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| 1 | Cultivation of aerobic granular sludge in a conventional, continuous flow, completely mixed activated sludge system显示文摘氧气的小粒在常规、连续流动被形成,完全混合的激活的污泥系统(CMAS ) 。反应堆与包含很少细丝的种子污泥被接种并且用合成市政的废水喂了。污泥和一般水准的安定时间溶解了氧() 反应堆, 2 是 h 和 4.2 mg 散瑮慲楴湯 ? 敷敲甠敳 ? 湩琠敨搠獥污湩瑡潩 ? 档浡敢 ? 潴猠畴祤琠敨攠晦 ' ?景椠湯挠湯散瑮慲楴湯吗? | Xi CHEN Linjiang YUAN Wenjuan LU Yuyou LI Pei LIU Kun NIE | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 3 |
| 2 | WEAR AND LIFE OF PCBN TOOLS WHEN DRY-CUTTING BEARING STEEL GCr15显示文摘The wear forms and reasons of PCBN tools when dry-cutting bearing steel GCr15 are studied systematically. The effect law of the workpiece hardness on PCBN tools is gained and tool wearing with the quickest speed at the workpiece critical hardness is proved. The life equation at two kinds of workpiece hardness demonstrates that the effect of the cutting speed on the PCBN tool life is less than that of carbide tools and ceramic tools. | Liu Xianli Zhang Zhongmin Li ZhenjiaDepartment of Mechanical Engingeering, Harbin University of Science and Technology,Harbin 150080, ChinaLiu Linjiang Yuan ZhejunJilin University Harbin Institute of Technology | 2002 | Chinese Journal of Mechanical Engineering2002，15，3： | 3 |
| 3 | Simultaneous denitrifying phosphorus accumulation in a sequencing batch reactor显示文摘In order to achieve simultaneous nitrogen and phosphorus removal in the biological treatment process,denitrifying phosphorus accumulation(DNPA)and its affecting factors were studied in a sequencing batch reactor(SBR)with synthetic wastewater.The results showed that when acetate was used as the sole carbon resource in the influent,the sludge acclimatized under anaerobic/aerobic operation had good phos-phorus removal ability.Denitrifying phosphorus accumulation was observed soon when fed with nitrate instead of aeration following the anaerobic stage,which is a vital premise to DNPA.If DNPA sludge is fed with nitrate prior to the anaerobic stage,the DNPA would weaken or even disappear.At the high concen-tration of nitrate fed in the anoxic stage,the longer anoxic time needed,the better the DNPA was.Induced DNPA did not disap-pear even though an aerobic stage followed the anoxic stage,but the shorter the aerobic stage lasted,the higher the proportions of phosphorus removal via DNPA to total removal. | YUAN Linjiang HAN Wei WANG Lei YANG Yongzhe WANG Zhiying | 2007 | Frontiers of Environmental Science & Engineering2007，1，1： | 3 |
| 4 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 5 | ~1H MAS NMR spectra of kao-linite/formamide intercalation compound显示文摘The high spinning speed 1H magic angle spinning nuclear magnetic resonance (1H MAS NMR) technique was employed to distinguish the two groups of surface hy-droxyls of kaolinite and investigate the intercalation mechanism of kaolinite/formamide compound. The proton chemical shifts of the inner hydroxyl and inner surface hydroxyl of kaolinte are in the range of δ-1.3--0.9 and δ 2.4-3.0 respectively. After formamide intercalation three proton peaks were detected. The proton peak of the inner surface hydrox-yls of the intercalation compound shifts to high-field with δ2.3-2.7, which is assigned to the formation of the hydrogen bond between the inner surface hydroxyl and formamide carbonyl group. Whereas, the proton peak of the inner hydroxyl shifts to δ-0.3 toward low-field, that is attributed to van der Waal’s effect between the inner hydroxyl proton and the amino group proton of the formamide which may be keyed into the ditrigonal hole of the kaolinite. The third peak, additional proton peak, is in the | Linjiang Wang Daqing Wu Peng Yuan Zhiwei Chen Zhong Chen | 2002 | Chinese Science Bulletin2002，47，6： | 1 |
| 6 | Investigation on the delaminated-pillared structure of TiO2-PILC synthesized by TiCl4 hydrolysis method 显示文摘 | Yuan Peng Yin Xiaoling He Hongping Yang Dan Wang Linjiang Zhu Jianxi | 2006 | Microporous and Mesoporous Materials2006，93，： | 1 |
| 7 | Synthesis of 7-Triazole-substituted Camptothecin via Click Chemistry and Evaluation of in vitro Antitumor Activity显示文摘Camptothecin(CPT)is a natural topoisomerase I inhibitor with powerful antineoplastic activity against colorectal,breast,lung and ovarian cancers.To discover more potent antitumor agents,a series of new CPT derivatives were synthesized utilizing click chemistry.All compounds were assessed for cytotoxicity against A549,HCT-116,HT-29,LoVo,MDA-MB-231 cell lines,and some compounds exhibited good in vitro potency.Furthermore,all compounds kept or enhanced Topo I inhibition. | Lei Wang Wei Yuan Jie Zhang Linjiang Tong Yu Luo Yi Chen Wei Lu Qingqing Huang | 2014 | Chinese Journal of Chemistry2014，32，2： | 1 |
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