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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 4 | Occurrence and properties of flavor-related bromophenols found in the marine environment: a review 显示文摘 | Boyle J L Lindsay R C Stuiber D A | 1993 | J Aquat Food Prod Technol1993，2，： | 2 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | A new Lagrangian model of Arctic sea ice显示文摘 | LINDSAY R W STERN H L | 2004 | Journal of Physical Oceanography2004，34，： | 1 |
| 7 | Anti-Rho(D) in two Rh positive receiving kidney grafts from an Rh immunized donor显示文摘 | Ramsey G Israel L Lindsay G | | 0，，01： | 1 |
| 8 | Development of a DTPA Soil Test for Zinc,Iron,Manganese,and Copper显示文摘 | LINDSAY W L NORVELL W A | 1978 | Soil Sci Am J1978，42，： | 1 |
| 9 | The solubility relationships of calcium and magnesium minerals in processed oil shales显示文摘 | Reddy K J Lindsay W L | 1986 | Journal of En- vironmental Quality1986，15，1： | 1 |
| 10 | Seven Strategies for Enabling Faculty Success in Distance Education显示文摘 | Farhad Saba Nathan K Lindsay | 2004 | Internet and Higher Education2004，，7： | 1 |
| 11 | Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis显示文摘 | Koshiol J Lindsay L Pimenta JM | 2008 | Am J Epidemiol2008，168，： | 1 |
| 12 | Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions:a meta-analysis update显示文摘 | Smith JS Lindsay L Hoots B | 2007 | Int J Cancer2007，121，3： | 1 |
| 13 | Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update显示文摘 | Smith JS Lindsay L Hoots B | 2007 | IntJ Cancer2007，121，3： | 1 |
| 14 | Medical perspectives on autism spetrum disorders显示文摘 | Lindsay | 2005 | Seminars in Hearing2005，26，4： | 1 |
| 15 | Development of a DTPA soil test for zinc,iron,manganese,and copper显示文摘 | Lindsay W L Norven W A | 1978 | Soil Science Society of America Journal1978，42，： | 1 |
| 16 | Development of a DTPA soil test forzine,iron,manganese and copper soil显示文摘 | LINDSAY W L NORVELL W A | 1978 | Sci Soc Am J1978，42，： | 1 |
| 17 | Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis:a paired biopsy study显示文摘 | Dempster DW Cosman F Kurland ES Zhou H Nieves J Woelfert L Shane E Plavetic K Muller R Bilezikian J Lindsay R | | 0，，10： | 1 |
| 18 | The RADARSAT geophysical processor system: quality of sea ice trajectory and deformation estimates显示文摘 | Lindsay W Stern R H L | 2003 | Journal of Atmospheric and Oceanic Technology2003，20，9： | 1 |
| 19 | Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions:a meta-analysis update显示文摘 | SMITH J S LINDSAY L HOOTS B | 2007 | Int J Cancer2007，121，3： | 1 |
| 20 | Development of DTPA soil test for zinc, iron, manganese and copper 显示文摘 | LINDSAY W L W L NORVELL | 1978 | Soil Science Society of America Journal1978，42，： | 1 |
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