|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Evolution and variation of the Tsushima warm current during the late Quaternary: Evidence from planktonic foraminifera, oxygen and carbon isotopes显示文摘The evolution and variation history of the Tsushima warm current during the late Quaternary was reconstructed based on the quantitative census data of planktonic foraminiferal fauna, together with oxygen and carbon isotope records of mixed layer dweller G. ruber and thermocline dweller N. dutertrei in piston core CSH1 and core DGKS9603 collected separately from the Tsushima warm current and the Kuroshio dominated area. The result showed that the Tsushima warm current vanished in the lowstand period during 40―24 cal ka BP, while the Kuroshio still flowed across the Okinawa Trough, arousing strong upwelling in the northern Trough. Meanwhile, the influence of freshwater greatly increased in the northern Okinawa Trough, as the broad East China Sea continental shelf emerged. The freshwater reached its maximum during the last glacial maximum (LGM), when the upwelling obviously weakened for the lowest sea-level and the depression of the Kuroshio. The modern Tsushima warm current began its development since 16 cal ka BP, and the impact of the Kuroshio increased in the middle and north- ern Okinawa Trough synchronously during the deglaciation and gradually evolved as the main water source of the Tsushima current. The modern Tsushima current finally formed at about 8.5 cal ka BP, since then the circulation structure has been relatively stable. The water of the modern Tsushima cur- rent primarily came from the Kuroshio axis. A short-term wiggle of the current occurred at about 3 cal ka BP, probably for the influences from the enhancement of the winter monsoon and the depression of the Kuroshio. The cold water masses greatly strengthened during the wiggle. | LI TieGang SUN RongTao ZHANG DeYu LIU ZhenXia LI Qing JIANG Bo | 2007 | Science China Earth Sciences2007，50，5： | 15 |
| 3 | Optimal Structural Design of the Midship of a VLCC Based on the Strategy Integrating SVM and GA显示文摘在这份报纸,当模特儿和优化的一个混合过程,集成一台支持向量机器(SVM ) 和基因算法(GA ) ,被介绍在轮船的结构的优化减少高时间费用。SVM,根植于统计学习理论和结构的风险最小化的方法的近似实现,能在真实问题并且因而的输入产量关系高减少的 metamodeling 提供好归纳表演时间在真实问题的分析花费了,例如女性的分析。作为一种强大的优化技术, GA 为几乎不能与普通基于坡度的优化方法被优化的问题拥有显著优点,它为优化 SVM 造的模型使它合适。基于 SVM-GA 策略,在一个很大的粗略的搬运人( VLCC )的船体中央部的结构的少量的优化轮船在普通结构的规则( CSR )根据直接力量评价方法被执行,它最后在优化轮船表明 SVM-GA 的高效率在重计算复杂性下面的结构的少量。有 SVM-GA 的这优化的时间费用严厉地被减少了,许多更多的环在时间的小数量以内被处理了,设计显著地被改进了。 | Li Sun (1) welqi1986@gmail.com Deyu Wang (1) | 2012 | Journal of Marine Science and Application2012，11，1： | 11 |
| 4 | Features of the fault system and its relationship with migration and accumulation of hydrocarbon in Liaodong Bay显示文摘The fault system of Liaodong Bay developed extensively under the control of the Tanlu Fault.The fault system can be grouped into strike-slip faults of grade I,trunk faults of grade II and branch faults (induced faults) of grade III respectively based on its developmental scale.The faults of grade I and II were deep,early and large while the faults of grade III were shallow,late and small.The formation,evolution and distribution features played a significant role in controlling the migration of oil and gas in both horizontal and vertical directions.The fluid transfer in the fault system occurred in the process of faulting.The strike-slip and trunk faults moved actively forming predominant pathways for oil and gas migration.The branch faults,with weak activity,generally controlled the development of traps and were beneficial for the accumulation and preservation of oil and gas.The faults of grade I and II formed the major migration pathways for oil and gas,but their fault activity rates appeared to vary along their strikes.The zones with a relatively low fault activity rate might be favorable for oil and gas accumulation.When the activities of strike-slip,trunk,and branch faults came to a halt,the fault seal behavior had a vitally important effect on the accumulation of oil and gas.The controlling role of the fault over fluid distribution was further analyzed by calculating the fault activity quantitatively. | Xu Guosheng Ma Ruolong Gong Deyu Zhou Donghong Li Jianping Guo Yonghua Yuan Haifeng Wu Changrong | 2011 | Petroleum Science2011，8，3： | 8 |
