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| 1 | Pulmonary embolism with chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease. The incidence of COPD is growing annually in China, and it is a significant and growing public health burden. Multivariate analysis showed that COPD was one of the independent risk factors for the occurrence of pulmonary embolism (PE),and the incidence of PE was significantly higher in COPD patients than in normal subjects. However, PE is often overlooked in patients with acute exacerbation of COPD (AECOPD) because there are many similarities in clinical symptoms between PE and AECOPD, which are difficult to distinguish, resulting in the failure of timely treatment and poor prognosis. Therefore, it is of great significance to understand the clinical manifestations, diagnosis, and treatment of COPD combined with PE for making a more accurate diagnosis, providing timely and effective treatment, and improving the prognosis of such patients. | Ruohan Yang Guiqing Liu Chaosheng Deng | 2021 | Chronic Diseases and Translational Medicine2021，7，3： | 12 |
| 2 | Correlation between lower gastrointestinal tract symptoms and quality of life in patients with stable chronic obstructive pulmonary disease显示文摘OBJECTIVE:To explore correlations between the symptoms of constipation and abdominal distention and severity of chronic obstructive pulmonary disease(COPD)in patients with stable disease.METHODS:We studied 191 patients with stable COPD(according to defined criteria)in this cross-sectional study from four three-level class A Chinese medicine hospitals in China.We built an Epidata 3.0 database and performed statistical analysis with SPSS,version 17.0.We analyzed correlations between the frequency of lower gastrointestinal tract symptoms(constipation and abdominal distention)and scores for major pulmonary symptoms(cough,sputum and wheezing)based on the St.George's Respiratory Questionnaire(SGRQ),6-minute walking distance(6MWD)and frequency of acute exacerbations of COPD(AECOPD).RESULTS:In addition to their pulmonary symptoms,39.79%and 40.31%of study patients withstable COPD reported constipation and abdominal distention,respectively.Scores for major pulmonary symptoms(cough,sputum and wheezing),AECOPD and SGRQ values in patients with constipation and abdominal distention were significantly greater,and the 6MWD markedly shorter,than in those without them.According to Pearson's correlation analysis,there were strong correlations between these lower gastrointestinal tract symptoms and scores for pulmonary symptoms,SGRQ,6MWD and AECOPD.CONCLUSION:Lower gastrointestinal tract symptoms such as constipation and abdominal distention can adversely affect pulmonary symptoms,frequency of acute exacerbations and quality of life in patients with stable COPD. | Yan Sun Fengjie Zheng Yuhang Li Ruohan Wu Yuchao Liu Miao Liu Jinchao Zhang Kuo Gao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 10 |
| 3 | In situ sulfur-doped graphene nanofiber network as efficient metal-free electrocatalyst for polysulfides redox reactions in lithium–sulfur batteries显示文摘The major challenge for realistic application of Li-S batteries lies in the great difficulty in breaking through the obstacles of the sluggish kinetics and polysulfides shuttle of the sulfur cathode at high sulfur loading for continuously high sulfur utilization during prolonged charge-discharge cycles.Here we demonstrate that large percentage of sulfur can be effectively incorporated within a three-dimensional(3D)nanofiber network of high quality graphene from chemical vapor deposition(CVD),through a simple ball-milling process.While high quality graphene network provided continuous and durable channels to enable efficient transport of lithium ions and electrons,the in-situ sulfur doping from the alloying effect of ball milling facilitated desirable affinity with entire sulfur species to prevent sulfur loss and highly active sites to propel sulfur redox reactions over cycling.This resulted in remarkable rate-performance and excellent cycling stability,together with large areal capacity at very high sulfur mass loading(Specific capacity over 666 mAh g-1after 300 cycles at 0.5 C,and areal capacity above 5.2 mAh cm-2at 0.2C at sulfur loading of 8.0 mg cm-2 and electrolyte/sulfur(E/S)ratio of 8μL mg-1;and high reversible areal capacities of 13.1 m Ah cm-2 at a sulfur load of 15 mg cm-2 and E/S of 5μL mg-1). | Shijie Zhang Peng Zhang Ruohan Hou Bin Li Yongshang Zhang Kangli Liu Xilai Zhang Guosheng Shao | 2020 | Journal of Energy Chemistry2020，29，8： | 4 |
