|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances and Trends on Tube Bending Forming Technologies显示文摘作为有庞大的数量和差异的一个种关键部件,弄弯的试管部分从材料和结构方面为无足轻重的人和高张力产品满足增加的需要。弄弯的试管广泛地在象航空,太空,造船,汽车,精力和护理那样的许多高端工业被使用了。弯曲的试管成为了为小产品形成生产技术的钥匙之一。经由把特征和多重缺点弄弯的分析,在试管弯曲探索普通问题上的进展在穹隆之内面关于起皱的不稳定性被总结,墙变瘦(裂开) 在拱背, springback 现象,剖面图变丑,形成的限制和过程 / 工具设计 / 优化。一些当前发达的弯曲技术以他们的优点和限制被考察。最后,鉴于高效的建筑群的迫切要求,在航空与 difficult-to-deform 和小材料把试管部件弄弯,太空域,发展趋势和相应挑战为认识到把变丑弄弯的精确、高效率的试管被介绍。 | YANG He LI Heng ZHANG Zhiyong ZHAN Mei LIU Jing LI Guanjun | 2012 | Chinese Journal of Aeronautics2012，25，1： | 86 |
| 2 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 3 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 4 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 5 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 6 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 7 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 8 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 9 | China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations显示文摘China faces the greatest challenge from stroke in the world.The death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in 2018.It ranked third among the leading causes of death behind malignant tumours and heart disease.The age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,respectively.According to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in 2017.The absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in 2017.The main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over time.Based on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco products.For those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during 2018.Of those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age of patients admitted was 66 years old,and nearly 60%were male.A total of 1555(0.1%),2774(0.6%)and 1347(1.4%)paediatric strokes(age<18 years)were identified among IS,ICH and SAH,respectively.Over one-third(1063892(35.3%))of the patients were covered by urban resident basic medical insurance,followed by urban employee basic medical insurance(699513(23.2%))and new rural cooperative medical schema(489361(16.3%)).The leading risk factor was hypertension(67.4%for IS,77.2%for ICH and 49.1%for SAH),and the leading comorbidity was pneumonia or pulmonary infection(10.1%for IS,31.4%for ICH and 25.2%for SAH).In-hospital death/discharge against medical advice rate was 8.3%for stroke inpatients,ranging from 5.8%for IS to 19.5%for ICH.The median and IQR of length of stay was 10.0(7.0-14.0)days,ranging from 10.0(7.0-13.0)in IS to 14.0(8.0-22.0)in SAH.Data from the Chinese Stroke Center Alliance demonstrated that the composite scores of guideline-recommended key performance indicators for patients with IS,ICH and SAH were 0.77±0.21,0.72±0.28 and 0.59±0.32,respectively. | Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 181 |
| 10 | The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer显示文摘China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. | Feng-Hua Wang Lin Shen Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li Qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long Guan Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 127 |
