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| 1 | Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution显示文摘Shenmai 注射(SMI ) 是中国保护专利的注射,它主要用红人参和根值 Ophiopogonis 做的并且广泛地使用了由增加 Qi 和有营养的殷治疗冠的心疾病和肿瘤。在这研究,我们检验了 SMI 是否能在 vivo 并且在 vitro 在 colorectal 癌症在 adriamycin (ADR ) 和 paclitaxel (PTX ) 的 cytoxicity 上生产直接合作的效果,并且探索了内在的 pharmacokinetic 机制。有 LoVo 结肠癌异种皮移植的 BALB/c 裸体老鼠 intraperitoneally 与 ADR 被注射(2 mg 踘? 郱?? 耰? 耰? | Wen-yue LIU Jing-wei ZHANG Xue-quanYAO Chao JIANG Ji-chao HE Pin NI Jia-li LIU Qian-ying CHEN Qing-ran LI Xiao-jie ZANG Lan YAO Ya-zhong LIU Mu-lan WANG Pei-qiang SHEN Guang-ji WANG Fang ZHOU | 2017 | Acta Pharmacologica Sinica2017，38，2： | 24 |
| 2 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 3 | Spatial pattern and decadal change of agro-meteorological disasters in the main wheat production area of China during 1991-2009显示文摘Agro-meteorological disasters(AMD) have become more frequent with climate warming. In this study, the temporal and spatial changes in the occurrence frequency of major meteorological disasters on wheat production were firstly explored by analyzing the observed records at national agro-meteorological stations(AMS) of China from 1991 to 2009. Furthermore, impact of climate change on AMD was discussed by comparing the warmer decade(2000–2009) with another decade(1991–2000). It was found that drought was the most frequent disaster during the last two decades, with a highest proportion of 79%. And the frequency of AMD increased significantly with climate change. Specifically, the main disasters occurred more frequently in the reproductive period than in the vegetative period. Besides, the spatial changes in the AMD frequency were characterized by region-specific. For example, the wheat cultivation areas located on the Loess Plateau and the middle-lower reaches of the Yellow River suffered mainly from drought. All these results were strongly linked to climate change in China. Therefore, sound adaptation options should be taken based on the latest changes of AMD under global warming to reduce agricultural damages. | ZHANG Zhao WANG Pin CHEN Yi ZHANG Shuai TAO Fulu LIU Xiaofei | 2014 | Journal of Geographical Sciences2014，24，3： | 19 |
| 4 | Impact of chilling injury and global warming on rice yield in Heilongjiang Province显示文摘这研究为米饭集中于索引在 Heilongjiang 省的寒心的损害在 19602009 期间。第一,我们比较了由与传统的方法种密度的米饭加权的一个新导出的气候数据,并且发现新的是更合理的在庄稼收益上估计气候变化的影响。就在第二,寒心的索引由气象学、国家、国际的层次定义的省寒心的米饭的频率和紧张而言被估计。,结果证明气象学的标准对延期类型损害合适国际的,在阀值(GDDn ) 下面种度白天的所谓的和,描绘的最好为米饭的无菌类型的寒心的损害。当二个独立变量到达了约 92% ,包括两损害的米饭收益时间系列模型的解释能力打字(p < 0.05 ) 。最后,我们断定到米饭收益的人和天气因素的贡献率是大约87.2%和12.8%分别地,并且作为光增加的趋势因为无菌类型的寒心的损害在在最近的年里出发到流动时期期间被发现,为在未来在 Heilongjiang 省种的米饭显示高寒心的风险全球温暖。 | LIU Xiaofei ZHANG Zhao SHUAI Jiabing WANG Pin SHI Wenjiao TAO Fulu CHEN Yi | 2013 | Journal of Geographical Sciences2013，23，1： | 16 |
| 5 | Existence of Qiongnan suture zone on the north margin of South China Sea显示文摘This paper aims to explore whether paleo-suture zone exists in the pre-Cenozoic basement of South China Sea (SCS). By taking advantage of integrated geophysical surveying data, including multi-channel reflection seismicity, oceanic bottom seismicity, gravity and magnetic data as well as paleomagnetism and drilling information, a comprehensive analysis on sedimentary stratigraphy, seismic stratigraphy, magmatic and metamorphic petrology, geochemistry, gravity study, magnetics, paleogeomagnetics as well as geotectonics was carried out, and the results clearly indicate that a pre-Cenozoic suture zone, i.e. “Qiongnan (south Hainan Island) suture zone”, does exist on the north margin of SCS. This suture zone starts in the west from the Jiusuo-Lingshui fault zone in the south of Hainan Island, extends eastward across the continental slope to the north of SCS, and links with Shoufeng fault in Taiwan. It is inferred that the Qiongnan suture zone was sutured approximately in