| 4 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 5 | Confining sulfur in intact freestanding scaffold of yolk-shell nanofibers with high sulfur content for lithium-sulfur batteries显示文摘Nanostructure design holds great potential in fabricating sulfur electrodes that host a high sulfur loading and still attain high electrochemical utilization for the developing of high-energy-density lithium-sulfur(Li-S) batteries. In this contribution, we introduce the yolk-shell structure into a freestanding carbon nanofibers film and construct a complete hollow yolk-shell Ti O2/carbon nanofibers@void@TiN@carbon(TiO2-CNFs@void@Ti N@C) composite. With inherent double conductive network and strong adsorption capability for polysulfides, the Ti O2-CNFs@void@Ti N@C composite can not only provide sufficient electrical contact for the insulating sulfur, but also effectively entrap polysulfides for prolonged cycle life. As a result, an excellent capacity retention ratio of 60.9% after 1000 cycles at 1 C as well as a high capacity of688.5 mA h g^(-1) at 5 C rate is accomplished with the cells employing Ti O2-CNFs@void@TiN @C as a cathode substrate for sulfur. Moreover, the TiO2-CNFs@void@Ti N@C composite, with a high S mass loading of9.5 mg cm^(-2), delivers a superb areal capacity of 8.2 mAh cm^(-2). | Xilai Zhang Peng Zhang Shijie Zhang Yongshang Zhang Ruohan Hou Kangli Liu Fujun Miao Guosheng Shao | 2020 | Journal of Energy Chemistry2020，29，12： | 2 |
| 6 | Sedimentary Characteristics and Formation Mechanisms of Lacustrine Beach-Bars in the Fourth Member of the Shahejie Formation in the Shubei Area, Western Depression of the Liaohe Oilfield, China显示文摘Beach-bars are well developed in the fourth member of the Shahejie Formation in the Shubei area, western depression of the Liaohe oilfield. The fourth member is composed of two three-order sequences, including a lower Sequence 1(SQ1) and an upper Sequence 2(SQ2). SQ2, which is the focus of this study, comprises a lowstand systems tract(LST) and a transgressive system tract(TST). Three types of beach-bars have been recognized: shallow-littoral lacustrine sandy beach-bars, semi-deep lacustrine storm-related sandy beach-bars and shallow-littoral lacustrine carbonate beach-bars. Paleo-environments during the deposition of SQ2, including the paleo-geomorphology, paleo-water depth and paleo-source have been reconstructed to determine the formation mechanisms of the different types of beach-bars. The shallow-littoral lacustrine sandy beach-bars formed mainly by waves and currents and were mostly deposited in the LST, where water depths ranged from 3 to 9 m and the terrestrial clast supply is sufficient. The storm-related sandy beach-bars developed in the TST in the southern part of the study area near previously massively deposited sand bodies where there was sufficient water depth to preserve them. The carbonate beach-bars formed primarily in the TST in the Shubei low buried hill belt where there was a lack of terrestrial clast supply and complex, uneven geomorphology that easily gave rise to a lagoonal environment. | Yi Gao Xiaolong Jiang Fang Liu Xuying Wang Ruohan Liu | 2017 | Journal of Earth Science2017，28，6： | 2 |
| 7 | A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo显示文摘Levels of reactive oxygen species(ROS)in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology.However,due to the lack of adequate tools,it is difficult to study the relationship between ROS,especially certain types of ROS(e.g.,HOCl),and cancer.We report herein an HOCl-specific fluorescent probe,FDOCl-20,containing a thiocarbamide group as a receptor,for the visualization of HOCl in solid tumors in vivo.This probe displays high selectivity and sensitivity to HOCl,and is appropriate for use in acidic conditions,including the tumor microenvironment.Using FDOCl-20 as a tool,we can visualize HOCl in solid tumors in vivo.Importantly,the fluorescent intensity of FDOCl-20 is proportional to tumor volume.Thus,FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors. | Peng Wei Lingyan Liu Wei Yuan Jiajia Yang Ruohan Li Tao Yi | 2020 | Science China Chemistry2020，63，8： | 2 |
