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| 1 | Preparation and Surface Properties of Silicon-Containing Waterborne Polyurethane Functionalized with Fluorine-Containing Acrylate and Micro-Nano Silica显示文摘In order to prepare hydrophobic waterborne polyurethane coatings with better performances, the silicon-containing waterborne polyurethane(SiWPU) with functional chain extender hydroxyethyl acrylate(HEA) was prepared first, and then a series of silicon&fluorine-containing polyurethane/acrylate(FSiPUA) emulsions were obtained with flourine containing acrylic monomer by seed emulsion polymerization, introducing micro-nano SiO_2 into FSiPUA emulsion to make the final hybrid emulsion. The properties of Si WPU, FSiPUA and SiO_2/FSiPUA were investigated by fourier transform infrared spectra(FTIR), transmission electron microscope(TEM), Scanning Electron Microscope(SEM) and some other analytical methods. The results revealed that FSiPUA emulsion particles possessed composite core-shell structure and FSiPUA films with suitable ratio performed better than Si WPU films in hardness, water resistance and solvent resistance. The SiO_2/FSiPUA films with micro-nano dual roughness structure showed a water contact angle of 136° with good resistance to acid and alkali. | 蔡棋 HUANG Jiemin 翁睿 LIU Shichen | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，1： | 6 |
| 2 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 3 | Effect of electro-scalp acupuncture on acute ischemic stroke: a randomized, single blind, trial显示文摘OBJECTIVE: To determine the clinical efficacy and safety of electro-scalp acupuncture in the treatment of patients with acute ischemic stroke.METHODS: Totally 74 patients with acute ischemic stroke were enrolled and divided into either body acupuncture(Control) or electro-scalp acupuncture(ESA) groups according to randomized controlled principle. The patients in the control group weregiven body acupuncture treatment once daily for28 d, whereas except for the body acupuncture,electro-scalp acupuncture was additional treatment given to the ESA group. Neurological deficits,everyday motor function and muscle strength were evaluated at baseline and the 28 th d by NIH Stroke Scale(NIHSS), Fugl-Meyer Assessment(FMA) and Modified Barthel Index Score(MBI), respectively.RESULTS: There were not obvious between-group differences in the baseline efficacy parameters(NIHSS, FMA and MBI)(all P > 0.05), whereas significant between-group differences were found in post-treatment NIHSS, FMA-UE and MBI scores(all P < 0.05). After acupuncture treatment, systematic within-group improvements were found in the two groups for any of the efficacy parameters assessed(all P < 0.01), and the ESA group showed higher significant improvements in NIHSS, FMA-UE and MBI scores(all P < 0.05).CONCLUSION: Electro-scalp acupuncture was efficacious in the treatment of acute ischemic stroke,which resulted in meaningful improvements in neurologic function, motor function and activities of daily living of patients. | Liu Xiaoxi Zhang Xuezhu Nie Kun Jia Yujie Li Jing Ling Zhenzhen Wang Yao Chang Shichen | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 5 |
| 4 | Fluid Property Discrimination in Dolostone Reservoirs Using Well Logs显示文摘The Ordovician Majiagou Formation is one of the main gas-producing strata in the Ordos Basin,China.The identification of hydrocarbon-bearing intervals via conventional well logs is a challenging task.This study describes the litholog of Ma 5(Member 5 of Majiagou Formation)dolostones,and then analyzes the responses of various conventional well logs to the presences of natural gas.The lithology of the gas bearing layers is dominantly of the dolomicrite to fine to medium crystalline dolomite.Natural gas can be produced from the low resistivity layers,and the dry layers are characterized by high resistivities.Neutron-density crossovers are not sensitive to the presences of natural gas.In addition,there are no significant increases in sonic transit times in natural gas bearing layers.NMR(nuclear magnetic resonance)logs,DSI(Dipole Sonic Imager)logs and borehole image logs(XRMI)are introduced to discriminate the fluid property in Majiagou dolostone reservoirs.The gas bearing intervals have broad NMR T2(transverse relaxation time)spectrum with tail distributions as well as large T2gm(T2 logarithmic mean values)values,and the T2 spectrum commonly display polymodal behaviors.In contrast,the dry layers and water layers have low T2gm values and very narrow T2 spectrum without tails.The gas bearing