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| 1 | Jurassic Tectonic Revolution in China and New Interpretation of the “Yanshan Movement”显示文摘摘要:与结构的地质的调查的新数据和高分辨率的同位素的标明日期数据的获得和累积,我们极大地改进了我们从迟了的侏罗记在时期期间发生在东方中国到早白垩纪的构造事件的理解并且可以给性质的新解释,预定并且 Yanshan 运动的 geodynamic 背景。在中间迟了的侏罗记期间(165 挠慬獳漠 ?? | DONG Shuwen ZHANG Yueqiao LONG Changxing YANG Zhenyu JI Qiang WANG Tao HU Jianmin CHEN Xuanhua | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 41 |
| 2 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 3 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 4 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 5 | The discovery of the oldest rocks in the Kuluketage area and its geological implications显示文摘The basement rocks in the Kuluketage area are composed predominately of tonalite-trondhjemite-granodiorite rocks, and occured mainly in Xinger and Korla. U-Pb dating of TTG gneiss near Korla yielded a late Neoarchean weighted mean 207Pb/206Pb age of 2.65 Ga, which is the oldest published age for the TTG rocks in the Kuluketage area and thus suggests that Archean terrane in the area was formed in the late Neoarchean. The Korla gneiss is much younger than the TTG rocks in the northern Altyn Tagh, eastern Tarim Craton, indicating that the oldest terrane of the Tarim Craton was exposed probably in the northern Altyn Tagh. Until late Neoarchean, the Tarim continent extends to the Kuluketage area and finally had generated a relatively large uniform Archean basement within the craton. Zircon Hf isotopic analyses of the TTG gneiss give low εHf(t) values (-5 to 1) with Paleoarchean to Mesoarchean two-stage model ages (TDM2) between 3.0 and 3.3 Ga, suggesting that the basement rocks in the northern Tarim Craton were derived dominately from partial melting of Paleoarchean to Mesoarchean juvenile crustal material. The Hf model ages, therefore, indicate that no continent crust older than 3.3 Ga existed in the Kuluketage area. | LONG XiaoPing YUAN Chao SUN Min XIAO WenJiao ZHAO GuoChun ZHOU KeFa WANG YuJing HU AiQin | 2011 | Science China Earth Sciences2011，54，3： | 16 |
| 6 | Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation显示文摘瞄准: 调查在鼻咽的癌(NPC ) 上位于 celecoxib 的 anticancer 效果下面的机制。 | Dong-bo LIU Guang-yuan HU Guo-xian LONG Hong QIU Qi MEI Guo-qing HU | 2012 | Acta Pharmacologica Sinica2012，33，5： | 16 |
| 7 | Underwater explosion in centrifuge partⅠ:Validation and calibration of scaling laws显示文摘Centrifuge is a promising tool for underwater explosion(UNDEX) research as both Mach and Froude similitudes could be satisfied with hyper-gravity in models, which would result in similarities in both shock wave and bubble oscillation. Scaling laws for UNDEX in centrifuge have been proposed based on dimensional analysis. Two dimensionless numbers, i.e.,π_3 and π_4, are used to characterize shock wave and bubble oscillation, respectively. To validate scaling laws, 17 UNDEX tests are designed by varying accelerations or explosive weights and positions in centrifuge. The tests are classified into different groups to validate scaling laws as well as calibrate coefficients in empirical formulae for both shock wave and bubble oscillation. The results show that changes of gravity acceleration or hydrodynamic pressure almost has no influence on shock wave peak pressure and time constant as long as π3 is constant. The dimensionless bubble period and maximum radius agreed with each other when π4 is constant. Based on the research, an example is exhibited to suggest method for the computation of initial loading conditions for a submerged obstacle subjected to UNDEX. | HU Jing CHEN ZuYu ZHANG XueDong WEI YingQi LIANG XiangQian LIANG JianHui MA GuoWei WANG QiuSheng LONG Yuan | 2017 | Science China(Technological Sciences)2017，60，11： | 14 |
| 8 | Experimental quantum secure direct communication with single photons显示文摘Quantum secure direct communication is an important mode of quantum communication in which secret messages are securely communicated directly over a quantum channel.Quantum secure direct communication is also a basic cryptographic primitive for constructing other quantum communication tasks,such as quantum authentication and quantum dialog.Here,we report the first experimental demonstration of quantum secure direct communication based on the DL04 protocol and equipped with single-photon frequency coding that explicitly demonstrated block transmission.In our experiment,we provided 16 different frequency channels,equivalent to a nibble of four-bit binary numbers for direct information transmission.The experiment firmly demonstrated the feasibility of quantum secure direct communication in the presence of noise and loss. | Jian-Yong Hu Bo Yu Ming-Yong Jing Lian-Tuan Xiao Suo-Tang Jia Guo-Qing Qin Gui-Lu Long | 2016 | Light(Science & Applications)2016，5，1： | 14 |
