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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Numerical Analysis of Wellbore Instability in Gas Hydrate Formation During Deep-Water Drilling显示文摘Gas hydrate formation may be encountered during deep-water drilling because of the large amount and wide distribution of gas hydrates under the shallow seabed of the South China Sea. Hydrates are extremely sensitive to temperature and pressure changes, and drilling through gas hydrate formation may cause dissociation of hydrates, accompanied by changes in wellbore temperatures, pore pressures, and stress states, thereby leading to wellbore plastic yield and wellbore instability. Considering the coupling effect of seepage of drilling fluid into gas hydrate formation, heat conduction between drilling fluid and formation, hydrate dissociation, and transformation of the formation framework, this study established a multi-field coupling mathematical model of the wellbore in the hydrate formation. Furthermore, the influences of drilling fluid temperatures, densities, and soaking time on the instability of hydrate formation were calculated and analyzed. Results show that the greater the temperature difference between the drilling fluid and hydrate formation is, the faster the hydrate dissociates, the wider the plastic dissociation range is, and the greater the failure width becomes. When the temperature difference is greater than 7℃, the maximum rate of plastic deformation around the wellbore is more than 10%, which is along the direction of the minimum horizontal in-situ stress and associated with instability and damage on the surrounding rock. The hydrate dissociation is insensitive to the variation of drilling fluid density, thereby implying that the change of the density of drilling fluids has a minimal effect on the hydrate dissociation. Drilling fluids that are absorbed into the hydrate formation result in fast dissociation at the initial stage. As time elapses, the hydrate dissociation slows down, but the risk of wellbore instability is aggravated due to the prolonged submersion in drilling fluids. For the sake of the stability of the wellbore in deep-water drilling through hydrate formation, the drilling fluid with low temperatures should be given priority. The drilling process should be kept under balanced pressures, and the drilling time should be shortened. | ZHANG Huaiwen CHENG Yuanfang LI Qingchao YAN Chuanliang HAN Xiuting | 2018 | Journal of Ocean University of China2018，17，1： | 8 |
| 3 | Positively charged microporous ceramic membrane for the removal of Titan Yellow through electrostatic adsorption显示文摘To develop a depth filter based on the electrostatic adsorption principle, positively charged microporous ceramic membrane was prepared from a diatomaceous earth ceramic membrane.The internal surface of the highly porous ceramic membrane was coated with uniformly distributed electropositive nano-Y_2O_3 coating. The dye removal performance was evaluated through pressurized filtration tests using Titan Yellow aqueous solution. It showed that positively charged microporous ceramic membrane exhibited a flow rate of 421 L/(m^2·hr) under the trans-membrane pressure of 0.03 bar. Moreover it could effectively remove Titan Yellow with feed concentration of 10 mg/L between pH 3 to 8. The removal rate increased with the enhancement of the surface charge properties with a maximum rejection of 99.6%. This study provides a new and feasible method of removing organic dyes in wastewater. It is convinced that there will be a broad market for the application of charged ceramic membrane in the field of dye removal or recovery from industry wastewater. | Xiuting Cheng Na Li Mengfu Zhu Lili Zhang Yu Deng Cheng Deng | 2016 | Journal of Environmental Sciences2016，28，6： | 5 |
| 4 | An experimental study on dynamic coupling process of alkaline feldspar dissolution and secondary mineral precipitation显示文摘In order to clarify the dynamic process of feldspar dissolution-precipitation and explore the formation mechanism of secondary porosity,six batch reactor experiments were conducted at 200℃and pH=7 measured at room temperature.Temporal evolution of fluid chemistry was analyzed with an inductively coupled plasma optical emission spectrometer(ICP-OES).Solid reaction products were retrieved from six batch experiments terminated after 36,180,276,415,766 and 1008 h.Scanning electron microscopy(SEM)revealed dissolution features and significant secondary mineral adhered on the feldspar surface.The process of feldspar dissolution-precipitation proceeded slowly and full equilibrium was not achieved after 1008 h.Saturation indices suggested that the albite and K-feldspar dissolution occurred throughout the experiments.The average dissolution rates for albite and K-feldspar were 2.28×10^-10 and 8.51×10^-11 mol m^-2 s^-1,respectively.Based on the experimental data,the reaction process of alkaline feldspar was simulated and the secondary porosity had increased 0.3%after the experiment. | Meirong Li -Chenchu Li Juntao Xing Xiuting Sun Guanghui Yuan Yingchang Cao | 2019 | Acta Geochimica2019，38，6： | 3 |
