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| 1 | Pulmonary embolism with chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease. The incidence of COPD is growing annually in China, and it is a significant and growing public health burden. Multivariate analysis showed that COPD was one of the independent risk factors for the occurrence of pulmonary embolism (PE),and the incidence of PE was significantly higher in COPD patients than in normal subjects. However, PE is often overlooked in patients with acute exacerbation of COPD (AECOPD) because there are many similarities in clinical symptoms between PE and AECOPD, which are difficult to distinguish, resulting in the failure of timely treatment and poor prognosis. Therefore, it is of great significance to understand the clinical manifestations, diagnosis, and treatment of COPD combined with PE for making a more accurate diagnosis, providing timely and effective treatment, and improving the prognosis of such patients. | Ruohan Yang Guiqing Liu Chaosheng Deng | 2021 | Chronic Diseases and Translational Medicine2021，7，3： | 12 |
| 2 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 3 | A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo显示文摘Levels of reactive oxygen species(ROS)in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology.However,due to the lack of adequate tools,it is difficult to study the relationship between ROS,especially certain types of ROS(e.g.,HOCl),and cancer.We report herein an HOCl-specific fluorescent probe,FDOCl-20,containing a thiocarbamide group as a receptor,for the visualization of HOCl in solid tumors in vivo.This probe displays high selectivity and sensitivity to HOCl,and is appropriate for use in acidic conditions,including the tumor microenvironment.Using FDOCl-20 as a tool,we can visualize HOCl in solid tumors in vivo.Importantly,the fluorescent intensity of FDOCl-20 is proportional to tumor volume.Thus,FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors. | Peng Wei Lingyan Liu Wei Yuan Jiajia Yang Ruohan Li Tao Yi | 2020 | Science China Chemistry2020，63，8： | 2 |
| 4 | Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme显示文摘This paper proposes a novel method for the continuum topology optimization of transient vibration problem with maximum dynamic response constraint.An aggregated index in the form of an integral function is presented to cope with the maximum response constraint in the time domain.The density filter solid isotropic material with penalization method combined with threshold projection is developed.The sensitivities of the proposed index with respect to design variables are conducted.To reduce computational cost,the second-order Amoldi reduction(SOAR)scheme is employed in transient analysis.Influences of aggregate parameter,duration of loading period,interval time,and number of basis vectors in the SOAR scheme on the final designs are discussed through typical examples while unambiguous configuration can be achieved.Through comparison with the corresponding static response from the final designs,the optimized results clearly demonstrate that the transient effects cannot be ignored in structural topology optimization. | Kai LONG Xiaoyu YANG Nouman SAEED Ruohan TIAN Pin WEN Xuan WANG | 2021 | Frontiers of Mechanical Engineering2021，16，3： | 1 |
| 5 | Donor-Acceptor Typed AIE Luminogens with Near-infrared Emission for Super-resolution Imaging显示文摘Aggregation-induced emission(AIE)luminogens(AIEgens)with high brightness in aggregates exhibit great potentials in biological imaging,but these AIEgens are seldom applied in super-resolution biological imaging,especially in the imaging by using the structural illumination microscope(SIM).Based on this consideration,we synthesized the donor-acceptor typed AIEgen of DTPA-BTN,which not only owns high brightness in the near-infrared(NIR)emission region from 600 nm to 1000 nm(photoluminescence quantum yield,PLQYs=11.35%),but also displays excellent photo-stability.In addition,AIE nanoparticles based on 4,7-ditriphenylamine-[1,2,5]-thiadiazolo[3,4-c]pyridine(DTPA-BTN)were also prepared with highly emissive features and excellent biocompatibility.Finally,the developed DTPA-BTN-based AIE nanoparticles were applied in the super-resolution cellular imaging via SIM,where much smaller full width at half-maximum values and high signal to noise ratios were obtained,indicating the superior imaging resolution.The results here imply that highly emissive AIEgens or AIE nanoparticles can be promising imaging agents for super-resolution imaging via SIM. | SHEN Qifei XU Ruohan WANG Zhi ZHAO Tianyu ZHOU Yu XU Yanzi YANG Zhiwei LEI Ming MENG Lingjie DANG Dongfeng | 2021 | Chemical Research in Chinese Universities2021，37，1： | 0 |
