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| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | The Stripe Rust Resistance Gene Yr10 Encodes an Evolutionary-Conserved and Unique CC-NBS-LRR Sequence in Wheat显示文摘对用一条基于地图的克隆途径从摩洛人小麦(Triticum aestivum L.) 孤立的条纹锈的第一棵幼苗或所有阶段抵抗(R) R 基因作为 Yr10 被识别。这基因的克隆 4B 编码一高度,进化保存和唯一的 CCNBSLRR 定序。克隆 4E, Yr10 的一个相当或相同的事物,而是缺乏的抄写开始地点(TSS ) 和通常认为的 TATA 盒子和 CAAT 盒子,是可能的非表示的 pseudogene。克隆 4B 和 4E 是 84% 在 intron 和 LRR 领域相同、分叉。基因 silencing 和 transgenesis 与无毒害、剧毒的条纹锈尽力表明 Yr10 功能的差别与接种一起被使用。Yr10 CCNBSLRR 顺序在在小麦的已知的 CCNBSLRR R 基因之中是唯一的,但是高度保存相当或相同的事物(E = 0.0 ) 包括 Hordeum vulgare 和 Brachypodium distachyon 在 Aegilops tauschii 和另外的 monocots 被识别。相关序列也在玉米的 genomic 数据库被识别,米饭,并且在里面蜀黍。这是在有在它的本国的主人的有限相同,但是与在为条纹锈是主人或非主人的相关 monocots 的众多的相应 R 基因的植物的 CCNBSLRR 抵抗基因的第一份报告。这些结果越过种类代表基因进化和分散的一个唯一的例子。 | Wei Liu Michele Frick Rene Huel Cory L. Nykiforuk Xiaomin Wang Denis A. Gaudet Francois Eudes Robert L. Conner Alan Kuzyk Zhensheng Kang Andre Laroche | 2014 | Molecular Plant2014，7，12： | 21 |
| 3 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 4 | Methylated and thiolated arsenic species for environmental and health research——A review on synthesis and characterization显示文摘Hundreds of millions of people around the world are exposed to elevated concentrations of inorganic and organic arsenic compounds, increasing the risk of a wide range of health effects. Studies of the environmental fate and human health effects of arsenic require authentic arsenic compounds. We summarize here the synthesis and characterization of more than a dozen methylated and thiolated arsenic compounds that are not commercially available. We discuss the methods of synthesis for the following14 trivalent(Ⅲ) and pentavalent() arsenic compounds: monomethylarsonous acid(MMA~Ⅲ), dicysteinylmethyldithioarsenite(MMA~Ⅲ(Cys)_2), monomethylarsonic acid(MMA~Ⅴ),monomethylmonothioarsonic acid(MMMTAⅤ) or monothio-MMA~Ⅴ, monomethyldithioarsonic acid(MMDTA~Ⅴ) or dithio-MMA~Ⅴ, monomethyltrithioarsonate(MMTTA~Ⅴ) or trithio-MMA~Ⅴ,dimethylarsinous acid(DMA~Ⅲ), dimethylarsino-glutathione(DMA~Ⅲ(SG)), dimethylarsinic acid(DMA~Ⅴ), dimethylmonothioarsinic acid(DMMTA~Ⅴ) or monothio-DMAⅤ, dimethyldithioarsinic acid(DMDTA~Ⅴ) or dithio-DMA~Ⅴ, trimethylarsine oxide(TMAO~Ⅴ), arsenobetaine(AsB), and an arsenicin-A model compound. We have reviewed and compared the available methods,synthesized the arsenic compounds in our laboratories, and provided characterization information. On the basis of reaction yield, ease of synthesis and purification of product, safety considerations, and our experience, we recommend a method for the synthesis of each of these arsenic compounds. | William R.Cullen Qingqing Liu Xiufen Lu Anthony McKnight-Whitford Hanyong Peng Aleksandra Popowich Xiaowen Yan Qi Zhang Michael Fricke Hongsui Sun X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 12 |