| 11 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 12 | Early Oligocene anatexis in the Yardoi gneiss dome,southern Tibet and geological implications显示文摘The Yardoi gneiss dome is located to the easternmost of the North Himalayan Gneiss Dome (NHGD),southern Tibet. It consists of metapelite,garnet amphibolite,granite and leucogranite,and is a key subject to constrain the formation and tectonic evolution of NHGD. SHRIMP zircon U/Pb data on the leucogranite yield an age of 35.3±1.1 Ma,which is substantially older than that of the similar leu-cogranites to the west. Sr and Nd isotope systematics indicate that this leucogranite was derived from partial melting of the mixed garnet amphibolite and metapelite. Our data suggest that (1) during the early stage of Himalayan magmatism,amphibolite dehydration melting overwhelmed that of the metapelite; and (2) such a melting at middle-lower crust might be a major factor that initiated the movement along the Southern Tibetan Detachment System (STDS). | ZENG LingSen LIU Jing GAO LiE XIE KeJia WEN Li | 2009 | Chinese Science Bulletin2009，54，1： | 61 |
| 13 | Clinical characteristics, diagnosis and management of respiratory distress syndrome in full-term neonates显示文摘然而,背景呼吸悲痛症候群(RDS ) 是新生的呼吸失败和新生的死亡的最普通的原因之一它的临床的特征与早熟的 RDS,和这些特征很不同很好没迄今为止被记录。这研究是在完整术语的出生不满一月的婴儿调查致病,临床的特征和 RDS 的管理策略,与开发为改进在有 RDS.Methods 的完整术语的出生不满一月的婴儿的结果的一个工作协议的目的有 RDS 的 125 个完整术语的婴儿的一个总数在这研究被注册。他们的临床并且实验室数据为分析 125 个案例包括了的完整术语的新生的 RDS.Results (1 ) 的特征被收集 94 男性和 31 个女婴儿,阴道交货在 45 种情况中发生在 80 种情况和剖腹产中。(2 ) RDS 的发作时间是(3.11 牧潯敶吗? | LIU Jing SHI Yun DONG Jian-ying ZHENG Tian LI Jing-ya LU Li-li LIU Jing-jing LIANG Jing ZHANG Hao FENG Zhi-chun | 2010 | Chinese Medical Journal2010，，19： | 79 |
| 14 | Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway显示文摘绝经后的骨质疏松症严重地使受危险人的健康。没有副作用,寻找治疗学的药必要性大。我们的学习被设计调查是否 resveratrol, SIRT1 的收缩筋,能在骨质疏松症上并且到有有利效果探索内在的机制。老鼠骨质疏松症模型(卵巢切除术组, OVX ) 被双边的卵巢切除术建立。resveratrol 的三不同剂量被使用:5 mg/kg/d (低剂量,物件 LD ), 25 mg/kg/d (开媒介,物件 MD ), 和 45 mg/kg/d (开高度,物件 HD ) 。结果显示出那物件 LD 没在 OVX 改变上显示出任何重要效果,当时物件 MD 和物件 HD 显著地提高了骨质疏松症导致的减少的骨头矿物质密度(物件 MD 0.205 吗? | Jing Feng Shuai Liu Sai Ma Jian Zhao Wei Zhang Wei Qi Pengchong Cao Zheng Wang Wei Lei | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 70 |
| 15 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 16 | Detection of serum TNF-α,IFN-γ,IL-6 and IL-8 in patients with hepatitis B显示文摘NTRODUCTIONSinceMuto[1]reportedthatTNFαandIL1wererelatedtofulminanthepatitis,thestudiesontherelationshipbetweencytokinesa... | WANG Jing Yan, WANG Xue Lian and LIU Pei | 1999 | World Journal of Gastroenterology1999，5，1： | 54 |
| 17 | 针刺太冲穴得气及疼痛激发相对抗的脑功能网络效应fMRI研究显示文摘目的:采用磁共振脑功能成像技术,比较针刺太冲穴得气及针刺疼痛时所激发的脑功能网络效应异同。方法:47例初次接受针刺的志愿者参加手针右侧太冲穴fMRI实验。针刺时脑fMRI扫描10min,共2次捻针,各2min,间隔3min。其中17例接受体表触觉刺激作为针刺对照,分为3组:①针刺得气组;②针刺得气合并尖锐性疼痛组(简称针刺疼痛组);③触觉对照组。采用Fisher’s精确检验和t检验分析感觉频率及强度;用AFNI处理fMRI数据,得到激活、负激活脑区;用种子相关分析法,以前扣带回膝部为种子点,分析其与全脑的功能网络联系图谱,并比较得气与疼痛组之间的差异。结果:针刺2组的酸痛、酸感、压感、麻感、钝痛等得气感觉的频率和强度均明显强于触觉刺激组;针刺2组间除尖锐性疼痛及酸痛外,各种感觉差异无统计学意义。针刺得气及疼痛2组均激活了体感及丘脑岛叶皮层,重要的是,针刺得气时在大脑边缘叶-旁边缘叶-新皮层系统(LPNN)产生了较强而广泛的负激活区,加强了负激活区之间的脑功能网络联系。此网络包括杏仁核、海马、旁海马、颞极、前额叶腹内侧回、前扣带回膝及下部、前楔叶内侧回和后扣带回(BA31,23_腹侧核,29,30),另外,小脑蚓部、导水管周围灰质及脑干网状结构也见负激活现象。然而,在针刺疼痛时,这些脑区负激活程度减低且区域缩小,大部分脑区fMRI信号逆转为激活信号,被疼痛激活的脑区之间功能网络明显增强。这些脑区参与了疼痛、镇痛(如感觉、情感、认知、自主性、内源性镇痛)功能调制环路。结合既往研究表明,负激活与脑血氧消耗及血流量下降呈正相关。本结果支持针刺通过调制LPNN和疼痛中枢网络的活动,产生其镇痛、抗焦虑和其他调节效应的假说。结论:针刺得气及针刺得气伴随疼痛产生了相对抗的脑功能网络效应。针刺得气对LPNN及疼痛脑中枢网络(Pain matrix)的负激活效应,可能与针刺镇痛脑中枢机制相关。LPNN和静息态默认网络(Default mode)之间的相似性,提示针刺需通过这一内在脑功能网络系统发挥其广泛的调制作用。 | 方继良 Hui KS Kathleen Liu Jing Nixon Erika 周科华 王小玲 朱兵 | 2012 | 中国中西医结合影像学杂志2012，10，1： | 52 |
