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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | A new Lagrangian model of Arctic sea ice显示文摘 | LINDSAY R W STERN H L | 2004 | Journal of Physical Oceanography2004，34，： | 1 |
| 3 | Optical-cell evidencefor superheated ice under gas-hydrate-forming Conditions显示文摘 | STERN L A DAVID L H DURHAM W B | 1998 | Journal of Physical Chemistry1998，102，： | 1 |
| 4 | The RADARSAT geophysical processor system: quality of sea ice trajectory and deformation estimates显示文摘 | Lindsay W Stern R H L | 2003 | Journal of Atmospheric and Oceanic Technology2003，20，9： | 1 |
| 5 | Diagnostic accuracy of TRODAT-1 SPECT imaging in early Parkinson's disease显示文摘 | Chou K L Hurtig H I Stern M B | 2004 | Parkinsonism & Related Disorders2004，10，6： | 1 |
| 6 | D&O insurance and IPO performance:What can we learn from insurers? 显示文摘 | Boyer M M Stern L H | 2014 | Journal of Financial Intermediation2014，23，4： | 1 |
| 7 | Endometrial carcinoma staging byMR imaging显示文摘 | Hricak H Stern J L Fisher M R | 1987 | Radiology1987，162，2： | 1 |
| 8 | Spatial scaling of Arctic sea ice deformation显示文摘 | Stern H L Lindsay R W | 2009 | Journal of Geophysical Research: Oceans2009，114，10017： | 1 |
| 9 | The Chlamydomonas reinhardtii plastid chromosome:islands of genes in a sea of repeats显示文摘 | MAUL J E LILLY J W CUI L DE PAMPHILIS C W MILLER W HARRIS E H STERN D B | 2002 | Plant Cell2002，14，11： | 1 |
| 10 | Zebrafish as a cancer model system 显示文摘 | Amatruda J F Shepard J L Stern H M | 2002 | Cancer Cell2002，1，3： | 1 |
| 11 | Examining the out-of-center distortion in the ^2- anion 显示文摘 | IZUMI H K KIRSCH J E STERN C L | 2005 | Inorg Chem2005，44，4： | 1 |
| 12 | Polycrystalline methane hydrate : synthesis from superheated ice, and low-temperature mechanical properties显示文摘 | Stern L Kirby S H | 1998 | Energy & Fuels1998，12，： | 1 |
| 13 | 查看详情显示文摘 | Woo J H Treu T Barth A J Wright S A Walsh J L Bentz M C Martini P Bennert A N Canalizo G Filippenko A V Gates E Greene J Malkan M A Stern D Minezaki T | | 0，，： | 1 |
| 14 | Anxiety, pregnancy, labor and the neonate显示文摘 | Burstein I Kinch R A H Stern L | 1974 | American Journal of Obstetric Gynaecoloy1974，118，2： | 1 |
| 15 | Electrochemical pretreat- ment of carbon electrodes as a function of potential, pH, and time 显示文摘 | Beilby A L Sasaki T A Stern H M | 1995 | Anal Chem1995，67，5： | 1 |
| 16 | Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES) 显示文摘 | Kramer U Sagi L Goldberg - Stern H | 2009 | Epilepsia2009，50，6： | 1 |
| 17 | A new Lagrangian model of arctic sea ice显示文摘 | LINDSAY R W STERN H L | 2004 | J Phys Oceanography2004，34，1： | 1 |
| 18 | Peculiarities of methane clathrate hydrate formation and solid-state deformation, including possible superheating of water ice显示文摘 | Stern L Kirby S H Dorbam W B | 1996 | Science1996，273，： | 1 |
| 19 | Temperature, pressure, and compositional effects on anomalous or 'self' preservation of gas hydrates 显示文摘 | Stern L A Circone S Kirby S H Durham W B | 2003 | Canadian Journal of Physics2003，81，12： | 1 |
| 20 | The role of water in gas hydrate dissociation 显示文摘 | Circone S Stern L A Kirby S H | 2004 | The Journal of Physical Chemistry B2004，108，18： | 1 |
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