| 8 | Sugarcane bagasse dietary fiber as an adjuvant therapy for stable chronic obstructive pulmonary disease:a four-center,randomized,double-blind,placebo-controlled study显示文摘OBJECTIVE:To evaluate the efficacy and safety of sugarcane bagasse dietary fiber as an adjuvant therapy for improving quality of life in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a multicenter,randomized,double-blind,placebo-controlled trial.A total of196 participants were randomized into a trial group(treated with 6 g/day sugarcane bagasse plus conventional treatment,n = 98) and a control group(treated with placebo plus conventional treatment,n = 98).All efficacy analyses were performed according to the intention-to-treat(ITT) principle.A per-protocol analysis set(PPS) was used to analyze the cases that completed the clinical trial with good compliance.The trial period was 30 days,with a 6-month follow-up.Pre-and post-treatmentpulmonary symptom scores(cough,sputum,wheezing,and dyspnea) were recorded for both groups.The St.George's Respiratory Questionnaire(SGRQ) and the modified Medical Research Council(m MRC) dyspnea scale were assessed before treatment and at the end of the 6-month follow-up.RESULTS:The ITT population was 178 and the PPS population was 166.Post-treatment pulmonary clinical symptoms and severity of dyspnea(m MRC and SGRQ evaluation) were significantly improved in both the trial group and the control group(ITT and PPS:P < 0.05).However,there was no statistical difference between the two groups in post-treatment pulmonary symptoms and m MRC.There was a greater reduction in the SGRQ subscales of activity,effect and total score in the trial group compared with the control group(ITT and PPS:P < 0.01).There was no statistical difference in pre-and post-treatment safety variables in either group.CONCLUSION:Sugarcane bagasse combined with conventional treatment improved quality of life in patients with stable COPD.Sugarcane bagasse appears to be a safe herbal medicine with potential for treating patients with stable COPD when taken orally as an adjuvant therapy. | Liu Miao Zheng Fengjie Ni Lei Sun Yan Wu Ruohan Zhang Tianyu Zhang Jinchao Zhong Xianggen Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 2 |
| 9 | Structural architecture of Neoproterozoic rifting depression groups in the Tarim Basin and their formation dynamics显示文摘The Tarim Basin is the largest, oil-bearing, superimposed basin in the northwest of China. The evolution and tectonic properties of the initial Tarim Basin have been hotly disputed and remain enigmatic. The Neoproterozoic basin is covered by a vast desert and a huge-thickness of sedimentary strata, has experienced multiple tectonic movements, had a low signal to noise ratios(SNRs) of deep seismic reflection data, all of which have posed critical obstacles to research. We analysed four field outcrops, 18 wells distributed throughout the basin, 27 reprocessed seismic reflection profiles with higher SNRs across the basin and many ancillary local 2D and 3D profiles and aeromagnetic data. We found about 20 normal fault-controlled rifting depressions of the Cryogenian and Ediacaran scattered throughout the basin, which developed on the Precambrian metamorphic and crystalline basement. The structural framework is clearly different from that of the overlying Phanerozoic. The rifting depressions consist of mainly half grabens, symmetrical troughs and horst-grabens. From the northeast to southwest of the basin,they are divided into three rifting depression groups with the WNW, ENE, and NW-trends that are mainly controlled by normal faults. The maximum thicknesses of the strata are up to 4100 m. From the Cryogenian to Ediacaran, most of the main inherited faults to active and eventually ceased at the end of the Ediacaran or Early Cambrian, while subsidence centres appeared and migrated eastward along the faults. They revealed that the different parts of the Tarim continental block were in NNE-SSWoriented and NNW-SSE-oriented extensional paleo-stress fields(relative to the present) during the Neoproterozoic, and were accompanied by clockwise shearing. According to