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| 1 | Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation显示文摘apelin/apelin 受体(APJ, apelinangiotensin 像受体 1 ) 系统是一最新 deorphanized G 联合蛋白质的受体系统。是重要规章的因素的 apelin 和 APJ 在心血管的系统被表示。我们的以前的研究显著地表明了那 apelin-13 刺激脉管的光滑的肌肉房间(VSMC ) 增长。在这份报纸,我们的数据建议表明 transduction 小径的 Jagged-1/Notch3 被支持 Cyclin D1 的表示涉及 apelin-13-induced VSMC 增长。结果显示 apelin-13 在集中依赖者和时间依赖者礼貌刺激 VSMC 和 Jagged-1 和 Notch3 的表示的增长。apelin-13 导致的 Jagged-1 和 Notch3 的增加的表示能被细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) 废除封锁。PD98059 (英皇家空军之阶级最低之兵禁止者) 能禁止 apelin-13 导致的 Jagged-1/Notch3 的激活。用小介入 RNA 的 Notch3 的下面规定禁止 Cyclin D1 的表示并且阻止 apelin-13-induced VSMC 增长。在结论, Jagged-1/Notch3 发信号 transduction 小径涉及 apelin-13 导致的 VSMC 增长。 | Lifang Li Lanfang Li Feng Xie Zidong Zhang Yu Guo Guotao Tang Deguan Lv Qixuan Lu Linxi Chen Jian Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 18 |
| 2 | Introduction of rice chitinase gene into wheat via low energy Ar^+ beam implantation显示文摘A chitinase gene (RCH8) in plasmid vector pCAMBIA1308 was delivered into 3 wheat cultivars (Yangmai 158, Wan 9210, Wanmai 32) by low energy Ar+ beam-mediated method. Preliminary calli from treated mature embryos were first selected on hygromycin (Hm, 20 or 30 mg/L) containing medium. After the resistant calli formed, they were transferred to the regeneration medium with 10 or 20 mg/L Hm. All the three wheat varieties obtained trans-genie plants. PCR and PCR-Southern assays showed that most plants regenerated from the resistant calli were positive transgenic plants. Southern blot of the positive green plants confirmed stable integration of alien DNA into wheat genome. The plant transformation frequencies varied with the variety and ion dose implanted. Wanmai 32 possessed the highest transformation frequency, reaching 3.8% at a suitable implantation dose. The transformation frequency of Yangmai 158 and Wan 9210 varied from 0.5% to 2.5% and from 0.5% to 1.4%, respectively. Progeny test for resistance to | WU Lifang LI Hong FENG Huiyun WU Lijun YU Zengliang | 2001 | Chinese Science Bulletin2001，46，4： | 14 |
| 3 | Effects of operational factors on soluble microbial products in a carrier anaerobic baffled reactor treating dilute wastewater显示文摘The effects of feed strength, hydraulic residence time (HRT), and operational temperatures on soluble microbial product (SMP) production were investigated, to gain insights into the production mechanism. A carrier anaerobic baffled reactor (CABR) treating dilute wastewater was operated under a wide range of operational conditions, namely, feed strengths of 300–600 mg/L, HRTs of 9– 18 h, and temperatures of 10–28°C. Generally, SMP production increased with increasing feed strength and decreasing temperature. At high temperature (28°C), SMP production increased with decreasing HRT. As the temperature was decreased to 18 and 10°C, the SMP production was at its peak for 12 h HRT. Therefore, temperature could be an important determinant of SMP production along with HRT. A higher SMP to soluble chemical oxygen demand (SCOD) ratio was found at high temperature and long HRT because of complete volatile fatty acid degradation. SMP accounted for 50%–75% of the SCOD in the last chamber of the CABR. As a secondary metabolite, some SMP could be consumed at lower feed strength. | FENG Huajun HU Lifang SHAN Dan FANG Chengran HE Yonghua SHEN Dongsheng | 2008 | Journal of Environmental Sciences2008，20，6： | 12 |
| 4 | OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection显示文摘 | Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li | 2014 | Molecular Plant2014，7，6： | 11 |