layers are characterized by low Vp/Vs ratios,low Poisson’s ratios and low P-wave impedances,therefore the fluid property can be discriminated using DSI logs,and the interpretation results show good matches with the gas test data.The apparent formation water resistivity(AFWR)spectrum can be derived from XRMI image logs by using the Archie’s formula in the flushed zone.The gas bearing layers have broad apparent formation water resistivity spectrum and tail distributions compared with the dry and water layers,and also the interpretation results from the image logs exhibit good agreement with the gas test data.The fluid property in Majiagou dolostone reservoirs can be discriminated through NMR logs,DSI logs and borehole image logs.This study helps establish a predictable model for fluid property in dolostones,and have implications in dolostone reservoirs with similar geological backgrounds worldwide. | WANG Guiwen LAI Jin LIU Bingchang FAN Zhuoying LIU Shichen SHI Yujiang ZHANG Haitao CHEN Jing | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 4 |
| 5 | Two soybean homologues of TERMINAL FLOWER 1 control flowering time under long day conditions显示文摘Flowering time is a key agronomic trait that directly affect the adaptation and yield of soybean.After whole genome duplications,about 75%of genes being represented by multiple copies in soybean.There are four TERMINAL FLOWER 1(TFL1)genes in soybean,and the TFL1b(Dt1)has been characterized as the determinant of stem growth habit.The function of other TFL1 homologs in soybean is still unclear.Here,we generated knockout mutants by CRISPR/Cas9 genome editing technology and found that the tfl1c/tfl1d double mutants flowered significantly earlier than wild-type plants.We investigated that TFL1c and TFL1d could physically interact with the b ZIP transcription factor FDc1 and bind to the promoter of APETALA1a(AP1a).RNA-seq and q RT-PCR analyses indicated that TFL1c and TFL1d repressed the expressions of the four AP1 homologs and delayed the flowering time in soybean.The two genes play important roles in the regulation of flowering time in soybean and mainly act as the flowering inhibitors under long-day conditions.Our results identify novel components in the flowering-time regulation network of soybean and will be invaluable for molecular breeding of improved soybean yield. | Lingshuang Wang Chun Lin Bohui Li Tong Su Shichen Li Haiyang Li Fanglei He Chuanjie Gou Zheng Chen Yanan Wang Jun Qin Baohui Liu Fanjiang Kong Lin Yue Sijia Lu Chao Fang | 2023 | The Crop Journal2023，11，3： | 3 |
| 6 | Cryo-EM structures of human m^(6)A writer complexes显示文摘N6-methyladenosine(m^(6)A)is the most abundant ribonucleotide modification among eukaryotic messenger RNAs.The m^(6)A“writer”consists of the catalytic subunit m^(6)A-METTL complex(MAC)and the regulatory subunit m^(6)A-METTL-associated complex(MACOM),the latter being essential for enzymatic activity.Here,we report the cryo-electron microscopy(cryo-EM)structures of MACOM at a 3.0-Åresolution,uncovering that WTAP and VIRMA form the core structure of MACOM and that ZC3H13 stretches the conformation by binding VIRMA.Furthermore,the 4.4-Åresolution cryo-EM map of the MACOM–MAC complex,combined with crosslinking mass spectrometry and GST pull-down analysis,elucidates a plausible model of the m^(6)A writer complex,in which MACOM binds to MAC mainly through WTAP and METTL3 interactions.In combination with in vitro RNA substrate binding and m^(6)A methyltransferase activity assays,our results illustrate the molecular basis of how MACOM assembles and interacts with MAC to form an active m^(6)A writer complex. | Shichen Su Shanshan Li Ting Deng Minsong Gao Yue Yin Baixing Wu Chao Peng Jianzhao Liu Jinbiao Ma Kaiming Zhang | 2022 | Cell Research2022，32，11： | 3 |
| 7 | Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment显示文摘Drug-eluting balloon(DEB)angioplasty has emerged as an effective treatment for cardiovascular and cerebrovascular diseases.However,distal embolism and late lumen restenosis could be caused by drug loss during DEB handling and rapid drug metabolization.Here,a drug-loaded balloon equipped with tip-separable microneedles on the balloon surface(MNDLB)was developed.Inbuilt near-infrared(NIR)ring laser inside the catheter inner shaft was introduced to activate the biodegradable microneedle tips for the first time.The drug-loaded tips thus could be embedded in the vasculature and then released antiproliferative drug-paclitaxel slowly via polymer degradation for more than half a year.A significant increase in drug delivery efficiency and superior therapeutic effectiveness compared with the standard DEB were demonstrated using an atherosclerosis rabbit model. | Li Huang Huaqiang Fang Teng Zhang Binbin Hu Shichen Liu Fanzhen Lv Zhaoxia Zeng Huijie Liu Weimin Zhou Xiaolei Wang | 2023 | Bioactive Materials2023，，5： | 2 |