| 5 | The Impact of Population Aging on Housing Demand in China Based on System Dynamics显示文摘In recent years, the proportion of China's elderly population is gradually increasing, and the real estate market is changing dramatically. Consequently the impact of population aging on housing demand has become increasingly prominent. On the theoretical basis of the relationship between population aging, family structure and housing demand, this paper firstly constructs a system dynamics model of the impact of population aging and family structure on housing demand in China. Then,the model is simulated, and several scenarios of population, family structure, and real estate policies are set up. The main conclusions of this paper are as follows: China's population will rise at first and then decrease, reaching a peak of 1.401 billion by 2023. As the proportion of elderly population increases, the degree of population aging is becoming increasingly serious. The size of the family will gradually shrink to 2.39 people per household in 2050. The housing demand will increase first and then decrease. Through the results of scenario simulation, this paper puts forward the following suggestion to effectively balance the housing demand in China: Completely relaxing family planning policies,imposing a real estate tax, canceling the pre-sale policy, and raising the loan rate. | MOU Xindi LI Xiuting DONG Jichang | 2021 | Journal of Systems Science & Complexity2021，34，1： | 3 |
| 6 | A Multi–fluid Constrain for the Forming of Potash Deposits in the Savannakhet Basin: Geochemical Evidence from Halite显示文摘The Khorat Plateau on the Indochina Terrane is known to have formed during the closure of the Tethys Ocean, although the origin of its potash mineral deposits is a topic of current debate. Data from a borehole on Savannakhet Basin is used in this study to re-define the evaporation processes of the study area. Geochemical analyses of halite from various borehole-derived evaporite strata have elucidated the fluid sources from which these ores formed. Measured δ11 B indicated that ore deposits formed primarily due to evaporation of seawater, although non-marine fluids affected the later stages of the evaporation process. Fluctuations in B and Br concentrations in carnallite-and sylvite-rich strata indicate the influence of fresh water. Boron concentration in carnallite unit indicated the influence of hydrothermal fluids. From the relative timings of these various fluid influxes, the evolution of these evaporates can be divided into four stages:(1) an initial marine evaporation at the beginning of the deposit's formation, where seawater(and minor fresh water) trapped on the uplifted Khorat Plateau produced sediments and salts with Br contents lower than those of normal marine-derived evaporites;(2) a transgression stage, where seawater recharged the basin;(3) a hydrothermal infiltration stage, which was coeval with the late Yanshan movement; and(4) a stage of fresh water supply, as recorded by fluctuations in B and Br contents, inferring intermittent fresh water influx into the basin. Thus, although evaporites on the Savannakhet Basin primarily formed via marine evaporation, they were also influenced to a significant degree by the addition of non–marine fresh water and hydrothermal fluids. | REN Qianhui DU Yongsheng GAO Donglin LI Binkai ZHANG Xiying LIU Xiuting YUAN Xiaolong | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 3 |