| 5 | Trust Access Authentication in Vehicular Network Based on Blockchain显示文摘Data sharing and privacy securing present extensive opportunities and challenges in vehicular network.This paper introducestrust access authentication scheme’as a mechanism to achieve real-time monitoring and promote collaborative sharing for vehicles.Blockchain,which can provide secure authentication and protected privacy,is a crucial technology.However,traditional cloud computing performs poorly in supplying low-latency and fast-response services for moving vehicles.In this situation,edge computing enabled Blockchain network appeals to be a promising method,where moving vehicles can access storage or computing resource and get authenticated from Blockchain edge nodes directly.In this paper,a hierarchical architecture is proposed consist of vehicular network layer,Blockchain edge layer and Blockchain network layer.Through a authentication mechanism adopting digital signature algorithm,it achieves trusted authentication and ensures valid verification.Moreover,a caching scheme based on many-to-many matching is proposed to minimize average delivery delay of vehicles.Simulation results prove that the proposed caching scheme has a better performance than existing schemes based on central-ized model or edge caching strategy in terms of hit ratio and average delay. | Shaoyong Guo Xing Hu Ziqiang Zhou Xinyan Wang Feng Qi Lifang Gao | 2019 | China Communications2019，16，6： | 10 |
| 6 | Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy显示文摘Apelin 高度在左室的肥大 Sprague Dawley 老鼠建模的老鼠被表示,并且它在心血管的系统起一个关键作用。这研究是澄清 apelin-13 是否在 H9c2 老鼠 cardiomyocytes 支持肥大并且调查它的内在的机制的目的。cardiomyocyte 肥大被测量 H9c2 房间的直径,体积,和蛋白质内容观察。autophagy 的激活被由传播电子显微镜学观察 autophagosomes 的形态学评估,观察由轻显微镜学的 LC3 的 subcellular 本地化,并且由西方的污点分析检测 LC3 的联系膜的形式。表明小径的 phosphatidylinositol 3-kinase (PI3K ) 被识别,蛋白质表示用西方的污点分析被检测。结果表明 apelin-13 增加了 H9c2 房间的直径,体积,和蛋白质内容并且支持了 PI3K, Akt, ERK1/2,和 p70S6K 的 phosphorylation。Apelin-13 激活 PI3K-Akt-ERK1/2-p70S6K 小径。PI3K 禁止者 LY294002, Akt 禁止者 1701-1, ERK1/2 禁止者 PD98059 稀释了房间直径的增加,体积,蛋白质内容由 apelin-13 导致了。Apelin-13 增加了 autophagosomes 并且起来调整 beclin 的表情 1 并且 LC3-II/I 短暂地并且稳定地。autophagy 禁止者 3MA 改善了被 apelin-13 导致的房间直径,体积,和蛋白质内容的增加。这些结果建议 apelin-13 经由 PI3K-Akt-ERK1/2-p70S6K 和导致 PI3K 的 autophagy 支持 H9c2 老鼠 cardiomyocyte 肥大。 | Feng Xie Wei Liu Fen Feng Xin Li Lu He Deguan Lv Xuping Qin Lifang Li Lanfang Li Linxi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 9 |
| 7 | Tetrahymena Gene Expression Database (TGED):A resource of microarray data and co-expression analyses for Tetrahymena显示文摘Tetrahymena thermophila is a model eukaryotic organism. Functional genomic analyses in Tetrahymena present rich opportunities to address fundamental questions of cell and molecular biology. The Tetrahymena Gene Expression Database (TGED; available at http://gffzz5d146715fb2e495ehopwp0uv5uw9q6u0b.ffgz.tsg.suse.edu.cn) is the first expression database of a ciliated protozoan. It covers three major physiological and developmental states: growth, starvation, and conjugation, and can be accessed through a user-friendly web interface. The gene expression profiles and candidate co-expressed genes for each gene can be retrieved using Gene ID or Gene description searches. Descriptions of standardized methods of sample preparation and the opportunity to add new Tetrahymena microarray data will be of great interest to the Tetrahymena research community. TGED is intended to be a resource for all members of the scientific research community who are interested in Tetrahymena and other ciliates. | XIONG Jie LU XingYi LU YuMing ZENG HongHui YUAN DongXia FENG LiFang CHANG Yue Josephine BOWEN Martin GOROVSKY FU ChengJie MIAO Wei | 2011 | Science China(Life Sciences)2011，54，1： | 5 |
| 8 | Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT),tributyltin (TBT),and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)显示文摘Dichlorodiphenyltrichloroethane (DDT),tributyltin (TBT),and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are persistent in the environment and cause continuous toxic effects in humans and aquatic life.Tetrahymena thermophila has the potential for use as a model for research regarding toxicants.In this study,this organism was used to analyze a genome-wide microarray generated from cells exposed to DDT,TBT and TCDD.To accomplish this,genes differentially expressed when treated with each toxicant were identified,after which their functions were categorized using GO enrichment analysis.The results suggested that the responses of T.thermophila were similar to those of multicellular organisms.Additionally,the context likelihood of relatedness method (CLR) was applied to construct a TCDD-relevant network.The T-shaped network obtained could be functionally divided into two subnetworks.The general functions of both subnetworks were related to the epigenetic mechanism of TCDD.Based on analysis of the networks,a model of the TCDD effect on T.thermophila was inferred.Thus,Tetrahymena has the potential to be a good unicellular eukaryotic model for toxic mechanism research at the genome level. | CHANG Yue FENG LiFang MIAO Wei | 2011 | Science China(Life Sciences)2011，54，7： | 3 |