Indosinian (Triassic) Epoch and is actually the vestige of “Qiongnan ocean basin”, the extension of the main paleo-Tethys ocean basin in SCS. The formation of Qiongnan suture zone marked the collision-accretion of the Qiongnan Block toward the Qiongzhong Block. The Qiongnan suture zone is linked to the west with the southward extension of the principal suture zone of the Paleo-Tethys at Bitu-Changning-Menglian-Bentong-Raub, across the southern segment of the Red River-East Vietnam-Wanna strike-slip fault zone, and connected to the east with the suture zone emplaced into the south margin of the Oki-Hida Pre-Jurassic terranes in southwest Japan, across the northerni2 e segment of the Manila trench fault zone in the northeast side of Taiwan Island. The discovery of this suture zone is believed to be potentially significant toward study of the pre-Cenozoic geotectonic pattern of SCS, the temporal and spatial distribution of the east paleo-Tethys structural domain in SCS and the relationship of recombination and superimposition between the east paleo-Tethys structural domain and the west Pacific structural domain, in addition to the oil/gas geological potentials in the pre-Cenozoic marine vestige-superimposed basin in the study area. | LIU Hailing YAN Pin LIU Yingchun DENG Hui | 2006 | Chinese Science Bulletin2006，51，B12： | 12 |
| 6 | Effect of Arctium lappa L.in the dextran sulfate sodium colitis mouse model显示文摘AIM:To analyze the possible protective role of Arctium lappa L.(AL)in a murine model of ulcerative colitis(UC).METHODS:BALB/c mice were administered 100 mg/kg AL powder orally each day.After 7 d,colitis was induced by administration of dextran sulfate sodium(DSS)(5% W/V)in drinking water for a further 8 consecutive days.Diarrhea and bloody stools as well as colonic histology were observed.The level of interleukin-6(IL-6)and tu-mor necrosis factor-α(TNF-α)in colonic sections were detected by immunohistochemistry.RESULTS:There were significant differences in mean body weight values and disease activity indices between controls and AL-treated animals.Moreover,the histological findings showed that AL treatment can prevent mucosal edema,submucosal erosions,ulceration,inflammatory cell infiltration and colon damage.In addition,immunohistochemistry analysis showed that the levels of the inflammatory cytokines,IL-6 and TNF-α were also decreased in AL-treated groups.CONCLUSION:We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis.Thus,AL could prove to be a useful food for UC. | Tzou-Chi Huang Shinn-Shyong Tsai Li-Fang Liu Yu Lin Liu Hung-Jen Liu Kuo Pin Chuang | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 7 | Scorpion toxin BmKI directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats显示文摘在主要感觉神经原的电压门钠隧道(VGSC ) 在把疼痛信号传给中央神经系统起一个关键作用。BmK 我, site-3 钠从蝎子 Buthus martensi Karsch 的隧道特定的毒素,在老鼠导致疼痛行为。然而,我不是的 BmK 指向的 VGSC 的子类型完全变清。我们因此调查了 BmK 的效果我在当前的振幅, gating 和 Na 在 DRG 神经原与 neuronal hyperexcitability 被联系的 v 1.8, 。它被发现我 dose-dependently 增加了的那 BmK Na v 1.8 电流在小型(< 25 ? m ) 尖锐地分裂的 DRG 神经原,它在快、慢的 inactivation 上与它的抑制相关。而且,电压依赖者激活和不变的 inactivation Na v 1.8 在一个 hyperpolarized 方向被转移。因此, BmK 我减少了 neuronal 易兴奋性的阀值并且增加了在 DRG 神经原开火的行动潜力。在结论,我们的数据清楚地表明了我调制了的那 BmK Na v 1.8 显著地,建议我为学习 Na v 1.8。并且 Nav1.8 是与 BmK 我唤起疼痛有关的一个重要目标。 | Pin Ye Yunlu Jiao Zhenwei Li Liming Hua Jin Fu Feng Jiang Tong Liu Yonghua Ji | 2015 | Protein & Cell2015，6，6： | 10 |
