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| 1 | Complications in the management of metastatic spinal disease显示文摘Metastatic spine disease accounts for 10% to 30% of new cancer diagnoses annually. The most frequent presentation is axial spinal pain. No treatment has been proven to increase the life expectancy of patients with spinal metastasis. The goals of therapy are pain control and functional preservation. The most important prognostic indicator for spinal metastases is the initial functional score. Treatment is multidisciplinary, and virtually all treatment is palliative. Management is guided by three key issues; neurologic compromise, spinal instability, and individual patient factors. Site-directed radiation, with or without chemotherapy is the most commonly used treatment modality for those patients presenting with spinal pain, causative by tumours which are not impinging on neural elements. Operative intervention has, until recently been advocated for establishing a tissue diagnosis, mechanical stabilization and for reduction of tumor burden but not for a curative approach. It is treatment of choice patients with diseaseadvancement despite radiotherapy and in those with known radiotherapy-resistant tumors. Vertebral resection and ante-rior stabilization with methacrylate or hardware(e.g., cages) has been advocated.Surgical decompression and stabilization, however, along with radiotherapy, may provide the most promising treatment. It stabilizes the metastatic deposited areaand allows ambulation with pain relief. In general, patients who are nonambulatory at diagnosis do poorly, as do patients in whom more than one vertebra is involved. Surgical intervention is indicated in patients with radiation-resistant tumors, spinal instability, spinal compression with bone or disk fragments, progressive neurologic deterioration, previous radiation exposure, and uncertain diagnosis that requires tissue diagnosis. The main goal in the management of spinal metastatic deposits is always palliative rather than curative, with the primary aim being pain relief and improved mobility. This however, does not come without complications, regardless of the surgical intervention technique used. These complication range from the general surgical complications of bleeding, infection, damage to surrounding structures and post operative DT/PE to spinal specific complications of persistent neurologic deficit and paralysis. | Eilis Catherine Dunning Joseph Simon Butler Seamus Morris | 2012 | World Journal of Orthopedics2012，3，8： | 8 |
| 2 | Central CB2 receptors in inflammation-driven neurodegeneration: dysregulation and therapeutic potential显示文摘In recent times there has been an intensification of interest in the pathological role of neuroinflammation in neurodegenerative disease.Neuroprotective strategies to slow,halt or reverse neurodegeneration have not proven fruitful clinically,and the notion of a multi-hit hypothesis in the progression of neurodegenerative disease has steered focus towards other contributory | Ruth M. Concannon Eilis Dowd | 2016 | Neural Regeneration Research2016，11，9： | 4 |
| 3 | The clinical significance of adhesions;focus on intenstional obstruction显示文摘 | Eilis H | 1997 | Eur J Surg Suppl1997，，557： | 1 |
| 4 | Basal like breast cancer: a criti- cal review 显示文摘 | Rakha EA Reis-Filhn JS Eilis IO | 2008 | J Clin Oncol2008，26，15： | 1 |
| 5 | Rigid fixation of mandibular condylar fractures 显示文摘 | EIlis E Dean J | 1993 | Oral Surg Oral Med Oral Pathol1993，76，1： | 1 |
| 6 | The ‘re-do' chest wall deformity correction显示文摘 | Eilis DG Snyder CL Mann CM | | 0，，： | 1 |
| 7 | Vital Signs: Carbapenem-Resistant Enterobacteriaceae显示文摘 | Jacob Jesse T Klein Eili Laxminarayan Ramanan Beldavs Zintars Lynfield Ruth Kallen Alexander J Ricks Philip Edwards Jonathan Srinivasan Arjun Fridkin Scott Rasheed J Kamile Lonsway David Bulens Sandie Herrera Rosa McDonald L Clifford Patel | 2013 | MMWR Morbidity and Mortality Weekly Report2013，，9： | 1 |