| 9 | Ground moving target signal model and power calculation in forward scattering micro radar显示文摘Forward scattering micro radar is used for situation awareness;its operational range is relatively short because of the battery power and local horizon,the free space propagation model is not appropriate. The ground moving targets,such as humans,cars and tanks,have only comparable size with the transmitted signal wavelength;the point target model and the linear change of observation angle are not applicable. In this paper,the signal model of ground moving target is developed based on the case of forward scattering micro radar,considering the two-ray propagation model and area target model,and nonlinear change of observation angle as well as high order phase error. Furthermore,the analytical form of the received power from moving target has been obtained. Using the simulated forward scattering radar cross section,the received power of theoretical calculation is near to that of measured data. In addition,the simulated signal model of ground moving target is perfectly matched with the experimented data. All these results show the correctness of analytical calculation completely. | LONG Teng HU Cheng MIKHAIL Cherniakov | 2009 | Science in China(Series F)2009，52，9： | 12 |
| 10 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 11 | Diagnostic accuracy of transient elastography (Fibro Scan) in detection of esophageal varices in patients with cirrhosis: A meta-analysis显示文摘AIM To investigate the diagnostic accuracy of Fibro Scan(FS) in detecting esophageal varices(EV) in cirrhotic patients.METHODS Through a systemic literature search of multiple databases, we reviewed 15 studies using endoscopy as a reference standard, with the data necessary to calculate pooled sensitivity(SEN) and specificity(SPE), positive and negative LR, diagnostic odds ratio(DOR) and area under receiver operating characteristics(AUROC). The quality of the studies was rated by the Quality Assessment of Diagnostic Accuracy studies-2 tool. Clinical utility of FS for EV was evaluated by a Fagan plot. Heterogeneity was explored using meta-regression and subgroup analysis. All statistical analyses were conducted via Stata12.0, MetaD isc1.4 and RevM an5.RESULTS In 15 studies(n = 2697), FS detected the presence of EV with the summary sensitivities of 84%(95%CI: 81.0%-86.0%), specificities of 62%(95%CI: 58.0%-66.0%), a positive LR of 2.3(95%CI: 1.81-2.94), a negative LR of 0.26(95%CI: 0.19-0.35), a DOR of 9.33(95%CI: 5.84-14.92) and an AUROC of 0.8262. FS diagnosed the presence of large EV with the pooled SEN of 0.78(95%CI: 75.0%-81.0%), SPE of 0.76(95%CI: 73.0%-78.0%), a positive and negative LR of 3.03(95%CI: 2.38-3.86) and 0.30(95%CI: 0.23-0.39) respectively, a summary diagnostic OR of 10.69(95%CI: 6.81-16.78), and an AUROC of 0.8321. A meta-regression and subgroup analysis indicated different etiology could serve as a potential source of heterogeneity in the diagnosis of the presence of EV group. A Deek's funnel plot suggested a low probability for publication bias.CONCLUSION Using FS to measure liver stiffness cannot provide high accuracy for the size of EV due to the various cutoff and different etiologies. These limitations preclude widespread use in clinical practice at this time; therefore, the results should be interpreted cautiously given its SEN and SPE. | Ke Pu Jing-Hong Shi Xu Wang Qian Tang Xin-Jie Wang Kai-Lin Tang Zhong-Qi Long Xing-Sheng Hu | 2017 | World Journal of Gastroenterology2017，23，2： | 12 |
| 12 | Recent Progress in Dual-Polarization Radar Research and Applications in China显示文摘Dual-polarization(dual-pol)radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler radar.The dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation(QPE).The recent progress in dual-pol radar research and applications in China is summarized in four aspects.Firstly,the characteristics of several representative dual-pol radars are reviewed.Various approaches have been developed for radar data quality control,including calibration,attenuation correction,calculation of specific differential phase shift,and identification and removal of non-meteorological echoes.Using dual-pol radar measurements,the microphysical characteristics derived from raindrop size distribution retrieval,hydrometeor classification,and QPE is better understood in China.The limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are summarized.The challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed. | Kun ZHAO Hao HUANG Mingjun WANG Wen-Chau LEE Gang CHEN Long WEN Jing WEN Guifu ZHANG Ming XUE Zhengwei YANG Liping LIU Chong WU Zhiqun HU Sheng CHEN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 12 |