| 9 | ATP-binding cassette transporter enhances tolerance to DDT in Tetrahymena显示文摘The reuse of dichlorodiphenyltrichloroethane(DDT) as an indoor residual spray was permitted by the World Health Organization in 2007, and approximately 14 countries still use DDT to control disease vectors. The extensive exposure of insects to DDT has resulted in the emergence of DDT resistance, especially in mosquitoes, and the mechanism for this resistance in mosquitoes has been widely reported. Spraying can also introduce DDT directly into surface water, and DDT can subsequently accumulate in microorganisms, but the mechanism for the resistance to DDT degradation in microorganisms is unclear. Using whole-genome microarray analysis, we detected an abcb15 gene that was up-regulated in a specific manner by DDT treatment in T. thermophile. The deduced ABCB15 peptide sequence had two transmembrane domains(TMDs) and two nucleotide-binding domains(NBDs) to form the structure TMD-NBD-TMD-NBD, and each NBD contained three conserved motifs: Walker-A, C-loop, and Walker-B, which indicated the T. thermophila abcb15 was a typical ABC transporter gene. The expression of ABCB15 fused with a C-terminal green fluorescent protein was found to be on the periphery of the cell, suggesting that ABCB15 was a membrane pump protein. In addition, cells with abcb15 partially knocked down(abcb15-KD) grew slower than wild-type cells in the presence of 256 mg L-1 DDT, indicating the tolerance of abcb15-KD strain to DDT exposure was decreased. Thus, we suggest that in Tetrahymena, the membrane pump protein encoded by ABCT gene abcb15 can enhance the tolerance to DDT and protect cells from this exogenous toxin by efficiently pumping it to the extracellular space. | NING YingZhi DANG Huai LIU GuangLong XIONG Jie YUAN DongXia FENG LiFang MIAO Wei | 2015 | Science China(Life Sciences)2015，58，3： | 3 |
| 10 | Impact of vitamin D supplementation on the outcome of tuberculosis treatment: a systematic review and meta-analysis of randomized controlled trials显示文摘 | Xia Jingyan Shi Liyun Zhao Lifang Xu Feng | 2014 | Chinese Medical Journal2014，，17： | 3 |
| 11 | A model of suitability evaluation of tourism development for the suburban mining wasteland and its empirical research显示文摘The model of suitability evaluation of tourism development for suburban mining wasteland was established in Fengquan District of Xinxiang City, with measurable methods to provide the basis for its tourism development and landscape planning. The construction and evaluation of the model was conducted with AHP method from the follow-ing four aspects: ecological importance, landscape importance, economic importance and social importance, vali-dated with the case. In the established evaluation system, weight values of six indexes are higher than 0.05, among which the weight of industrial characteristics is the highest, and the weight of area, pollution conditions, air quality conditions, landscape diversity and topography were also higher. There are still seven indicators with weight values of higher than 0.02, including land price, transportation accessibility, geological conditions, water conditions, finan-cial security, distance to cities and similar competition. Weight values of five indexes are lower than 0.02, including government function, vegetation conditions, soil conditions, urban economic level and major tourism environment. We have tried to set a weighting set by AHP to avoid the shortcomings in ordinary weighting process, to perform the tourism evaluation with a maturely-developed method and solve the multi-indicator evaluation problems which in-volve the fuzziness and variability of scaling effectively. Our calculating method is a simple, reasonable, quantitative and feasible one, with general signif icance to non-structuralized project as development of wasteland. | Qiao Lifang Zhang Yichuan Feng Lei | 2008 | Ecological Economy2008，4，3： | 2 |