| 8 | 欧盟法律框架下的股本证券国际发行显示文摘肇始于20世纪80年代的股本证券国际发行,曾几何时美国市场风光无限,然萨班斯法案对公司治理义务的强化,加之技术、投资者信心、流动性等各方面因素的影响,美国市场不再风光旖旎,但股本证券国际发行市场的监管竞争却不断推动着监管制度的趋同化:国际财务报告标准在欧洲的适用、2007年美国SEC允许外国私人发行人适用国际财务报告标准、部分国家的相互认可协议等一系列监管制度的趋同做法都为股本证券的国际发行监管框架的建立奠定基础。本文全面分析了欧盟法律框架下的股本证券国际发行制度:《招股说明书指令》的适用与豁免、《透明度义务指令》的民事责任、欧洲证券监管机构委员会的同行评估与同行压力及对证券监管全球发展的观察等,并对有关国外发行人在美国公开发行与获取上市的法律加以概述,为两大经济体在股本证券国际发行制度方面的趋同提供了规范的分析路径。 | Eilis Ferran 罗培新 | 2011 | 证券法苑2011，，2： | 1 |
| 9 | A double-blind comparison Of nefazodone,imipramine,an placebo in major depression显示文摘 | Fontaine R Ontiveros A Eilie R | 1994 | Clin Psychiatry1994，55，6： | 1 |
| 10 | Transthoracic echocardiographic predictors of left atrial appendage thrombus显示文摘 | EIlis K Ziada KM Vivekananthan D | 2006 | Am J Cardiol2006，97，3： | 1 |
| 11 | Postoperative Anemia and Quality of Life After Primary Hip Arthroplasty in Patients Over 65 Years Old显示文摘 | Niamh P. Conlon Eilis P. Bale G Peter Herbison Maire McCarroll | 2008 | Anesthesia & Analgesia2008，，4： | 1 |
| 12 | Smoking and Parkinson'sdisease:using parental smoking as a proxy to explorecausality 显示文摘 | Eilis J O^Reilly Chen H | 2009 | Am J Epidemiol2009，，： | 1 |
| 13 | Sindbis Virus Infection in Resident Birds, Migratory Birds, and Humans, Finland 显示文摘 | Satu Kurkela Osmo Ratti Eili Huhtamo | | Emerging Infectious Diseases0，14，1： | 1 |
| 14 | The Thermogel Chronicle——From Rational Design of Thermogelling Copolymers to Advanced Thermogel Applications显示文摘CONSPECTUS:Temperature responsive supramolecular hydrogels,also known as thermogels,are produced by the self-assembly of amphiphilic copolymers in solution following temperature stimulus.They are a class of high caliber novel materials possessing highly attractive properties such as injectability,ability to undergo temperature controlled reversible sol−gel phase transitions,high biocompatibility,and tunable biodegradability.Much research vigor has been dedicated to designing advanced amphiphilic copolymers and investigating their molecular interactions in order to enhance the properties of the thermogelling systems and expand the scope of their applications.As such,thermogelling systems have since become well established in the field of sustained localized drug or protein delivery and have also been demonstrated as high potential materials for niche applications such as threedimensional cell culture,wound healing patches,and vitreous endotamponades.Recent developments saw the advent of thermogelling systems with advanced biomedical applications ranging from enhanced cancer therapy to radiology imaging to tissue engineering,and these are usually achieved by the conjugating of biologically relevant molecules such as drugs and peptides to the thermogel copolymer or by incorporating nanoparticles into the thermogel systems.New developments in this field see a shift away from employing traditional synthetic polymers such as polypropylene glycol(PPG)and poly(lactic-co-glycolic acid)(PLGA)to utilizing more advanced nature-derived bioactive molecules and also introducing chiral moieties in the thermogelling copolymer backbone. | Qianyu Lin Cally Owh Jason Y.C.Lim Pei Lin Chee Michelle P.Y.Yew Eilis T.Y.Hor Xian Jun Loh | 2021 | Accounts of Materials Research2021，2，10： | 1 |
| 15 | Psoriasis advances in understanding its pathogenesis and treatment显示文摘 | Krueger G EIlis CN | 2005 | J Am Acad Dermatol2005，53，1： | 1 |
| 16 | The East Timor Issue in the Context of EU Indonesia Relations,1975-99显示文摘 | Peter Carey | 2001 | Indonesia and The Malay World2001，24，83： | 1 |
| 17 | Aneurysmal bone cyst of the maxilla显示文摘 | Eilis DJ Walters PT | 1972 | Oral Surg Oral Med Oral Pathol1972，34，1： | 1 |
| 18 | A double blind Comparisonof nafazodone,and placebo in major depression显示文摘 | Fontaine K Ontiveros A Eilie K | 1994 | Olin psychia-try1994，55，： | 1 |
| 19 | Expression of CD44R1 adhesion molecule in colon carcinomas and metastasis 显示文摘 | Tanabe KK EIlis LM Saya H | 1993 | Lancet1993，341，8847： | 1 |
| 20 | Relationship between acid tolerance, cytoplasmic pH, and ATP and H^+ -ATPase levels in chemostat cultures of Lactococcus lactis 显示文摘 | EILIS Osullivan SEAMUS Condon | 1999 | Applied and Environmental Microbiology1999，65，6： | 1 |
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