| 13 | Effect of slurry conditioning on flocculant-aided filtration of coal tailings studied by low-field nuclear magnetic resonance and X-ray micro-tomography显示文摘The present work aimed to study the effect of slurry conditioning on flocculant-aided filtration of coal tailings by the analysis of filtration kinetics and filter cake structure.Laboratory filtration tests of the coal tailings showed that both the shear rate and agitation time have significant effects on filtration rate and cake moisture.Moderate agitation at the shear rate of 92 s^-1 was favorable for fast filtration,but high cake moisture was encountered.The low-field 1H nuclear magnetic resonance(NMR)measurements of the filter cake showed that the slurry conditioning has a significant effect on the residual water in large pores and a negligible effect on the residual water in small pores.The X-ray micro-tomography(XRM)measurements indicated that the filter cake formed at the shear rate of 92 s^-1 has more macro-pores and higher porosity than that formed at the shear rate of 53 s1,hence more residual water was entrapped in filter cake.The slurry conditioning in the presence of flocculant will change the structure of filter cake and affect the filtration performance.There was a paradox between fast filtration rate and low filter cake moisture.The findings enable better understanding of the effect of slurry conditioning on flocculant-aided filtration of coal tailings. | Pengfei Hu Long Liang Guangyuan Xie Shaoqi Zhou Yaoli Peng | 2020 | International Journal of Mining Science and Technology2020，30，6： | 12 |
| 14 | Growing Season Ecosystem Respirations and Associated Component Fluxes in Two Alpine Meadows on the Tibetan Plateau显示文摘From 30 June to 24 September in 2003 ecosystem respiration (Re) in two alpine meadows on the Tibetan Plateau were measured using static chamber-and gas chromatography-(GC) based techniques. Simultaneously, plant removal treatments were set to partition Re into plant autotrophic respiration (Ra) and microbial heterotrophic respiration (Rh). Results indicated that Re had clear diurnal and seasonal variation patterns in both of the meadows. The seasonal variability of Re at both meadow sites was caused mainly by changes in Ra, rather than Rh. Moreover, at the Kobresia humilis meadow site (K_site), Ra and Rh accounted for 54% and 46% of Re, respectively. While at the Potentilla fruticosa scrub meadow (P_site), the counterparts accounted for 61% and 39%, respectively. T test showed that there was significant difference in Re rates between the two meadows (t = 2.387, P = 0.022). However, no significant difference was found in Rh rates, whereas a significant difference was observed in Ra rates between the two meadows. Thus, the difference in Re rate between the two meadows was mainly attributed to plant autotrophic respirations. During the growing season, the two meadows showed relatively low Q10 values, suggesting that Re, especially Rh was not sensitive to temperature variation in the growing season. Additionally, Re and Rh at the K_site, as well as Rh at the P_site was negatively correlated with soil moisture, indicating that soil moisture would also play an important role in respirations. | Qi-Wu Hu Qin Wu Guang-Min Cao Dong Li Rui-Jun Long Yue-Si Wang | 2008 | Journal of Integrative Plant Biology2008，50，3： | 11 |
| 15 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 16 | Current advances in orthodontic pain显示文摘Orthodontic pain is an inflammatory pain that is initiated by orthodontic force-induced vascular occlusion followed by a cascade of inflammatory responses, including vascular changes, the recruitment of inflammatory and immune cells, and the release of neurogenic and pro-inflammatory mediators. Ultimately, endogenous analgesic mechanisms check the inflammatory response and the sensation of pain subsides. The orthodontic pain signal, once received by periodontal sensory endings, reaches the sensory cortex for pain perception through three-order neurons: the trigeminal neuron at the trigeminal ganglia, the trigeminal nucleus caudalis at the medulla oblongata and the ventroposterior nucleus at the thalamus. Many brain areas participate in the emotion,cognition and memory of orthodontic pain, including the insular cortex, amygdala, hippocampus, locus coeruleus and hypothalamus. A built-in analgesic neural pathway—periaqueductal grey and dorsal raphe—has an important role in alleviating orthodontic pain. Currently, several treatment modalities have been applied for the relief of orthodontic pain, including pharmacological, mechanical and behavioural approaches and low-level laser therapy. The effectiveness of nonsteroidal antiinflammatory drugs for pain relief has been validated, but its effects on tooth movement are controversial. However, more studies are needed to verify the effectiveness of other modalities. Furthermore, gene therapy is a novel, viable and promising modality for alleviating orthodontic pain in the future. | Hu Long Yan Wang Fan Jian Li-Na Liao Xin Yang Wen-Li Lai | 2016 | International Journal of Oral Science2016，8，2： | 11 |
