控作用与实验物种-玉米系统发育距离无关;(iii)相对于本土植物,外来植物(尤其多年生物种)被土壤生物抑制的程度更高。这些结果表明,植物生长潜力能够有效预测土壤生物对植物生长的调控作用,而且新近荒废农田土壤生物具有抵御外来植物入侵的潜力。 | Chunqiang Wei Bingbing Jia Lunlun Gao Zhen Liu Yuming Liang Xin Zhang Xinmin Lu | 2023 | Journal of Plant Ecology2023，16，1： | 1 |
| 19 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 20 | A Distributed Decision Making Method in Cognitive Radio Networks for Spectrum Management显示文摘 | GE Yuming SUN Yi LU Shan Eryk Dutkiewicz | 2010 | Chinese Journal of Electronics2010，19，2： | 1 |
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