the analysis of the activities of syn-sedimentary faults, filling sediments,magmatic events, and coordination with aeromagnetic anomalies, the tectonic properties of the fault depressions are different and are primarily continental rifts or intra-continental fault-controlled basins. The rifting phases mainly occurred from 0.8–0.61 Ga.The formation of the rifting depression was associated with the initial opening of the South Altun-West Kunlun Ocean and the South Tianshan Ocean, which were located at the northern and southern margins of the Tarim Block, respectively, in response to the break-up of the Supercontinent Rodinia and the initial opening of the Proto-Tethys Ocean. | Bizhu HE Cunli JIAO Taizhu HUANG Xingui ZHOU Zhihui CAI Zicheng CAO Zhongzheng JIANG Junwen CUI Zhuoyin YU Weiwei CHEN Ruohan LIU Xiaorui YUN Guangming HAO | 2019 | Science China Earth Sciences2019，62，3： | 2 |
| 10 | Unraveling the reaction mechanisms of electrode materials for sodiumion and potassium‐ion batteries by in situ transmission electron microscopy显示文摘Sodium ion batteries(SIBs)and potassium ion batteries(PIBs)have caught numerous attention due to the low cost and abundant availability of sodium and potassium.However,their power density,cycling stability and safety need further improvement for practical applications.Investigations on the reaction mechanisms and structural degradation when cycling are of great importance.In situ transmission electron microscopy(TEM)is one of the most significant techniques to understand and monitor electrochemical processes at an atomic scale with real-time imaging.In this review,the current progress in unraveling reaction mechanisms of electrode materials for SIBs and PIBs via in situ TEM is summarized.First,the importance of in situ TEM is highlighted.Then,based on the three types of electrochemical reaction,i.e.,intercalation reac-tion,conversion reaction and alloying reaction,the structural evolution and reaction kinetics at atomic resolution,and their relation to the electrochemical performance of electrode materials are reviewed and described in detail.Fi-nally,future directions of in situ TEM for SIBs and PIBs are proposed.Therefore,the in‐depth understanding revealed by in situ TEM will give an instructive guide in rational design of electrode materials for high performance electrode materials of SIBs and PIBs. | Hong Wang Fang Liu Ruohan Yu Jinsong Wu | 2022 | Interdisciplinary Materials2022，1，2： | 2 |
| 11 | Forecasting Tesla’s Stock Price Using the ARIMA Model显示文摘The stock market is an important economic information center.The economic benefits generated by stock price prediction have attracted much attention.Although the stock market cannot be predicted accurately,the stock market’s prediction of the trend of stock prices helps in grasping the operation law of the stock market and the influence mechanism on the economy.The autoregressive integrated moving average(ARIMA)model is one of the most widely accepted and used time series forecasting models.Therefore,this paper first compares the return on investment(ROI)of Apple and Tesla,revealing that the ROI of Tesla is much greater than that of Apple,and subsequently focuses on ARIMA model’s prediction on the available time series data,thus concluding that the ARIMA model is better than the Naïve method in predicting the change in Tesla’s stock price trend. | Qiangwei Weng Ruohan Liu Zheng Tao | 2022 | Proceedings of Business and Economic Studies2022，5，5： | 1 |
| 12 | A multicenter randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of rhubarb in treating acute exacerbation of chronic obstructive pulmonary disease of the syndrome type phlegm-heat obstructing the lungs显示文摘Objective:To observe the clinical efficacy and safety of oral administration of the traditional Chinese herb rhubarb to treat acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:This was a multicenter randomized double-blinded placebo controlled study that took place in 7 provinces of China that enrolled 244 patients(aged 18e80 years)who had acute exacerbation of COPD with the traditional Chinese syndrome pattern of phlegm-heat obstructing lung.Participants were divided into experimental and control groups.The experimental group received 4.5 g of rhubarb granules twice daily