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| 1 | Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future. | Penny L Jeffery Michael A McGuckin Sara K Linden | 2011 | World Journal of Gastroenterology2011，17，10： | 12 |
| 2 | Second harmonic generation spectroscopy on hybrid plasmonic/dielectric nanoantennas显示文摘Plasmonic nanoantennas provide unprecedented opportunities to concentrate light fields in subwavelength-sized volumes.By placing a nonlinear dielectric nanoparticle in such a hot spot,one can hope to take advantage of both the field enhancement provided by nanoantennas and the large,nonlinear optical susceptibility of dielectric nanoparticles.To test this concept,we combine gold gap nanoantennas with second-order,nonlinear zinc sulfide nanoparticles,and performsecond harmonic generation(SHG)spectroscopy on the combined hybrid dielectric/plasmonic nanoantennas as well as on the individual constituents.We find that SHG from the bare gold nanoantennas,even though it should be forbidden due tosymmetry reasons,is several orders ofmagnitude larger than that of the bare zinc sulfide nanoparticles.Even stronger second harmonic signals are generated by the hybrid dielectric/plasmonic nanoantennas.Control experiments with nanoantennas containing linear lanthanumfluoride nanoparticles reveal;however,that the increasedSHG efficiency of the hybrid dielectric/plasmonic nanoantennas does not depend on the nonlinear optical susceptibility of the dielectric nanoparticles but is an effect of the modification of the dielectric environment.The combination of a hybrid dielectric/plasmonic nanoantenna,which is only resonant for the incoming pump light field,with a second nanoantenna,which is resonant for the generated second harmonic light,allows for a further increase in the efficiency of SHG.As the second nanoantenna mediates the coupling of the second harmonic light to the far field,this double-resonant approach also provides us with control over the polarization of the generated light. | Heiko Linnenbank Yevgen Grynko Jens Förstner Stefan Linden | 2016 | Light(Science & Applications)2016，5，1： | 7 |
| 3 | Attenuation of gastric mucosal inflammation induced by aspirin through activation of A_(2A) adenosine receptor in rats显示文摘瞄准:决定特定的腺苷 A (2A ) 受体收缩筋(ATL-146e ) 是否能改善在老鼠的导致阿司匹林的胃的粘膜损害,和还原剂 neutrophil 累积和支持 inflammatory cytokines.METHODS 的生产:胃的损害被阿司匹林(200 mg/kg ) 和 HCl 的口头的管饲法生产(0.15 mol/L, 8.0 mL/kg ) 。4-{3-[6-Amino-9-(5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl )-9H- purin-2-yl ]-prop-2-ynyl}-cyclohexanecarboxylic 酸甲基酉旨(ATL-146e, 2.5-5 mug/kg, IP ) 被注射在阿司匹林的管理前的 30 min。在胃粘膜的织物 myeloperoxidase (军邮局) 集中作为嗜中性的渗入的一个索引被测量。肿瘤坏死 factor-alpha (TNF-alpha ) 和 interleukin-1beta (IL-1beta ) 的胃的粘膜集中被 ELISA 决定。另外,我们在织物上检验了 ATL-146e 的效果前列腺素E-2(PGE2 ) 生产和胃的 secretion.RESULTS:阿司匹林的胃内管理在老鼠胃粘膜导致了多重出血性的侵蚀。在控制老鼠的胃的侵蚀(溃疡索引) 的全部的长度是 29.8+/-7.75 公里并且与 5.0 g/kg ATL-146e (P<0.01 ) 在预告的处理以后被归结为 3.8+/-1.42 公里。军邮局和支持 inflammatory cytokines 的胃的内容都在阿司匹林的管理以后被增加并且由 ATL-146e 归结为将近正常的层次。胃的粘膜 PGE2 集中没被 ATL-146e.CONCLUSION 的腹膜内注射影响:特定的腺苷 A (2A ) 受体收缩筋, ATL-146e,有势力反溃疡效果大概由它的反煽动性的性质调停了。 | MasaruOdashima MichiroOtaka MarioJin KogaKomatsu IsaoWada YouheiHorikawa TamotsuMatsuhashi NatsumiHatakeyama JinkoOyake ReinaOhba SumioWatanabe Joel Linden | 2006 | World Journal of Gastroenterology2006，12，4： | 5 |
| 4 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 5 | CPB的冠脉手术病人主要麻醉方法的选择影响术后ICU住院时间显示文摘 | Stefan G.De Hert Philippe J.Van der Linden Stefanie Cromheecke Roel Meeus Pieter W.ten Broecke Ivo G.De Blier Bernard A.tockman Inez E.Rodrigus 刘功俭(译) 曾因明(审) | 2004 | 国外医学(麻醉学与复苏分册)2004，25，4： | 4 |