| 5 | Oral health in China: from vision to action显示文摘Chinese president Xi Jinping made clear at the National Health and Wellness Conference that health is the prerequisite for people's all-around development and a precondition for the sustainable development of China. Oral health is an indispensable component of overall health in humans. However, the long neglect of oral health in overall health agendas has made oral diseases an increasing concern. With this perspective, we described the global challenges of oral diseases, with an emphasis on the challenges faced by China. We also described and analyzed the recently released health policies of the Chinese government, which aim to guide midterm and long-term oral health promotion in China. More importantly, we called for specific actions to fulfill the larger goal of oral health for the nation. The implementation of primordial prevention efforts against oral diseases, the integration of oral health into the promotion of overall health, and the management of oral diseases in conjunction with other chronic non-communicable diseases with shared risk factors were highly recommended. In addition, we suggested the reform of standard clinical residency training, the development of domestic manufacturing of dental equipment and materials, the revitalization traditional Chinese medicine for the prevention and treatment of oral diseases, and integration of oral health promotion into the Belt and Road Initiative. We look forward to seeing a joint effort from all aspects of the society to fulfill the goal of Healthy China 2030 and ensure the oral health of the nation. | Xuedong Zhou Xin Xu Jiyao Li Deyu Hu Tao Hu Wei Yin Yujiang Fan Xingdong Zhang | 2018 | International Journal of Oral Science2018，10，1： | 7 |
| 6 | A New Rational-based Optimal Design Strategy of Ship Structure Based on Multi-level Analysis and Super-element Modeling Method显示文摘A new multi-level analysis method of introducing the super-element modeling method, derived from the multi-level analysis method first proposed by O. F. Hughes, has been proposed in this paper to solve the problem of high time cost in adopting a rational-based optimal design method for ship structural design. Furthermore,the method was verified by its effective application in optimization of the mid-ship section of a container ship. A full 3-D FEM model of a ship,suffering static and quasi-static loads, was used as the analyzing object for evaluating the structural performance of the mid-ship module, including static strength and buckling performance. Research results reveal that this new method could substantially reduce the computational cost of the rational-based optimization problem without decreasing its accuracy, which increases the feasibility and economic efficiency of using a rational-based optimal design method in ship structural design. | Li Sun Deyu Wang | 2011 | Journal of Marine Science and Application2011，10，3： | 6 |
| 7 | Wide river or narrow river:Future river training strategy for Lower Yellow River under global change显示文摘The choice of a river training strategy is extremely important for the Lower Yellow River(LYR). Currently,the wide-river training strategy applies in the training of the LYR. However, remarkable changes in the hydrological processes in the Yellow River basin, as well as immediate pressure from socio-economic development in the Yellow River basin, make it necessary to consider if there is a possibility to change the river training strategy from wide-river training to narrow-river training. This research investigates the impacts of different river training strategies on the LYR through numerical simulations. A onedimensional(1-D) model was used to simulate the fluvial processes for the future 50 years and a threedimensional(3-D) model was applied to study typical floods. The study focused on river morphology, the results show that if the present decreasing trend in both water discharge and sediment load persists, the deposition rate in the LYR will further decrease no matter what strategy is applied. Especially, narrowriver training can