| 8 | On the Analysis of Evolutionary Programming with Self-adaptive Cauchy Operation显示文摘 | LIANG Xiao YUE Lihua XIONG Yan CHENG Wenjuan LIU Shichen | 2012 | Chinese Journal of Electronics2012，21，2： | 2 |
| 9 | Characteristics of road network forms in historic districts of Japan显示文摘 | Ze Liu Shichen Zhao | 2015 | Frontiers of Architectural Research2015，4，4： | 1 |
| 10 | Propagation properties of foreshock cavitons: Cluster observations显示文摘Foreshock cavitons are transient phenomena observed in the terrestrial foreshock region.They are characterized by a simultaneous depression of magnetic field magnitude and plasma density,which are bounded with enhancements of these two parameters and surrounded by ultralow frequency(ULF)waves.Previous studies focused on the interplanetary magnetic field(IMF)conditions,solar wind(SW)conditions,and the growth of the foreshock waves related to the generation of foreshock cavitons.Previously,a multipoint spacecraft analysis method using Cluster data was applied to analyze only two foreshock cavitons,and this method did not consider uncertainties.In this study,multipoint spacecraft analysis methods,including the timing method,the minimum directional derivative(MDD)method,and the spatiotemporal difference(STD)method are applied to determine the velocity in both spacecraft and solar wind frames.The propagation properties show good agreement with previous results from simulations and observations that most cavitons move sunward in the solar wind frame,with the velocities larger than the Alfvén speed.The propagation properties of foreshock cavitons support the formation mechanism of cavitons in previous simulations,which suggested that cavitons are formed due to the nonlinear evolution of compressive ULF waves.We find that there is clear decreasing trend between the size of cavitons and their velocity in the solar wind frame.In addition,the timing method considering errors has been applied to study the evolution properties by comparing the velocities with errors of the leading and trailing edges,and we identify three stable cavitons and one contracting caviton,which has not been studied before.Most cavitons should remain stable when they travel toward the Earth’s bow shock.The relationship between the size of foreshock cavitons and their distance from the bow shock is also discussed. | WANG MengMeng YAO ShuTao SHI QuanQi ZHANG Hui TIAN AnMin DEGELING Alexander William ZHANG Shuai GUO RuiLong SUN WeiJie LIU Ji BAI ShiChen SHEN XiaoChen ZHU XiaoQiong FU SuiYan PU ZuYin | 2020 | Science China(Technological Sciences)2020，63，1： | 1 |
| 11 | Formation and Urban Transformation of Lhasa City显示文摘 | ZHANG Yingzi ZHAO Shichen LIU Jiaping | 2011 | Journal of Architectural and Urban Design2011，，6： | 1 |
| 12 | Upconversion nanoparticles regulated drug&gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation显示文摘Thromboembolism is the leading cause of cardiovascular mortality.Currently,for the lack of targeting,short half-life,low bioavailability and high bleeding risk of the classical thrombolytic drugs,pharmacological thrombolysis is usually a slow process based on micro-pumping.In addition,frequently monitoring and regulating coagulation functions are also required during(and after)the process of thrombolysis.To address these issues,a targeted thrombolytic and anticoagulation nanoplatform(UCATS-UK)is developed based on upconversion nanoparticles(UCNPs)that can convert 808 or 980 nm near-infrared(NIR)light into UV/blue light.This nanoplatform can target and enrich in the thrombus site.Synergistic thrombolysis and anticoagulation therapy thus could be realized through the controlled release of urokinase(UK)and nitric oxide(NO).Both in vitro and in vivo experiments have confirmed the excellent thrombolytic and anticoagulative capabilities of this multifunctional nanoplatform.Combined with the unique fluorescent imaging capability of UCNPs,this work is expected to contribute to the development of clinical thrombolysis therapy towards an integrated system of imaging,diagnosis and treatment. | Shichen Liu Yao Sun Teng Zhang Longtao Cao Zhiwei Zhong Haoxin Cheng Qingqing Wang Zhuang Qiu Weimin Zhou Xiaolei Wang | 2022 | Bioactive Materials2022，7，12： | 1 |