| 17 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 18 | Spatial heterogeneity of soil respiration in a Larix gmelinii forest and the response to prescribed fire in the Greater Xing0an Mountains,China显示文摘This study was conducted in a fire-prone region in the Greater Xing'an Mountains,the primary forested area of northeastern China.We measured soil respiration and the affecting soil factors,i.e.,soil microbial biomass and soil moisture,within an experimental plot of Larix gmelinii Rupr.A low-intensity,prescribed fire was applied as the treatment.Traditional descriptive statistics and geostatistics were used to analyze the spatial heterogeneity of soil respiration and the response of respiration to fire disturbance.Coefficients of variation(CVs) for pre-fire and post-fire soil respiration were 23.4 and 32.0 %,respectively.CVs for post-fire soil respiration increased significantly,with a moderate variation of all CVs.Soil respiration pre-fire was significantly correlated with soil microbial biomass carbon,biomass nitrogen,and soil moisture(W);post-fire soil respiration was not correlated with these factors.From the geostatistical analyses,the C_0+C(sill) for post-fire soil respiration increased significantly,indicating that the post-fire spatial heterogeneity of soil respiration increased significantly.The nugget effect(nc) of soil respiration and the affecting factors pre-fire and post-fire disturbance were in the range of 12.5–50 %,with strong spatial autocorrelation.Fire disturbance changed the components of spatial heterogeneity,and the proportion of functional heterogeneity increased significantly post-fire.The ranges(a) for pre-fire and post-fire soil respiration were 81.0 and 68.2 m,respectively.The homogeneity of the distribution of post-fire soil respiration decreased and the spatial heterogeneity increased,thus the range for postfire soil respiration decreased significantly.The fractal dimension(D) for soil respiration increased post-fire,the spatial heterogeneity of soil respiration affected by random components increased,indicating that the change in spatial heterogeneity of post-fire soil respiration should be considered within the scale of the forest stand.Following Kriging interpolation,the increase in the patchiness of post-fire soil respiration was illustrated using a contour map.Based on these preliminary results,the change in the spatial heterogeneity of post-fire soil respiration was likely caused by changes in the distribution of soil moisture and microbial activity within the experimental plot at the scale of the forest stand. | Haiqing Hu Tongxin Hu Long Sun | 2016 | Journal of Forestry Research2016，27，5： | 11 |
| 19 | Inheritance and molecular characterization of resistance to AHAS- inhibiting herbicides in rapeseed显示文摘Rapeseed is a very important oil crop in China;however,its production is challenging due to the absence of effective weed management strategies.This is predominantly because of a shortage of herbicide resistance genes.Acetohydroxyacid synthase(AHAS) herbicides inhibit AHAS,a key enzyme involved in branched-chain amino acid synthesis that is required for plant growth.A rapeseed line designated M342 with AHAS herbicide resistance was developed through seed mutagenesis and was studied to assess the level and mode of inheritance of the resistance and to identify the molecular basis of resistance.M342 possessed a high level of cross-resistance to sulfonylureas(SUs) and imidazolinones(IMIs).This resistance was due to AHAS insensitivity to these herbicides and was inherited as a dominant trait conferred by a single nuclear-encoded gene.Molecular analysis revealed the presence of a Trp574 Leu mutation in M342,and an allele-specific cleaved amplified polymorphic sequence(AS-CAPS) marker was developed and cosegregated with herbicide resistance in the F2,BC1,and BC2 populations.This mutation altered the transcript levels of Bn AHAS1 and Bn AHAS3 in M342 compared with those in the wild type,but it did not affect the agronomic or quality traits.The simple genetic inheritance of this mutation and the availability of the cleaved amplified polymorphic sequence(CAPS) marker and herbicide resistance gene should facilitate the development of herbicide-resistant rapeseed cultivars for effective weed control in China. | HU Mao-long PU Hui-ming GAO Jian-qin LONG Wei-hua CHEN Feng ZHOU Xiao-ying ZHANG Wei PENG Qi CHEN Song ZHANG Jie-fu | 2017 | Journal of Integrative Agriculture2017，16，11： | 11 |
| 20 | Physical modeling and spectrum spread analysis of surface clutter in forward scattering radar显示文摘In this paper, based on the processing results of measured clutter data in forward scattering radar, a special phenomenon that the clutter spectrum spread is insensitive to the wind speed and carrier frequency is observed. The pendulum model is first time introduced into the physical modeling and formation mechanism analysis of surface clutter, and the quantitative expression of clutter spectrum spread is analytically obtained. Under the assumption of pendulum model, the processing results of measured clutter data agree well with the results of theoretical analysis, which fully verifies the correctness of pendulum model and reveals the formation mechanism of surface clutter spectrum in forward scattering radar. Furthermore, according to the stability of clutter spectrum spread with respect to carrier frequencies and wind speed, the optimal cutofrequencies of clutter filter can be obtained, which establishes the basis for moving target detection and accurate parameters estimation. | LONG Teng, HU Cheng, ZENG Tao & LI XiaoLiang Radar Research Laboratory, Department of Electronic Engineering, Beijing Institute of Technology, Beijing 100081, China | 2010 | Science China(Information Sciences)2010，53，11： | 11 |
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