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| 1 | Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling显示文摘Triple-negative breast cancer (TNBC) is a heterogeneous disease with a poor prognosis due to the lack of an effective targeted therapy. Histone lysine methyltransferases (KMTs) have emerged as attractive drug targets for cancer therapy. However, the function of the majority of KMTs in TNBC has remained largely unknown. In the current study, we found that KMT nuclear receptor binding SET domain protein 2 (NSD2) is overexpressed in TNBC tumors and that its overexpression is associated with poor survival of TNBC patients. NSD2 regulates TNBC cell survival and invasion and is required for tumorigenesis and tumor growth. Mechanistically, NSD2 directly controls the expression of EGFR and ADAM9, a member of the ADAM (a disintegrin and metalloproteinase) family that mediates the release of growth factors, such as HB-EGF. Through its methylase activity, NSD2 overexpression stimulates EGFR-AKT signaling and promotes TNBC cell resistance to the EGFR inhibitor ge?tinib. Together, our results identify NSD2 as a major epigenetic regulator in TNBC and provide a rationale for targeting NSD2 alone or in combination with EGFR inhibitors as a targeted therapy for TNBC. | Jun-Jian Wang June X. Zou Hong Wang Zhi-Jian Duan Hai-Bin Wang Peng Chen Pei-Qing Liu Jian-Zhen Xu Hong-Wu Chen | 2019 | Acta Pharmacologica Sinica2019，40，8： | 4 |
| 2 | Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy显示文摘Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS. | Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 3 | A Branch and Bound-Based Algorithm for the Weak Linear Bilevel Programming Problems显示文摘最真实世界的优化问题是层次的包含非合作的目的。许多能这些问题被提出以(上面的水平) 首先,客观功能在印射的答案集合上正在被最小化第二(底层) 优化问题。经常上面的水平决定制造者是风险反对的。问题的产生的类被称为弱上下两层的编程问题。这篇论文论述把一个惩罚功能方法嵌进一个分支的一个新算法和界限算法处理一个弱线性上下两层的编程问题。一个例子说明建议算法的可行性。 | LIU June HONG Yunfei ZHENG Yue | 2018 | Wuhan University Journal of Natural Sciences2018，23，6： | 1 |
| 4 | Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors 显示文摘 | Zhang Shou Edelmann Lambert Liu June | 2008 | J Neurosci2008，28，2： | 1 |
| 5 | Constitutive and regulated expression of telomerase reverse transcriptase(hTERT) in human lymphocyte 显示文摘 | Liu K Schoon MM Levine BL June CH Hode RJ Weng NP | 1999 | Proc Natl Acad Science1999，96，9： | 1 |
| 6 | Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary artery constriction model显示文摘Background: Right ventricle failure(RVF) is associated with serious cardiac and pulmonary diseases that contribute significantly to the morbidity and mortality of patients. Currently, the mechanisms of RVF are not fully understood and it is partly due to the lack of large animal models in adult RVF. In this study, we aim to establish a model of RVF in adult ovine and examine the structure and function relations in the RV.Methods: RV pressure overload was induced in adult male sheep by revised pulmonary artery constriction(PAC). Briefly, an adjustable hydraulic occluder was placed around the main pulmonary artery trunk. Then, repeated saline injection was performed at weeks 0, 1, and 4, where the amount of saline was determined in an animal-specific manner. Healthy, age-matched male sheep were used as additional controls. Echocardiography was performed bi-weekly and on week 11 post-PAC, hemodynamic and biological measurements were obtained.Results: This PAC methodology resulted in a marked increase in RV systolic pressure and decreases in stroke volume and tricuspid annular plane systolic excursion, indicating signs of RVF. Significant increases in RV chamber size, wall thickness, and Fulton's index were