achieve the aim to increase the sediment transport capacity in the LYR compared with wide-river training. However, if the incoming water and sediment load recovers to the mean level of the last century, main channel shrinkage due to sedimentation inevitably occurs for both wide-river and narrow-river training. Most importantly, this study shows that narrow-river training reduces the deposition amount over the whole LYR, but it provides little help in alleviating the development of the'suspended river'. Instead, narrow-river training can cause aggradation in the transitional reach where the river pattern changes from highly wandering to meandering, further worsening the 'hump deposition' there. Because of uncertainty regarding future changes in hydrological processes in the Yellow River basin, and the lack of feasible engineering measures to mitigate 'suspended river' and'hump deposition' problems in the LYR, caution should be exercised with respect to changes in the river training strategy for the LYR. | Xiaonan Li Deyu Zhong Y.Joseph Zhang Yanjun Wang Yongqiang Wang Hongwu Zhang | 2018 | International Journal of Sediment Research2018，33，3： | 5 |
| 8 | Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety显示文摘Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a–c) and substituted isothiocyanates (9a–d),chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a–l were prepared and completely characterized by elemental analysis,physical and spectral (IR,1H NMR,13C NMR,31P NMR) data.The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%,64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%,50.8% respectively),which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%),respectively.Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV. | YANG Xuan SONG BaoAn JIN LinHong WEI Xue BHADURY S Pinaki LI XiangYang YANG Song HU DeYu | 2011 | Science China Chemistry2011，54，1： | 5 |
| 9 | Exploration of presence/absence variation and corresponding polymorphic markers in soybean genome显示文摘This study was designed to reveal the genome‐wide distribution of presence/absence variation(PAV) and to establish a database of polymorphic PAV markers in soybean. The 33 soybean whole‐genome sequences were compared to each other with that of Williams 82 as a reference genome. A total of 33,127 PAVs were detected and 28,912 PAV markers with their primer sequences were designed as the database NJAUSoyPAV_1.0. The PAVs scattered on whole genome while only 518(1.8%) overlapped with simple sequence repeats(SSRs) in BARCSOYSSR_1.0database. In a random sample of 800 PAVs, 713(89.13%) showed polymorphism among the 12 differential genotypes. Using 126 PAVs and 108 SSRs to test a Chinese soybean germplasm collection composed of 828 Glycine soja Sieb. et Zucc. and Glycine max(L.) Merr. accessions, the per locus allele number and its variation appeared less in PAVs than in SSRs. The distinctness among alleles/bands of PCR(polymerase chain reaction) products showed better in PAVs than in SSRs, potential in accurate marker‐assisted allele selection. The association mapping results showed SSR t PAV was more powerful than any single marker systems.The NJAUSoyPAV_1.0 database has enriched the source of PCR markers, and may fit the materials with a range of per locus allele numbers, if jointly used with SSR markers. | Yufeng Wang Jiangjie Lu Shouyi Chen Liping Shu Reid G.Palmer Guangnan Xing Yan Li Shouping Yang Deyue Yu Tuanjie Zhao Junyi Gai | 2014 | Journal of Integrative Plant Biology2014，56，10： | 5 |
| 10 | Catastrophe mechanism and disaster countermeasure for soft rock roadway surrounding rock in Meihe mine显示文摘The soft rock's heterogeneity and nonlinear mechanical behavior cause extremely difficult maintenance on the soft rock roadway. Aiming at the asymmetric deformation and destruction phenomenon appearing after excavating and supporting the 7101 air return way in Meihe mine, this paper comprehensively adopted a variety of methods to analyze the roadway surrounding rock deformation rule, obtaining the roadway surrounding rock stress and plastic zone distribution rule under no supporting condition and the roadway surrounding rock deformation features under original symmetric supporting condition.Furthermore, this paper revealed the catastrophe mechanism, and proposed the concept of ‘‘weak structure'' and the disaster countermeasure of ‘‘overall stabilizing the roadway and strengthening the support of weak structure''. The industrial test shows that the disaster control technology can realize the coordination deformation of the supporting structure and roadway surrounding rock, thus significantly controlling the deformation of roadway surrounding rock. | Yu Yang Zhu Caikun Chong Deyu Liu Yang Li Sichao | 2015 | International Journal of Mining Science and Technology2015，25，3： | 5 |