| 6 | DNA damage-induced cell death: lessons from the central nervous system显示文摘脱氧核糖核酸损坏不能,但是总是,导致房间死亡。当连接脱氧核糖核酸的几条小径损坏信号到线粒体依赖者,独立死亡机械被阐明了时,这些小径的连接由多重其它服从于规定不好的因素理解。我们建议了二个概念的模型解释推迟并且对脱氧核糖核酸的可变房间死亡反应损坏:综合监视对自治小径。在这评论,我们讨论这二个模型怎么可以解释在死亡反应被辐射剂量,房间周期地位和 neuronal 开发调整的地方,离子辐射(红外) 在发展中的中枢神经系统导致的房间死亡的体内规定。 | Helena Lobo Borges Rafael Linden Jean YJ Wang | 2008 | Cell Research2008，18，1： | 4 |
| 7 | Surface functionalized N-C-TiO_(2)/C nanocomposites derived from metal-organic framework in water vapour for enhanced photocatalytic H generation显示文摘Surface-functionalized nitrogen/carbon co-doped polymorphic TiO_(2) phase junction nanoparticles uniformly distributed in porous carbon matrix were synthesized by a simple one-step pyrolysis of titanium based metal-organic framework(MOF),NH_(2)-MIL^(-1)25(Ti) at 700℃ under water vapour atmosphere.Introducing water vapour during the pyrolysis of NH_(2)-MIL^(-1)25(Ti) not only functionalizes the derived porous carbon matrix with carboxyl groups but also forms additional oxygen-rich N like interstitial/intraband states lying above the valence band of TiO2 along with the self-doped carbo n,which further narrows the energy band gaps of polymorphic TiO2 nanoparticles that enhance photocatalytic charge transfer efficiency.Without co-catalyst,sample N-C-TiO2/CArW demonstrates H_(2) evolution activity of 426 μmol gcat-1h^(-1),which remarkably outperforms commercial TiO_(2)(P-25) and N-C-TiO_(2)/CAr with a 5-fold and 3-fold H_(2) generation,respectively.This study clearly shows that water vapour atmosphere during the pyrolysis increases the hydrophilicity of the Ti-MOF derived composites by functionalizing porous carbon matrix with carboxylic groups,as well as enhancing the electrical conductivity and charge transfer efficiency due to the formation of additional localized oxygen-rich N like interstitial/intraband states.This work also demonstrates that by optimizing the anatase-rutile phase composition of the TiO2 polymorphs,tuning the energy band gaps by N/C co-doping and functionalizing the porous carbon matrix in the N-C-TiO2/C nanocomposites,the photocatalytic H_(2) generation activity can be further enhanced. | Mian Zahid Hussain Zhuxian Yang Bart van der Linden Zheng Huang Quanli Jia Erik Cerrato Roland A.Fischer Freek Kapteijn Yanqiu Zhu Yongde Xia | 2021 | Journal of Energy Chemistry2021，30，6： | 3 |
| 8 | 美国器官捐献和移植立法主要事件显示文摘 | Linden PK 蒋婉洁 吴幼民 | 2009 | 中华移植杂志(电子版)2009，3，3： | 3 |
| 9 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 10 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 11 | Integrated preclinical and clinical development of S- trans, trans -farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer显示文摘 | Daniel Laheru Preeti Shah N. V. Rajeshkumar Florencia McAllister Gretchen Taylor Howard Goldsweig Dung T. Le Ross Donehower Antonio Jimeno Sheila Linden Ming Zhao Dongweon Song Michelle A. Rudek Manuel Hidalgo | 2012 | Investigational New Drugs2012，，6： | 2 |
| 12 | On the fiftieth anniversary Postinfectious irritable bowel syndrome: mechanisms related to pathogens显示文摘 | M. Grover M. Camilleri K. Smith D. R. Linden G. Farrugia | 2014 | Neurogastroenterol. Motil2014，，2： | 2 |
| 13 | Genetic dissection of drought tolerance and recovery potential by quantitative trait locus mapping of a diploid potato population显示文摘 | A. M. Anithakumari Karaba N. Nataraja Richard G. F. Visser C. Gerard Linden | 2012 | Molecular Breeding2012，，3： | 2 |