observed. Cardiomyocyte hypertrophy and collagen accumulation(particularly type III collagen) were evident, and these structural changes were correlated with RV dysfunction.Conclusion: In summary, the animal-specific, repeated PAC provided a robust approach to induce adult RVF, and this ovine model will offer a useful tool to study the progression and treatment of adult RVF that is translatable to human diseases. | Michael Nguyen-Truong Wenqiang Liu June Boon Brad Nelson Jeremiah Easley Eric Monnet Zhijie Wang | 2020 | Animal Models and Experimental Medicine2020，3，2： | 1 |
| 7 | Determinants of ac- cepting wireless mobile data services in China 显示文摘 | June Lu Chang Liu Chun - Sheng Yu | 2008 | Information & Management2008，45，1： | 1 |
| 8 | Beyond concern: A privacy-trust-behavioral intention model of electronic commerce 显示文摘 | Liu Chang Marchewka J T Lu June | 2004 | Information & Management2004，42，1： | 1 |
| 9 | Comparative study of activity and beat stability of limit dextrinase in 16 barley cultivars 显示文摘 | Li Fen Zhang June Liu Hongmei | 2008 | Cereal Chem2008，85，3： | 1 |
| 10 | A case study of digital-twin-modelling analysis on power-plant-performance optimizations显示文摘China Energy’s National Institute of Clean-and-Low-Carbon Energy(NICE)is developing a Power Plant Smart Management(PPSM)platform that employs digital-twin technology to undertake techno-economic modelling analysis on China Energy’s existing coal-fired power-plant units and explore cost-effective solutions to improve those plant units’thermal efficiencies and operating performance.This paper presents a case study of PPSM on a 320-MWe coal-fired thermal power-plant unit,demonstrating how the digital-twin technology was employed to explore and analyse optimization solutions.Various optimization solutions and their cost-effectiveness were assessed using the digital-twin-modelling analysis;the results indicated the optimization solutions are expected to improve the plant unit’s operating efficiency and reduce its current electricity-generation coal consumption by up to 3.5 g/kWh standard coal equivalent(sce),worth annual fuel-cost savings of approximately 4 million RMB for a single unit or 8 million RMB for the two identical 320-MWe units that the power plant currently operates.The digital twin was also employed to assess the power-plant unit’s operating economics during both summer and winter.In summer,when the unit operates in electricity-generation-only mode,the unit’s operating thermal efficiency could drop by up to 6%points following the grid demand of load changes from 100%maximum continuous rating(MCR)down to 30% MCR,resulting in an~45 RMB/MWh increase of electricity-generation cost.In winter,when the unit operates in combined heat and power(CHP)cogeneration mode,for the same boiler load,the CHP operation increases the plant unit’s operating profit with increasing district-heating duty,although the relative profit gain from the CHP cogeneration could start to decrease when the district-heating steam-extraction flow increases to a certain point that varies depending on the market prices of heat and electricity,while the fuel cost was found to be equivalent to~50% of the unit’s total CHP income cogenerated from its electricity and district heat outputs. | Bin Xu June Wang Xinping Wang Zhihong Liang Liming Cui Xiao Liu Anthony Y.Ku | 2019 | Clean Energy2019，3，3： | 1 |
| 11 | Learning style, learning patterns, and learning performance in a WebCT-based MIS course显示文摘 | June Lu Chun Sheng Yu & Chang Liu (2003) | 2003 | Information & Management2003，6，40： | 1 |
| 12 | Determinants of accepting wireless mobile data services in China显示文摘 | June Lu Chang Liu Chun-Sheng Yu Kanliang Wang | 2007 | Information & Management2007，，1： | 1 |