| 7 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 8 | Effect of AAPH oxidation on digestion characteristics of seed watermelon(Citrullus lanatus var)kernels protein isolates显示文摘Seed watermelon kernel is a typical complex food with high fat and protein contents.During storage and processing,it is often affected by various factors to undergo interactions between components,which lead to its quality change.In this experiment,seed watermelon kernels were used as research objects,and the effects of 2-Azobis(2-amidinopropane)dihydrochloride(AAPH)on seed watermelon kernel protein isolates(WMP)were investigated.The structure and digestion characteristics of WMP after oxidation were studied.The results showed that with the increase of AAPH concentration(0.05−5 mol/L),WMP showed obvious aggregation,and its solubility decreased from 6.76 mg/mL to 9.59 mg/mL.The free sulfhydryl content of WMP was 18.24 mmol/g decreased to 11.25 mmol/g,α-helix decreased andβ-sheet decreased in secondary structure,and its disulfide bond increased by 43.06 mmol/g from 39.57 mmol/g,enthalpy(H)and denaturation temperature increased(Td)(P<0.05).By mass spectrometry results of simulated gastric digestion products,it was found that oxidation adversely affected the digestion characteristics of WMP.It can be seen that the lipid oxidation product APPH of seed watermelon kernel can significantly affect the structure and function of the protein extracted from the seed kernel. | Shugang Li Zhihao Li Xiuting Li Ping Wang Xiongwei Yu Qinli Fu Sihai Gao | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 9 | A Study on the Relationship Between Land Finance and Housing Price in Urbanization Process: An Empirical Analysis of 182 Cities in China Based on Threshold Panel Models显示文摘Scholars have a variety of theoretical explanations for housing price growth. However, few scholars have studied the internal influence mechanism among urbanization, land finance, and housing price. Based on the data of 182 prefecture-level cities from 2009 to 2016, this paper studies the influence of land finance on housing price under different urbanization rate levels. The study finds that with the increase of urbanization rate, the effect of land finance on housing price presents a 'U' shape.Specifically, an increase in land finance by 1% results in a corresponding increase in average housing price by 0.18%, with relatively low urbanization rate, 0.06% with medium level of urbanization rate,and 0.38% with high level of urbanization rate. | Meiting HU Jichang DONG Lijun YIN Chun MENG Xiuting LI | 2021 | Journal of Systems Science and Information2021，9，1： | 2 |
| 10 | An experimental study on microscopic characteristics of gas-bearing sediments under different gas reservoir pressures显示文摘Gas-bearing sediments are widely distributed in five continents all over the world.Most of the gases exist in the soil skeleton in the form of discrete large bubbles.The existence of gas-phase may increase or decrease the strength of the soil skeleton.So far,bubbles’structural morphology and evolution characteristics in soil skeleton lack research,and the influence of different gas reservoir pressures on bubbles are still unclear.The micro characteristics of bubbles in the same sediment sample were studied using an industrial CT scanning test system to solve these problems.Using the image processing software,the micro variation characteristics of gas-bearing sediments in gas reservoir pressure change are obtained.The results show that the number and volume of bubbles in different equivalent radius ranges will change regularly under different gas reservoir pressure.With the increase of gas reservoir pressure,the number and volume of tiny bubbles decrease.In contrast,the number and volume of large bubbles increase,and the gas content in different positions increases and occupies a dominant position,driving the reduction of pore water and soil skeleton movement. | Zhenqi Guo Tao Liu Lei Guo Xiuting Su Yan Zhang Sanpeng Li | 2021 | Acta Oceanologica Sinica2021，40，10： | 2 |
| 11 | Controllable Strong and Ultralight Aramid Nanofiber‑Based Aerogel Fibers for Thermal Insulation Applications显示文摘High-performance polymer-based aerogel fibers with ultrahigh porosity,mechanical robustness and outstanding thermal stability are demanded for applying in effective thermal insulation devices,especially in harsh environment.However,the poor mechanical properties and thermal stability of the commonly reported polymer-based aerogel fibers restricted their applications in many areas.As a special nano-build-block,aramid nanofiber-based aerogel fiber is expected to conquer this problem in virtue of the outstanding performance,intrinsically related to aramid fibers.Herein,a series of aramid nanofiber-based aerogel fibers were fabricated via a facial wet-spinning method combined with freeze-drying technique.The effects of coagulation bath temperature and the solid contents of the spinning precursors on their morphologies and mechanical properties were systematically studied.The obtained aerogel fibers