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| 1 | Nuclear factor kB activity in patients with acute severe cholangitis显示文摘瞄准:在外部血决定 NF-kB 活动在有严重类型(ACST ) 和相互关联的尖锐胆管炎的病人的单音的原子房间(PBMC ) 有胆汁的道感染和临床的结果的严厉的 NF-kB 激活的度。方法:有 ACST 的二十个病人被划分成幸存者组(13 个盒子) 并且非幸存者组(7 个盒子) 。经历选任的 gastrectomy 或腹股沟的脱肠修理的另外的十个病人作为控制组被选择。外部血样品手术后地被花 24 个小时。PBMC 被密度坡度 centrifugation 分开,然后原子的蛋白质从 PBMC 被孤立,并且 Electrophoretic 活动性移动试金(EMSA ) 使用了坚定。结果被扫描一个简历图象分析系统的 densitometer 确定并且表示了同样相对的光密度(杆) 。在有 ACST 和健康控制题目的病人的血浆的 TNF-alpha, IL-6,和 IL-10 的层次被使用连接酶的免疫分析(ELISA ) 决定。结果:NF-kB 活动是 5.02 +/- 1.03 在里面非幸存者组, 0.51 在幸存者组织的 2.98 +/- 和 1.06 +/- 0.34 在控制组。在三个组(P<0.05 ) 有统计差别。在血浆的 TNF-alpha 和 IL-6 的层次是( 498 +/- 53 ) ng.L ( -1)and ( 587 +/- 64 ) ng.L ( -1)in 非幸存者组,( 284 +/- 32 ) ng.L (-1)并且( 318 +/- 49 ) ng.L ( -1)in 幸存者组并且( 89 +/- 11 ) ng.L (-1)并且( 102 +/-13 ) ng.L ( -1)in 控制组。有 ACST 的所有病人增加了 TNF-alpha 和 IL-6 的层次,它是控制组的比那些大的许多褶层,并且有一条证据在那些显著地高级非幸存者组比那在幸存者组(P<0.05 ) 。在血浆的 IL-10 的层次是(378+/-32 ) ng.L (-1),(384+/-37 ) ng.L (-1) 并且(68+/-11 ) ng.L (在三个组的 -1) 分别地。当与控制相比组(P<0.05 ) ,而是 IL-10 层次不是显著地更高级的在时,所有病人也增加了 IL-10 的层次非幸存者比在幸存者(P>0.05 ) 。结论:在在有 ACST 的病人的 PBMC 的 NF-kB 活动显著地增加并且 NF-kB 激活的度与胆汁的道感染和临床的结果的严厉被相关。 | Jian-Ping Gong Chong-An Liu Chuan-Xin Wu Sheng-Wei Li Yu Jun Shi Xu-Hong Li,Department of General Surgery,The Second College of Clinical Medicine & the Second Affiliated Hospital of Chongqing University of Medical Science,74 Linjiang Road,Central District,Chongqing 400010,China | 2002 | World Journal of Gastroenterology2002，8，2： | 31 |
| 2 | Structure and photocatalytic properties of TiO_2-Graphene Oxide intercalated composite显示文摘TiO2-Graphene Oxide intercalated composite (TiO2-Graphene Oxide) has been successfully prepared at low temperature (80°C) with graphite oxide (GO) and titanium sulfate (Ti(SO4)2) as initial reactants.GO was firstly exfoliated by NaOH and formed single and multi-layered graphite oxide mixture which can be defined as graphene oxide,[TiO]2+ induced by the hydrolysis of Ti(SO4)2 diffused into graphene oxide interlayer by electrostatic attraction.The nucleation and growth of TiO2 crystallites took place at low temperature and TiO2-Graphene Oxide composite was successfully synthesized.Furthermore,the photocatalytic properties of TiO2-Graphene Oxide under the irradiation of UV light were also studied.The results show that the degradation rate of methyl orange is 1.16 mg min-1 g-1(refer to the efficiency of the initial 15 min).Compared with P25 powder,this kind of intercalation composite owns much better efficiency.On the other hand,the reusable properties and stable properties of TiO2-Graphene Oxide intercalated composite are also discussed in this paper.At last,crystalline structure,interface status,thermal properties and microscopic structure of TiO2-Graphene Oxide were characterized by X-ray diffraction (XRD),X-ray photoelectron spectroscopy (XPS),thermogravimetric analysis (TGA),field emission scanning electron microscopy (FESEM) and high-resolution Transmission Electron Microscopy (HRTEM).Also,we have analyzed major influencing factors and mechanism of the composite structures which evidently improve the photocatalytic properties. | ZHANG Qiong HE YunQiu CHEN XiaoGang HU DongHu LI LinJiang YIN Ting JI LingLi | 2011 | Chinese Science Bulletin2011，56，3： | 14 |
| 3 | A DFT study on PtMo resistance to SO_2 poisoning显示文摘Pt is a catalyst in proton exchange membrane fuel cell (PEMFC), and its activity will be degraded in the air due to the existence of SOx impurities. On strategy is introducing of Mo into the Pt catalyst because it can improve the SOx -tolerance capacity. Based on the aforementioned phenomenon, a density function theory (DFT) study on SO x adsorbed on Pt(111) and PtMo(111) was performed to enhance Pt catalytic activity. The adsorption energy of adsorbed species, the net change, partial density of state (PDOS), and d-band center were calculated and analyzed comparatively. The results show that the presence of Mo-atom weakens the S-Pt bond strength and reduces the adsorption energies for SO2 , S and SO3 on PtMo(111). Moreover, the Mo atom weakens the effects of SO2 on the PtMo(111) electronic structure and makes the catalyst maintains its original electronic structure after SO2 adsorption as compared with Pt(111). | XIA MeiRong LIU Ying LI Li XIONG Kun QI XueQiang YANG LinJiang HU BaoShan XUE Yun WEI ZiDong | 2013 | Science China Chemistry2013，56，7： | 4 |
