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| 1 | chemokine/chemokine receptor pair CC L20/CC R6 in humancolorectal malignancy:An overview显示文摘Chemokines belong to a superfamily of small, cytokinelike proteins, which induce multiple physiological functions, particularly cytoskeletal rearrangement and compartment-specific migration through their interaction with G-protein-coupled receptors. Chemokines and their receptors have been widely acknowledged as essential and selective mediators in leukocyte migration in inflammatory response. It is now established that the chemokine/chemokine receptor system is also used by cancer cells to direct lymphatic and haematogenous spreading and additionally has an impact on the site of metastatic growth of different tumours. In recent years an increasing number of studies have drawn attention to CC-chemokine cysteine motif chemokine ligand 20(CCL20) and its physiological sole receptor CCR6 to play a role in the onset, development and metastatic spread of various gastrointestinal cancer entities. Among various cancer types CCR6 was also demonstrated to be significantly overexpressed in colorectal cancer(CRC) and stimulation by its physiological ligand CCL20 has been reported to promote CRC cell proliferation and migration in vitro. Further, the CCL20/CCR6 system apparently plays a role in the organ-selective liver metastasis of CRC. Here we review the literature on expression patterns of CCL20 and CCR6 and their physiological interactions as well as the currently presumed role of CCL20 and CCR6 in the formation of CRC and the development of liver metastasis, providing a potential basis for novel treatment strategies. | Vilma Oliveira Frick Claudia Rubie Ulrich Keilholz Pirus Ghadjar | 2016 | World Journal of Gastroenterology2016，22，2： | 8 |
| 2 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 3 | miR-21 and its target gene CCL20 are both highly overexpressed in themicroenvironment of colorectal tumors: Significance of their regulation显示文摘 | Benjamin Vicinus Claudia Rubie Nathalie Stegmaier Vilma Frick Kathrin K?lsch Anne Kauffels Pirus Ghadjar Mathias Wagner Matthias Glanemann | 2013 | Oncology Reports2013，，3： | 2 |
| 4 | CXC receptor-4 mRNA silencing abrogates CXCLl2 -induced migration of colorectal cancer cells 显示文摘 | Rubie C Frick VO Ghadjar P et a1 | 2011 | J Transl Med2011，9，1： | 1 |
| 5 | Chemokine re- ceptor CCR6 expression level and liver metastases in colorec- tal cancer显示文摘 | GHADJAR P COUPLAND S E NA I K | 2006 | Journal of Clinical Oncology2006，24，12： | 1 |
| 6 | The chemokine CC 120 and its receptor CCR6 in human malignancy with focus on colorectal cancer显示文摘 | Ghadjar P Rubie C Aebersold DM | 2009 | Int J Cancer2009，125，4： | 1 |
| 7 | CXC receptor - 4 mRNA silencing abrogates CXCL12 -induced migration of colorectal cancercells显示文摘 | Rubie C Frick V Ghadjar P | 2011 | J Transl Med2011，9，1： | 1 |
| 8 | Top-10 list of herbal and supplemental medicines used by cosmetic patients: What the plastic surgeon needs to know显示文摘 | HellerJ GabbayJS Ghadjar K | 2006 | Plast Reconstr Surg2006，117，： | 1 |
| 9 | Modem radiation therapy andpotential fertility preservation strategies in patients with cervicalcancer undergoing chemoradiation显示文摘 | Ghadjar P Budach V Kohler C | 2015 | Radiat Oncol2015，10，1： | 1 |
| 10 | Chemokine receptor CCR6 expression level and liver metastases in eolorectal cancer显示文摘 | Ghadjar P Coupland SE Na IK | 2006 | J Clin Oncol2006，24，12： | 1 |
| 11 | The chemokine CCL20 and its receptor CCR6 in human malignancy with {ocus on colorectal cancer显示文摘 | Ghadjar P Rubie C Aebersold DM | 2009 | Int J Cancei2009，125，4： | 1 |
| 12 | CCL20/CCR6 expression profile in pancreatic cancer显示文摘 | Ruble C Frick VO Ghadjar P | 2010 | J Transl Med2010，8，： | 1 |
| 13 | Modem radiation ther-apy and potential fertility preservation strategies in pa- tients with cervical cancer undergoing chemoradiation显示文摘 | Ghadjar Budaeh V Kohler C | 2015 | Radiat Oncol2015，10，1： | 1 |
| 14 | Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer显示文摘 | Ghadjar P Coupland SE Na IK | 2006 | J Clin Oncol2006，24，12： | 1 |
| 15 | Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer显示文摘 | GHADJAR P COUPLAND SE NA IK | 2006 | J Clin Oncol2006，24，12： | 1 |
| 16 | The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer显示文摘 | GHADJAR P RUBIE C AEBERSOLD D M | 2009 | Int J Cancer2009，125，： | 1 |
| 17 | Impact of dose to the bladder trigone on long-term urinary function after high-dose intensity modulated radiation therapy for local- ized prostate cancer显示文摘 | Ghadjar P Zelefsky MJ Spratt DE | 2014 | Int J Radiat Oneol Biol Phys2014，88，2： | 1 |
| 18 | The chemo- kine CCL20 and its receptor CCR6 in human malignancy with focus on calorectal cancer显示文摘 | GHADJAR P RUBIE C AEBERSOLD D M | 2009 | Int J Cancer2009，125，4： | 1 |
| 19 | Changes in CX- CL12/CXCR4-chemokine expression during onset of eolorectaI malignancies显示文摘 | Oliveira Frick V Ruble C Ghadjar P | 2011 | Tumour Biol2011，32，1： | 1 |
| 20 | Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer显示文摘 | GHADJAR P COUPLAND S E NA I K | 2006 | J Clin Oncol2006，24，： | 1 |
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