| 14 | Effects of a general practitioner cooperative co-located with an emergency department on patient throughput显示文摘BACKGROUND:In 2013 a General Practitioner Cooperative(GPC) was introduced at the Emergency Department(ED) of our hospital.One of the aims of this co-located GPC was to improve throughput of the remaining patients at the ED.To determine the change in patient flow,we assessed the number of self-referrals,redirection of self-referrals to the GPC and back to the ED,as well as ward and ICU admission rates and length of stay of the remaining ED population.METHODS:We conducted a four months' pre-post comparison before and after the implementation of a co-located GPC with an urban ED in the Netherlands.RESULTS:More than half of our ED patients were self-referrals.At triage,54.5%of these selfreferrals were redirected to the GPC.After assessment at the GPC,8.5%of them were referred back to the ED.The number of patients treated at the ED declined with 20.3%after the introduction of the GPC.In the remaining ED population,there was a significant increase of highly urgent patients(P<0.001),regular admissions(P<0.001),and ICU admissions(P<0.001).Despite the decline of the number of patients at the ED,the total length of stay of patients treated at the ED increased from 14 682 hours in the two months' control period to 14 962 hours in the two months' intervention period,a total increase of 270 hours in two months(P<0.001).CONCLUSION:Introduction of a GPC led to efficient redirection of self-referrals but failed to improve throughput of the remaining patients at the ED. | Michiel J.van Veelen Crispijn L.van den Brand Resi Reijnen M.Christien van der Linden | 2016 | World Journal of Emergency Medicine2016，7，4： | 2 |
| 15 | 经皮治疗外周血管畸形后病人远期满意度的研究显示文摘目的考察病人对经皮使用硬化剂(硬化疗法)和(或)动脉栓塞治疗外周血管畸形(VM)的远期满意度。这种治疗是成功的,但有关远期效果的文献匮乏。方法本回顾性研究经机构伦理委员会批准,评估了107例有症状而接受血管畸形治疗的病人。获知情同意后发给66例病人关于治疗效果和病人满意度的调查表,收回病人的资料和复习影像资料以获得关于VM和VM治疗的信息。构建Kaplan-Meier生存曲线,以分析随时间推移的临床成功率。 | E.van der Linden P.M.T.Pattynama B.C.Heeres S.C.de Jong W.C.J.Hop L.J.M.Kroft 赵蕾 | 2009 | 国际医学放射学杂志2009，32，4： | 2 |
| 16 | Transjugular Intrahepatic Portosystemic Shunt in Patients With Chronic Portal Vein Occlusion and Cavernous Transformation显示文摘 | Alexandra Wils Edwin van der Linden Bart van Hoek Peter M.T. Pattynama | 2009 | Journal of Clinical Gastroenterology2009，，10： | 2 |
| 17 | Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: Effects on right ventricular function显示文摘 | P Van der Linden O Le Moine M Ghysels M Ortinez J Deviere | 1996 | Hepatology1996，，5： | 2 |
| 18 | Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats显示文摘AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats.METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and VIP.Density analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were analyzed.RESULTS:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C group.Diabetes also significantly increased the areas of neurons,glial cells and VIP-IR varicosities.Supplementation with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C group.Quercetin induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D groups.CONCLUSION:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation. | Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria Pereira Alves der Paulo Belato Alves David Robert Linden Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 19 | Muc1 Mucin Limits Both Helicobacter pylori Colonization of the Murine Gastric Mucosa and Associated Gastritis显示文摘 | Michael A. McGuckin Alison L. Every Caroline D. Skene Sara K. Linden Yok Teng Chionh Agnieszka Swierczak Julie McAuley Stacey Harbour Maria Kaparakis Richard Ferrero Philip Sutton | 2007 | Gastroenterology2007，，4： | 2 |
| 20 | Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation显示文摘 | Philip A. Linden Richard J. Gilbert Beow Y. Yeap Kathleen Boyle Aaron Deykin Michael T. Jaklitsch David J. Sugarbaker Raphael Bueno | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，2： | 2 |
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