|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients. | Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | NAC Transcription Factor ORE1 and Senescence- Induced BIFUNCTIONAL NUCLEASE1 (BFN1) Constitute a Regulatory Cascade in Arabidopsis显示文摘老朽是包含很多抄写因素的行动的一个高度调整的过程。NAC 抄写因素 ORE1 (ANAC092 ) 最近被显示了在断然在 Arabidopsis thaliana 控制老朽起一个关键作用;然而,它通过施加它的分子的功能的直接目标基因都没以前被识别。这里,我们报导那 BIFUNCTIONAL NUCLEASE1 (BFN1 ) ,著名提高老朽的基因,被 ORE1 直接调整。我们已经检测了 BFN1 的提高的表示在在 estradiol 可诱导的 ORE1 overexpression 线的 ORE1 的正式就职以后的 2 h 和在有 35S:ORE1 的 Arabidopsis 叶肉房间原物的 transfection 以后的 6 h 构造。当在衰老的叶子和成熟的花机关的截去地区的 BFN1 表示在 ore1 异种背景是几乎不在的时, ORE1 和 BFN1 表示模式大部分重叠,由 promoterreporter 显示出基因(GUS ) 熔化。在 vitro 绑定地点试金揭示了一个由两部组成的 ORE1 有约束力的地点,类似于 ORS1 的, ORE1 的 paralog。一个由两部组成的 ORE1 有约束力的地点在 BFN1 倡导者被识别;变异在全身的 BFN1 倡导者的上下文以内的 cis 元素急速地减少了调停 ORE1 的 transactivation 能力在短暂地 transfected Arabidopsis 叶肉房间原物。而且,染色质 immunoprecipitation (薄片) 在 ORE1 有约束力的 vivo 示威到 BFN1 倡导者。我们也在 vivo 表明 ORE1 的绑定到二另外的联系老朽的基因的倡导者,也就是 SAG29/SWEET15 和 SINA1,在老朽期间支持 ORE1 的中央角色。 | Lilian R Matallana-Ramirez Mamoona Rauf Sarit Farage-Barhom Hakan Dortay Gang-Ping Xue Wolfgang Droge-Laser Amnon Lers Salma Balazadeh Bernd Mueller-Roeber | 2013 | Molecular Plant2013，6，5： | 8 |
| 3 | 黄斑蜂族的系统学研究:几何形态测量方法 (膜翅目:切叶蜂科)显示文摘利用采集于土耳其安纳托利亚中部(Middle Anatolia)的切叶蜂科6个种92头标本,选取虫体上的30个特征点(1andmarks)(其中前翅16个,后翅6个,头部8个),利用UPGMA等数值分类方法对不同属和种的亲缘关系进行了探讨.据此对一些种的归属和一些属的划分提出了一些与传统分类观点相同或不同的见解,但各种分析方法的结果都支持切叶蜂族Megachilini起源的单系性. | Yasemin GüLER A.MuratAYTEKN Nee?AATAY | 2006 | 昆虫学报2006，49，3： | 8 |
| 4 | 表面离子注入降低池式沸腾条件下CaSO_4污垢生成显示文摘通过离子注入技术,对加热器表面进行处理,改善了金属表面的抗垢性能。在池式沸腾装置中对CaSO4溶液的结垢过程进行了实验研究,并将离子注入表面的抗垢性能与未处理表面进行了比较。研究表明,经离子注入的加热器表面具有良好的抗垢性能。 | 任晓光 刘嘉敏 刘长厚 赵起 Hans Mler Steinhagen | 2001 | 高校化学工程学报2001，15，5： | 8 |
| 5 | Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis显示文摘BACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal gland.In this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis.METHODS:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation.The first group had only acute pancreatitis and served as the control.Surgical pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic tissue.RESULT:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue.CONCLUSION:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis. | Cavit l Kahraman Dinler O■uz Hasdemir Oktay Büyüka■ik Güler Bu■dayci | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 6 | 一种人工天青石矿的浮选及夹带行为的统计分析(英文)显示文摘研究浮选参数对泡沫浮选脉石回收率的影响,测试了pH=10时起泡剂类型和捕收剂用量对浮选性能的影响。采用方差分析了测试结果。在用油酸钠作捕收剂的情况下,亲水性矿物的浮选主要是由于Ca+2离子对石英的活化产生的疏水性而导致的夹带作用所引起的;夹带和矿泥包裹层对浮选也有一定的影响。在浮选产物中脉石的夹带程度随着矿石颗粒粒度的减小而增加。实验结果表明,通过增大捕收剂用量、缩短浮选时间,可以减小水流夹带作用,提高浮选的选择性。 | Taki GüLER ünal AKDEMR | 2012 | Transactions of Nonferrous Metals Society of China2012，22，1： | 5 |
