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36篇 您的检索式:作者名="LIU SenLin"
    题名 作者 年代 出处 被引量
15-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake 2017Cell Research2017,27,10:17
2Phase behavior of TXs/toluene/water microemulsion systems for solubilization absorption of toluene显示文摘Triton Xs(TXs) surfactants/cosurfactant/water/oil(toluene) microemulsion systems for enhancing toluene solubilization were proposed and its potential was investigated for toluene removal from gas stream.The results indicated that TX-100 was superior to other TXs surfactants in removing toluene without cosurfactant.The efficiency of cosurfactants for improving toluene solubilization capacity follows the order:amine>alcohol>acid.According to the factor analysis,the linear cosurfactants are better than the branched ones.The effects of hydrophile-lipophile balance(HLB),salt(NaCl) concentration and temperature on the formation of microemulsion system were also discussed.The results suggested that the optimum value of HLB was 15,the effect of NaCl concentration on the system was inconspicuous and the lower temperature enhanced the solubilization capacity.Nonionic surfactant-based microemulsions had a significant absorption enhancement for toluene,indicated by as much as 82.72% of toluene in phase composition diagram,which will have a great prospect in air pollution treatment.Lian Liu,Senlin Tian ,Ping Ning Faculty of Environmental Science and Engineering,Kunming University of Science and Technology,Kunming 650093,China 2010Journal of Environmental Sciences2010,22,2:13
3Activation of Mitochondrial orf355 Gene Expression by a Nuclear-Encoded DREB Transcription Factor Causes Cytoplasmic Male Sterility in Maize显示文摘Coordination between mitochondria and the nucleus is crucial for fertility determination in plants with cytoplasmic male sterility(CMS).Using yeast one-hybrid screening,we identified a transcription factor,ZmDREB1.7,that is highly expressed in sterile microspores at the large vacuole stage and activates the expression of mitochondria-encoded CMS gene orf355.Δpro,a weak allele of ZmDREB1.7 with the loss of a key unfolded protein response(UPR)motif in the promoter,partially restores male fertility of CMS-S maize.ZmDREB1.7 expression increases rapidly in response to antimycin A treatment,but this response is attenuated in theΔpro allele.Furthermore,we found that expression of orf355 in mitochondria activates mitochondrial retrograde signaling,which in turn induces ZmDREB1.7 expression.Taken together,these findings demonstrate that positive-feedback transcriptional regulation between a nuclear regulator and a mitochondrial CMS gene determines male sterility in maize,providing new insights into nucleus-mitochondria communication in plants.Senlin Xiao Jie Zang Yuanrong Pei Jie Liu Juan Liu Wei Song Zi Shi Aiguo Su Jiuran Zhao Huabang Chen 2020Molecular Plant2020,13,9:10
4Atomic mobilities and diffusivities in Al alloys显示文摘Knowledge of diffusivity is a prerequisite for understanding many scientific and technological disciplines.In this paper,firstly major experimental methods,which are employed to provide various diffusivity data,are briefly described.Secondly,the fundamentals of various computational methods,including first-principles method,embedded atomic method/molecular dynamic simulation,semi-empirical approaches,and phenomenological DICTRA technique,are demonstrated.Diffusion models recently developed for order/disorder transitions and stoichiometric compounds are also briefly depicted.Thirdly,a newly established diffusivity database for liquid,fcc_A1,L12,bcc_A2,bcc_B2,and intermetallic phases in the multicomponent Al alloys is presented via a few case studies in binary,ternary and quaternary systems.And the integration of various computational techniques and experimental methods is highlighted.The reliability of this diffusivity database is validated by comparing the calculated and measured concentration profiles,diffusion paths,and Kirkendall shifts in various binary,ternary and quaternary diffusion