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| 1 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019,,4: | 3 |
| 2 | Late in-the-bag spontaneous IOL dislocation: risk factors and surgical outcomes显示文摘AIM: To evaluate the possible predisposing risk factors for late in-the-bag spontaneous IOL dislocations and to study the early surgical and visual outcomes of repositioning and exchange surgeries.METHODS: Medical and surgical records of 39 eyes of 39 patients who underwent IOL repositioning or exchange surgery for dislocation between 2010 and 2018 were reviewed. Possible predisposing risk factors and some characteristics of late in-the-bag spontaneous IOL dislocations;outcomes of IOL repositioning and exchange surgeries, including visual acuity, refractive status before and after surgery and postoperative complications were evaluated.RESULTS: The predisposing factors for late in-the-bag spontaneous IOL dislocations were pseudoexfoliation [PEX;12/39(30.8%)], previous vitreoretinal surgery [7/39(17.9%)], axial myopia [3/39(7.7%)], both PEX and axial myopia [1/39(2.6%)], both previous vitreoretinal surgery and axial myopia [2/39(5.1%)] and uveitis (1/39(2.6%))The mean interval between cataract and dislocation surgery was 7.23 y, greater in PEX positive group(8.63 y). The mean best corrected visual acuity(BCVA) improved significantly after dislocation surgery(P<0.001) and also improved significantly after exchange surgery(P=0.001). The mean value of spherical equivalant decreased significantly after dislocation surgery(P=0.011), whereas corneal astigmatism increased but this difference was not significant after dislocation surgery and exchange surgery(P=0.191, P=0.074, respectively).CONCLUSION: The most prevelant risk factors for late inthe-bag spontaneous IOL dislocations are PEX, previous vitreoretinal surgery and axial myopia. In the management of IOL dislocations, exchange surgery with small corneal incision seemed effective with improved BCVA and safety with low postoperative complications. | Sevgi Subasi Nursen Yuksel V.Levent Karabas Busra Yilmaz Tugan | 2019 | International Journal of Ophthalmology(English edition)2019,12,6: | 2 |
| 3 | Genetic dissection of drought tolerance and recovery potential by quantitative trait locus mapping of a diploid potato population显示文摘 | A. M. Anithakumari Karaba N. Nataraja Richard G. F. Visser C. Gerard Linden | 2012 | Molecular Breeding2012,,3: | 2 |
| 4 | A comparison of the short-term hypotensive effects and side effects of unilateral brimonidine and apraclonidine in patients with elevated intraoeular pressure显示文摘 | Yuksel N Karabas L Altintas O | 2002 | Ophthalmologica2002,216,: | 1 |
| 5 | Effect of cefuroxime and moxifloxacin on Staphylococcus epidermidis adher- ence to intraocular lenses 显示文摘 | KARADAG S OZKAN B KARABAS V L | 2009 | Can J Ophthalmol2009,44,: | 1 |
| 6 | Effect of cefuro-xime and moxifloxacin on Staphylococcus epidermidis ad-herence to intraocular lenses显示文摘 | Karada S Ozkan B Karaba VL | 2009 | Can J Ophthalmol2009,44,6: | 1 |
| 7 | Improvement of water use efficiency in rice by expression of HARDY,an Arabidop- s/s drought and salt tolerance gene显示文摘 | KARABA A DIXIT S GRECO R | 2007 | PNAS2007,104,15: | 1 |
| 8 | Diurnal intraocular pressure variation in pseudoexfoliation syndrome显示文摘 | Altintas O Yuksel N Karabas VL | 2004 | Eur J Ophthalmol2004,14,6: | 1 |
| 9 | Solutions to the exploration/exploitation dilemma: networks as a new level of analysis显示文摘 | STADLER C RAJWANI T KARABA F | 2014 | International Journal of Management Re- views2014,16,2: | 1 |
| 10 | Improvement of wa- ter use efficiency in rice by expression of HARDY, an Arabidopsis drought and salt tolerance gene 显示文摘 | Karaba A Dixit S Greco R | 2007 | Proc Natl Acad Sci USA2007,104,15: | 1 |
| 11 | A comparison of topical or retro- bulbar anesthesia for 23-gauge posterior vitrectomy 显示文摘 | Celiker H Karabas L Sahin O | 2014 | J Ophthal- mol2014,2014,23: | 1 |
| 12 | Improvement of water use efficiency in rice by expression of HARDY,an Arabidopsis drought and salt tolerance gene显示文摘 | Karaba A Dixit S Greco R | 2007 | Proc Natl Acad Sci USA2007,104,15: | 1 |