| 5 | chemokine/chemokine receptor pair CC L20/CC R6 in humancolorectal malignancy:An overview显示文摘Chemokines belong to a superfamily of small, cytokinelike proteins, which induce multiple physiological functions, particularly cytoskeletal rearrangement and compartment-specific migration through their interaction with G-protein-coupled receptors. Chemokines and their receptors have been widely acknowledged as essential and selective mediators in leukocyte migration in inflammatory response. It is now established that the chemokine/chemokine receptor system is also used by cancer cells to direct lymphatic and haematogenous spreading and additionally has an impact on the site of metastatic growth of different tumours. In recent years an increasing number of studies have drawn attention to CC-chemokine cysteine motif chemokine ligand 20(CCL20) and its physiological sole receptor CCR6 to play a role in the onset, development and metastatic spread of various gastrointestinal cancer entities. Among various cancer types CCR6 was also demonstrated to be significantly overexpressed in colorectal cancer(CRC) and stimulation by its physiological ligand CCL20 has been reported to promote CRC cell proliferation and migration in vitro. Further, the CCL20/CCR6 system apparently plays a role in the organ-selective liver metastasis of CRC. Here we review the literature on expression patterns of CCL20 and CCR6 and their physiological interactions as well as the currently presumed role of CCL20 and CCR6 in the formation of CRC and the development of liver metastasis, providing a potential basis for novel treatment strategies. | Vilma Oliveira Frick Claudia Rubie Ulrich Keilholz Pirus Ghadjar | 2016 | World Journal of Gastroenterology2016，22，2： | 8 |
| 6 | ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology显示文摘 | J. Arends G. Bodoky F. Bozzetti K. Fearon M. Muscaritoli G. Selga M.A.E. van Bokhorst-de van der Schueren M. von Meyenfeldt G. Zürcher R. Fietkau E. Aulbert B. Frick M. Holm M. Kneba H.J. Mestrom A. Zander | 2006 | Clinical Nutrition2006，，2： | 6 |
| 7 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 8 | The Level of Expression of Thioredoxin is Linked to Fundamental Properties and Applications of Wheat Seeds显示文摘有谷物(大麦和小麦) 和荚(Medicago truncatula ) 的工作作为种子的中央规章的蛋白质建立了 thioredoxin h (Trx h ) 。Trx h 由减少二硫化物(SS ) 扮演一些多样的种子蛋白质(存储蛋白质,酶,和酶禁止者) ,从而便于萌芽。早,在 vitro,蛋白质研究与有在内乳的 Trx h overexpressed 的大麦种子在显示出加速的萌芽和联系的酶(淀粉酶和 pullulanase ) 的早或提高的表示的实验被补充。当前的学习扩大转基因的工作到小麦。二条途径被跟随在内乳改变 Trx h 基因的表示:(1 ) 一个大麦蛋白倡导者和它指向顺序的蛋白质身体导致了 Trx h5 的 overexpression,并且(2 ) Trx h9 的 antisense 构造导致了那基因(Arabidopsis 指明) 的 cytosolic underexpression。Trx h9 的 Underexpression 导致了对在萌芽的 barleyretardation 为 overexpression Trx h5 观察并且推迟了或减少联系的酶的表示的那些相反的效果。类似的酶变化在开发种子被观察。有 underexpressed Trx 的小麦线看了发芽的推迟的 preharvest 没有减少,什么时候在最后的产量在温室或领域成长。有 overexpressed Trx h5 的小麦显示出与同量的变化在 vitro 工作更早:二硫化物蛋白质的增加的溶解度和麦胶蛋白质部分的更低的 allergenicity。结果是在谷物内乳的 Trx h 的水平决定基本性质以及种子的潜在的应用程序的进一步的证据。 | Yong-Chun Li Jiang-Ping Ren Myeong-Je Cho Su-Mei Zhou Yong-Bum Kim Hong-Xiang Guo Joshua H. Wong Hong-Bin Niu Hyun-Kyung Kim Susumu Morigasaki Peggy G. Lemaux Oscar L. Frick Jun Yin Bob B. Buchanan | 2009 | Molecular Plant2009，2，3： | 5 |