| 6 | Revitalizing Human-Robot Interaction: Phygital Twin Driven Robot Avatar for China-Sweden Teleoperation显示文摘1 Introduction Digital Twin(DT)is built and maintained in the digital rather physical realm[1,2].Dynamic DT mirrors the exact state of the physical system by means of multidimensional models describing the behavior of physical entity,and sensors providing the real-time coupling to models[3].Te outbreak of COVID-19 pandemic results in speeding up the virtualization and digitization of the physical entity with the support from DT.Nevertheless,quarantine and division led by COVID-19 pandemic make human beings’eyes for the physical interaction become more eager.Te physical world and the digital world are becoming interwoven,which indicates a new opportunity towards phygital twin.As is so often the question:how can I get closer to my distant companion?How can I extend my service or emotional concern to facilitate interaction in spite of space obstruction?Tese questions deserve thinking as a lesson learned from outbreak of COVID-19 pandemic. | Huiying Zhou Honghao Lv Ruohan Wang Haiteng Wu Geng Yang | 2023 | Chinese Journal of Mechanical Engineering2023，36，5： | 0 |
| 7 | Synthesis of D-A typed AIE luminogens in isomeric architecture and their application in latent fingerprints imaging显示文摘Among the emitters in powder dusting to visualize the latent fingerprints(LFPs),aggregation-induced emission luminogens(AIEgens)are well employed for their high brightness and resistance to photobleaching.However,the serious background interference and low resolution still limit their fast development.Therefore,to further enhance the signal-to-noise ratio in LFPs imaging,especially to improve the analysis for level 3 details,donor-acceptor(D-A)typed AIEgens of DTPA-2,3-P,DTPA-2,5-P and DTPA-2,6-P are designed here.It is observed that strong emission covering from 450nm to 650nm can be obtained for all these molecules,especially that a high PLQY value of 10.06%in solids is achieved in DTPA-2,3-P.This is much higher than that of the other two cases(0.80%and 0.51%).By utilizing the DTPA-2,3-P in powder dusting,fluorescence imaging of LFPs can be clearly captured on both smooth and rough substrates.Moreover,confocal laser scanning microscope(CLSM)enables us to achieve high-resolution LFPs imaging in both 2D and 3D views,providing more detailed information of fingerprints pores in width,distance,distribution,and shapes.The results here demonstrate that highly emissive AIEgen of DTPA-2,3-P could be an excellent candidate for the visualization of fingerprints,thus providing the potential application in criminal investigation in the future. | Peijuan Zhang Qifei Shen Yu Zhou Fengyi He Bo Zhao Zhi Wang Ruohan Xu Yanzi Xu Zhiwei Yang Lingjie Meng Dongfeng Dang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 8 | Activating Inert Sites in Cobalt Silicate Hydroxides for Oxygen Evolution through Atomically Doping显示文摘Metal silicate hydroxides have been recognized as efficient oxygen evolution reaction(OER)electrocatalysts,yet tailoring of their intrinsic activity remains confused.Herein,Fe had been incorporated into cobalt silicate hydroxide nanosheets and the resulted material achieves a competitive OER catalytic activity.It is found that the doping state obviously affects the electrical transport property.Specifically,highly dispersed Fe atoms(low-concentration Fe doping)trigger slight electron transfer to Co atoms while serried Fe(highconcentration Fe doping)attract vast electrons.By introducing 6 at.%Fe doping,partial relatively inert Co sites are activated by atomically dispersed Fe,bearing an optimal metal 3d electronic occupation and adsorption capacity to oxygen intermediate.The introduced Co-O-Fe unit trigger the p-donation effect and decrease the number of electrons in p*-antibonding orbitals,which enhance the Fe-O covalency and the structural stability.As a result,the sample delivers a low overpotential of 293 mV to achieve a current density of 10 mA cm^(-2).This work clarifies the superiority of atomically dispersed doping state,which is of fundamental interest to the design of doped catalyst. | Jiexin Zhu Lixue Xia Wenxuan Yang Ruohan Yu Wei Zhang Wen Luo Yuhang Dai Wei Wei Liang Zhou Yan Zhao Liqiang Mai | 2022 | Energy & Environmental Materials2022，5，2： | 0 |