| 12 | Rational Quasi-Interpolation Approximation of Scattered Data in R^(3)显示文摘This paper is concerned with a piecewise smooth rational quasi-interpolation with algebraic accuracy of degree(n+1)to approximate the scattered data in R 3.We firstly use the modified Taylor expansion to expand the mean value coordinates interpolation with algebraic accuracy of degree one to one with algebraic accuracy of degree(n+1).Then,based on the triangulation of the scattered nodes in R^(2),on each triangle a rational quasi-interpolation function is constructed.The constructed rational quasi-interpolation is a linear combination of three different expanded mean value coordinates interpolations and it has algebraic accuracy of degree(n+1).By comparing accuracy,stability,and efficiency with the C^(1)-Tri-interpolation method of Goodman[16]and the MQ Shepard method,it is observed that our method has some computational advantages. | Renzhong Feng Lifang Song | 2018 | Numerical Mathematics(Theory,Methods and Applications)2018，11，1： | 2 |
| 13 | Nonfunctional alleles of long-day suppressor genes independently regulate flowering time显示文摘Due to the remarkable adaptability to various environments, rice varieties with diverse flowering times have abeen domesticated or improved from Oryza rufipogon.Detailed knowledge of the genetic factors controlling flowering time will facilitate understanding the adaptation mechanism in cultivated rice and enable breeders to design appropriate genotypes for distinct preferences. In this study,four genes(Hd1, DTH8, Ghd7 and OsPRR37) in a rice long-day suppression pathway were collected and sequenced in 154, 74,69 and 62 varieties of cultivated rice(Oryza sativa)respectively. Under long-day conditions, varieties with nonfunctional alleles flowered significantly earlier than those with functional alleles. However, the four genes have different genetic effects in the regulation of flowering time: Hd1 and Os PRR37 are major genes that generally regulate rice flowering time for all varieties, while DTH8 and Ghd7 only regulate regional rice varieties. Geographic analysis and network studies suggested that the nonfunctional alleles of these suppression loci with regional adaptability were derived recently and independently. Alleles with regional adaptability should be taken into consideration for genetic improvement. The rich genetic variations in these four genes,which adapt rice to different environments, provide the flexibility needed for breeding rice varieties with diverse flowering times. | Xiao-Ming Zheng Li Feng Junrui Wang Weihua Qiao Lifang Zhang Yunlian Cheng Qingwen Yang | 2016 | Journal of Integrative Plant Biology2016，58，6： | 2 |
| 14 | Preliminary Experimental Results of ac Operation in the CT-6B Tokamak显示文摘The preliminary experimental results of ac plasma discharges in the CT-6B tokamak have been achieved by an active plasma current feedback system and the keys to a smooth transition through current zero and some phenomena related to the current reversal phase are also presented. | YANG Xuanzong ZHENG Shaobai JIANG Diming HAN Gonghe FENG Chunhua QI Xiazhi WANG Wenshu LI Wenlai LI Zanliang DONG Lifang | 1995 | Chinese Physics Letters1995，12，6： | 2 |
| 15 | Effect of a Novel Phosphorous-nitrogen Containing Intumescent Flame Retardant on the Fire Retardaney and the Thermal Behaviour of Poly( butylene terephthalate) 显示文摘 | Feng Gao Lifang Tong Zhengping Fang | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 16 | Influence of psychological,family and contextual factors on residential energy use behaviour:An empirical study of China显示文摘 | Sun Yah Feng Lifang | | 0，，： | 1 |
| 17 | 显示文摘 | Gao Feng Tong Lifang Fang Zhengping | 2006 | Polymer Deg- radation and Stability2006，91，6： | 1 |
| 18 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 19 | Changes in microbial and postharvest quality of shiitake mushroom ( Lentinus edodes ) treated with chitosan–glucose complex coating under cold storage显示文摘 | Tianjia Jiang Lifang Feng Jianrong Li | 2011 | Food Chemistry2011，，3： | 1 |
| 20 | On properties and structure of the AOT - water - isooctane reverse micellar mieroreactor for nanoparticles显示文摘 | Cheng Guoxiang Shen Feng Yang Lifang | 1998 | Materials Chemistry and Physics1998，56，2： | 1 |
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