possessed high porosity(>92%),good mechanical prop-erties(tensile strength~8.1 MPa)and high specific surface area(~239 m^(2)/g).Meanwhile,the woven textiles exhibited a low thermal conductivity(~34 mW/(m·K))and outstanding thermal insulation properties under a wide range of temperature.In addition,surface modification by Teflon resin could make the ANAFs hydrophobic,thus exhibiting their applicational pros-pects in a humid environment.Overall,the aramid nanofiber-based aerogel fibers and their textile throw light in a favorable direction for developing high-performance thermal insulation fibers and textiles. | Mengmeng Li Xian Chen Xiuting Li Jie Dong Xin Zhao Qinghua Zhang | 2022 | Advanced Fiber Materials2022，4，5： | 2 |
| 12 | Purification and characterization of a cellulase-free,thermostable xylanase from Streptomyces rameus L2001 and its biobleaching effect on wheat straw pulp显示文摘 | Li Xiuting She Yuanli Sun Baoguo | 2010 | Biochemical Engineering Journal2010，52，1： | 1 |
| 13 | Purification and characterization of a cellulase-free, thermostable xy- lanase from Streptomyces rameus L2001 and its biobleaching effect on wheat straw pulp显示文摘 | Li Xiuting She Yuanli Sun Baoguo | 2010 | Biochemical Engineering Journal2010，51，： | 1 |
| 14 | Geochemistry and Zircon U-Pb Geochronology of Early Paleozoic S-type Granites in the Eastern Qilian Block,Northwest China显示文摘The Qilian Block(QB)is a Precambrian micro-continent located in the northeastern Qinghai–Tibet Plateau.Prevalent Lower Paleozoic granitic magmatic rocks crop out in the QB.A new integrated study of zircon U-Pb ages and systematic whole-rock geochemical data for the Xindian,Dongjiazhuang and Xiaogaoling granites in the eastern segment of the QB constrains their emplacement ages,petrogenesis,and regional evolutionary history.U-Pb dating reveals that the Xindian granite was emplaced 454 Ma,and both the Dongjiazhuang and Xiaogaoling granites were emplaced ca.440 Ma.Geochemical study shows that all granites belong to the high-K calc-alkaline to shoshonitic series and are S-type granites formed by partial melting of continental crust,mainly metagraywacke.We infer that these ca.454–445 Ma granites formed in a syn-collisional setting during the continental collisional between the Qaidam and Qilian blocks. | LIU Xiuting LI Binkai HAN Jilong REN Erfeng GAO Donglin DU Yongsheng REN Qianhui ZHANG Yan | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 15 | Purification and character- ization of a cellulase-free, thermostable xylanase from Streptomyces rameus L2001 and its biobleaching effect on wheat straw pulp显示文摘 | LI Xiuting SHE Yuanli SUN Baoguo | 2010 | Biochemical Engineering Journal2010，52，1： | 1 |
| 16 | High activity xylanase production by Streptomyces olivaceoviridis E-86显示文摘 | DING Changhe JIANG Zhengqiang LI Xiuting | 2004 | World Journal of Microbiology and Biotechnology2004，20，： | 1 |
| 17 | Characterization of efficient aerobic denitrifiers isolated from two different sequencing batch reactors by 16S-rRNA analysis显示文摘 | Wang ping Li xiuting Xiang mufei | 2007 | Journal of Bioscience and Bioengingeering2007，103，6： | 1 |
| 18 | Simple aspects of femtosecond stimulated Raman spectroscopy显示文摘Femtosecond stimulated Raman spectroscopy(FSRS),using an overlapping pair of narrow band Raman pump and broadband probe pulses with heterodyne detection along the probe pulse direction,is a new nonlinear spectroscopic technique to record vibrational spectra of even highly fluorescent molecules and to study vibrational dynamics on excited electronic states of molecules,as in photoisomerization.FSRS is described by diagrammatic third-order perturbation theory with wave packet analysis.The phase matching condition gives rise to forty-eight terms for FSRS,but the resonant condition reduces it to just eight terms,which can be depicted by Feynman dual time-line diagrams,or closed time path loop diagrams,or the complementary four-wave mixing energy level diagrams.The eight terms fall into four sets-SRS(I),SRS(II),IRS(I),IRS(II)-where SRS stands for stimulated Raman scattering and IRS stands for inverse Raman scattering.The SRS(I) set can also account for spontaneous Raman scattering,but the remaining SRS(II),IRS(I) and IRS(II) terms are only present in stimulated scattering with the presence of a probe field.The SRS(I) set accounts for the Stokes Raman lines while the IRS(I) term accounts for the anti-Stokes lines,relative to the Raman pump frequency,in the FSRS spectrum.The remaining SRS(II) and IRS(II) terms give rise to broad baselines.Using a harmonic