| 13 | A New Variant of Penalty Method for Weak Linear Bilevel Programming Problems显示文摘我们在场为解决弱线性上下两层的编程问题的惩罚方法的新变体,与存在惩罚方法不同,。我们然后用 Kuhn 衣领 optimality 状况把它转变成一个单人赛级的优化问题并且讨论在他们之间的关系。最后,二个例子被用来说明建议惩罚方法的可行性。 | LIU June HONG Yunfei ZHENG Yue | 2018 | Wuhan University Journal of Natural Sciences2018，23，4： | 1 |
| 14 | Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation显示文摘有最大的反肿瘤活动的 T 房间的产生将显著地影响 T-cell-based 采纳免疫疗法的地。在这份报告,我们发现 OKT3/IL-2-stimulated T 房间是 phenotypically 更异构,与在 vitro 的提高的反肿瘤活动并且当局部地在一只稳固的肿瘤老鼠管理了时,当模特儿。为了推进,改进生产过程的 OKT3/IL-2-based T 房间,我们开发了外部血 mononuclear 房间在是有编码对 CD3 和 CD28 和 4-1BB (OKT3-28BB ) 的细胞内部的领域由单个链的可变碎片组成的妄想的膜蛋白质的 mRNA 的 electroporated 的新奇 T 房间刺激和扩大方法。扩展 T 房间 phenotypically 并且机能上地类似于房间由 OKT3/IL-2 扩展了的 T。而且, CD86 和 4-1BBL 的 co-electroporation 能进一步改变显型并且提高在里面 vivo 反肿瘤活动。尽管 T 房间与 CD86 由 OKT3-28BB 的 co-electroporation 膨胀了, 4-1BBL 显示出增加的中央记忆显型, T 房间仍然维持了肿瘤 lysin 的活动同样多象那些一样 OKT3/IL-2 或 OKT3-28BB-stimulated T 房间。在不同肿瘤老鼠模型, OKT3-28BB RNA electroporation 扩展的 T 房间显示出 OKT3/IL-2 T 房间的比那些优异的反肿瘤活动。因此,有少些区分的显型和有势力的 T 房间杀死能力的肿瘤能被 RNA electroporation,和生产过程的这个 T 房间产生能被简单地共同交付进一步优化其它 RNA 拼接,因此为为采纳免疫疗法产生高质量的 T 房间提供一个简单、划算的方法。 | Xiaojun Liu Shuguang Jiang Chongyun Fang Hua Li Xuhua Zhang Fuqin Zhang Carl H. June Yangbing Zhao | 2017 | Protein & Cell2017，8，7： | 1 |
| 15 | HASBE: A Hierarchical Attribute-Based Solution for Flexible and Scalable Access Control in Cloud Computing显示文摘 | WAN Zhiguo LIU June DENG R H | 2012 | IEEE Transactions on Information Forensics and Security2012，7，2： | 1 |
| 16 | Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults显示文摘 | Ulla A. Hvidtfeldt Janne S. Tolstrup Marianne U. Jakobsen Berit L. Heitmann Morten Gr?nb?k Eilis O?Reilly Katarina B?lter Uri Goldbourt G?ran Hallmans Paul Knekt Simin Liu Mark Pereira Pirjo Pietinen Donna Spiegelman June Stevens Jarmo Virtamo Walter C. W | 2010 | Circulation2010，，14： | 1 |
| 17 | A Detection Method of WLAN Security Mechanisms Based on MAC Frame Resolution显示文摘Security mechanism detection is not only an important content of vulnerabilities evaluation but also the foundation of key strength test for wireless local area network(WLAN). This paper analyzes the specifications of WLAN security mechanisms and points out the defects in design of security mechanisms detection algorithm based on the standards. By capturing and analyzing a large number of Beacon frames from different vendor's access points(APs),we summarize the relevant fields and information elements in a Beacon frame,and present their values or status when an AP is set to every specific security mechanism. A detection algorithm of WLAN security mechanisms is proposed based on the experimental study result and the pseudo code of a reference implementation for the algorithm is designed. The validity of the algorithm is illustrated by examples,which shows it can detect every WLAN security mechanism accurately. | LI June YUAN Kai ZHOU Liang HAN Lifang LI Ling WANG Zhihao LIU Yinbin HUANG Wenbin | 2017 | Wuhan University Journal of Natural Sciences2017，22，2： | 1 |
| 18 | Beyond Concern:A Privacy-trust-behavioral Intention Model of Electronic Commerce显示文摘 | Liu C Jack T M June L Chun-Sheng Yu | 2004 | Information & Management2004，42，1： | 1 |
| 19 | Technology acceptance model for wireless Internet显示文摘 | June Lu Chun-Sheng Yu Chang Liu James E. Yao | 2003 | Internet Research2003，，： | 1 |
| 20 | Determinants of Accepting Wireless Mobiles data Service in China显示文摘 | June Lu Chang Liu Chun - Sheng Yu Kanliang Wang | 2008 | Information and Management2008，，： | 1 |
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