couples.Next,the established diffusivity databases along with thermodynamic and other thermo-physical properties are utilized to simulate the microstructural evolution for Al alloys during solidification,interdiffusion and precipitation.A special discussion is presented on the phase-field simulation of interdiffusion microstructures in a series of Ni-Al diffusion couples composed of γ,γ',and β phases under the effects of both coherent strain and external compressive force.Future orientations in the establishment of next generation of diffusivity database are finally addressed.DU Yong ZHANG LiJun CUI SenLin ZHAO DongDong LIU DanDan ZHANG WeiBin SUN WeiHua JIE WanQi 2012Science China(Technological Sciences)2012,55,2:6
5A top-down positioning scheme for underwater wireless sensor networks显示文摘In order to increase the localization coverage while keeping the localization error small in a unique network architecture in which there are not evenly distributed anchor nodes with great ability of communication or additional infrastructure,a Top-down Positioning Scheme(TPS)for underwater acoustic sensor networks is proposed.By defining node’s confidence reasonably,TPS insures the quality of the new reference nodes.TPS also refines the nodes which have just been positioned via the gradient method and helps non-localized nodes search for more reference nodes via the new scheme for 3D Euclidean distance estimation.By comparing the new scheme for 3D Euclidean distance estimation with the existing scheme,the new scheme is shown to have greater ability to estimate two-hop Euclidean distance in 3D space.Simulation results show that TPS which integrates node’s confidence defined reasonably,the gradient method,and the new scheme for 3D Euclidean distance estimation can increase the localization coverage ratio,while keeping the localization error small.ZHANG SenLin ZHANG Qiang LIU MeiQin FAN Zhen 2014Science China(Information Sciences)2014,57,3:4
6Dietary L-arginine supplementation reduces lipid accretion by regulating fatty acid metabolism in Nile tilapia(Oreochromis niloticus)显示文摘Background: Excessive white fat accumulation in humans and other animals is associated with the development of multiple metabolic diseases. It is unknown whether dietary L-arginine supplementation reduces lipid deposition in high fat diet-fed Nile tilapia(Oreochromis niloticus).Results: In the present study, we found that dietary supplementation with 1% or 2% arginine decreased the deposition and concentration of fats in the liver;the concentrations of triglycerides, low-density lipoprotein, total cholesterol, and high-density lipoprotein in the serum;and the diameter of adipocytes in intraperitoneal adipose tissue. Compared with the un-supplementation control group, the hepatic activities of alanine aminotransferase,aspartate aminotransferase, and lactate dehydrogenase, and hepatic concentration of malondialdehyde were reduced but these for catalase and superoxide dismutase were enhanced by dietary supplementation with 2% arginine. Arginine supplementation reduced the total amounts of monounsaturated fatty acids, while increasing the total amounts of n-3 and n-6 polyunsaturated fatty acids in the liver. These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis(sterol regulatory element-binding protein-1, acetyl-CoA carboxylase α, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid β-oxidation(carnitine palmitoyltransferase 1α and peroxisome proliferator-activated receptor α). In addition, hepatic mRNA levels for Δ4 fatty acyl desaturase 2 and elongase 5 of very long-chain fatty acids were enhanced by arginine supplementation.Conclusion: These results revealed that dietary L-arginine supplementation to tilapia reduced high fat diet-induced fat deposition and fatty acid composition in the liver by regulating the expression of genes for lipid metabolism.Senlin Li Yunchang Zhang Ning Liu Jingqing Chen Lina Guo Zhaolai Dai Chao Wang Zhenlong Wu Guoyao Wu 2021Journal of Animal Science and Biotechnology2021,12,1:3
