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| 1 | Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli显示文摘瞄准:当在在为家庭腺瘤息肉病关口 i (FAP ) 的 proctocolectomy 以后的病人是稀罕的时, Pouchitis 在小袋外科以后在开始的 10 年期间与 ulcerative 在多达 50% 病人在 ileoanal 小袋发展症候群。Defensins 是天生的免疫系统的主要部件并且在胃肠的微生物引起的动态平衡起一个重要作用。小袋 defensin 和 cytokine 表示与小袋发炎的状态被相关在 pouchitis 学习他们的角色。方法:有 ulcerative 和 FAP 症候群的病人在外科以后与小袋被成层进组,小袋没有或与 pouchitis。从从健康的肠或从有 ulcerative 的病人的正常终端回肠的终端回肠的活体检视用作控制。从小袋和控制的 mRNA 为 defensin 和 cytokine 表示被分析。结果:defensins 的表示在外科以后立即在所有小袋被增加,与控制的回肠相比。开始,在 ulcerative 的小袋比 FAP 小袋揭示了更高的 defensin 表示。Defensin 表示在两个耐心的组衰退了并且与 ulcerative 在病人在 pouchitis 稍微再增加了。没有 pouchitis 的 FAP 小袋有 beta-defensin hBD-1 的强壮的表示,当所有另外的 defensins 在底层留下了时。在 ulcerative 小袋的 Cytokine 表示高,当 FAP 小袋仅仅在外科以后显示出中等提高的 cytokines 时。结论:pouchitis 的开发除了 cytokines 的高表示在 ulcerative 与减少的 defensin 表示相关。在 FAP 小袋的 pouchitis 的低发生与低 cytokine 层次联合与 hBD-1 beta-defensin 的增加的表示相关。 | Karlheinz Kiehne Gabriele Brunke Franziska Wegner Tomas Banasiewicz Ulrich R F lsch Karl-Heinz Herzig | 2006 | World Journal of Gastroenterology2006，12，7： | 8 |
| 2 | Practical guidelines for the treatment of inflammatory bowel disease显示文摘In recent years, great progress has been made regarding the treatment of inflammatory bowel disease (IBD), particularly in the field of biological therapies. Nevertheless, the ultimate treatment is not in sight. With the development of new medication, it has become clear that we need a new understanding of IBD. Therapy needs to fit the different subtypes of IBD; e.g. mild disease in comparison to severe chronic active disease or Crohn's disease with or without fistulation or stenosis. The following article gives a practical overview of actual treatments for IBD. The intention of this article is not to provide a complete review of all new scientific developments, but to give a practical guideline for therapy of IBD. | T Kuhbacher UR Flsch | 2007 | World Journal of Gastroenterology2007，13，8： | 3 |
| 3 | Vision-based hand-gesture applications显示文摘 | Juan Pablo Wachs Mathias K?lsch Helman Stern Yael Edan | 2011 | Communications of the ACM2011，，2： | 2 |
| 4 | miR-21 and its target gene CCL20 are both highly overexpressed in themicroenvironment of colorectal tumors: Significance of their regulation显示文摘 | Benjamin Vicinus Claudia Rubie Nathalie Stegmaier Vilma Frick Kathrin K?lsch Anne Kauffels Pirus Ghadjar Mathias Wagner Matthias Glanemann | 2013 | Oncology Reports2013，，3： | 2 |
| 5 | Imatinib mesylate,a new kid on the block for the treatment of anti-neutrophil cytoplasmic autoantibodies-associated vasculitis显示文摘 | Kālsch AI Soboletzki M Schmitt WH | 2008 | Clin Exp Immunol2008，151，3： | 1 |
| 6 | Effect of 1-desoxynojirimy-cin derivatives on small intestinal disaccharidase activities and on active transport in vitro digestion显示文摘 | Lembcke B F(o)lsch U R Creutzfeldt W | 1985 | Digestion1985，31，23： | 1 |
| 7 | M essenger ribonucleic acid levels of inter leukin-1 beta, interleukin-6 and interleukin- 8 in the lower uterine segment increased significantly at final cervieal dilatation during term parturition, while those of rum or necrosis factor alpha remained unchanged显示文摘 | Maul H Nage 1 S W e lsch G | 2002 | Eur J Obstet Gynecol Reprod Bio2002，102，14： | 1 |
| 8 | Alimentary lipemia enhances procoagulatory effects of inflammation in patients with a history of acute myocardial infarction complicated by ventricular Fibrillation显示文摘 | Klsch T Elmas E Nguyen XD | 2008 | Int J Cardiol2008，123，2： | 1 |
| 9 | Comparative Clinical Evaluation of the 13C-Mixed Triglyceride Breath Test as an Indirect Pancreatic Function Test显示文摘 | CHR. L? SER C. BRAUER S. AYGEN O. HENNEMANN U. R. F? LSCH | 1998 | Scandinavian Journal of Gastroenterology1998，，： | 1 |
| 10 | Explaining the phenomenon of nitrate tolerance显示文摘 | Münzel T Daiber A Mülsch A | | 0，，： | 1 |
| 11 | Randomized comparison of effects of suture-based and collagen-based vascular closure devices on post-procedural leg perfusion显示文摘 | Hagen I. M. K?lsch MD Holger Eggebrecht MD Susanne Mayringer Thomas Konorza MD B. Sievers MD Stefan Sack MD Raimund Erbel MD Knut Kroeger MD | 2008 | Clinical Research in Cardiology2008，，1： | 1 |
| 12 | Explaining the phenomenon of nitrate tolerance 显示文摘 | MüNZEL T DAIBER A MüLSCH A | 2005 | Circ Res2005，97，7： | 1 |
| 13 | Effects of estrogen on brain development and neuroprotection--implications for negative symptoms in schizophrenia显示文摘 | Rao ML K?lsch H | 2003 | Psychoneuroendocrinology2003，28，2： | 1 |
| 14 | The use of reduced-size liver transplantation in children,including split livers and living related liver transplants显示文摘 | BR(O)LSCH C E STEVENS L H WHITINGTON P F | 1991 | Eur J Pediatric Surg1991，1，3： | 1 |
| 15 | Zeolite Membranes-state of Their Development and Perspective显示文摘 | Caro J Noack M Klsch P Schfer R | 2000 | Microporous and Mesoporous Materials2000，38，： | 1 |
| 16 | Explaining the phenomenon of nitrate tolerance显示文摘 | Münzel T Daiber A Mülsch A | 2005 | Circ Res2005，97，7： | 1 |
| 17 | Polymorphisms in glu- tathione S-transferals omega-1 and AD, vascular dementia and stroke 显示文摘 | K lsch H Linnebank M Lutjohann D | 2004 | Neurology2004，63，12： | 1 |
| 18 | In activated mast cells,IL-1 up-regulates the production of several Th2-related cytokines including IL-9显示文摘 | Hültner L K(o)lsch S Stassen M | 2000 | J Immunol2000，164，11： | 1 |
| 19 | Polymorphisms in glutathione S-transferase omega-1 and AD,vascular dementia,and stroke显示文摘 | K(o)lsch H Linnebank M Lütjohann D | 2004 | Neurology2004，63，12： | 1 |
| 20 | The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine显示文摘 | Daiber A Mülsch A Hink U Mollnau H Warnholtz A Oelze M | 2005 | Am J Cardiol2005，96，7： | 1 |
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