|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Numerical Analysis of Wellbore Instability in Gas Hydrate Formation During Deep-Water Drilling显示文摘Gas hydrate formation may be encountered during deep-water drilling because of the large amount and wide distribution of gas hydrates under the shallow seabed of the South China Sea. Hydrates are extremely sensitive to temperature and pressure changes, and drilling through gas hydrate formation may cause dissociation of hydrates, accompanied by changes in wellbore temperatures, pore pressures, and stress states, thereby leading to wellbore plastic yield and wellbore instability. Considering the coupling effect of seepage of drilling fluid into gas hydrate formation, heat conduction between drilling fluid and formation, hydrate dissociation, and transformation of the formation framework, this study established a multi-field coupling mathematical model of the wellbore in the hydrate formation. Furthermore, the influences of drilling fluid temperatures, densities, and soaking time on the instability of hydrate formation were calculated and analyzed. Results show that the greater the temperature difference between the drilling fluid and hydrate formation is, the faster the hydrate dissociates, the wider the plastic dissociation range is, and the greater the failure width becomes. When the temperature difference is greater than 7℃, the maximum rate of plastic deformation around the wellbore is more than 10%, which is along the direction of the minimum horizontal in-situ stress and associated with instability and damage on the surrounding rock. The hydrate dissociation is insensitive to the variation of drilling fluid density, thereby implying that the change of the density of drilling fluids has a minimal effect on the hydrate dissociation. Drilling fluids that are absorbed into the hydrate formation result in fast dissociation at the initial stage. As time elapses, the hydrate dissociation slows down, but the risk of wellbore instability is aggravated due to the prolonged submersion in drilling fluids. For the sake of the stability of the wellbore in deep-water drilling through hydrate formation, the drilling fluid with low temperatures should be given priority. The drilling process should be kept under balanced pressures, and the drilling time should be shortened. | ZHANG Huaiwen CHENG Yuanfang LI Qingchao YAN Chuanliang HAN Xiuting | 2018 | Journal of Ocean University of China2018，17，1： | 8 |
| 3 | Positively charged microporous ceramic membrane for the removal of Titan Yellow through electrostatic adsorption显示文摘To develop a depth filter based on the electrostatic adsorption principle, positively charged microporous ceramic membrane was prepared from a diatomaceous earth ceramic membrane.The internal surface of the highly porous ceramic membrane was coated with uniformly distributed electropositive nano-Y_2O_3 coating. The dye removal performance was evaluated through pressurized filtration tests using Titan Yellow aqueous solution. It showed that positively charged microporous ceramic membrane exhibited a flow rate of 421 L/(m^2·hr) under the trans-membrane pressure of 0.03 bar. Moreover it could effectively remove Titan Yellow with feed concentration of 10 mg/L between pH 3 to 8. The removal rate increased with the enhancement of the surface charge properties with a maximum rejection of 99.6%. This study provides a new and feasible method of removing organic dyes in wastewater. It is convinced that there will be a broad market for the application of charged ceramic membrane in the field of dye removal or recovery from industry wastewater. | Xiuting Cheng Na Li Mengfu Zhu Lili Zhang Yu Deng Cheng Deng | 2016 | Journal of Environmental Sciences2016，28，6： | 5 |
| 4 | Mechanism of Suppressing Transverse Wavevectors for Antidiffracting Propagation via Coherent Beam Combination显示文摘The elimination of transverse wavevectors during the propagation of electromagnetic waves is highly desirable because this would have a wide range of applications in probing,imaging,and communication.In this research,we propose and experimentally demonstrate a simple method to suppress transverse wavevectors by using coherent wave combinations.Using theoretical analysis and numerical simulation,we show that transverse wavevectors can be greatly suppressed during propagation.For further verification,we perform experiments with light waves to realize coherently combined beams;our experimental results are in good agreement with the simulated results.More importantly,we generate pin-like optical beams using this method,and pin-like optical beams exhibit superior propagation behavior over conventional Gaussian beams in turbulent fluids. | Yang Xiuting Ren Yuhang Zhang Ze Liang Xinli Chen Yan Gao Lu Zhao Juanying Cheng Wang Christodoulides Demetrios Chen Zhigang | 2021 | 激光与光电子学进展2021，58，7： | 0 |
| 5 | Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients:A Multi-Center Retrospective Study in China显示文摘Coronavirus disease 2019(COVID-19)has become a worldwide pandemic.Hospitalized patients of COVID-19 suffer from a high mortality rate,motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients.Here,we have developed a risk score using clinical data from 1479 inpatients admitted to Tongji Hospital,Wuhan,China(development cohort)and externally validated with data from two other centers:141 inpatients from Jinyintan Hospital,Wuhan,China(validation cohort 1)and 432 inpatients from The Third People’s Hospital of Shenzhen,Shenzhen,China(validation cohort 2).The risk score is based on three biomarkers that are readily available in routine blood samples and can easily be translated into a probability of death.The risk score can predict the mortality of individual patients more than 12 d in advance with more than 90%accuracy across all cohorts.Moreover,the Kaplan-Meier score shows that patients can be clearly differentiated upon admission as low,intermediate,or high risk,with an area under the curve(AUC)score of 0.9551.In summary,a simple risk score has been validated to predict death in patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);it has also been validated in independent cohorts. | Ye Yuan Chuan Sun Xiuchuan Tang Cheng Cheng Laurent Mombaerts Maolin Wang Tao Hu Chenyu Sun Yuqi Guo Xiuting Li Hui Xu Tongxin Ren Yang Xiao Yaru Xiao Hongling Zhu Honghan Wu Kezhi Li Chuming Chen Yingxia Liu Zhichao Liang Zhiguo Cao Hai-Tao Zhang Ioannis Ch.Paschaldis Quanying Liu Jorge Goncalves Qiang Zhong Li Yan | 2022 | Engineering2022，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员