oscillator model,analytic results are obtained for the four-time correlation functions in the third-order polarizations.The issue of high time and high frequency resolution in time-resolved FSRS spectra is discussed.Calculations are made with the theory to compare with experimental results for:(a) resonance FSRS of fluorescent Rhodamine 6G and(b) 2D-FSRS from a coherent vibrational state that has been prepared by an impulsive,off-resonant pump pulse on CDCl3.The calculated results compared well with experimental results,and in the case of 2D-FSRS on CDCl3 there is a dominant cascade effect contributing to the FSRS spectra. | ZHAO Bin NIU Kai LI XiuTing LEE Soo-Ying | 2011 | Science China Chemistry2011，54，12： | 1 |
| 19 | Tough polyimide composites synergistically reinforced by carbon nanofiber-grafted carbon fiber and rGO for improved heat dissipation and electromagnetic interference shielding显示文摘The rapid miniaturization and a consequent increase in electromagnetic wave(EM)and heat emission in integrated electronic devices are now urgently desiring for multifunctional polymer composites that simultaneously possess high mechanical properties,excellent electromagnetic interference(EMI)shield-ing ability and heat dissipation capability.Herein,a series of novel polyimide-based composite films were constructed by rationally assembling the carbon nanofiber-grafted carbon fiber(NCF)and reduced graphene oxide(rGO)into a highly electrically and thermally conductive pathway within polyimide ma-trix via a sequential bidirectional freezing casting and hot-pressing strategy.The combination of high tensile strength and toughness was obtained by incorporating rGO into the NCF-reinforced PI composite,giving rise to a hierarchical reinforcing structure of NCF and crack deflection induced by rGO nanosheets.The high electrical conductivity(7.0×10^(3) S m^(-1))endows the PI/NCF30/rGO3.5 composite film with a good EMI shielding effectiveness of 45 dB.Moreover,the well-aligned thermally conductive NCF and rGO and strong interfacial bonding between the polymer matrix and reinforcing fibers give rise to improved thermal conductivity(λ),particularly along the in-plane direction.Typically,the PI/NCF30/rGO3.5 exhibits an in-plane thermal conductivity of 5.18 W m^(-1) K^(-1),∼4.7 times increment compared to the pure PI(0.91 W m^(-1) K^(-1)).Besides,the resultant PI/NCF30/rGO3.5 composite film presents a superior Joule heat-ing performance with some features of fast thermal response,ease of regulation and sufficient reliability.Accordingly,the developed multifunctional polyimide-based composite films demonstrate high potential as advanced EMI shielding materials with excellent heat dissipation. | Zhiqiang Wu Jie Dong Xiuting Li Xin Zhao Wenjun Tan Chengchang Ji Qinghua Zhang | 2023 | Journal of Materials Science & Technology2023，，18： | 0 |
| 20 | CNTs/CNF-supported multi-active components as highly efficient bifunctional oxygen electrocatalysts and their applications in zincair batteries显示文摘Rational construction of active components has been the biggest challenge in preparing efficient bifunctional oxygen electrocatalysts.Herein,electrospinning and chemical vapor deposition(CVD)were employed to embed active species including FeCo nanoparticles,MNx(M=Fe,Co),and FePx in porous and graphitized carbon nanotubes(CNTs)/carbon nanofiber(CNF).The as-prepared FeCo@CoNx@FePx/C exhibited a half-wave potential as high as 0.86 V in oxygen reduction reaction(ORR)and low oxygen evolution reaction(OER)overpotential of 368 mV at 10 mA·cm^(−2),which are superior to Pt/C(0.83 V)and IrO_(2)(375 mV)respectively.The assembled Zn-air battery(ZAB)showed a high energy efficiency(Edischarge/Echarge)of 65%at 20 mA·cm^(−2)and stabilized for 700 charge-discharge cycles.The spectroscopic and microscopic characterizations evidenced that the outstanding bifunctionality of the electrocatalyst can be ascribed to three main reasons:First,FeCo nanoparticles are rich in MOH/MOOH active sites for OER,and FePx/CNTs constructed with CVD also modulate electronic structure to improve electron transfer;second,both MNx in carbon matrix and FePx/CNTs are highly active towards ORR;third,the CNTs/CNF are highly porous and graphitized,which promotes mass transport and improves electrical conductivity and stability of the electrocatalysts.This work gives important implications on the design of bifunctional electrocatalysts. | Weiyuan Ding Ali Saad Yuchen Wu Zhiwei Wang Xiuting Li | 2023 | Nano Research2023，16，4： | 0 |
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