7Energy-aware routing for delay-sensitive underwater wireless sensor networks显示文摘The energy reduction is a challenging problem in the applications of underwater wireless sensor networks(UWSNs). The embedded battery is difficult to be replaced and it has an upper bound on its lifetime.Multihop relay is a popular method to reduce energy consumption in data transmission. The energy minimum path from source to destination in the sensor networks can be obtained through the shortest path algorithm.However, because of the node mobility, the global path planning approach is not suitable for the routing in UWSNs. It calls for an energy-efficient routing protocol for the high dynamic UWSNs. In this paper, we propose the modified energy weight routing(MEWR) protocol to deal with the energy-efficient routing of delaysensitive UWSNs. MEWR is a low flooding routing protocol. It can tolerate the node mobility in UWSNs and achieve a low end-to-end packet delay. MEWR can provide lower energy consumption than the existing low delay routing protocols through the dynamic sending power adjustment. The simulation results demonstrate the effectiveness of MEWR.ZHANG SenLin WANG ZiXiang LIU MeiQin QIU MeiKang 2014Science China(Information Sciences)2014,57,10:2
8A low dose cell therapy system for treating osteoarthritis:In vivo study and in vitro mechanistic investigations显示文摘Mesenchymal stem cells(MSCs)can be effective in alleviating the progression of osteoarthritis(OA).However,low MSC retention and survival at the injection site frequently require high doses of cells and/or repeated injections,which are not economically viable and create additional risks of complications.In this study,we produced MSC-laden microcarriers in spinner flask culture as cell delivery vehicles.These microcarriers containing a low initial dose of MSCs administered through a single injection in a rat anterior cruciate ligament(ACL)transection model of OA achieved similar reparative effects as repeated high doses of MSCs,as evaluated through imaging and histological analyses.Mechanistic investigations were conducted using a co-culture model involving human primary chondrocytes grown in monolayer,together with MSCs grown either within 3D constructs or as a monolayer.Co-culture supernatants subjected to secretome analysis showed significant decrease of inflammatory factors in the 3D group.RNA-seq of co-cultured MSCs and chondrocytes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed processes relating to early chondrogenesis and increased extracellular matrix interactions in MSCs of the 3D group,as well as phenotypic maintenance in the co-cultured chondrocytes.The cell delivery platform we investigated may be effective in reducing the cell dose and injection frequency required for therapeutic applications.Bin Wang Wei Liu Jiao Jiao Li Senlin Chai Dan Xing Hongsheng Yu Yuanyuan Zhang Wenjin Yan Zhihong Xu Bin Zhao Yanan Du Qing Jiang 2022Bioactive Materials2022,7,1:2
9Standardization of tritiated water by the CIEMAT/NIST and TDCR methods显示文摘The activity of tritiated water has been standardized by two liquid scintillation counting methods:The CIEMAT/NIST method with the54Mn-standard efficiency tracing and the triple-to-double coincidence ratio(TDCR)method.The samples were prepared with Ultima Gold TM AB liquid scintillation cocktail in low-potassium glass vials.In the application of the CIEMAT/NIST method,the computer program EMILIA was used to calculate the efficiency of3H and54Mn according to the KL1L2L3M atomic rearrangement model.And the detection efficiency of the TDCR counter was calculated using TDCR07 code,which makes it possible to allow for the potential asymmetry between the three photomultiplier tubes.The influence of stopping power and k B factor is discussed in the paper.When a power approach is adopted for the stopping power for electrons below 1ke V and k B is chosen to be 0.0075 cm/Me V,the relative deviation will be only 0.3%between the two methods.WU YongLe LIU HaoRan LIANG JunCheng LIU JiaCheng XIONG WenJun YUE HuiGuo LIU SenLin YANG YuanDi YUAN DaQing 2015Science China(Technological Sciences)2015,58,3:1