| 9 | Realizing Plain Optimization of the Thermoelectric Properties in BiCuSeO Oxide via Self-Substitution-Induced Lattice Dislocations显示文摘Seeking new strategies to tune the intrinsic defect and optimize the thermoelectric performance via no or less use of external doped elements(i.e.,plain optimization)is an important method to realize the sustainable development of thermoelectric materials.Meanwhile,creating dislocation defects in oxide systems is quite challenging because the rigid and stiff ionic/covalent bonds can hardly tolerate the large strain energy associated with dislocations.Herein,taking BiCuSe_(O) oxide as an example,the present work reports a successful construction of dense lattice dislocations in BiCuSe_(O) by self-doping of Se at the O site(i.e.,Se_(O) self-substitution),and achieves plain optimization of the thermoelectric properties with only external Pb doping.Owing to the self-substitution-induced large lattice distortion and the potential reinforcement effect by Pb doping,high-density(about 3.0×10^(14 )m^(−2))dislocations form in the grains,which enhances the scattering strength of mid-frequency phonon and results in a substantial low lattice thermal conductivity of 0.38 W m^(−1) K^(−1) at 823 K in Pb-doped BiCuSe_(O).Meanwhile,PbBi doping and Cu vacancy markedly improve the electrical conductivity while maintaining a competitively high Seebeck coefficient,thereby contributing to a highest power factor of 942μW m^(−1) K^(−2).Finally,a remarkably enhanced zT value of 1.32 is obtained at 823 K in Bi_(0.94)Pb_(0.06)Cu_(0.97)Se_(1.05)O_(0.95) with almost compositional plainification.The high-density dislocation structure reported in this work will also provide a good inspiration for the design and construction of dislocations in other oxide systems. | Rui Xu Zhiwei Chen Qizhu Li Xiaoyu Yang Han Wan Mengruizhe Kong Wei Bai Nengyuan Zhu Ruohan Wang Jiming Song Zhou Li Chong Xiao Binghui Ge | 2023 | Research2023，，4： | 0 |
| 10 | Distributed Event-Triggered Tracking Control of Heterogeneous Discrete-Time Multi-Agent Systems with Unknown Parameters显示文摘In this paper,a novel design framework is developed to solve the cooperative tracking problem of heterogeneous discrete-time multi-agent systems with unknown agent parameters and directed communication topologies.First,a distributed event-triggered observer is developed to handle the heterogeneity of the multi-agent systems.An event-triggering mechanism is proposed to reduce the amount of data transmission between neighboring agents.Then,based on the proposed observer,a discrete-time distributed model reference adaptive controller is presented to deal with the unknown parameters of the multi-agent systems.It is shown that by using the proposed observer and the model reference adaptive controller,the proposed design framework could achieve output tracking of the unknown multi-agent systems for any communication graph containing a directed spanning tree.Finally,an example is presented to illustrate the effectiveness of the proposed controller. | YANG Ruohan ZHOU Deyun | 2022 | Journal of Systems Science & Complexity2022，35，4： | 0 |