| 13 | Development and validation of InDel markers for identification of QTL underlying flowering time in soybean显示文摘Soybean [Glycine max(L.) Merrill] is a major plant source of protein and oil. An accurate and well-saturated molecular linkage map is a prerequisite for forward genetic studies of gene function and for modern breeding for many useful agronomic traits. Next-generation sequence data available in public databases provides valuable information and offers new insights for rapid and efficient development of molecular markers. In this study, we attempted to show the feasibility and facility of using genomic resequencing data as raw material for identifying putative In Del markers. First, we identified 17,613 In Del sites among 56 soybean accessions and obtained 12,619 primer pairs. Second, we constructed a genetic map with a random subset of 2841 primer pairs and aligned 300 polymorphic markers with the 20 consensus linkage groups(LG). The total genetic distance was 2347.3 c M and the number of mapped markers per LG ranged from 10 to 23 with an average of 15 markers. The largest and smallest genetic distances between adjacent markers were 52.3 c M and 0.1 cM, respectively. Finally, we validated the genetic map constructed by newly developed In Del markers by QTL analysis of days to flowering(DTF) under different environments. One major QTL(qDTF4) and four minor QTL(qDTF20, qDTF13, qDTF12,and q DTF11) on 5 LGs were detected. These results demonstrate the utility of the In Del markers developed in this work for map-based cloning and molecular breeding in soybean. | Jialin Wang Lingping Kong Kanchao Yu Fengge Zhang Xinyi Shi Yanping Wang Haiyang Nan Xiaohui Zhao Sijia Lu Dong Cao Xiaoming Li Chao Fang Feifei Wang Tong Su Shichen Li Xiaohui Yuan Baohui Liu Fanjiang Kong | 2018 | The Crop Journal2018，6，2： | 1 |
| 14 | Carbon source recovery from waste sludge reduces greenhouse gas emissions in a pilot-scale industrial wastewater treatment plant显示文摘Carbon cycle regulation and greenhouse gas(GHG)emission abatement within wastewater treatment plants(WWTPs)can theoretically improve sustainability.Currently,however,large amounts of external carbon sources used for deep nitrogen removal and waste sludge disposal aggravate the carbon footprint of most WWTPs.In this pilot-scale study,considerable carbon was preliminarily recovered from primary sludge(PS)through short-term(five days)acidogenic fermentation and subsequently utilized on-site for denitrification in a wool processing industrialWWTP.The recovered sludge-derived carbon sources were excellent electron donors that could be used as additional carbon supplements for commercial glucose to enhance denitrification.Additionally,improvements in carbon and nitrogen flow further contributed to GHG emission abatement.Overall,a 9.1%reduction in sludge volatile solids was achieved from carbon recovery,which offset 57.4%of external carbon sources,and the indirect GHG emissions of the target industrial WWTP were reduced by 8.05%.This study demonstrates that optimizing the allocation of carbon mass flow within a WWTP has numerous benefits. | Qiandi Wang Xiqi Li Wenzong Liu Siyuan Zhai Qiongying Xu Chang'an Huan Shichen Nie Qinghua Ouyang Hongcheng Wang Aijie Wang | 2023 | Environmental Science and Ecotechnology2023，，2： | 1 |
| 15 | Studies on the micellization and intermicellar interaction of CTAB in dilute solution 显示文摘 | YANG HAIYANG ZHENG SHICHEN LIU HE | 2005 | Material Science2005，22，： | 1 |
| 16 | Terbium-doped zinc oxide constructed dual-light-responsive nitric oxide-releasing platform for bacterial keratitis treatment显示文摘Bacterial keratitis(BK)is a principal factor contributing to corneal ulcers and ocular complications,and has become a significant killer of global vision health.Traditional antibiotic therapy has unsatisfactory therapeutic effect due to short residence time and low utilization rate of drug,and the long-term abuse of antibiotics can easily incur the prevalence of drug-resistant bacteria.Furthermore,antibiotics are not effective in addressing the excessive inflammatory response caused by infection.Here,we developed a terbium-doped zinc oxide constructed dual-light-responsive nitric oxide(NO)-releasing nanoparticle(ZT@P@B)and modified it on the surface of contact lenses(CL-ZT@P@B)to boost its bioavailability.In vitro and in vivo experimental results verified that ZT@P@B could simultaneously respond to green light(GL)and 808 nm near-infrared(NIR)without obvious damage to the eyes,releasing reactive oxygen species(ROS)and NO,which could effectively kill bacteria(including drug-resistant strains)and reduce inflammatory response.The platform provides a promising strategy for the prevention and treatment of BK. | Yue Sun Wei Zhang Menghui Wang Huijie Liu Qun Li Jiazhe Luo Mengzhen Zhao Shichen Liu Xiaolei Wang | 2023 | Nano Research2023，16，1： | 0 |