and the control group received placebo granules.Both groups also received conventional Western therapy consisting of oxygen therapy,an antibiotic,expectorant,and a bronchodilator.Treatment lasted 10 days.Symptom scores for cough,sputum volume and color,wheezing and chest tightness before treatment and on days 3,5,7,and 10 during the treatment were recorded.Lung function,arterial blood gas and levels of serum inflammatory factors,interleukin-4(IL-4),interleukin-8(IL-8),and interleukin-10(IL-10)and tumor necrosis factor-alpha(TNF-a),before and after treatment were measured.Results:The sample size of the full analysis set(FAS)was 244 participants,and the sample size of per protocol set(PPS)was 235.Following 10 days’treatment,symptom scores of the experimental group were markedly lower than those of the placebo group(FAS:mean difference1.67,95%CI:e2.66 to0.69,P Z 0.001;PPS:mean difference1.55,95%CI:2.56 to0.54,P Z 0.003).Lung function in the experimental group was significantly higher than in the placebo group(FEV1,FAS:mean difference 0.12,95%CI:0.06 to 0.18;P<0.001;PPS:mean difference 0.12,95%CI 0.05 to 0.18;P<0.001.FVC:FAS:mean difference 0.16,95%CI:0.06 to 0.26;P Z 0.002;PPS:mean difference 0.16,95%CI 0.05 to 0.26;P Z 0.003.FEV1%,FAS:mean difference 5.95,95%CI:3.36 to 8.53;P<0.001;PPS:mean difference 5.92,95%CI 3.28 to 8.56;P<0.001.).PaO2,PaCO2,as well as serum inflammatory factors were also improved when compared to the placebo group.There were no significant differences in the incidence rate of adverse reaction between the two groups.Conclusions:Compared with placebo,rhubarb granules significantly reduced symptom scores,improved blood oxygen level,controlled systemic inflammatory response,without significant adverse effects.Thus,rhubarb may be a beneficial adjuvant method for treating the phlegm-heat obstructing the lung syndrome pattern of AECOPD. | Fengjie Zheng Yan Sun Xianggen Zhong Yueqi Wang Ruohan Wu Miao Liu Yuchao Liu Kuo Gao Yuhang Li | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，2： | 1 |
| 13 | Health benefits from the rapid reduction in ambient exposure to air pollutants after China’s clean air actions:progress in efficacy and geographic equality显示文摘Clean air actions(CAAs)in China have been linked to considerable benefits in public health.However,whether the beneficial effects of CAAs are equally distributed geographically is unknown.Using high-resolution maps of the distributions of major air pollutants(fine particulate matter[PM_(2.5)]and ozone[O_(3)])and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to PM_(2.5)and O_(3)from 2013 to 2020.We used a method established by the Global Burden of Diseases Study.By analyzing the changes in loss of life expectancy(LLE)attributable to PM_(2.5)and O_(3),we calculated the gain of life expectancy(GLE)to quantify the health benefits of the air-quality improvement.Finally,we assessed the geographic inequality embedded in the GLE using the Gini index(GI).Based on risk assessments of PM_(2.5)and O_(3),during the first stage of CAAs(2013 to 2017),the mean GLE was 1.87 months.Half of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed(GI 0.44).During the second stage of CAAs(2017 to 2020),the mean GLE increased to 3.94 months and geographic inequality decreased(GI 0.18).According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health inequalities.The enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of PM_(2.5)and O_(3)levels.Our findings will contribute to optimizing future CAAs. | Tao Xue Ruohan Wang Meng Wang Yanying Wang Dan Tong Xia Meng Conghong Huang Siqi Ai Fangzhou Li Jingyuan Cao Mingkun Tong Xueqiu Ni Hengyi Liu Jianyu Deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu | 2024 | National Science Review2024，11，2： | 0 |