| 7 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 8 | Localization of the Arabidopsis Senescence- and Cell Death-Associated BFN1 Nuclease: From the ER to Fragmented Nuclei显示文摘植物联系老朽或联系 PCD 的核酸酶从不同有机体与核酸酶分享重要相同。然而,他们的功能的知识是有限的。Arabidopsis 联系老朽、联系 PCD 的核酸酶 BFN1 的细胞内部的本地化被调查。在短暂地转变的烟草原物的 BFN1GFP 本地化的分析表明在细丝状的结构的起始的本地化在整个细胞质传播了,它然后在原物开始衰老的原子核附近聚类。这些细丝状的结构作为具有被识别嗯起源。在 BFN1GFP 转基因的 Arabidopsis 植物, BFN1GFP 的类似的本地化在年轻叶子被观察,也就是说,在细丝状的结构,那仅仅在开始衰老在原子核附近重新组织房间。在迟了的老朽, BFN1GFP 与在包膜的泡的碎裂的原子核是局部性的。BFN1 的要求的功能作为 nucleic,在老朽和 PCD 的酸降级的酶被它的本地化模式支持。我们的结果建议在老朽和 PCD 的 nucleic 酸降级处理的调停的奉献分隔空间的存在。 | Sarit Farage-Barhom Shaul Burd Lilian Sonego Ana Mett Eduard Belausov David Gidoni Amnon Lers | 2011 | Molecular Plant2011，4，6： | 5 |
| 9 | Sodium alendronate loaded poly(L-lactideco-glycolide)microparticles immobilized on ceramic scaffolds for local treatment of bone defects显示文摘Bone tissue regeneration in critical-size defects is possible after implantation of a 3D scaffold and can be additionally enhanced once the scaffold is enriched with drugs or other factors supporting bone remodelling and healing.Sodium alendronate(Aln),a widely used anti-osteoporosis drug,exhibits strong inhibitory effect on bone resorption performed by osteoclasts.Thus,we propose a new approach for the treatment of bone defects in craniofacial region combining biocompatible titanium dioxide scaffolds and poly(L-lactide-co-glycolide)microparticles(MPs)loaded with Aln.The MPs were effectively attached to the surface of the scaffolds’pore walls by human recombinant collagen.Drug release from the scaffolds was characterized by initial burst(2466% of the drug released within first 24 h)followed by a sustained release phase(on average 5 mg of Aln released per day from Day 3 to Day 18).In vitro tests evidenced that Aln at concentrations of 5 and 2.5 mg/ml was not cytotoxic for MG-63 osteoblast-like cells(viability between 8166% and 9863% of control),but it prevented RANKL-induced formation of osteoclast-like cells from macrophages derived from peripheral blood mononuclear cells,as shown by reduced fusion capability and decreased tartrateresistant acid phosphatase 5b activity(5665% reduction in comparison to control after 8 days of culture).Results show that it is feasible to design the scaffolds providing required doses of Aln inhibiting osteoclastogenesis,reducing osteoclast activity,but not affecting osteoblast functions,which may be beneficial in the treatment of critical-size bone tissue defects. | Lucja Rumian Cornelia Wolf-Brandstetter Sina Roβler Katarzyna Reczynska Hanna Tiainen Havard J.Haugen Dieter Scharnweber Elzbieta Pamula | 2020 | Regenerative Biomaterials2020，7，3： | 5 |
| 10 | 快速产品开发——一种整体的产品开发模式显示文摘传统的产品开发方法变得越来越不能胜任今天的需求,产品开发中那种连续的、严格分工的泰勒工作方式日益表现出其不足之处。这里介绍的快速产品开发(RPD)模式提供了一种集成的方法,它能够保证整体的考虑,兼顾组织、经济和技术的观点。由于其中一些原理目前还缺少广泛的实际应用和评价,作者在这里只是提供了一个用RPD模式重组产品开发过程的实例。 | 吕新生 H.-J.Bullinger J.Warschat K.F.Wiβler V.Seitz | 1997 | 工程设计学报1997，，3： | 4 |
| 11 | CO_2对离体欧芹叶片中蛋白质代谢的影响显示文摘以离体欧芹叶片为实验系统 ,研究了CO2 对叶片中蛋白质降解的影响。对离体欧芹叶片中游离氨基酸含量及可溶蛋白含量的分析结果表明 :CO2 具有抑制离体欧芹叶片中蛋白质降解的作用 ,这为进一步了解CO2 延缓叶片衰老的作用机理很有意义。 | 姜微波 Amnon LERS Nehemia AHARONI | 2000 | 植物学通报2000，17，2： | 4 |
| 12 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 13 | Industrial Communication with Ethernet and Fieldbuses显示文摘 | Martin Müler | 2004 | 自动化博览2004，21，4： | 3 |