| 11 | To explore the curative effect of CT-guided Iodine-125 radioactive seed implantation in the treatment of stage Ⅳprimary hepatocellular carcinoma显示文摘Objectives: To explore the clinical efficacy and survival of CT-guided Iodine-125 radioactive seed implantation in the treatment of stage Ⅳ primary hepatocellular carcinoma.Methods: A retrospective study of 62 patients with primary hepatocellular carcinoma in our hospital from January2017 to December 2018 [60 males, 2 females, age(52.76 ± 10.82) years old], All patients were implanted with Iodine-125 radioactive seeds under CT guidance, followed up regularly after operation to observe the clinical efficacy, including comparison of changes in cancer size before and after treatment, tumor marker AFP, and improvement in complications such as abdominal pain and ascites. Follow-up 3–36 months to assess patient survival.Results: Among the 62 patients, 3 months after Iodine-125 radioactive seed implantation, 5 cases(8.1%) had complete remission of cancer, 33 cases(53.2%) had partial remission, 12 cases(19.4%) had stable lesions, and 12 cases(19.4%) had disease progression. The effective rate was 61.3%. The tumor volume(31.44 ± 14.51 cm3) was significantly smaller than before(50.96 ± 30.13 cm3)(t=5.303, p < 0.05). The tumor marker AFP(69.28 ±50.99) ug/L of 3 months after implantation was significantly lower than that before treatment(90.63 ± 68.58)ug/L(t=3.702, P < 0.05). The average survival time of Iodine-125 seed implantation for stageⅣhepatocellular carcinoma is 11.47 ± 0.85 months, and the median survival time is 9 months. The survival time of the group with better pathological differentiation(grade Ⅰ+ⅡⅠ) was significantly better than that of the group with poor differentiation(grade Ⅲ+Ⅳ)(x2=6.869 p < 0.05). Among the 38 patients with different degrees of abdominal pain,22 patients improved better than before;15 of 28 patients with different degrees of ascites were better than before. All patients had no serious complications related to treatment.Conclusions: Iodine-125 radioactive seed implantation therapy can safely and effectively treat hepatocellular carcinoma, and relieve the clinical symptoms of abdominal pain and ascites. | Fuqiang Zhang Lin Zheng Deyu Li Hui Yang | 2021 | Journal of Interventional Medicine2021，4，2： | 4 |
| 12 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 13 | Corrosion protection properties of vanadium films formed on zinc surfaces显示文摘Vanadium films were prepared on zinc surfaces by using a solution containing vanadate.Corrosion protection properties of vanadium-treated (V-treated),chromium-treated (Cr-treated),and untreated zinc surfaces in contact with a 3.5 wt.% NaCl solution were studied using potentiodynamic polarization,electrochemical impedance spectroscopy (EIS),and neutral salt spray (NSS) tests.According to these results,the V-treated layer significantly improved the corrosion resistance of zinc surfaces.In comparison with the Cr-treated layer,the V-treated layer exhibited a better corrosion resistance.The composition of the V-treated layer was studied using X-ray photoelectron spectroscopy (XPS).XPS measurements indicated that the vanadium layer formed on zinc surfaces and the vanadium-rich coating was a hydrated oxide with a composition of V2O5,VO2,and its hydrates such as V2O5·nH2O and VO(OH)2. | ZOU Zhongli LINing LI Deyu | 2011 | Rare Metals2011，30，2： | 4 |