| 8 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 9 | Banxia Xiexin Decoction(半夏泻心汤)Treats Diabetic Gastroparesis through PLC-IP3-Ca^2+/NO-cGMP-PKG Signal Pathway显示文摘Objective To test the effect of Banxia Xiexin Decoction(半夏泻心汤,BXD)on the contraction and relaxation of gastric smooth muscle(SM)in diabetic gastroparesis(DGP)model rats,and to explore the mechanism of BXD in the prevention and treatment of DGP through experiments of signal pathway both in vivo and in vitro.Methods Sixty Sprague-Dawley rats were divided into 6 groups according to a random number table:control group,model group,high-,medium-and low-dose BXD groups(9.2,4.6 and 1.8 g/(kg·d),respectively),and domperidone group(10 mg/(kg·d)),10 rats per group.DGP model was established initially by a single intraperitoneal injection of streptozotocin(STZ),and was confirmed by recording gastric emptying,intestinal transport velocity and gastric myoelectric activity of rats after 2 months.Each group was treated with a corresponding drug for 4 weeks.The mRNA and protein expressions of phospholipase C(PLC),inositol triphosphate(IP3),neuronal nitric oxide synthase(nNOS),and cyclic guanosine monophosphate(cGMP)dependent protein kinase G(PKG)were detected by reverse transcription-polymerase chain reaction and Western blot,respectively,while nitric oxide(NO)and cGMP expressions were detected by enzyme-linked immunosorbent assay.Gastric tissues were obtained from rats for primary cell culture preparation.Gastric SM cells were treated with 0.8µmol/L of STZ or STZ plus 1,000,500 and 200µg/mL of BXD or STZ plus 2.5µmol/mL of domperidone for 24,48,72 or 96 h,respectively.The length of gastric SM cells and intracellular Ca^2+concentration([Ca^2+]i)before and after BXD treatment was measured.Results Compared with the model group,high-and medium-dose BXD and domperidone significantly increased the expressions of PLC,IP3,NO,nNOS,cGMP and PKG in rat’s gastric tissue(P<0.01).Gastric SM cells treated with BXD showed a time-and dose-dependent increase in cell viability(P<0.01).The treatment with high-and medium-dose BXD and domperidone inhibited the increase in gastric SM cells length and increased[Ca^2+]i compared with the model cells(P<0.01).Conclusions Treatment with high-and medium-dose BXD significantly attenuated STZ-induced experimental DGP in rats.The therapeutic effect of BXD on DGP rats might be associated with the PLC-IP3-Ca^2+/NO-cGMP-PKG signal pathway. | WANG Bin ZENG Ke-wu HONG Zi-fu Tl Gui-xiang WANG Li-yun LU Pin LIU Zhen | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 8 |
| 10 | Numerical Simulation on Fluid Flow in Hot Metal Pretreatment显示文摘Basing on the commercial CFD metho d ,several models are adopted to simulate water model. The numerical simulation results are in good agreement with the experimental data of water model under the same experimental conditions. Then the numerical simulation method is presented to investigate the flow field, the vortex on gas-liquid surface and the uniform mixing time in hot metal ladles. This research shows: the vortex depth increases with increasing of immersion depth and rotation speed; Overflow appears in N=120rpm and h=3.2m; the turbulent kinetic energy increases with increasing immersion depth and rotation speed; uniform mixing time decreases with the decreasing of immersion depth and the rotation speed of stirring ; the optimal uniform mixing time is 23.5s on the conditions of N=100rpm and h=3.2m within the allowable range. | SHAO Pin, ZHANG Ting-an, LIU Yan, ZHAO Hong-liang, HE Ji-cheng (Laboratory of Ecological Untilization of Multi-Metal Intergrown Ores of Education Ministry, Shenyang 110004, Liaoning, China) | 2011 | Journal of Iron and Steel Research(International)2011，18，S2： | 8 |
| 11 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 12 | Determination of resveratrol in red wine by solid phase extraction-flow injection chemiluminescence method显示文摘一个敏感流动注射化合光方法基于 resveratrol 能极大地在硫酸媒介提高在 KMnO4 和 HCHO 之间的化合光反应的事实在红酒为 resveratrol 的察觉被开发了。Analytes 在稳固的吸着剂(C18 稳固阶段的萃取柱柱体) 上被预先集中。在最佳条件下面,建议方法在 1.32 × 的范围上允许 resveratrol 的测量 10 (? 8 )到 1.32 × 10 (? 5 )有 3.30 × 的检测极限的 mol/L 10 (? 9 ) mol/L ,并且为 1.32 × 的相对标准偏差 10 (? 5 ) mol/L resveratrol ( n = 11 )是3.8%。这个方法成功地被申请了在红酒的 resveratrol 的决心。而且,可能的反应机理也被讨论。 | Juan Juan Ren Hai Yan Liu Yu Hong Hao Pin Gang He Yu Zhi Fang | 2007 | Chinese Chemical Letters2007，18，8： | 7 |