| 14 | Characteristics and Cause Analysis of Variations in Light Precipitation Events in the Central and Eastern Tibetan Plateau,China,During 1961–2019显示文摘The Tibetan Plateau(TP)is one of the most sensitive areas and is more susceptible to climate change than other regions in China.The TP also experiences extremely frequent light precipitation events compared to precipitation of other intensities.However,the definition,influencing factors,and characteristics of light precipitation in the TP have not been accurately explained.This study investigated the variation characteristics of light precipitation with intensities(Pre)of 0.1-10.0 mm/d based on climate data from 53 meteorological stations over the central and eastern TP from 1961 to 2019.For detailed analysis,light precipitation events were classified into five grades:G1[0.1-2.0 mm/d),G2[2.0-4.0 mm/d),G3[4.0-6.0 mm/d),G4[6.0-8.0 mm/d),and G5[8.0-10.0 mm/d).The results showed that both the amount of precipitation and number of precipitation days had increased significantly at rates of 4.0-6.0 mm/10 yr and 2.0-4.0 d/10 yr,respectively,and most precipitation events were of low intensity(0.1≤Pre<2.0 mm/d).Light precipitation events mainly occurred in the southeast of the study area,and it showed an increasing trend from the northwest to the southeast.Abrupt changes in light precipitation primarily occurred in the 1980 s.A comprehensive time series analysis using the Mann-Kendall test and Morlet wavelet was performed to characterize the abrupt changes and cycles of light precipitation.During the study period,the main periods of light precipitation corresponded to the 6 yr cycle,with obvious periodic oscillation characteristics,and this cycle coexisted with cycles of other scales.Significant correlations were observed between the amount of light precipitation and temperature over the study area.The findings will enhance our understanding of changes in light precipitation in the TP and provide Scientific basis for the definition of light precipitation in the future. | LI Kaifang CAO Liguo ZHOU Zhengchao JIAO Lei WANG Ning LIU Ruohan | 2022 | Chinese Geographical Science2022，32，1： | 0 |
| 15 | The appearance of cytoplasmic cytochrome C precedes apoptosis during Drosophila salivary gland degradation显示文摘Apoptosis is an important process for organism development that functions to eliminate cell damage,maintain homeostasis,and remove obsolete tissues during morphogenesis.In mammals,apoptosis is accompanied by the release of cytochrome C(Cyt-c)from mitochondria to the cytoplasm.However,whether this process is conserved in the fruit fly,Drosophila melanogaster,remains controversial.In this study,we discovered that during the degradation of Drosophila salivary gland,the transcription of mitochondria apoptosis factors(MAPFs),Cyt-c,and death-associated APAF1-related killer(Dark)encoding genes are all upregulated antecedent to initiator and effector caspases encoding genes.The proteins Cyt-c and the active caspase 3 appear gradually in the cytoplasm during salivary gland degradation.Meanwhile,the Cyt-c protein colocates with mito-GFP,the marker indicating cytoplasmic mitochondria,and the change in mitochondrial membrane potential coincides with the appearance of Cyt-c in the cytoplasm.Moreover,impeding or promoting 20E-induced transcription factor E93 suppresses or enhances the staining of Cyt-c and the active caspase 3 in the cytoplasm of salivary gland,and accordingly decreases or increases the mitochondrial membrane potential,respectively.Our research provides evidence that cytoplasmic Cyt-c appears before apoptosis during Drosophila salivary gland degradation,shedding light on partial conserved mechanism in apoptosis between insects and mammals. | Shihui Long Wenxin Cao Yongyu Qiu Ruohan Deng Jiali Liu Lidan Zhang Renke Dong Fengxin Liu Sheng Li Haigang Zhao Na Li Kang Li | 2024 | Insect Science2024，31，1： | 0 |
| 16 | IL-21 regulates macrophage activation in human monocytic THP-1-derived macrophages显示文摘Background:Interleukin-21(IL-21)has a regulatory effect on various immune cells.Its effect on macrophage function remains unclear.Aims:This study aimed to investigate the effect of IL-21 on the macrophagesmediated inflammatory response and explore its mechanism.Materials&Methods:Phorbol myristate acetate was used to induce THP-1-derived macrophages.Then,cells were stimulated with IL-21 and/or lipopolysaccharide(LPS).To determine the effect of IL-21 on the production of inflammatory factors in THP-1-derived macrophages,the messenger RNA(mRNA)and protein levels of IL-6,tumor necrosis factor-α(TNF-α),IL-8,and IL-10 were detected by real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA),respectively.Meanwhile,to explore the effect of IL-21 on macrophage polarization,macrophage phenotype,gene