| 14 | Calculation and Regulation of Residual Stress Distributionfor Superhybrid Composites显示文摘The distribution of residual stresses of ARALL with different prestresses i5 calculated by finite element theory. A new method for regulating the residual stress, that is, introducing interim layer between aramid and Al layers. is given out. Applying prestress to the laminate has strong effects on the distribution of normal stress along the fiber direction. The interim layer in fiber direction presents a state with gradient distribution. | Zhong, Weihong Cui, Deyu Gu, Zhifen Chen, Changqi Li, Hongyun
| 1999 | Journal of Materials Science & Technology1999，15，2： | 3 |
| 15 | Relationship between triphasic mechanical properties of articular cartilage and osteoarthritic grade显示文摘The purpose of this study was to explore the triphasic mechanical properties of osteoarthritic cartilage with different pathological grades.First,samples of cartilage from rabbits with different stages of osteoarthritis (OA) were graded.Following this,the cartilage was strained by a swelling experiment,and changes were measured using a high-frequency ultrasound system.The result,together with fixed charge density and water volume fraction of cartilage samples,was used to estimate the uniaxial modulus of the cartilage tissue,based on a triphasic model.For the control cartilage samples,the uniaxial elastic modulus on the cartilage surface was lower than those in the middle and deep layers.With an increase in the OA grade,the uniaxial elastic modulus of the surface,middle and deep layers decreased.A significant difference was found in the surface elastic modulus of different OA grades (P<0.01),while no significant differences were identified for OA cartilages of Grades 1 and 2 in the middle and deep layers (P<0.01).Compared with Grades 1 and 2,there was a significant reduction in the elastic modulus in the middle and deep layers of Grade 3 OA cartilage (P<0.05).Overall,this study may provide a new quantitative method to evaluate the severity of OA using the mechanical properties of cartilage tissue. | NIU HaiJun LIU ChengRui LIAng WANG Qing WANG YueXiang LI DeYu FAN YuBo | 2012 | Science China(Life Sciences)2012，55，5： | 3 |
| 16 | A recombinant receptor-binding domain in trimeric form generates protective immunity against SARSCoV-2 infection in nonhuman primates显示文摘A safe and effective vaccine is critical to combat the COVID-19 pandemic.Here,we developed a trimeric SARS-CoV-2 receptor-binding domain(RBD)subunit vaccine candidate that simulates the natural structure of the spike(S)trimer glycoprotein.Immunization with the RBD trimer-induced robust humoral and cellular immune responses,and a high level of neutralizing antibodies was maintained for at least 4.5 months.Moreover,the antibodies that were produced in response to the vaccine effectively cross-neutralized the SARS-CoV-2501Y.V2 variant(B.1.351).Of note,when the vaccine-induced antibodies dropped to a sufficiently low level,only one boost quickly activated the anamnestic immune response,conferring full protection against a SARSCoV-2 challenge in rhesus macaques without typical histopathological changes in the lung tissues.These results demonstrated that the SARS-CoV-2 RBD trimer vaccine candidate is highly immunogenic and safe,providing long-lasting,broad,and significant immunity protection in nonhuman primates,thereby offering an optimal vaccination strategy against COVID-19. | Limin Yang Deyu Tian Jian-bao Han Wenhui Fan Yuan Zhang Yunlong Li Wenqiang Sun Yanqiu Wei Xiaodong Tian Dan-dan Yu Xiao-li Feng Gong Cheng Yuhai Bi Yong-tang Zheng Wenjun Liu | 2021 | The Innovation2021，2，3： | 3 |
| 17 | Ultrasound speed and attenuation in progressive trypsin digested articular cartilage显示文摘Subtle changes of articular cartilage(AC) can lead to tissue degeneration and even osteoarthritis(OA).The early degeneration of AC is closely related to a change in proteoglycans(PG) content.The observation of PG is therefore an appropriate way of studying OA and evaluating the degree of AC degeneration.In this study,20 cartilage-bone samples were prepared from normal porcine femoral condyle cartilage and 10 samples were digested over 2 h using 0.25% trypsin solution.The dynamic process of PG-digestion was explored using a conventional A-mode ultrasound(US) experimental system with a 10 MHz center frequency.Quantitative