| 4 | Cultivation of aerobic granular sludge in a conventional, continuous flow, completely mixed activated sludge system显示文摘氧气的小粒在常规、连续流动被形成,完全混合的激活的污泥系统(CMAS ) 。反应堆与包含很少细丝的种子污泥被接种并且用合成市政的废水喂了。污泥和一般水准的安定时间溶解了氧() 反应堆, 2 是 h 和 4.2 mg 散瑮慲楴湯 ? 敷敲甠敳 ? 湩琠敨搠獥污湩瑡潩 ? 档浡敢 ? 潴猠畴祤琠敨攠晦 ' ?景椠湯挠湯散瑮慲楴湯吗? | Xi CHEN Linjiang YUAN Wenjuan LU Yuyou LI Pei LIU Kun NIE | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 3 |
| 5 | WEAR AND LIFE OF PCBN TOOLS WHEN DRY-CUTTING BEARING STEEL GCr15显示文摘The wear forms and reasons of PCBN tools when dry-cutting bearing steel GCr15 are studied systematically. The effect law of the workpiece hardness on PCBN tools is gained and tool wearing with the quickest speed at the workpiece critical hardness is proved. The life equation at two kinds of workpiece hardness demonstrates that the effect of the cutting speed on the PCBN tool life is less than that of carbide tools and ceramic tools. | Liu Xianli Zhang Zhongmin Li ZhenjiaDepartment of Mechanical Engingeering, Harbin University of Science and Technology,Harbin 150080, ChinaLiu Linjiang Yuan ZhejunJilin University Harbin Institute of Technology | 2002 | Chinese Journal of Mechanical Engineering2002，15，3： | 3 |
| 6 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 7 | The discovery of colchicine-SAHA hybrids as a new class of antitumor agents显示文摘 | Xuan Zhang Jie Zhang Linjiang Tong Yu Luo Mingbo Su Yi Zang Jia Li Wei Lu Yi Chen | 2013 | Bioorganic & Medicinal Chemistry2013，，11： | 1 |
| 8 | Engineering stress tolerance of Escherichia coli by stress‐induced mutagenesis (SIM)‐based adaptive evolution显示文摘 | Linjiang Zhu Zhen Cai Yanping Zhang Yin Li | 2014 | Biotechnology Journal2014，，1： | 1 |
| 9 | Bid BH3 peptide,but not its mutant form G^(94)E, induces permeability transition pore opening and cytochrome c release in vitro显示文摘It has been shown that Bid and its truncated form tBid could induce cytochrome c (cyt c) release without impacting on PTP. We first show that Bid BH3 peptide, but not its mutant form of Bid BH3 peptide G94E, which is unable to bind to Bcl-xL, induces permeability transition pore (PTP) opening in a dose dependent manner. Bid BH3 peptide also induces the reduction of mitochondria membrane potential (Ψm) and cyt c release from mitochondrial in vitro. PTP opening and the loss of Ψm, were inhibited by Bcl-xL, cyclosporin A and ruthenium red, and the latter was an inhibitor of Ca2+ uniporter in the mitochondrial membrane. These results indicate that Bid BH3 peptide could antagonize Bcl-xL to induced PTP opening and mitochondrial dysfunction. | XIATian, JIANG Chunsun, LI Linjiang, ZHANG Yong, JIN Haijing, LIU Shusen, WU Caihong & CHEN QuanThe National Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China The National Ke | 2002 | Chinese Science Bulletin2002，47，7： | 1 |
| 10 | Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma显示文摘Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly controlled.Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM treatment.Therefore,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against GBM.SYHA1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in vivo.SYHA1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive tumors.Notably,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM xenografts.Moreover,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 antibody.As a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I trial.The data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380). | Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li Linjiang Tong Fang Feng Yan Li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 11 | Mechanism of mitochondrial respiratory control in cas-pase-3 induced positive feed-back loop in apoptosis显示文摘Caspase-3 plays a central role in the execution of apoptosis. Besides many substrates of caspase-3, mitochondria seem to be one of the candidate targets in the apop-totic process. We evaluated the effects of caspase-3 on the isolated mitochondria in detail, and especially focused on the mechanism involved in mitochondrial functions, which were not fully assessed till now. Our results showed that re-combinant caspase-3 induced the increase of superoxide production, the dissipation of mitochondrial membrane potential and rate increasing of mitochondrial state 4 respiration. Caspases inhibitor, z-VAD-fmk can inhibit these effects of caspase-3 on mitochondria. Bcl-xL and cyclosporin A were also shown to be able to inhibit these changes. These results suggested a possible mechanism in caspase-3 induced disruption of mitochondrial membrane barrier which formed a positive feedback loop in apoptosis. | XIA Tian JIANG Chunsun LI Linjiang CHEN Quan WU Caihong LIU Shusen | 2002 | Chinese Science Bulletin2002，47，6： | 0 |