10Synthesis of nitrogen-doped carbon spheres using the modified Stober method for supercapacitors显示文摘Nitrogen-doped carbon spheres (NCSs) with uniform and regular morphology were facilely prepared by the modified Stober method. Hexamethylenetetramine (HMT) was selected as the starting material, which decomposed to provide nitrogen and carbon sources for the synthesis of NCSs. The decomposition product formaldehyde polymerized to form carbon skeleton with resorcinol after carbonization, and the in-situ nitrogen doping was achieved with the decomposed nitrogen source. NCSs were obtained with regular spherical morphology, high specific surface area, and suitable nitrogen doping. When used as the electrode material, NCSs exhibited good capacitance and electrochemical stability, indicating that NCSs be the promising candidate for the electrode material of high-performance supercapacitors.Meng LIU Lei LIU Yifeng YU Haijun LV Aibing CHEN Senlin HOU 2019Frontiers of Materials Science2019,13,2:1
11CmRAV1 shows differential expression in two melon (Cucumis melo L.) cultivars and enhances salt tolerance in transgenic Arabidopsis plants显示文摘The growth and development of melon(Cucumis melo L.)are severely affected by soil salinization in many areas of the world,but the understanding of the molecular mechanisms underlying salt tolerance in melon remains limited.In this study,a new RAV(related to ABI3/VP1)gene,CmRAV1,was identified in melon.Protein structure homology analysis revealed that CmRAV1 contains an AP2 domain and a B3 domain,and subcellular localization assay revealed that CmRAV1 is localized in the nucleus.The transcript level of CmRAV1 was closely correlated with NaCl treatment,and the expression pattern of CmRAV1 differed between two cultivars(salt-tolerant and salt-sensitive cultivars)under NaCl treatment.In addition,yeasts transformed with CmRAV1 showed notably improved growth on medium containing 200 mM NaCl compared with wild-type ones.The overexpression of CmRAV1 in transgenic Arabidopsis thaliana resulted in enhanced salt tolerance at the seed germination and seedling growth stages.This study demonstrated that the expression of CmRAV1 was associated with saline stress and can potentially be utilized to improve plant salt tolerance.Lina Zhao Furong Zhang Bin Liu Senlin Yang Xue Xiong Danial Hassani Yidong Zhang 2019Acta Biochimica et Biophysica Sinica2019,51,11:1
12Forward prediction for tunnel geology and classification of surrounding rock based on seismic wave velocity layered tomography显示文摘Excavation under complex geological conditions requires effective and accurate geological forward-prospecting to detect the unfavorable geological structure and estimate the classification of surround-ing rock in front of the tunnel face.In this work,a forward-prediction method for tunnel geology and classification of surrounding rock is developed based on seismic wave velocity layered tomography.In particular,for the problem of strong multi-solution of wave velocity inversion caused by few ray paths in the narrow space of the tunnel,a layered inversion based on regularization is proposed.By reducing the inversion area of each iteration step and applying straight-line interface assumption,the convergence and accuracy of wave velocity inversion are effectively improved.Furthermore,a surrounding rock classification network based on autoencoder is constructed.The mapping relationship between wave velocity and classification of surrounding rock is established with density,Poisson’s ratio and elastic modulus as links.Two numerical examples with geological conditions similar to that in the field tunnel and a field case study in an urban subway tunnel verify the potential of the proposed method for practical application.Bin Liu Jiansen Wang Senlin Yang Xinji Xu Yuxiao Ren 2023Journal of Rock Mechanics and Geotechnical Engineering2023,15,1:1
13The estimation on thenumber of underground coal miners and the annual dose to coal minersin China 显示文摘Liu Fudong Pan Ziqiang Liu Senlin 2007Health Physics2007,91,2:1