| 13 | All-transRetinoic Acid Regulates Th1/Th2 Balance in CD4+T cells When GATA-3 is Deficient显示文摘The essential effect of vitamin A on immune function occurs through various mechanisms including direct effect on Th1-Th2 balance modulation.However,it is unclear whether or not vitamin A can regulate Th1-Th2 balance under a strong Th1-polarizing condition.Therefore,the purpose of our study was to examine the effect of vitamin A metabolite all-trans retinoic acid(ATRA)on Th1-Th2 differentiation in CD4+T cells under GATA-3 deficiency,which can induce Th1-polarizing condition.In the present study,GATA-3 deficiency T cells were induced by siRNA and checked | ZHU Yan Feng HU Jia Zhe ZHAO Pin Nan LIU Lin Xi and LI Yun | 2013 | Biomedical and Environmental Sciences2013，26，9： | 6 |
| 14 | Exploring the obscure profiles of pharmacological binding sites on voltage-gated sodium channels by BmK neurotoxins显示文摘Diverse subtypes of voltage-gated sodium channels(VGSCs)have been found throughout tissues of the brain,muscles and the heart.Neurotoxins extracted from the venom of the Asian scorpion Buthus martensi Karsch(BmK)act as sodium channel-specific modulators and have therefore been widely used to study VGSCs.α-type neurotoxins,named BmK I,BmKαIV and BmK abT,bind to receptor site-3 on VGSCs and can strongly prolong the inactivation phase of VGSCs.In contrast,β-type neurotoxins,named BmK AS,BmK AS-1,BmK IT and BmK IT2,occupy receptor site-4 on VGSCs and can suppress peak currents and hyperpolarize the activation kinetics of sodium channels.Accumulating evidence from binding assays of scorpion neurotoxins on VGSCs,however,indicate that pharmacological sensitivity of VGSC subtypes to different modulators is much more complex than that suggested by the simpleα-type and β-type neurotoxin distinction.Exploring the mechanisms of possible dynamic interactions between site 3-/4-specific modulators and region-and/or speciesspecific subtypes of VGSCs would therefore greatly expand our understanding of the physiological and pharmacological properties of diverse VGSCs.In this review,we discuss the pharmacological and structural diversity of VGSCs as revealed by studies exploring the binding properties and cross-competitive binding of site 3-or site 4-specific modulators in VGSC subtypes in synaptosomes from distinct tissues of diverse species. | Zhi-Rui Liu Pin Ye Yong-Hua Ji | 2011 | Protein & Cell2011，2，6： | 6 |
| 15 | The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts显示文摘Various surface bioactivation technology has been confirmed to improve the osteogenic ability of porous titanium(pTi)implants effectively.In this study,a three-layered composite coating,i.e.outer layer of hydroxyapatite(HA),middle layer of loose titanium dioxide(L-TiO2)and inner layer of dense TiO2(D-TiO2),was fabricated on pTi by a combined processing procedure of pickling,alkali heat(AH),anodic oxidation(AO),electrochemical deposition(ED)and hydrothermal treatment(HT).After soaking in simulated body fluid for 48 h,the surface of the AHAOEDHT-treated pTi was completely covered by a homogeneous apatite layer.Using MC3T3-E1 pro-osteoblasts as cell model,the cell culture revealed that both the pTi without surface treatment and the AHAOEDHT sample could support the attachment,growth and proliferation of the cells.Compared to the pTi sample,the AHAOEDHT one induced higher expressions of osteogenesis-related genes in the cells,including alkaline phosphatase,Type I collagen,osteopontin,osteoclast inhibitor,osteocalcin and zinc finger structure transcription factor.As thus,besides the good corrosion resistance,the HA/L-TiO2/D-TiO2-coated pTi had good osteogenic activity,showing good potential in practical application for bone defect repair. | Xi Fu Xingyu Zhou Pin Liu Hewei Chen Zhanwen Xiao Bo Yuan Xiao Yang Xiangdong Zhu Kai Zhang Xingdong Zhang | 2020 | Regenerative Biomaterials2020，7，5： | 5 |