| 17 | Time-Dependent Demographic Prediction Based on Time-Back-Propagation Method显示文摘In various applications like personalized search and recommendation, full demographic information is a precondition for many applications' well performance,but such ideal dataset rarely exists in practical scenarios.What's worse, absence of key characteristics(e.g., baby's age in maternal and infant commodity recommendation)makes these applications struggle. We design a novel solution to solve the problem of time-dependent demographic prediction. The key insight behind our approach is, we leverage a Time-back-propagation(TBP) method to take the internal time correlation of historical behaviours into consideration and collect all available data to train a classifier, which is a mapping from user's historical behaviours to the demographic information. We demonstrate the effectiveness of our method through experiments of baby's age prediction. Our algorithm performs more balanced on each age group, and can predict Baby's age(BA) accurately in 78.2% on a real-world dataset with 2,058,909 items of a ma jor E-commerce site. | KE Yuyang XIONG Yan HU Yiqing LIU Shichen | 2018 | Chinese Journal of Electronics2018，27，1： | 0 |
| 18 | Yellow responsive material based modification to reduce earphone induced Infection and hearing loss显示文摘Today,earphones have almost been owned by everyone.However,wearing earphones for a long time can cause two serious problems:(1)irreversible damage to hearing;(2)rapid proliferation of bacteria in the ear canal.Herein,an earphone modification strategy is developed for the first time,to reduce hearing loss and inhibit bacteria simultaneously.This earphone is equipped with a high purity yellow light(YL)light-emitting diode chip developed by our university.Then,the surface of the earphone is loaded with porous zinc oxide and silver nanoparticle composite material(ZnO-Ag)that can respond to the YL.Under the excitation of YL,the porous ZnO-Ag can release reactive oxygen species with strong antibacterial activity.More importantly,we discover that YL can reduce the expression of matrix metalloproteinase-3,the secretion of inflammatory factors,and apoptosis in the cochlea,thereby effectively reduce hearing loss. | Haoxin Cheng Hongmei Liu Zhiqiang Liu Ziying Xu Xiaorong Liu Shuang Jia Chaonan He Shichen Liu Jiao Zhang Xiaolei Wang | 2022 | Nano Research2022，15，7： | 0 |
| 19 | SHARPIN激活HOIP用于线性泛素链组装的结构透视显示文摘文章简介线性泛素链组装复合物LUBAC是目前唯一被发现的、催化线性泛素链合成的E3泛素连接酶复合物,它由HOIP,HOIL-1L和SHARPIN三个蛋白组成。 | Jianping Liu Yingli Wang Yukang Gong Tao Fu Shichen Hu Zixuan Zhou 潘李峰 | 2018 | 科学新闻2018，0，4： | 0 |
| 20 | Vertical graphene-coated Cu wire for enhanced tolerance to high current density in power transmission显示文摘Cu wires(CuWs)are widely used as electric transmission lines.However,their limited thermal and chemical stabilities become challenges under the high-power and harsh environment.Graphene is regarded as an ideal protective barrier for CuW benefiting from its impermeability to all atoms and molecules.Particularly,the excellent hydrophobicity of vertical graphene(VG)will strengthen its protective capability as a corrosion and oxidation barrier.Herein,VG is directly synthesized on CuW by plasmaenhanced chemical vapor deposition method.The hydrophobic VG coating with a high water contact angle can effectively exclude the corrosive liquid and moisture from CuW surface and prevent their further penetration.Consequently,the electrochemical corrosion rate of VG-CuW is reduced by~13,8,and 2 times,compared with bare CuW,VG-CuW with hydrophilic treatment,and CuW coated with thick horizontal graphene layers,respectively.Negligible oxidation occurs on VGCuW after the long-time exposure to humid air at~200℃ along with the largely enhanced tolerance under high-current operating condition.This study reveals the impressive potentials of hydrophobic VG as a robust corrosion and oxidation barrier for metal wires used in high-power cables and electronic devices in harsh environment. | Kun Wang Shuting Cheng Qingmei Hu Feng Yu Yi Cheng Kewen Huang Hao Yuan Jun Jiang Wenjuan Li Junliang Li Shichen Xu Jianbo Yin Yue Qi Zhongfan Liu | 2022 | Nano Research2022，15，11： | 0 |
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