| 18 | Validity of Asthma Control Test in Chinese patients显示文摘在中国,背景到目前为止在那里有不是有效或容易的过程定义气喘的控制。这研究估计中国 patients.Methods 的气喘控制测试的有效性三张问询表(气喘控制测试,气喘控制问询表和 30 第二气喘测试) 越过中国从 10 所教学医院予 305 个气喘病人被以。呼吸量测定法也被使用。气喘专家在第一秒根据病人的症状,药和强迫的吐气的体积评估了气喘的控制。病人被划分成 noncontrolled 组并且根据专家的 rating.Reliability,实验有效性和屏蔽精确性控制了组为气喘控制测试分数被进行。屏蔽精确性在 3 张问询表之中被比较。病人的自我等级和专家正在评价也是 5 条款气喘控制测试的内部一致性可靠性是的 compared.Results 0.854。测试和专家正在评估的在气喘控制之间的关联系数是 0.729,它比另外的仪器高。在一些在预言的百分比不同的病人之间区别的气喘控制测试分数在第一秒强迫了吐气的体积(F=26.06, P0.0001 ) ,专家气喘控制的等级(F=88.24, P0.0001 ) 并且气喘控制问询表分数(F=250.57, P0.0001 ) 。气喘控制测试没在正确地分类的百分比与气喘控制问询表显示出重要差别,当百分比正确地分类由时气喘控制测试比 30 第二气喘测试高得多。病人的自我等级与对专家的评价一样(t=0.65, P=0.516 ) 气喘控制测试是的 .Conclusion 为在中国估计气喘控制的一个有效、适用的方法。 | ZHOU Xin DING Feng-ming LIN Jiang-tao YIN Kai-sheng CHEN Ping HE Quan-ying SHEN Hua-hao WAN Huan-ying LIU Chun-tao LI Jing WANG Chang-zheng | 2007 | Chinese Medical Journal2007，，12： | 46 |
| 19 | Plasma exchange-centered artificial liver support system in hepatitis B virus-related acute-onchronic liver failure:a nationwide prospective multicenter study in China显示文摘BACKGROUND:Plasma exchange(PE)-centered artificial liver support system reduced the high mortality rate of hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).But the data were diverse in different medical centers.The present prospective nationwide study was to evaluate the effects of PE on patients with HBV-ACLF at different stages.METHODS:From December 2009 to December 2011,we evaluated 250 patients at different stages of HBV-ACLF from 10 major medical centers in China.All the laboratory parameters were collected at admission,before and after PE.RESULTS:Among the 250 patients who underwent 661 rounds of PE,one-month survival rate was 61.6%; 141(56.4%) showed improvement after PE.Variables such as age(P=0.000),levels of total bilirubin(TB,P=0.000),direct bilirubin(P=0.000),total triglycerides(P=0.000),low-density lipoprotein(P=0.022),Na+(P=0.014),Cl–(P=0.038),creatinine(Cr,P=0.007),fibrinogen(P=0.000),prothrombin time(PT,P=0.000),white blood cell(P=0.000),platelet(P=0.003) and MELD(P=0.000) were significantly related to prognosis.Multivariate logistic regression analysis showed that age,disease stage,TB,Cr and PT levels were independent risk factors of mortality among HBV-ACLF patients.CONCLUSIONS:PE can improve the clinical outcome of patients with HBV-ACLF.Levels of TB,Cr and PT,age and disease stage help to predict prognosis. | Jia-Jia Chen Jian-Rong Huang Qian Yang Xiao-Wei Xu Xiao-Li Liu Shao-Rui Hao Hui-Fen Wang Tao Han Jing Zhang Jian-He Gan Zhi-Liang Gao Yu-Ming Wang Shu-Mei Lin Qing Xie Chen Pan Lan-Juan Li | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 48 |
| 20 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
您所在的机构暂未开通此部分的功能，请联系管理员