14The expressions and significance of α-,β-catenins and cyclin D1 in breast cancers显示文摘Objective:To study the relationship between expressions of α-,β-catenins and cyclin D1 and the occurrence, infiltration and metastasis of breast cancer. Methods: High sensitive S-P immunohistochemical method was used to detect the protein expressions of α-,β-catenins and cyclin D1 in the 60 cases of breast cancer tissues. Results: Abnormal immu-noreactivities of α-and β-catenins were observed in 37 (61.7%) and 42 (70%) cases of breast cancer tissues, respectively. There were 28 cases (46.7%) who showed cyclin D1 overexpression. The abnormal expression rates of α-and β-catenins in infiltrating lobular carcinoma (ILC) were significantly higher than those in infiltrating ductal carcinoma (IDC) (P<0.05), but they had no relations to the extent of differentiation and lymphatic metastasis of breast cancer (P>0.05). The overexpression rate of cyclin D1 was correlated with tumor stage and lymphatic metastasis of breast cancer (P<0.05), but not with histological type and the extent of differentiation (P>0.05). Cyclin D1 overexpression was observed in 57.1% (24/42) of these cases that showed abnormal staining of β-catenin, but only observed in 22.2% (4/18) of these cases with normal membranous staining of β-catenin. There was a significantly positive correlation between the abnormal expression of β-catenin and overexpression of cyclin D1 (rs=0.321, P<0.05). Conclusion: The abnormal expression of β-catenin may play an important role in the genesis of breast cancer by triggering cyclin D1 overexpression in breast cancer. The abnormal expressions of α-and β-catenins are not a key factor in malignant cell metastasis in breast cancer, but may also involve in the progress.Liang Zeng Senlin Chen Zhihong Liu Jianfeng Yang 2008The Chinese-German Journal of Clinical Oncology2008,7,6:1
15A modified Sutherland equation for obtaining diffusivities in liquid and its effect on microstructure simulation of WC-Ti(C,N)-Co gradient cement-ed carbides显示文摘Chen Weimin Zhang Lijun Du Yong Liu Dandan Zhang Weibin Cui Senlin Tan Chengyu Wang Shequan Wen Guanghua Xie Wen 2012Metall Mater Trans A2012,,:1
16Chain Structure and Thermal Behavior of Reactive Blends of Poly(Ethylene- Terephthalate)/Poly(Butylene Terephthalate) by Addition of 2,2-(1,4-Phenyl) Bisoxazoline显示文摘Liu Senlin Li Wengang Liang Borun 2000European Polymer2000,,36:1
17A quasi-solid-state electrolyte with high ionic conductivity for stable lithium-ion batteries显示文摘The practical applications of solid-state electrolytes in lithium-ion batteries(LIBs)are hindered by their low ionic conductivity and high interfacial resistance.Herein,an ethoxylated trimethylolpropane triacrylate based quasi-solid-state electrolyte(ETPTAQSSE)with a three-dimensional(3D)network is prepared by a one-step in-situ photopolymerization method.The 3D network is designed to overcome the contradiction between the plasticizer-related ionic conductivity and the thickness-dependent mechanical property of quasi-solid-state electrolytes.The ETPTA-QSSE achieves superb room-temperature ionic conductivity up to 4.55×10^(−3)S cm^(−1),a high lithium ion transference number of 0.57,along with a wide electrochemical window of 5.3 V(vs.Li+/Li),which outperforms most ever of the reported solid-state electrolytes.Owing to the robust network structure and the cathodeelectrolyte integrated electrode design,Li metal symmetrical cells show reduced interface resistance and reinforced electrode/electrolyte interface stability.When applying the ETPTA-QSSE in LiFePO_(4)||Li cells,the quasi-solid-state cell demonstrates an enhanced initial discharge capacity(155.5 mAh g^(−1)at 0.2 C)accompanied by a high average Coulombic efficiency of greater than 99.3%,offering capacity retention of 92%after 200 cycles.Accordingly,this work sheds light on the strategy of enhancing ionic conductivity and reducing interfacial resistance of quasi-solid-state electrolytes,which is promising for high-voltage LIBs.ZHANG WenJing LI SenLin ZHANG YuRong WANG XingHui LIU JingDong ZHENG YuanHui 2022Science China(Technological Sciences)2022,65,10:1