| 12 | A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy显示文摘Oncogenes are critical factors in tumorigenesis of diverse cancer types and play essential roles in tumor immune escape.Mutations in Kirsten rat sarcoma viral oncogene homolog(KRAS)and epidermal growth factor receptor(EGFR)are among the most frequent gain-of-function alterations[1].After many years of in-depth research,inhibitors targeting EGFR or KRAS mutations have been successfully developed,however,their clinical benefit is relatively limited,and they will inevitably encounter the challenge of drug resistance.The emergence of resistance is attributed to secondary mutations in driver genes and other complicated factors. | Yingqiang Liu Linjiang Tong Mengge Zhang Qi Zhang Qiupei Liu Fang Feng Yan Li Mengzhen Lai Haotian Tang Yi Chen Meiyu Geng Wenhu Duan Jian Ding Hua Xie | 2024 | Cancer Communications2024，44，3： | 0 |
| 13 | 2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S(Cys797 to Ser797)mutant显示文摘Extensive structure-activity relationships(SARs)study of JND3229 was conducted to yield a series of new reve rsible 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine privileged scaffold as EGFRC797 S inhibitors.One of the most potent compound 6 i potently suppressed EGFRL858 R/T790 M/C797 S kinase with an IC50 value of 3.1 nmol/L,and inhibited the proliferation of BaF3 cells harboring EGFRL858 R/T790 M/C797 S and EGFR19 D/T790 M/C797 S mutants with IC50 values of 290 nmol/L and 316 nmol/L,respectively.Further,6 i dose-dependently induced suppression of the phosphorylation of EGFRL858 R/T790 M/C797 S and EGFR19 D/T790 M/C797 S in BaF3 cells.Compound 6 i may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer(NSCLC)patients. | Xianglong Hu Qiuju Xun Tao Zhang Su-Jie Zhu Qian Li Linjiang Tong Mengzhen Lai Tao Huang Cai-Hong Yun Hua Xie Ke Ding Xiaoyun Lu | 2020 | Chinese Chemical Letters2020，31，5： | 0 |
| 14 | Misorientation characteristics and textural changes induced by dense twins in high-purity Ti sheet after small strain rolling显示文摘A high-purity Ti(HP-Ti)sheet was subjected to small strain rolling(10%reduction)with microstructural and textural characteristics examined by electron channeling contrast imaging and electron backscatter diffraction techniques.Particular attentions were paid to misorientation and textural changes aroused by twins in the rolled HP-Ti sheet.Results show that after the 10%rolling,almost all the prior equiaxed grains in the initial specimen are twinned,leading to remarkable grain refinement.The presence of two major misorientation angle peaks around 65°and 85°is ascribed to{11-22}<11-23>and{10-12}<10-11>twinning,respectively,and two minor peaks around 47°and 77°are due mainly to impingement of various variants of such twins.Distinct from earlier work,the small strain rolling is confirmed to be able to induce drastic textural changes in pure Ti sheets:largely reduced texture intensity and appearance of new textural components.This can essentially be attributed to enhanced twinning activity due to much lower impurity contents of the present material.Primary{11?22}twins are mainly responsible for the new textural component of c-axes aligned near the rolling direction with spread,while the component of caxes parallel to the normal direction is due to reorientation of secondary{10-12}twins.This study clearly demonstrates the capability of small strain rolling to effectively modify both microstructures and textures of the HP?Ti sheet and may shed some light on exploring feasible processings for such materials. | DAI JiaHong ZENG LingGuo LI ZhiJun CHAI LinJiang ZHENG ZhiYing WU Hao MURTY KL GUO Ning | 2019 | Science China(Technological Sciences)2019，62，11： | 0 |
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