| 9 | Immunosuppression for in vivo research: state-of-the-at protocols and experimental approaches显示文摘几乎,用非自体同源的房间,织物或机关移植的每试验性的治疗策略在临床的翻译前在小、大的动物模型被测试。因为这些策略在大多数情况中要求免疫力的抑制,抑制免疫力的协议是在移植实验的一个关键元素。然而,没有详细知识,标准抑制免疫力的协议经常在特别试验性的背景以内并且在选择模型种类关于他们的功效被使用。如此的协议的优化对到人的病人的试验性的结果的翻译恰当,因此,保证推进调查。这评论与种类特定的药 metabolization 和副作用的考虑关于抑制免疫力的药类以及他们的剂量和应用程序政体总结当前的知识。它也总结新奇 immunomodulatory 策略的当代的知识,例如间充质的干细胞或抗体的使用。因此,这评论被打算用作一个最先进的概要让研究人员精制应用试验性的免疫力的抑制和 immunomodulation 策略提高现出症状之前的潜的移植研究的预兆的价值。 | Rita Diehl Fabienne Ferrara Claudia Müller Antje Y Dreyer Damian D McLeod Stephan Fricke Johannes Boltze | 2017 | Cellular & Molecular Immunology2017，14，2： | 5 |
| 10 | 巴斯夫技术资料之五薄膜复合用水性聚合物胶乳显示文摘 | Hans Joachim Fricke Dr.Lothar Maempel | 1997 | 粘接1997，18，3： | 3 |
| 11 | The role of calcium in acute pancreatitis显示文摘 | Thomas W. Frick | 2012 | Surgery2012，，3： | 2 |
| 12 | Fatigue analysis of welded joints: state of development显示文摘 | Wolfgang Fricke | 2002 | Marine Structures2002，，3： | 2 |
| 13 | Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells显示文摘 | Frick AG Joseph TD Pang LY | 2000 | J Immunol2000，164，： | 2 |
| 14 | Continuous Low-Level Vagus Nerve Stimulation Reduces Stellate Ganglion Nerve Activity and Paroxysmal Atrial Tachyarrhythmias in Ambulatory Canines显示文摘 | Mark J. Shen Tetsuji Shinohara Hyung-Wook Park Kyle Frick Daniel S. Ice Eue-Keun Choi Seongwook Han Mitsunori Maruyama Rahul Sharma Changyu Shen Michael C. Fishbein Lan S. Chen John C. Lopshire Douglas P. Zipes Shien-Fong Lin Peng-Sheng Chen | 2011 | Circulation2011，，20： | 2 |
| 15 | Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer显示文摘 | Andrea Formentini Philipp Braun Harald Fricke Karl-Heinrich Link Doris Henne-Bruns Marko Kornmann | 2012 | International Journal of Colorectal Disease2012，，10： | 2 |
| 16 | miR-21 and its target gene CCL20 are both highly overexpressed in themicroenvironment of colorectal tumors: Significance of their regulation显示文摘 | Benjamin Vicinus Claudia Rubie Nathalie Stegmaier Vilma Frick Kathrin K?lsch Anne Kauffels Pirus Ghadjar Mathias Wagner Matthias Glanemann | 2013 | Oncology Reports2013，，3： | 2 |
| 17 | MR Evaluation of Rectal Cancer: Current Concepts显示文摘 | Claire Beaumont Tarun Pandey R. Gaines Fricke Jonathan Laryea Kedar Jambhekar | 2013 | Current Problems in Diagnostic Radiology2013，，3： | 2 |
| 18 | Atorvastatin decreases vascular endothelial grouth factor in patients with coronary artery disease显示文摘 | Dulals J Frick M | 2002 | J AM Coll Cardiol2002，39，12： | 1 |
| 19 | Impaired chronotropic response to beta-stimulation in chronic coronary artery disease显示文摘 | Frick M H Huttunen J K Harkonen M | 1973 | The American Journal of Medicine1973，55，3： | 1 |
| 20 | Globalization and factor mobility: The impact of the 'Bosman-Ruling' on player migration in professional soccer 显示文摘 | Bernd Frick | 2009 | Journal of Sports Economics2009，10，1： | 1 |
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