acoustic parameters were calculated from ultrasonic radio-frequency echo signals and included US speed(USS),US amplitude attenuation coefficient(UAA) and broadband US attenuation coefficient(BUA).The experimental results showed that the conventional A-mode ultrasound is valuable for tracking the degree of PG-digestion.Histology also confirmed the validity of the ultrasound observations.For every AC sample,the degree of PG-digestion within a given time was different and was affected by individual differences.After two hours of degeneration,USS showed a mean decrease of 0.4%(P<0.05).UAA was significantly lower after a two-hour PG depletion period(from(2.45±0.23) to(2.28±0.41) dB mm?1).BUA showed no significant differences during this process.In conclusion,conventional ultrasound can provide useful information about trypsin-induced progressive PG depletion in AC and can reflect variations of PG content via the quantitative acoustic parameters USS and UAA.The results of this study may be used to identify an indirect indicator of cartilage matrix integrity and OA disease progression. | NIU HaiJun LI LiFeng SUN Feng YAN Yan WANG YueXiang LI DeYu FAN YuBo | 2011 | Science China(Life Sciences)2011，54，11： | 3 |
| 18 | FILTERING OF MEDICAL ULTRASONIC IMAGES BASED ON A MODIFIED ANISTROPIC DIFFUSION EQUATION显示文摘Speckle noise reduction is a key problem of the image analysis of medical UltraSound images. In this paper, two important improvements have been developed to a fast anisotropic diffusion algorithm for speckle noise reduction. The Gaussian filter is firstly used before gradient calculation, and then the adaptive algorithm of the factor k is proposed. Numerous experimental results show that the proposed model is superior to other methods in noise removal, fidelity and edge preservation. It is suitable for the preprocessing of a great number of medical UltraSound images, such as three dimen- sional reconstruction. | Wang Ling Li Deyu Wang Tianfu Lin Jiangli Peng Yun Rao Li Zheng Yi | 2007 | Journal of Electronics(China)2007，24，2： | 3 |
| 19 | Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs显示文摘The progression and metastasis of solid tumors strongly rely on the process of forming nascent blood vessels.However,using angiogenesis inhibitors alone does not meet the cancer treatment needs.Herein,we used the amphiphilic drug-drug conjugate(ADDC)strategy to fabricate a new drug conjugate with the combination of chemotherapeutic drug and antiangiogenesis drug together.With one-step esterification of hydrophilic floxuridine(FUDR)and hydrophobic pseudolaric acid B(PAB),the conjugate was synthesized.The amphiphilic property of FUDR-PAB conjugate induced the self-assembly to form nanoparticles in water.From further in vitro and in vivo experiments,this FUDR-PAB conjugate does not only have a high antitumor effect,but also shows efficient antianiogenesis property.These results offer a promising ADDC strategy for designing drugs with combination of chemotherapeutic drug and antiangiogenesis drug together. | Mo Sun Qiuhui Qian Leilei Shi Li Xu Qunfang Liu Linzhu Zhou Xinyuan Zhu Jian-Min Yue Deyue Yan | 2020 | Science China Chemistry2020，63，1： | 3 |
| 20 | pH-responsive poly(2-diethylaminoethyl methacrylate)-functionalized multiwalled carbon nanotubes显示文摘Poly(2-diethylaminoethyl methacrylate) (PDEAEMA)-coated multiwalled carbon nanotubes (MWNT- PDEAEMA) were successfully prepared by MWNT-surface initiated atom transfer radical polymerization (ATRP). The obtained MWNT-PDEAEMA nanocylinders have a core of MWNT and a shell of PDEAEMA and this core-shell struc- ture was confirmed by TEM observations. The UV-Vis and AFM measurements showed that the MWNT-PDEAEMA exhibited obvious pH sensitivity. The solubility of PDEAEMA-coated MWNT dramatically decreased when pH increased to ca. 7.0. Because of the giant molecular weight of the molecular hybrids and local high density of polymeric grafts linked onto MWNTs, the resulting MWNT-PDEAEMA nanocomposites are easier to aggregate, or more sensitive to pH, as compared with the neat PDEAEMA. | LI Wenwen KONG Hao GAO Chao YAN Deyue | 2005 | Chinese Science Bulletin2005，50，20： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员