| 11 | SRSFs mediate the function of AR in the ovarian granulosa cells of patients with PCOS显示文摘Ovarian hyperandrogenism is one of the characteristics of polycystic ovary syndrome(PCOS)and androgen receptor(AR)in ovarian granulosa cells(GCs)functions as an important element to the accumulation of androgens.This study verified the existence of alternative splicing variant of AR(AR-SVs)in the GCs of PCOS patients and found that the function of AR decreased significantly in the presence of AR-SVs.And compared to the normal individuals,the expression of Serine/arginine-rich splicing factor 2(SRSF2)was higher and the expression of SRSF3 was lower in the GCs of patients with AR-SVs.More importantly,we found that the expression of SRSF2 was inhibited and that the expression of AR was decreased after the successful upregulation of miRNA-183,and testostrone(T)concentrations in the culture medium were increased.The results also showed that the expression of SRSF3 decreased when miRNA-124 was successfully upregulated,while the expression of AR significantly increased;however,the function of AR was also inhibited when T concentration in the culture medium was increased.This study has proved that SRSFs are regulated by corresponding miRNAs,and the altered expression of SRSFs interferenced the alternative splicing process of AR and ultimately decreased the function of AR,leading to the accumulation of androgens in the ovary. | Jing Luo Hong Ye Lijuan Hao Yixuan Sun Ruohan Li Yanxi Li Zhu Yang | 2021 | Genes & Diseases2021，8，1： | 0 |
| 12 | A Study on the Relationship Paths Between Leisure and Well-Being of Elderly Residents显示文摘With the increasing of the elderly population in China,the aging of population has become an important issue that cannot be ignored in the development of our country.Based on the social support theory,this study surveyed elderly residents in Shanghai to construct and explore the driving model of well-being of elderly residents in China.The results indicated that leisure motivation of elderly residents in China significantly affected their leisure involvement;leisure involvement was related to leisure satisfaction of the elderly;leisure satisfaction had a significant positive effect on well-being of the elderly.Moreover,a series of managerial implications and recommendations were provided to formulate leisure management policies for the elderly,meet their leisure needs,and improve their well-being. | YANG Ruohan DONG Kun HU Hongji SHI Ruiting GUO Yingzhi | 2022 | Journal of Tourism and Hospitality Management2022，10，3： | 0 |
| 13 | Reservoir Characteristics and Controlling Factors of Silurian Lower Kepingtage Formation in Tahe Area, Tarim Basin, NW China显示文摘With the breakthrough of exploration in Well TP16-1, the lower Kepingtage Formation becomes a key target for petroleum exploration of deep clastic reservoir in Tahe area. In this paper we focused on the research of the reservoir characteristics and its controlling factors in two sub-member formations(S_1k_1~1 and S_1k_1~3). Based on X-ray diffraction, conventional physical properties data(porosity and permeability) and reservoir storage space data(casting thin section and scanning electron microscope), we determined that the S_1k_1 Formation belongs to extra-low porosity and permeability reservoir, although the upper S_1k_1~3 Formation shows relative better physical characteristic than the lower S_1k_1~1 Formation. The development of storage space in the study area is controlled by sedimentary microfacies, diagenesis process. Reservoirs in S_1k_1 Formation are mainly located in channel(S_1k_1~1 sandstones) and sand flat(S_1k_1~3 sandstones). The sand flat sediments with a more coarse grain size compared with the channel. In diagenesis, compaction is the major controlling factor for reducing the porosity, followed by cementation. Dissolution of diagenesis is the major controlling factor in enhancing the reservoir porosities. Compared with channel(S_1k_1~1) sandstones, sand flat sandstones(S_1k_1~3) have better reservoir quality for its weaker compaction, cementation and stronger dissolution. On the basis of sedimentary characteristics(grain size and subfacies), physical property(porosity and permeability) and reservoir storage space, we divide the S_1k_1 reservoir into three categories(I, II and III). Type I reservoir is high quality reservoir. It is mainly distributed in the south area of S_1k_1~1 and S_1k_1~3 reservoir. Type II is moderate reservoir. It is located in the middle of S_1k_1~1 reservoir and in the north of S_1k_1~3 reservoir. Type III is the poor reservoir. It is only located in the north of S_1k_1~1 reservoir. | Ruohan Liu Zaixing Jiang Ming Wang Weili Yang Jingxiang Guo Minghao Wu Yi Gao Shanyazi Wei Zhihong Nie Hong He | 2017 | Journal of Earth Science2017，28，6： | 0 |
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