| 16 | Effects of rotor structure on performance of small size axial flow fans显示文摘Small size axial flow fans are used as a cooling component for computers,electronic equipment and other electronic components.With the increasing power of electrical equipment,the demand for lower noise and higher ventilation of cooling fan is also increasing.Traditional methods of improving ventilation by raising the fan's rotation speed causes a decrease in efficiency and an increase in noise.In this paper,different structures of fans were simulated,and as a result,the counter-rotating fan can achieve higher pressure,efficiency and facilitate ventilation in a smaller space.Furthermore,some other conclusions are as follows:(1) Higher pressure rise can be obtained by a counter-rotating fan than by the two-stage rotor fan in the same axial length.Meanwhile,the counter-rotating fan has a broader work scope.(2) The main noise type of the counter-rotating fan is rotating noise;the small peak pulse caused by vortex noise mainly due to the eddy current produced by small eddies.(3) When the distance of counter-rotating fans is smaller than 2 times the chord,the greater distance the greater total pressure of the circum-averages and along the axial direction,the total pressure begin to decline until the distance is three times the chord,so there is an optimal distance between rotors.The simulation results are of important significance to the quantitative analysis and optimization design of the counter-rotating fan. | Pin Liu Yingzi Jin Yanping Wang | 2011 | Journal of Thermal Science2011，20，3： | 5 |
| 17 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 18 | Studies on bio-antioxidants——Ⅱ.An ESR study on the antioxidant efficiency of ascorbyl palmitate in micelles显示文摘The kinetics for the reaction of ascorbyl palmitate and 4-hydroxy-TEMPO,4-methoxy-TEMPO or 4-hexanoyloxy-TEMPO in CTAB and SDS micelles was studied by ESR spectroscopy.It was found that the behavior of ascorbyl palmitate is remarkably different from ascorbic acid in theirantioxidant activity in micelles.The predominant factors governing the activity in micelles involvethe lipophilicity of the antioxidant and the oxidant,the charge type of the substrates and the concentra-tion of the surfactant.As high as 2×10~4 fold rate variation was observed by changing the lipophilicityof the antioxidant and the microenvironment of the reaction medium. | LIU,Zhong-Li HAN,Zheng-Xu CHENG,Pin WU,Lung-Min LIU,You-Cheng National Laboratory on Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou,730000 | 1991 | Chinese Journal of Chemistry1991，9，2： | 4 |
| 19 | Editor's note显示文摘In this paper,a new version of the general form of the main inequality of Reich-Strebel is given.As applications,we improve the strong triangle inequality and generalize the Delta inequality in certain sense. | LIU ZongXiang XIE WeiXin WANG Pin YU You | 2014 | Science China(Information Sciences)2014，57，4： | 4 |
| 20 | Aging Strengthening in Rapidly Solidified Cu-Cr-Sn- Zn Alloy显示文摘It is known that the strength of alloys can be successfully improved by rapid solidification. The paper presents a process where Cu-Cr-Sn-Zn lead frame alloy is produced by rapid solidification and aging. The microcrystalline structure of rapidly solidified Cu-Cr-Sn-Zn alloy is smaller grain structure examined by optical metallography. The effects of aging processes on the microstructure and properties of the lead frame alloy were investigated. Aged at 500°C for 15 min the fine coherent precipitates Cr distribute in Cu matrix observed by transmission electron microscopy and the properties of hardness and electrical conductivity properties can reach 178HV and 61%IACS, respectively. | Juanhua Su Fengzhang Ren Baohong Tian Pin Liu Qiming Dong | 2009 | Journal of Materials Science & Technology2009，25，2： | 4 |
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