| 14 | 渗碳钢的高温渗碳显示文摘提高渗碳处理时的加热温度可以缩短处理时间。通过奥氏体化处理确定出了对常用渗碳钢能保证稳定的细晶粒结构组织的最佳渗碳温度和时间。试验表明,对于20MnCr、17CrNiMo6、20MoCrS4和EX55钢渗C温度可提高到1000℃以上而不致出现晶粒长大。此时渗碳时间可缩短到两小时以下。 | V.Schüler B.Huchtemann E.Wulfmeier 陈世杰 | 1991 | 国外金属热处理1991，12，5： | 3 |
| 15 | Radioembolization of Symptomatic, Unresectable Neuroendocrine Hepatic Metastases Using Yttrium-90 Microspheres显示文摘 | Philipp M. Paprottka Ralf-T. Hoffmann Alexander Haug Wieland H. Sommer Franziska Rae?ler Christoph G. Trumm Gerwin P. Schmidt Nima Ashoori Maximilian F. Reiser Tobias F. Jakobs | 2012 | CardioVascular and Interventional Radiology2012，，2： | 2 |
| 16 | Geographic routing in city scenarios显示文摘 | Christian Lochert Martin Mauve Holger Fü?ler Hannes Hartenstein | 2005 | ACM SIGMOBILE Mobile Computing and Communications Review2005，，1： | 2 |
| 17 | Corrosion behavior of steels for CO 2 injection显示文摘 | O. Yevtushenko D. Bettge S. Bohraus R. B??ler A. Pfennig A. Kranzmann | 2013 | Process Safety and Environmental Protection2013，，： | 2 |
| 18 | Estimation of Throughfall Erosivity in a Highly Diverse Forest Ecosystem Using Sand-Filled Splash Cups显示文摘Sand-filled splash cups were used to study the erosive power of rainfall and throughfall in the humid subtropics of Southeast China. The splash cup measurements yielded precise and reproducible results under both open field conditions and forest vegetation. The splash cups were exposed to specific forest stands of different ages and to selected species (Schima superba, Castanopsis eyrei, Daphniphyllum oldhamii, Lithocarpus glaber) in the Gutianshan (古田山) National Nature Reserve (GNNR). The results of the measurements under forest vegetation show that the erosive power of throughfall drops to be 2.59 times higher compared to the open field. This accentuates the importance of shrub, herb and litter layers in forest ecosystems to protect the soil against erosion. Coalescing drops from leaves and branches (drips) are responsible for this notable gain in erosive power. Moreover, differences in sandloss between the investigated tree species (deciduous, evergreen) revealed that the erosion potential and the spatial heterogeneity of throughfall are species-specific. This highlights the importance of selecting specific species for afforestation projects considering the prevention of soil erosion. | Christian Geiβler Peter Kühn 史学正 Thomas Scholten | 2010 | Journal of Earth Science2010，21，6： | 2 |
| 19 | Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4显示文摘 | Jennifer Nichols Branko Zevnik Konstantinos Anastassiadis Hitoshi Niwa Daniela Klewe-Nebenius Ian Chambers Hans Sch?ler Austin Smith | 1998 | Cell1998，，3： | 2 |
| 20 | Fatal Outcome of Lung Transplantation in Cystic Fibrosis Patients due to Small-Colony Variants of the Burkholderia cepacia Complex显示文摘 | S. H?u?ler C. Lehmann C. Breselge M. Rohde M. Cla?en B. Tümmler P. Vandamme I. Steinmetz | 2003 | European Journal of Clinical Microbiology & Infectious Diseases2003，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员