expression,and cytokine secretion mediated by THP-1-derived macrophage were detected by flow cytometry,RT-PCR,and ELISA.Results:First,we found that the IL-21 receptor was expressed in THP-1-derived macrophages.IL-21 enhanced LPS-mediated TNF-α,IL-6,and IL-10 production in THP-1-derived macrophages.During the polarization of THP-1-derived macrophages to M1-like macrophages,IL-21 induced the expression of macrophage surface markers CD86 and CD80,and related genes,such as TNF-α,IL-6,IL-1β,and DC-SIGN mRNA,inhibited Dectin-1 mRNA expression and promoted the secretion of TNF-α.During the polarization of THP-1-derived macrophages to M2-like macrophages,IL-21 enhanced the expression of macrophage surface markers CD86 and CD163,and related genes,such as TNF-α,IL-1β,IL-10,Dectin-1,and DC-SIGN mRNA,and promoted the secretion of IL-10.Conclusion:IL-21 promotes LPS-mediated production of inflammatory cytokines by THP-1-derived macrophages;IL-21 plays a two-way regulatory role in THP-1-derived macrophage polarization. | Leilei Jian Changhong Li Lin Sun Zhenzhen Ma Xinyu Wang Ruohan Yu Xiangyuan Liu Jinxia Zhao | 2021 | Rheumatology & Autoimmunity2021，1，1： | 0 |
| 17 | Single-Atom Lithiophilic Sites Confined within Ordered Porous Carbon for Ultrastable Lithium Metal Anodes显示文摘Attributing to the high specific capacity and low electrochemical reduction potential,lithium(Li)metal is regarded as the most promising anode for high-energy Li batteries.However,the growth of lithium dendrites and huge volume change seriously limit the development of lithium metal batteries.To overcome these challenges,an ordered mesoporous N-doped carbon with lithiophilic single atoms is proposed to induce uniform nucleation and deposition of Li metal.Benefiting from the synergistic effects of interconnected three-dimensional ordered mesoporous structures and abundant lithiophilic single-atom sites,regulated local current density and rapid mass transfer can be achieved,leading to the uniform Li deposition with inhibition of dendrites and buffered volume expansion.As a result,the as-fabricated anode exhibits a high CE of 99.8%for 200 cycles.A stable voltage hysteresis of 14 mV at 5 mA cm^(−2)could be maintained for more than 1330 h in the symmetric cell.Furthermore,the full cell coupled with commercial LiFePO_(4)exhibits high reversible capacity of 108 mAh g^(−1)and average Coulombic efficiency of 99.8%from 5th to 350th cycles at 1 C.The ordered mesoporous carbon host with abundant lithiophilic single-atom sites delivers new inspirations into rational design of high-performance Li metal anodes. | Wenzhong Huang Shanlin Liu Ruohan Yu Liang Zhou Zhenhui Liu Liqiang Mai | 2023 | Energy & Environmental Materials2023，6，3： | 0 |
| 18 | Controlling Factors and Accumulation Model of Hydrocarbon Reservoirs in the Upper Cretaceous Yogou Formation, Koulele Area, Termit Basin, Niger显示文摘Based on the sedimentary and tectonic background of the Termit Basin, this paper focuses on the Upper Cretaceous Yogou Formation and uses organic geochemistry, logging, oil testing and seismic data to analyze the primary control factors of the hydrocarbon accumulation and establish corresponding model in order to predict favorable exploration target zones of hydrocarbon reservoirs. This study demonstrates that the Upper Cretaceous Yogou Formation is a self-generation and self-accumulation type reservoir. The Yogou Formation hydrocarbon reservoirs in the Koulele area are controlled by four factors:(1) the source rock is controlled by a wide range of YS1-YS2 marine shale,(2) the sandstone reservoir is controlled by the YS3 underwater distributary channel and storm dunes,(3) migration of hydrocarbons is controlled by faults and the regional monocline structure, and(4) the accumulation of hydrocarbons is controlled by lateral seal. The structures in the western Koulele area are primarily reverse fault-blocks with large throws, and the structures in the east are dominantly fault-blocks with small throws(co-rotating and reverse) and a fault-nose. In the western Koulele area, where the facies are dominated by storm dunes on a larger scale, it is easier to form lithologic reservoirs of sandstone lens. In the eastern Koulele area, high-quality channel sandstone reservoirs, fault-blocks with small throws, and the monocline structure benefit for the formation of updip pinch out lithologic traps, fault lithologic reservoirs and fault-nose structural reservoirs. Future exploration targets should be focused in the western storm dunes zone and eastern distributary channel sand zone with small fault-blocks. | Xuying Wang Lunkun Wan Zaixing Jiang Ruohan Liu Xiabin Wang Wangxin Tang Yi Gao Shengqian Liu Wenmao Xu | 2017 | Journal of Earth Science2017，28，6： | 0 |