| 13 | Comparison of two different treatment regimens’ efficacy in neovascular age-related macular degeneration in Turkish population—based on real life data-Bosphorus RWE Study Group显示文摘AIM: To compare two different anti-vascular endothelial growth factor(anti-VEGF) treatment regimens'-a priori pro re nata(PRN) and PRN regimen following^(th)e loading phaseanatomical and functional results in neovascular agerelated macular degeneration(n AMD) patients. METHODS: Totally 544 n AMD patients followed and treated with aflibercept(n=135) and ranibizumab(n=409)at 9 different centers between 2013 and 2015 were enrolled into^(th)is retrospective multicenter study. Patients with initial best corrected visual acuity(BCVA) interval of 1.3-0.3(log MAR) and a minimum follow-up of 12 mo were included. Patients under two different regimens-a priori pro re nata(1+PRN) or 3 consecutive intravitreal injections followed by a PRN regimen(3+PRN)-were compared in BCVA at 3^(th), 6^(th) and 12^(th) months, and in central macular^(th)ickness(CMT) at 6^(th) and 12^(th) months. The total study group, intravitreal ranibizumab(IVR) and intravitreal aflibercept(IVA) groups were evaluated separately. RESULTS: The mean CMT decreased in^(th)e 1+PRN(n=101) regimen from 407 to 358 and 340 μm and in^(th)e 3+PRN(n=443) group from 398 to 318 and finally to 310 μm at months 6 and 12, respectively. Anatomically,^(th)e CMT reduction at 6^(th) month(48.5 vs 76.4;P<0.05) was statistically significant in favor of 3+PRN group. BCVA changed in 1+PRN group from 0.77 to 0.78, 0.75 and 0.75;in 3+PRN group from 0.81 to 0.69, 0.72, and 0.76 at months 3, 6, and 12, respectively. Visual gain was statistically better in 3+PRN group at 3^(th) month(-0.01 vs 0.12;P<0.001). In IVR group, CMT reduction was in greater in 3+PRN at 6^(th)(44 vs 72) and 12^(th) month(61 vs 84), but statistically insignificant. The 3+PRN group revealed statistically better visual results at 3^(th) month(-0.02 vs 0.11, P<0.05). In IVA group, although statistically insignificant, CMT reduction(61 vs 89, 6^(th) month;85 vs 97, 12^(th) month) and visual gain(0.02 vs 0.16;0.02 vs 0.14;0.05 vs 0.11) was found in favor of 3+PRN group at all visits.CONCLUSION: The loading dose of anti-VEGF treatments in n AMD leads to significantly better anatomical and functional results, regardless of the agent, specially in early follow-up interval. | Burak Erden Selim Bolükbasi Abdullah Ozkaya Levent Karabas Cengiz Alagoz Zeynep Alkin Ozgür Artunay Sadik Etka Bayramoglu Gokhan Demir Mehmet Demir Ali Demircan Gürkan Erdogan Mehmet Erdogan Erdem Eris Havva Kaldirim Ismail Umut Onur Ozen Ayranci Osmanbasoglu Sezin Ozdogan Erkul Mine Oztürk Irfan Perente Kübra Sarici Nihat Sayin Dilek Yasa Ihsan Yilmaz Zeynep Yilmazabdurrahmanoglu 无 | 2020 | International Journal of Ophthalmology(English edition)2020,13,1: | 1 |
| 14 | Solutions to the exploration/exploitation dilemma:networks as a new level of analysis显示文摘 | STADLER C RAJWANI T KARABA F | 2014 | International Journal of Management Reviews2014,16,2: | 1 |
| 15 | Effect of cefuroxime and moxifl oxacin on Staphylococcus epidermidis adherence to intraocular lenses显示文摘 | Karadag S Ozkan B Karabas VL | 2009 | Can J Ophthalmol2009,44,: | 1 |
| 16 | BOLITA, an Arabidopsis AP2/ERF-like transcription factor that affects cell expansion and proliferation/differentiation pathways显示文摘 | Nayelli Marsch-Martinez Raffaella Greco J?rg D. Becker Shital Dixit Jan H. W. Bergervoet Aarati Karaba Stefan Folter Andy Pereira | 2006 | Plant Molecular Biology2006,,6: | 1 |
| 17 | Improvement of water use efficiency in rice by expression of HARDY,an Arabidopsis drought and salt tolerance gene显示文摘 | KARABA A DIXIT S GRECO R | 2007 | PNAS2007,104,15: | 1 |
| 18 | Improvement of water use efficiency in rice by expression of HARDY, an Arabidopsis drought and salt tolerance gene显示文摘 | Karaba A Dixit S Greco R | 2007 | PANS2007,104,15: | 1 |
| 19 | Improvement of water use efficiency in rice by expression of HARDY, an Ar- ~bidopsis drought and salt tolerance gene显示文摘 | Aarati Karaba Shital Dixit Raffaella Greco | 2007 | PNAS2007,104,15: | 1 |
| 20 | Improvement of water use efficiency in rice by expression of HARDY, an Arabidopsis drought and salt tolerance gene显示文摘 | Karaba A Dixit S Greco R | 2007 | Proceedings of the National Academy of Sciences2007,104,15: | 1 |