18Transfer-free chemical vapor deposition graphene for nitride epitaxy: challenges, current status and future outlook显示文摘Graphene, a two-dimensional material with outstanding electrical and mechanical properties, has attracted considerable attention in the field of semiconductor technologies due to its potential use as a buffer layer for the epitaxial Ⅲ-nitride growth. In recent years, significant progress has been made in the chemical vapor deposition growth of graphene on various insulating substrates for the nitride epitaxy, which offers a facile, inexpensive, and easily scalable methodology. However, certain challenges are still present in the form of producing high-quality graphene and achieving optimal interface compatibility with Ⅲ-nitride materials.In this review, we provide an overview of the bottlenecks associated with the transferred graphene fabrication techniques and the state-of-the-art techniques for the transfer-free graphene growth. The present contribution highlights the current progress in the transfer-free graphene growth on different insulating substrates, including sapphire, quartz, SiO_(2)/Si, and discusses the potential applications of transfer-free graphene in the Ⅲ-nitride epitaxy. Finally, it includes the prospects of the transfer-free graphene growth for the Ⅲ-nitride epitaxy and the challenges that should be overcome to realize its full potential in this field.Xiang Gao Senlin Li Jingfeng Bi Kaixuan Zhou Meng Li Zhongfan Liu Jingyu Sun 2024Science China Chemistry2024,67,3:0
19Physiological and biomass partitioning shifts to water stress under distinct soil types in Populus deltoides saplings显示文摘土壤类型是影响植物分布和生产力的重要环境因素,但有关土壤环境异质性对植物抗逆性效应的研究非常缺乏。本研究以美洲黑杨(Populus deltoids)为对象,以3种典型土壤类型(红壤、黄壤和黄棕壤)为栽培基质,在控制实验条件下,经过三个月的干旱胁迫(25%田间持水量)处理,测定了不同处理条件下美洲黑杨的气体交换速率、抗氧化能力、氮代谢特征、生物量积累与分配特征。研究结果表明,在红壤和黄壤条件下,与对照(75%田间持水量)相比,干旱胁迫显著降低了美洲黑杨各器官的生物量、光合速率、叶片氮同化酶的活性,显著增加了叶片中过氧化氢、丙二醛和无机氮的含量。在黄棕壤条件下,干旱对美洲黑杨总生物量、光合速率、氮同化酶以及质膜完整性的负面影响较小,这与其维持较高的超氧化物歧化酶,过氧化物酶和过氧化氢酶的活性相关,也与其生物量分配模式(如提高根冠比)密切相关。由此可见,生长在黄棕壤条件下的美洲黑杨表现出较强的抗旱能力,这可能与其土壤母质中较高的土壤养分和良好的通气状况相关。因此,就土壤类型而言,与红壤和黄壤相比,黄棕壤提供的土壤环境条件有利于美洲黑杨的抗逆表现和栽培利用。Senlin Yang Jian Shi Lianghua Chen Jian Zhang Danju Zhang Zhenfeng Xu Jiujin Xiao Peng Zhu Yang Liu Tiantian Lin Li Zhang Hanbo Yang Yu Zhong 2020Journal of Plant Ecology2020,13,5:0
20Atomically dispersed dual Fe centers on nitrogen-doped bamboo-like carbon nanotubes for efficient oxygen reduction显示文摘Interfacial atomic configuration between dual-metal active species and nitrogen-carbon substrates is of great importance for improving the intrinsic activity of catalysts toward oxygen reduction reaction(ORR).Thus,from the atomic-scale engineering we develop a high intrinsic activity ORR catalyst in terms of incorporating atomically dispersed dual Fe centers(single Fe atoms and ultra-small Fe atomic clusters)into bamboo-like N-doped carbon nanotubes.Benefiting from atomically dispersed dual-Fe centers on the atomic interface of Fe-Nx/carbon nanotubes,the fabricated dual Fe centers catalyst exhibits an extremely high ORR activity(E_(onset)=1.006 V;E_(1/2)=0.90 V),beyond state-of-the-art Pt/C.Remarkably,this catalyst also shows a superior kinetic current density of 19.690 mA·cm^(−2),which is 7 times that of state-of-the-art Pt/C.Additionally,based on the excellent catalyst,the primary Zn-air battery reveals a high power density up to 137 mW·cm^(−2) and sufficient potential cycling stability(at least 25 h).Undoubtedly,given the unique structure–activity relationship of dual-Fe active species and metal-nitrogen-carbon substrates,the catalyst will show great prospects in highly efficient electrochemical energy conversion devices.Ligang Ma Junlin Li Zhiwei Zhang Hao Yang Xueqin Mu Xiangyao Gu Huihui Jin Ding Chen Senlin Yan Suli Liu Shichun Mu 2022Nano Research2022,15,3:0
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