| 19 | Reservoir Characteristics and Controlling Factors of Silurian Lower Kepingtage Formation in Tahe Area, Tarim Basin, NW China显示文摘With the breakthrough of exploration in Well TP16-1, the lower Kepingtage Formation becomes a key target for petroleum exploration of deep clastic reservoir in Tahe area. In this paper we focused on the research of the reservoir characteristics and its controlling factors in two sub-member formations(S_1k_1~1 and S_1k_1~3). Based on X-ray diffraction, conventional physical properties data(porosity and permeability) and reservoir storage space data(casting thin section and scanning electron microscope), we determined that the S_1k_1 Formation belongs to extra-low porosity and permeability reservoir, although the upper S_1k_1~3 Formation shows relative better physical characteristic than the lower S_1k_1~1 Formation. The development of storage space in the study area is controlled by sedimentary microfacies, diagenesis process. Reservoirs in S_1k_1 Formation are mainly located in channel(S_1k_1~1 sandstones) and sand flat(S_1k_1~3 sandstones). The sand flat sediments with a more coarse grain size compared with the channel. In diagenesis, compaction is the major controlling factor for reducing the porosity, followed by cementation. Dissolution of diagenesis is the major controlling factor in enhancing the reservoir porosities. Compared with channel(S_1k_1~1) sandstones, sand flat sandstones(S_1k_1~3) have better reservoir quality for its weaker compaction, cementation and stronger dissolution. On the basis of sedimentary characteristics(grain size and subfacies), physical property(porosity and permeability) and reservoir storage space, we divide the S_1k_1 reservoir into three categories(I, II and III). Type I reservoir is high quality reservoir. It is mainly distributed in the south area of S_1k_1~1 and S_1k_1~3 reservoir. Type II is moderate reservoir. It is located in the middle of S_1k_1~1 reservoir and in the north of S_1k_1~3 reservoir. Type III is the poor reservoir. It is only located in the north of S_1k_1~1 reservoir. | Ruohan Liu Zaixing Jiang Ming Wang Weili Yang Jingxiang Guo Minghao Wu Yi Gao Shanyazi Wei Zhihong Nie Hong He | 2017 | Journal of Earth Science2017，28，6： | 0 |
| 20 | Enhanced stability of nitrogen-doped carbon-supported palladium catalyst for oxidative carbonylation of phenol显示文摘Enhancing the stability of supported noble metal catalysts emerges is a major challenge in both science and industry.Herein,a heterogeneous Pd catalyst(Pd/NCF)was prepared by supporting Pd ultrafine metal nanoparticles(NPs)on nitrogen-doped carbon;synthesized by using F127 as a stabilizer,as well as chitosan as a carbon and nitrogen source.The Pd/NCF catalyst was efficient and recyclable for oxidative carbonylation of phenol to diphenyl carbonate,exhibiting higher stability than Pd/NC prepared without F127 addition.The hydrogen bond between chitosan(CTS)and F127 was enhanced by F127,which anchored the N in the free amino group,increasing the N content of the carbon material and ensuring that the support could provide sufficient N sites for the deposition of Pd NPs.This process helped to improve metal dispersion.The increased metal-support interaction,which limits the leaching and coarsening of Pd NPs,improves the stability of the Pd/NCF catalyst.Furthermore,density functional theory calculations indicated that pyridine N stabilized the Pd^(2+)species,significantly inhibiting the loss of Pd^(2+)in Pd/NCF during the reaction process.This work provides a promising avenue towards enhancing the stability of nitrogen-doped carbon-supported metal catalysts. | Xiaojing Liu Ruohan Zhao Hao Zhao Zhimiao Wang Fang Li Wei Xue Yanji Wang | 2024 | Chinese Journal of Chemical Engineering2024，65，1： | 0 |
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